Negative / Null Result ReportOpen accessMedicine
Vasileios Angelis, Alicia Okines · 2023 · Cancers
Despite recent advances, HER2-positive advanced breast cancer (ABC) remains a largely incurable disease, with resistance to conventional anti-HER2 drugs ultimately unavoidable for all but a small minority of patients who achieve an enduring remission and possibly cure. Over the past two decades, significant advances in our understanding of the underlying molecular mechanisms of HER2-driven oncogenesis have translated into pharmaceutical advances, with the developing of increasingly sophisticated therapies directed against HER2. These include novel, more potent selective HER2 tyrosine kinase in
View details →DOI: 10.3390/cancers16010023Cited by 9 Negative / Null Result ReportOpen accessMedicine
Lujun Shen, Fei Cao, Ying Liu et al. · 2025 · BMC Medicine
BACKGROUND: Hepatic arterial infusion chemotherapy (HAIC) with a combination of oxaliplatin, fluorouracil, and leucovorin (FOLFOX) has shown excellent local control for patients with Barcelona Clinic Liver Cancer (BCLC) stage C…
View details →DOI: 10.1186/s12916-025-04110-1Cited by 9 Negative / Null Result ReportMedicine
Yanna Zhang, Ming Yan, Jiehua He et al. · 2010 · Journal of obstetrics and gynaecology research
AIM: In the past 10 years, therapeutic advances have led to improved short-term efficacy for cervical carcinoma; however, the 5-year survival rate was not significantly enhanced. To investigate the effects of blood vessel invasion (BVI)…
View details →DOI: 10.1111/j.1447-0756.2010.01271.xCited by 9 Negative / Null Result ReportOpen accessMedicine
Jwa Hoon Kim, Jae Ho Jeong, Baek‐Yeol Ryoo et al. · 2020 · Cancer Research and Treatment
PURPOSE: This study evaluated the efficacy of adjuvant chemotherapy (AC) in patients with resected ampulla of Vater (AoV) carcinoma. MATERIALS AND METHODS: Data from 646 patients who underwent surgical resection at Asan Medical Center…
View details →DOI: 10.4143/crt.2020.953Cited by 9 Negative / Null Result ReportOpen accessMedicine
S. Lot Aronson, Bram Thijssen, Marta López‐Yurda et al. · 2025 · Nature Communications
While immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, their efficacy in high-grade serous ovarian cancer (HGSOC) remains limited. Some patients, however, achieve lasting responses, emphasizing the need to…
View details →DOI: 10.1038/s41467-025-58440-yCited by 9 Negative / Null Result ReportOpen accessMedicine
Sha Sha, Lina Ren, Xiaona Xing et al. · 2025 · Neural Regeneration Research
Alzheimer's disease, a devastating neurodegenerative disorder, is characterized by progressive cognitive decline, primarily due to amyloid-beta protein deposition and tau protein phosphorylation. Effectively reducing the cytotoxicity of…
View details →DOI: 10.4103/nrr.nrr-d-24-00846Cited by 9 Negative / Null Result ReportOpen accessMedicine
Kristin A. Higgins, Chen Hu, Helen J. Ross et al. · 2026 · Journal of Clinical Oncology
PURPOSE NRG Oncology/Alliance LU005 (ClinicalTrials.gov identifier: NCT03811002 ) tested the addition of atezolizumab to concurrent chemoradiation (CRT) in this open-label, phase III international trial. METHODS Patients with limited-stage…
View details →DOI: 10.1200/jco-25-01569Cited by 9 Negative / Null Result ReportOpen accessMedicine
Louis Pechmajou, Éloi Marijon, Olivier Varenne et al. · 2020 · Circulation Cardiovascular Interventions
Background: Conflicting data exist regarding the benefit of urgent coronary angiogram and percutaneous coronary intervention (PCI) after sudden cardiac arrest, particularly in the absence of ST-segment elevation. We hypothesized that the…
View details →DOI: 10.1161/circinterventions.119.009181Cited by 9 Negative / Null Result ReportOpen accessMedicine
Adam Brufsky, Michael T. Lotze · 2020 · Journal of Medical Virology
Muller's ratchet1 predicts that when mutation rates are high and a significant proportion of mutations are deleterious, a kind of irreversible ratchet mechanism will gradually decrease the mean fitness of small populations of asexual organisms.2 In cell culture, serial passage of genetically bottlenecked vesicular stomatitis virus, which grew quite rapidly on HeLa cells, severely reduced in fitness and virulence within 20 passages in a novel BHK host cell.2 Genetic bottlenecks are likely important in intraspecies viral transmission.3 RNA-based viruses are particularly prone to repeated bottlen
View details →DOI: 10.1002/jmv.26067Cited by 9 Negative / Null Result ReportMedicine
Leah Amundson, Brandon Boelts, Vivek Kataria et al. · 2021 · Infectious Diseases in Clinical Practice
To the Editor: Coronavirus disease 2019 (COVID-19) has resulted in a widespread pandemic in which various therapeutics have been studied. Targeted therapies focus on either the viral or the inflammatory phase to ultimately reduce disease…
View details →DOI: 10.1097/ipc.0000000000001035Cited by 9 Negative / Null Result ReportOpen accessMedicine
Stefan Sjørslev Bodilsen, Mette Aadahl, Troels Wienecke et al. · 2023 · Frontiers in Rehabilitation Sciences
Purpose: Type 2 diabetes and sedentary behavior pose serious health risks in stroke survivors. Using a co-creation framework, this study aimed to develop an intervention in collaboration with stroke survivors with type 2 diabetes, relatives, and cross-sectoral health care professionals to reduce sedentary behavior and increase physical activity. Materials and methods: = 10) to develop the intervention. A content analysis was used to analyze data. Results: The developed "Everyday Life is Rehabilitation" (ELiR) intervention consisted of a tailored 12-week home-based behavior change intervention
View details →DOI: 10.3389/fresc.2023.1114537Cited by 9 Negative / Null Result ReportOpen accessMedicine
Lucy Plumb, Anna Casula, Manish D. Sinha et al. · 2023 · Clinical Kidney Journal
ABSTRACT Background Few studies describe the epidemiology of childhood acute kidney injury (AKI) nationally. Laboratories in England are required to issue electronic (e-)alerts for AKI based on serum creatinine changes. This study…
View details →DOI: 10.1093/ckj/sfad070Cited by 9 Negative / Null Result ReportOpen accessMedicine
Abdullahi Ahmed Mohamed, Camilla Fuchs Andersen, Daniel Mølager Christensen et al. · 2025 · Cardiovascular Diabetology
BACKGROUND: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) increase haemoglobin and haematocrit levels, potentially causing secondary erythrocytosis-defined as a haemoglobin level above 16.5 g/dL in men and 16.0 g/dL in women-which is…
View details →DOI: 10.1186/s12933-025-02871-wCited by 9 Negative / Null Result Report
M. Müllner, K. Zwintz, E. Corsaro et al. · 2021 · Astronomy & Astrophysics
Context. In recent years, our understanding of solar-like oscillations from main sequence to red giant stars has improved dramatically thanks to pristine data collected from space telescopes. One of the remaining open questions focuses on…
View details →DOI: 10.1051/0004-6361/202039578Cited by 9 Negative / Null Result Report
Hannah R. Spaulding, Tiffany Quindry, Kayleen Hammer et al. · 2019 · Journal of Applied Physiology
Progressive muscle injury and weakness are hallmarks of Duchenne muscular dystrophy. We showed previously that quercetin (Q) partially protected dystrophic limb muscles from disease-related injury. As quercetin activates PGC-1α through…
View details →DOI: 10.1152/japplphysiol.00162.2019Cited by 9 Negative / Null Result Report
Sue M Hudson, Kathie Binysh, Stephen W Duffy · 2022 · Journal of Medical Screening
Objective The Covid-19 pandemic created a backlog of women awaiting an invitation for breast screening in the UK. To recover in a timely fashion, the National Health Service programme opted to issue open invitations (OI) to women rather…
View details →DOI: 10.1177/09691413221127583Cited by 9 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Breanne Cuddington, Meghan L. Verschoor, Ali A. Ashkar et al. · 2015 · Molecular Therapy — Oncolytics
Oncolytic viruses selectively replicate in cancer cells by exploiting biochemical differences between normal and tumor cells. Treatment with epigenetic modifiers such as 5-Azacytidine, a DNA methyltransferase inhibitor, increases the…
View details →DOI: 10.1038/mto.2015.4Cited by 9 Negative / Null Result Report
Sam J. Griffiths, Dan E. Browne · 2024 · Physical Review Research
The union-find decoder is a leading algorithmic approach to the correction of quantum errors on the surface code, achieving code thresholds comparable to minimum-weight perfect matching (MWPM) with amortized computational time scaling…
View details →DOI: 10.1103/physrevresearch.6.013154Cited by 9 Negative / Null Result ReportOpen accessMedicine
Padma Kaul, Dat T. Tran, Roopinder K. Sandhu et al. · 2020 · Journal of the American College of Emergency Physicians Open
STUDY OBJECTIVE: Patients with syncope are frequently admitted to the hospital, but whether this improves outcome is unknown. We tested whether hospitalization reduced mortality in patients who presented to emergency departments (EDs) with…
View details →DOI: 10.1002/emp2.12229Cited by 9 Negative / Null Result Report
Jung Hyun Yoon, Jin Young Kwak, Hee Jung Moon et al. · 2019 · Ultrasound Quarterly
Abstract In this study, we evaluated the role of ultrasonography-guided core needle biopsy (US-CNB) in deciding upon management for prior atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS)…
View details →DOI: 10.1097/ruq.0000000000000400Cited by 9 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Dana Lengel, Paul J. Kenny · 2023 · Addiction Neuroscience
Diseases associated with nicotine dependence in the form of habitual tobacco use are a major cause of premature death in the United States. The majority of tobacco smokers will relapse within the first month of attempted abstinence.…
View details →DOI: 10.1016/j.addicn.2023.100103Cited by 9 Negative / Null Result Report
Wei Tang, Yuwei Qiu, Huijie Lu et al. · 2021 · Frontiers in Surgery
Study Objective: This study aimed to investigate whether stroke volume variation (SVV)-guided goal-directed therapy (GDT) can improve postoperative outcomes in elderly patients undergoing minimally invasive esophagectomy (MIE) compared…
View details →DOI: 10.3389/fsurg.2021.794272Cited by 9 Negative / Null Result ReportOpen accessMedicine
Ecaterina E. Dumbrava, Thomas E. Stinchcombe, Mrinal M. Gounder et al. · 2025 · Clinical Cancer Research
PURPOSE: Mouse double minute 2 (MDM2) is an E3 ubiquitin ligase that degrades the tumor suppressor p53. In cancers, MDM2 amplification (MDM2amp) leads to overexpression of MDM2, inducing p53 degradation and a p53-null phenotype even in the…
View details →DOI: 10.1158/1078-0432.ccr-25-0762Cited by 9 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
James M. Barron, Nathan R. Jensen, Paul J. Anders et al. · 2013 · North American Journal of Aquaculture
Abstract The survival and percentage of North American Burbot Lota lota maculosa larvae and metamorphosing larvae presumed to have been cannibalized during a 15-d period immediately following a size-grading event were compared with those of fish in nongraded control groups. In larvae (mean TL, 11.8 mm), grading immediately produced a size distinction, as the group that passed the grader was significantly narrower and shorter than the group retained by the grader. The mean coefficient of variation of the length of larvae in the retained group was significantly lower than that of the control gro
View details →DOI: 10.1080/15222055.2013.829146Cited by 9 Negative / Null Result ReportOpen accessMedicine
Divya Narayanan, John David Rodriguez, Garrick Wallstrom et al. · 2020 · BMC Ophthalmology
BACKGROUND: To prevent irreversible vision loss in age-related macular degeneration (AMD), it is critical to detect retinal dysfunction before permanent structural loss occurs. In the current study we evaluated a series of visual function tests to identify potential endpoints to detect visual dysfunction in non-advanced AMD. METHODS: A series of visual function tests were performed on 23 non-advanced AMD subjects (AREDS grade 1-4 on simplified scale) and 34 age-matched normals (AREDS grade 0). Tests included some commonly used endpoints such as ETDRS visual acuity (VA), low luminance (LL) 2.0N
View details →DOI: 10.1186/s12886-020-01683-8Cited by 9 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Marcin A. Sowa, Haoyu Sun, Tricia T. Wang et al. · 2024 · JACC Basic to Translational Science
We investigated the impact of antiplatelet therapy on the megakaryocyte (MK) and platelet transcriptome. RNA-sequencing was performed on MKs treated with aspirin or P2Y12 inhibitor, platelets from healthy volunteers receiving aspirin or…
View details →DOI: 10.1016/j.jacbts.2024.05.014Cited by 9 Negative / Null Result ReportOpen accessMedicine
Jianbo Wang, Hussein A. Tawbi · 2021 · Neuro-Oncology Advances
Brain metastases from solid tumors are increasing in incidence, especially as outcomes of systemic therapies continue to extend patients' overall survival. The long-held notion that the brain is an immune sanctuary has now been largely…
View details →DOI: 10.1093/noajnl/vdab138Cited by 9 Negative / Null Result ReportEnvironmental Science
Justin J. Robert, Sarah M. Larocque, Steven J. Cooke · 2012 · North American Journal of Fisheries Management
Abstract Catch and release is a common practice among recreational anglers. In instances when fish are deeply hooked, the proper techniques for promoting survival are poorly understood, although evidence suggests that the fishing line…
View details →DOI: 10.1080/02755947.2012.703161Cited by 9 Negative / Null Result ReportOpen accessMedicine
Zeev Elkoshi · 2021 · Frontiers in Immunology
A binary model for the classification of chronic diseases has formerly been proposed. The model classifies chronic diseases as “high Treg” or “low Treg” diseases according to the extent of regulatory T cells (Treg) activity (frequency or function) observed. The present paper applies this model to severe acute respiratory syndrome coronavirus 2 (SARS - CoV - 2) infection. The model correctly predicts the efficacy or inefficacy of several immune-modulating drugs in the treatment of severe coronavirus disease 2019 (COVID-19) disease. It also correctly predicts the class of pathogens mostly associ
View details →DOI: 10.3389/fimmu.2021.716084Cited by 9 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
A. AbdAllah · 2026 · RSC Advances
In an attempt to collect clinical data about HDAC inhibitors as very significant anticancer drugs we aimed to compare data and reveal the impact of the structural features, concluding the points of interest that are likely to help further development of better cancer therapy. We presented results of different clinical phases of HDAC inhibitors classified as hydroxamic acid derivatives, cyclic peptides, benzamides, and short chain aliphatic acids in a coherent and cohesive manner. It was found that HDAC inhibitors are preferentially combined with other antitumor drugs, mainly anti PD-1 and doxo
View details →DOI: 10.1039/d5ra09034bCited by 9 