A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
750 results in Failed Experiment Report · page 17 of 25
Radha S, Arends M, Kislinger G et al. · 2026 · PLoS biology
Rapid information processing in complex organisms depends on myelin, which consists of a multilamellar membrane that tightly adheres to the axonal surface along the internode and at paranodal loops, where specialized adhesion proteins…
El Hayek M, Koop A · 2026 · Obesity surgery
Gastroesophageal reflux disease (GERD) is a frequent postoperative concern after bariatric surgery, particularly following laparoscopic sleeve gastrectomy (LSG). This study aimed to identify clinical factors associated with GERD in…
Xu Z, Guo Y, Shao Y et al. · 2026 · Journal of affective disorders
Background Differentiating the depressive phase of bipolar disorder (BD) from major depressive disorder (MDD) remains a significant clinical challenge. As CACNA1C is a prominent susceptibility gene for BD across diverse populations, this…
Hamidi F, Muhler F, Skopp G et al. · 2026 · Clinical research in cardiology : official journal of the German Cardiac Society
Background Out-of-hospital cardiac arrest (OHCA) is associated with poor outcomes and presents a considerable treatment challenge. Here, we investigated the association of prior beta-blocker treatment with outcomes in patients with OHCA.…
Kalinowska V, Hughes L, Lancki N et al. · 2026 · Preprint
Abstract Purpose To evaluate whether peri-trigger serum hormone dynamics are associated with mature oocyte yield in planned oocyte cryopreservation cycles across ovulation trigger protocols. Methods We conducted a retrospective study of…
Nakamura K, Sakai N, Hirai H et al. · 2026 · British journal of clinical pharmacology
Aims Enzyme replacement therapy (ERT) for mucopolysaccharidosis II (MPS II) requires long-term, weekly intravenous infusions often lasting over 3 h each time, which can burden paediatric patients and caregivers and negatively affect their…
Hennigar SR, Miller KM, Murphy RD et al. · 2026 · The Journal of nutrition
Background Iron deficiency (ID) is associated with decreased appetite and altered mood, which can contribute to feelings of early satiety and reduced overall well-being. Few studies have examined differences in appetite, satiety, and mood…
Portero-Prados FJ, Pabón-Carrasco M, Ponce-Blandón JA · 2026 · Intensive & critical care nursing
Objectives To compare the effectiveness and dermatological safety of chlorhexidine gluconate (CHG)-impregnated dressings versus conventional transparent dressings in preventing central line-associated bloodstream infection (CLABSI) in…
Apostolopoulos V, Mahdal M, Kubíček M et al. · 2026 · SICOT-J
Background Distal femoral megaprosthetic reconstruction is a standard limb-salvage procedure after tumor resection. This study aimed to evaluate implant survival and associated factors, the incidence of mechanical failure, and functional…
Wegener GH · 2026 · Preprint
This Technical Note formalizes the public diagnostic protocol by which an observed AI-fabric condition is translated into a SORT-AI structural assessment case. The protocol defines a repeatable path from observation through V1 , V2 , V3 ,…
Rao LH, Yang ZX, Huang L et al. · 2026 · Journal of pain research
Objective This study aimed to compare the effects of oliceridine and sufentanil on the quality of postoperative recovery in patients undergoing laparoscopic cholecystectomy (LC). Methods This study is of single-center, randomized,…
Chandra S, Rai PJ, Singh N et al. · 2026 · Cureus
Background Streptokinase is widely used for thrombolysis in acute myocardial infarction (AMI), but concerns about complications have led to its underutilization in elderly patients. This study aimed to compare the efficacy and safety of…
Wikkeling OR, VAN Rijn MJ, Witte ME et al. · 2026 · The Journal of cardiovascular surgery
Background Pelvic venous disease (PeVD) and lymphedema are traditionally regarded as distinct clinical entities and are usually investigated and managed within separate clinical frameworks. However, both conditions may coexist in patients…
Ley Urzaiz L, Carrasco Moro R · 2026 · Preprint
Background: /Objectives: Trigeminal neuralgia associated with multiple sclerosis (TN-MS) is a secondary facial pain syndrome whose clinical and therapeutic features differ substantially from those of classical TN. Although the literature…
Huang J, Deng X, Zhou L et al. · 2026 · BMC medical research methodology
Background Evidence quality assessment is critical for informed public health decision-making, but manual approaches are time-consuming and subject to variability. Automated support tools have been proposed to improve efficiency and…
Dias Maile AA, Andronova E, Ball F et al. · 2026 · Preprint
Decision making often requires the integration of noisy bottom-up sensory evidence with top-down prior expectations learned from past experiences. Acetylcholine and noradrenaline have been proposed to shape these computations, yet it…
Tan S, Teoh TT, Joseph P et al. · 2026 · Preprint
Abstract Scenarios involving concealed-cavity fire spread has contributed to major facade fires, dating from Knowsley Heights (1991) to Grenfell Tower (2017). However, post-Grenfell regulatory responses diverged widely, and no study has…
Melendez Vassall I, Mannino JE, Watters P et al. · 2026 · Advances in neonatal care : official journal of the National Association of Neonatal Nurses
Metabolic bone disease (MBD) is a disorder affecting bone mineralization that leads to short and long-term consequences. A daily exercise regimen consisting of passive range of motion (ROM) and gentle compression of upper and lower…
Williams T, Phillips NJ, Stein DJ et al. · 2026 · The Cochrane database of systematic reviews
Background Posttraumatic stress disorder (PTSD) is a prevalent and disabling disorder. Evidence that PTSD is characterised by specific psychobiological dysfunctions has contributed to a growing interest in the use of medication in its…
Petri AC, Martins TB, Martins TB et al. · 2026 · Sports medicine - open
Background Gait retraining has been proposed as a strategy to modify running biomechanics and reduce symptoms in runners with patellofemoral pain (PFP). However, review-level evidence remains heterogeneous regarding clinical effects,…
Mori H, Shimomura K, Miyazaki K et al. · 2026 · Preprint
Abstract Background. In Japan, much preventive medicine outside mandated national programmes is left to municipal discretion, yet the nationwide alignment between these locally administered programmes and graded evidence remains…
Kloc K, Toumi M, Łukomska E et al. · 2026 · Journal of market access & health policy
The Joint Clinical Assessment (JCA) evaluates the relative effectiveness (RE) of interventions over comparators. While randomised control trials (RCTs) are considered the gold standard, single-arm trials (SATs) require an external control…
Chen X, Qin X, Xu B et al. · 2026 · Preprint
Background: Social cognition research increasingly emphasizes cognitive processes in social contexts, with growing attention to socially shared retrieval-induced forgetting (SS-RIF). Behavioral evidence suggests that the mechanisms of…
Zaher F, Ahrens J, Raucher-Chéné D et al. · 2026 · Bipolar disorders
Clinicians aspire to predict the emergence of Bipolar Disorder (BD) in a timely manner. To accomplish this, markers reflecting mental states that can be gathered non-invasively and at large scale are needed. Here, we systematically…
Weiss A · 2026 · Preprint
A recent paper (Minkov, 2026) claimed that great ape personality is not well-described by the five personality dimensions found in humans, those being Neuroticism, Extraversion, Openness to Experience, Agreeableness, and Conscientiousness.…
Nuss ZJ, DeYoung C, Gross D · 2026 · Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners
ObjectiveTo evaluate current pharmacotherapeutic strategies for H3 K27M-mutant diffuse midline glioma (DMG), with emphasis on the clinical evidence for dordaviprone, its place in therapy, and its implications for oncology practice.Study…
Bellissimo J, Hall B, Hali K et al. · 2026 · The Journal of arthroplasty
Background Orthobiologic therapies such as platelet-rich plasma (PRP), bone marrow aspirate concentrate (BMAC), and hyaluronic acid (HA) are increasingly offered for orthopaedic conditions, but their online promotion may not accurately…
Taylor AJ, Miller BP, Copeland A · 2026 · Journal of the experimental analysis of behavior
Behavioral economic accounts posit that distorted valuation processes underlie cannabis decisions; however, less is known about the moment-to-moment dynamics through which value influences observable choice behavior. This study explored…
Anarna K, Fiander M, Mitra S · 2026 · The Cochrane database of systematic reviews
Rationale Preterm and low-birthweight infants are at risk of anemia due to a variety of factors, including low levels of erythropoietin. They may therefore benefit from erythropoiesis-stimulating agents (ESAs). However, controversy remains…
Wu R, Jin H, Shen J · 2025 · Preprint
Abstract Despite known benefits in normal diet, capsaicin's effects under obesogenic conditions remain unexplored. Based on capsaicin's established metabolic benefits, we hypothesized that capsaicin supplementation would extend lifespan in…