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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21697 results · page 173 of 724

Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

A Coarse-Grained Molecular Dynamics Perspective on the Release of 5-Fluorouracil from Liposomes

Roxana-Maria Amărandi, Luminița Marin, Brînduşa Drăgoi et al. · 2024 · Molecular Pharmaceutics

High Resolution Image Download MS PowerPoint Slide Liposomes, small bilayer phospholipid-containing vesicles, are frequently used to ensure slow drug release for a prolonged and improved therapeutic effect. Nevertheless, current findings…

View details →DOI: 10.1021/acs.molpharmaceut.4c00328Cited by 9
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Genomics of Neotropical biodiversity indicators: Two butterfly radiations with rampant chromosomal rearrangements and hybridization

Eva S. M. van der Heijden, Karin Näsvall, Fernando Seixas et al. · 2025 · Proceedings of the National Academy of Sciences

A central question in evolutionary biology is what drives the diversification of lineages. Rapid, recent radiations are ideal systems for this question because they still show key morphological and ecological adaptations associated with speciation. While most research on recent radiations focuses on those occurring in insular environments, less attention has been given to continental radiations with complex species interactions. Here, we study the drivers of continental radiations of Melinaea and Mechanitis butterflies (Nymphalidae: Ithomiini), which have rapidly radiated in the continental Ne

View details →DOI: 10.1073/pnas.2410939122Cited by 9
Negative / Null Result ReportOpen accessMedicine

Heterogeneous endocrine cell composition defines human islet functional phenotypes

Carmella Evans‐Molina, Yasminye D. Pettway, Diane C. Saunders et al. · 2026 · Nature Communications

Phenotyping and genotyping initiatives within the Integrated Islet Distribution Program (IIDP), the largest source of human islets for research in the U.S., provide standardized assessment of islet preparations distributed to researchers…

View details →DOI: 10.1038/s41467-026-70689-5Cited by 9
Negative / Null Result ReportOpen accessVeterinary

Socializing AI: Integrating Social Network Analysis and Deep Learning for Precision Dairy Cow Monitoring—A Critical Review

Sibi Chakravathy Parivendan, Kashfia Sailunaz, Suresh Neethirajan · 2025 · Animals

This review critically analyzes recent advancements in dairy cow behavior recognition, highlighting novel methodological contributions through the integration of advanced artificial intelligence (AI) techniques such as transformer models and multi-view tracking with social network analysis (SNA). Such integration offers transformative opportunities for improving dairy cattle welfare, but current applications remain limited. We describe the transition from manual, observer-based assessments to automated, scalable methods using convolutional neural networks (CNNs), spatio-temporal models, and at

View details →DOI: 10.3390/ani15131835Cited by 9
Negative / Null Result ReportOpen accessMedicine

Perspectives on Artificial Intelligence in Dermatology: An International Cross-Sectional Study

Emmanouil Karampinis, Christina-Marina Zoumpourli, Aimilios Lallas et al. · 2026 · Medicina

Background and Objectives: Artificial intelligence (AI) has transitioned to an integral part of dermatology in only few years, yet perceptions of its use vary widely, reflecting diverse hopes, concerns, and perceived clinical utility. Materials and Methods: In this study, 300 dermatologists from 13 countries, representing a range of experience levels and AI usage statuses, were surveyed regarding the characteristics and applications of AI in dermatology. Results: Among respondents, 61.33% reported having used AI tools in clinical practice. Adoption of AI was observed across all age groups, cou

View details →DOI: 10.3390/medicina62040759Cited by 9
Negative / Null Result ReportOpen accessMedicine

Performance of adult-trained artificial intelligence models in paediatric imaging—a scoping review

Lene Bjerke Laborie, Jennifer Lee, Edward Antram et al. · 2026 · European Radiology

OBJECTIVES: This scoping review aims to evaluate the performance of artificial intelligence (AI) models designed for adults when applied to paediatric imaging datasets without additional adaptations, and to quantify performance degradation across different modalities, use-cases and age groups. MATERIALS AND METHODS: A literature search was conducted covering 10 years (1/01/2014-23/06/2025) using terms relating to "child", "adult", "artificial intelligence", "radiology" and "validation/performance". Two reviewers independently extracted data using standardised templates and conducted a narrativ

View details →DOI: 10.1007/s00330-026-12354-5Cited by 9
Negative / Null Result ReportOpen accessNeuroscience

A ratiometric ER calcium sensor for quantitative comparisons across cell types and subcellular regions

Ryan J. Farrell, S. Thomas Hennigan, Kirsten G. Bredvik et al. · 2026 · The Journal of General Physiology

The ER is an important regulator of Ca2+ in cells and dysregulation of ER Ca2+ homeostasis can lead to numerous pathologies. Understanding how various pharmacological and genetic perturbations of ER Ca2+ homeostasis impact cellular…

View details →DOI: 10.1085/jgp.202413564Cited by 9
Negative / Null Result ReportOpen accessMaterials Science

Dual rare-earth modification and interface engineering in SiC-based heterostructures for multi-frequency electromagnetic wave absorption

Jingyi Xu, Zhanming Wu, Yunan Tan et al. · 2026 · Journal of Advanced Ceramics

Abstract The escalating complexity of the electromagnetic environment calls for advanced electromagnetic wave (EMW) absorption materials capable of efficient multi-frequency attenuation. Silicon carbide (SiC) is a promising dielectric candidate but is hindered by intrinsic impedance mismatch and limited polarization loss. Herein, we report a novel ternary heterostructure absorber consisting of SiC nanowires synergistically coupled with dual rare-earth silicides (Ce5Si4 and Pr5Si4) fabricated via a combined magnesiothermic and carbothermal reduction process using an MFI-type zeolite precursor.

View details →DOI: 10.26599/jac.2026.9221325Cited by 9
Negative / Null Result Report

Evolutionary opportunity and the limits of community similarity in replicate radiations of island lizards

Luke Owen Frishkoff, Gavia Lertzman‐Lepofsky, D. Luke Mahler · 2022 · Ecology Letters

Abstract Ecological community structure ultimately depends on the production of community members by speciation. To understand how macroevolution shapes communities, we surveyed Anolis lizard assemblages across elevations on Jamaica and…

View details →DOI: 10.1111/ele.14098Cited by 8
Negative / Null Result Report

Inflation in 2022 did not affect congressional voting, but abortion did

Diana C. Mutz, Edward D. Mansfield · 2024 · Proceedings of the National Academy of Sciences

This study examines voting in the 2022 United States congressional elections, contests that were widely expected to produce a sizable defeat for Democratic candidates for largely economic reasons. Based on a representative national…

View details →DOI: 10.1073/pnas.2319512121Cited by 8
Negative / Null Result Report

Significant Prognostic Factors Influencing the Survival Difference of Oral Tongue Squamous Cell Carcinoma

Sarinya Boonpoapichart, Pattama Punyavong, Kamonwan Jenwitheesuk et al. · 2021 · Plastic and Reconstructive Surgery - Global Open

Background: Oral tongue squamous cell carcinoma is the most common malignancy in the oral cavity. Overall survival varies across many countries, and poor prognosis is prevalent in developing countries, including Thailand. Our study aimed…

View details →DOI: 10.1097/gox.0000000000003889Cited by 8
Negative / Null Result Report

Phytoplankton settling quality has a subtle but significant effect on sediment microeukaryotic and bacterial communities

Séréna Albert, Per Hedberg, Nisha H. Motwani et al. · 2021 · Scientific Reports

Abstract In coastal aphotic sediments, organic matter (OM) input from phytoplankton is the primary food resource for benthic organisms. Current observations from temperate ecosystems like the Baltic Sea report a decline in spring bloom…

View details →DOI: 10.1038/s41598-021-03303-xCited by 8
Negative / Null Result Report

Biologically relevant small variations of intra-cellular pH can have significant effect on stability of protein–DNA complexes, including the nucleosome

Alexey V. Onufriev · 2023 · Frontiers in Molecular Biosciences

Stability of a protein-ligand complex may be sensitive to pH of its environment. Here we explore, computationally, stability of a set of protein-nucleic acid complexes using fundamental thermodynamic linkage relationship. The nucleosome,…

View details →DOI: 10.3389/fmolb.2023.1067787Cited by 8
Negative / Null Result Report

NUMBER OF RUNS VARIATIONS ON AUTODOCK 4 DO NOT HAVE A SIGNIFICANT EFFECT ON RMSD FROM DOCKING RESULTS

M.R.F. Pratama, S. Siswandono · 2021 · Pharmacy & Pharmacology

The aim . The number of runs in the docking process with AutoDock 4 is known to play an important role in the validity of the results obtained. The greater the number of runs it is often associated with the more valid docking results.…

View details →DOI: 10.19163/2307-9266-2020-8-6-476-480Cited by 8
Negative / Null Result Report

Effect of Significant Postoperative Complications on Decision Regret After Laparoscopic Sleeve Gastrectomy: a Case–Control Study

Katarzyna Bartosiak, Michał R. Janik, Maciej Walędziak et al. · 2022 · Obesity Surgery

Abstract Background Thus far, no data are available on decision regret about sleeve gastrectomy (SG), particularly in patients who experienced perioperative complications. This study aimed to assess whether patients with postoperative…

View details →DOI: 10.1007/s11695-022-06113-wCited by 8
Negative / Null Result Report

Significant sex difference in the association between C‐reactive protein concentration and anthropometry among 13‐ to 19‐year olds, but not 6‐ to 12‐year olds in Nepal

Shoko Konishi, Rajendra Prasad Parajuli, Erica Takane et al. · 2014 · American Journal of Physical Anthropology

ABSTRACT Life history theory predicts a trade‐off between immunostimulation and growth. Using a cross‐sectional study design, this study aims to test the hypothesis that C‐reactive protein (CRP) is negatively associated with height‐for‐age…

View details →DOI: 10.1002/ajpa.22470Cited by 8
Negative / Null Result Report

Glyceryl Trinitrate Ointment Did Not Reduce Pain After Stapled Hemorrhoidectomy: A Randomized Controlled Trial

Trent Cross, Lynne Bartlett, Chrispen Mushaya et al. · 2012 · International Surgery

Abstract Medications, including topical 0.2% glyceryl trinitrate (GTN), can reduce anal spasm and pain after excisional hemorrhoidectomy. GTN after stapled hemorrhoidopexy was compared with routine postoperative management. Patients with…

View details →DOI: 10.9738/cc92.1Cited by 8
Negative / Null Result Report

Together We can Figure It out: Groups Find Hospitality Robots Easier to Use and Interact With Them More than Individuals

Harrison Preusse, Rebecca Skulsky, Marlena R. Fraune et al. · 2021 · Frontiers in Robotics and AI

As robots are becoming more prevalent and entering hospitality settings, understanding how different configurations of individuals and groups interact with them becomes increasingly important for catering to various people. This is…

View details →DOI: 10.3389/frobt.2021.730399Cited by 8
Negative / Null Result Report

Content Analysis of YouTube Videos That Demonstrate Periapical Radiography

Marlene Grillon, Andy Wai Kan Yeung · 2022 · Applied Sciences

No prior study has evaluated the content of YouTube videos that demonstrated how to take periapical radiographs, one of the commonest radiographic examinations in dentistry. This study provided a content analysis on these YouTube videos.…

View details →DOI: 10.3390/app12199602Cited by 8
Negative / Null Result Report

Did Expanded Dental Insurance Reduce Out-of-Pocket Expenditures on Dental Care among Older Adults in Korea? Interrupted Time-Series Analysis

Nam-Hee Kim, Se-Hwan Jung, Ichiro Kawachi · 2021 · International Journal of Environmental Research and Public Health

The Korean National Health Insurance extended its coverage to reduce the economic burden of receiving dentures and implants for older adults in 2012 and 2014, respectively. We examined whether the new policy resulted in reduced…

View details →DOI: 10.3390/ijerph18063003Cited by 8
Negative / Null Result Report

How can we better use Twitter to find a person who got lost due to dementia?

Kelvin K. F. Tsoi, Nicholas B. Chan, Felix C. H. Chan et al. · 2018 · npj Digital Medicine

Abstract Twitter is a social media platform for online message sharing. The aim of this study is to evaluate the effectiveness of using Twitter to search for people who got lost due to dementia. The online messages on Twitter, i.e.,…

View details →DOI: 10.1038/s41746-018-0017-5Cited by 8
Negative / Null Result Report

Combining a transosseous cerclage wire after patellar tendon reattachment to treat patella distal pole fracture did not improve functional outcome

Li-Yang Kuo, Chun-Yu Chen, Kai-Cheng Lin · 2022 · Scientific Reports

Abstract This study aims to investigate whether an augmented wire in the treatment of patella distal pole fracture could improve knee range of motion (ROM) and radiographic features. Thirty-five consecutive patients with patellar distal…

View details →DOI: 10.1038/s41598-022-13641-zCited by 8
Negative / Null Result Report

Subclinical Systemic Sclerosis Primary Heart Involvement by Cardiovascular Magnetic Resonance Shows No Significant Interval Change

Raluca B. Dumitru, Lesley‐Anne Bissell, Bara Erhayiem et al. · 2023 · ACR Open Rheumatology

Objective Subclinical systemic sclerosis (SSc) primary heart involvement is commonly described. Whether these findings progress over time is not clear. The study aimed to investigate cardiovascular magnetic resonance (CMR) interval change…

View details →DOI: 10.1002/acr2.11515Cited by 8
Negative / Null Result Report

Association of oral contraceptive and metformin did not improve insulin resistance in women with polycystic ovary syndrome

Margareth Chiharu Iwata, Livia Porquere, Isabel C. Espósito Sorpreso et al. · 2015 · Revista da Associação Médica Brasileira

Summary Objective: Objective: to compare clinical and laboratory parameters in women with polycystic ovary syndrome (PCOS) using metformin or combined oral contraceptive (COC) after 6 months. Methods: retrospective study analyzing records…

View details →DOI: 10.1590/1806-9282.61.03.215Cited by 8
Negative / Null Result Report

Response of extreme significant wave height to climate change in the South China Sea and northern Indian Ocean

Yao Luo, Hui Shi, Weiqiang Wang · 2021 · Aquatic Ecosystem Health & Management

Abstract The frequency of extreme wave events is increasing with climate change. The temporal and spatial variations of extreme wave height affect both human livelihood and the usage of ocean resources. The South China Sea and northern…

View details →DOI: 10.14321/aehm.024.03.12Cited by 8
Negative / Null Result Report

The significant yet short‐term influence of research covidization on journal citation metrics

Xiang Zheng, Chaoqun Ni · 2024 · Journal of the Association for Information Science and Technology

Abstract COVID‐19 has emerged as a major research hotspot and trending topic in recent years, leading to increased publications and citations of related papers. While concerns exist about the potential citation boost in journals publishing…

View details →DOI: 10.1002/asi.24939Cited by 8
Negative / Null Result Report

Evening Caffeine Did Not Improve 100-m Swimming Time Trials Performed 60 Min Post-Ingestion or the Next Morning After Sleep

Josh W. Newbury, Bryan Saunders, Lewis A. Gough · 2022 · International Journal of Sport Nutrition and Exercise Metabolism

The potential ergogenic benefits of caffeine (CAF) are well known within the athletic community, often leading to its use in adolescent swimming cohorts to enhance their performance. However, it has previously been reported that CAF has…

View details →DOI: 10.1123/ijsnem.2022-0042Cited by 8