e-ISSN: Pending
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19815 results in Negative / Null Result Report · page 153 of 661

Negative / Null Result Report

Ethanol Extract of Fructus ligustri lucidi Increased Circulating 1,25(OH) 2 D 3 Levels, but Did Not Improve Calcium Balance in Mature Ovariectomized Rats

Xiao-Li Dong, Si-Si Cao, Li-Ping Zhou et al. · 2016 · The American Journal of Chinese Medicine

Our previous studies found that different extracts or fractions of Fructus ligustri lucidi (FLL) played different roles in altering the regulation of bone and mineral metabolism in different animal models. The present study was designed to…

View details →DOI: 10.1142/s0192415x16500695Cited by 7
Negative / Null Result Report

Drug‐target Mendelian randomization revealed a significant association of genetically proxied metformin effects with increased prostate cancer risk

Xiaohui Sun, Jie Ping, Xingyi Guo et al. · 2024 · Molecular Carcinogenesis

Abstract The association between metformin use and risk of prostate cancer remains controversial, while data from randomized trials is lacking. We aim to evaluate the association of genetically proxied metformin effects with prostate…

View details →DOI: 10.1002/mc.23692Cited by 7
Negative / Null Result Report

Beta‐alanine did not improve high‐intensity performance throughout simulated road cycling

Pedro Perim, Nathan Gobbi, Breno Duarte et al. · 2021 · European Journal of Sport Science

ABSTRACT This study investigated the effect of beta‐alanine supplementation on short‐duration sprints and final 4‐km simulated uphill cycling time‐trial performance during a comprehensive and novel exercise protocol representative of the…

View details →DOI: 10.1080/17461391.2021.1940304Cited by 7
Negative / Null Result Report

Long‐chain alcohols did not improve predictions of the composition of tall fescue and red clover mixtures over n ‐alkanes alone

N. Vargas Jurado, A. E. Tanner, S. R. Blevins et al. · 2014 · Grass and Forage Science

Abstract Feed intake and diet choice affect production efficiency in livestock. Plant waxes, in particular n ‐alkanes, have been used as markers to predict intake and diet preferences. Still, when n ‐alkane profiles of plants within mixed…

View details →DOI: 10.1111/gfs.12134Cited by 7
Negative / Null Result Report

Normocalcaemic hyperparathyroidism and primary hyperparathyroidism: least significant change for adjusted serum calcium

Marian Schini, Richard Jacques, Eleanor Oakes et al. · 2021 · European Journal of Endocrinology

Introduction The least significant change (LSC) is a term used in individuals in order to evaluate whether one measurement has changed significantly from the previous one. It is widely used when assessing bone mineral density (BMD) scans.…

View details →DOI: 10.1530/eje-20-0634Cited by 7
Negative / Null Result Report

Biological variation of thiopurine methyltransferase enzyme activity: when has a significant change taken place?

Remco van Egmond, Murray L Barclay, Paul KL Chin et al. · 2013 · Annals of Clinical Biochemistry: International Journal of Laboratory Medicine

Background Thiopurine methyltransferase (TPMT) enzyme activity is measured before initiating thiopurine therapy to reduce the risk of severe drug-associated myelotoxicity in patients with low enzyme activity. TPMT activity may vary over…

View details →DOI: 10.1177/0004563212473441Cited by 7
Negative / Null Result Report

The occurrence of nonglycosylated forms of N ‐glycoprotein upon proteasome inhibition does not confirm cytosolic deglycosylation

Chengcheng Huang, Tadashi Suzuki · 2020 · FEBS Letters

N‐ Glycosylated substrates that undergo ER‐associated degradation (ERAD) are often deglycosylated by the cytosolic peptide: N ‐glycanase (Ngly1) during their proteasomal degradation in the cytosol. Consequently, the presence of non‐ or…

View details →DOI: 10.1002/1873-3468.13734Cited by 7
Negative / Null Result Report

State Anxiety after Exergame Beach Volleyball Did Not Differ between the Single and Multiplayer Modes in Adult Men

Vinnycius de Oliveira, Ricardo Viana, Naiane Morais et al. · 2021 · International Journal of Environmental Research and Public Health

This study compared the exergame beach volleyball’s acute effects on state anxiety level in single vs. multiplayer mode in adult men. Sixty adult men (age: 21.98 [4.58] years, body mass: 75.40 [15.70] kg, height: 1.77 [0.09] m, and body…

View details →DOI: 10.3390/ijerph182010957Cited by 7
Negative / Null Result Report

No significant association of repeated messages with changes in health compliance in the COVID-19 pandemic: a registered report on the extended parallel process model

Jingwen Yang, Xue Wu, Kyoshiro Sasaki et al. · 2021 · PeerJ

When people are confronted with health proposals during the coronavirus disease 2019 (COVID-19) pandemic, it has been suggested that fear of COVID-19 can serve protective functions and ensure public health compliance. However, health…

View details →DOI: 10.7717/peerj.11559Cited by 7
Negative / Null Result Report

Significant Improvement of Somatic Symptom Disorder With Brief Psychoeducational Intervention by PMHNP in Primary Care

Kim K. Johnson, Carole Bennett, Haresh Rochani · 2020 · Journal of the American Psychiatric Nurses Association

Objective: Patients with somatic symptom disorders (SSD) are prevalent in primary care, urgent care, and emergency rooms and present with reduced quality of life, increased disability, and suicidality . Criteria for SSD include (1) somatic…

View details →DOI: 10.1177/1078390320960524Cited by 7
Negative / Null Result Report

Randomized trial within a trial of yellow ‘post‐it notes’ did not improve questionnaire response rates among participants in a trial of treatments for neck pain

Helen E Tilbrook, Taeko Becque, Hannah Buckley et al. · 2014 · Journal of Evaluation in Clinical Practice

Abstract Rationale Attrition is a threat to the validity of randomized trials. Few randomized studies have been conducted within randomized trials to test methods of reducing attrition. Aim To test whether using yellow post‐it notes on…

View details →DOI: 10.1111/jep.12284Cited by 7
Negative / Null Result Report

Significant individual change should be used as a lower bound for anchor based estimates of meaningful change on patient-reported outcome scores

John Devin Peipert, David Cella, Ron D. Hays · 2024 · Quality of Life Research

Abstract Interpretation of patient-reported outcome (PRO) scores has been supported by identifying score thresholds or ranges that indicate clinical importance. There has been a recent focus on the estimation of meaningful within patient…

View details →DOI: 10.1007/s11136-024-03788-9Cited by 6
Negative / Null Result Report

Gum Guar fiber associated with fructose reduces serum triacylglycerol but did not improve the glucose tolerance in rats

Caio SM Motoyama, Mônica JS Pinto, Fabio S Lira et al. · 2010 · Diabetology & Metabolic Syndrome

Abstract Introduction The increased intake of dietary fructose can be associated with alterations on energy homeostasis and lipid/carbohydrate metabolism, such as insulin resistance and dislipidemia. On the other hand, the ingestion of…

View details →DOI: 10.1186/1758-5996-2-61Cited by 6
Negative / Null Result Report

Confirm Rx insertable cardiac monitor for primary atrial fibrillation detection in high‐risk heart failure patients ( Confirm‐AF trial)

Mehmet K. Aktas, Wojciech Zareba, Javed Butler et al. · 2022 · Annals of Noninvasive Electrocardiology

Abstract Background Patients with heart failure (HF) represent a large population of patients who are at high risk for complications related to undiagnosed atrial fibrillation (AF). However, currently there are limited modalities available…

View details →DOI: 10.1111/anec.13021Cited by 6
Negative / Null Result Report

Significant change in ZAP‐70 expression during the course of chronic lymphocytic leukemia

Vladimira Vroblova, Filip Vrbacky, Monika Hrudkova et al. · 2010 · European Journal of Haematology

Abstract Introduction: It is widely accepted that expression of ZAP‐70 in chronic lymphocytic leukemia (CLL) remains stable in time. However, data supporting this notion are surprisingly scarce. Therefore, we assessed expression of ZAP‐70…

View details →DOI: 10.1111/j.1600-0609.2010.01425.xCited by 6
Negative / Null Result Report

Do Bilinguals Outperform Monolinguals in Switching Tasks? Contrary Evidence for Nonlinguistic and Linguistic Switching Tasks

Ernest Mas-Herrero, Daniel Adrover-Roig, María Ruz et al. · 2021 · Neurobiology of Language

Abstract The benefits of bilingualism in executive functions are highly debated. Even so, in switching tasks, these effects seem robust, although smaller than initially thought (Gunnerud et al., 2020; Ware et al., 2020). By handling two…

View details →DOI: 10.1162/nol_a_00059Cited by 6
Negative / Null Result Report

Supplementing 2 g per day bovine lactoferrin from late gestation until weaning did not improve lactation performance of mixed parity sows

Fan Liu, Jordon Hogg, Susie Kracht et al. · 2019 · Animal Production Science

Context Lactoferrin is a non-haem binding protein that possesses antimicrobial, antioxidant and anti-inflammatory properties. A previous study showed lactoferrin supplementation from early gestation to weaning improved lactation…

View details →DOI: 10.1071/an18286Cited by 6
Negative / Null Result Report

Micro-ultrasound for the detection of clinically significant prostate cancer in biopsy-naive men with negative MRI

Patrick Albers, Jacob Bennett, Moira Evans et al. · 2024 · Canadian Urological Association Journal

Introduction: Despite a negative magnetic resonance imaging (MRI), some patients may still harbor clinically significant prostate cancer (csPCa, Gleason grade group ≥2). High-resolution micro-ultrasound (microUS) is a novel imaging…

View details →DOI: 10.5489/cuaj.8626Cited by 6
Negative / Null Result Report

The most significant change for Colombian medical trainees going transformative learning on cultural safety: qualitative results from a randomised controlled trial

Juan Pimentel, Paola López, Anne Cockcroft et al. · 2022 · BMC Medical Education

Abstract Background Cultural safety training is not yet standard in Colombian medical education. If incorporated, it could address currently adversarial interactions between health professionals and the 40% of people who use traditional…

View details →DOI: 10.1186/s12909-022-03711-1Cited by 6
Negative / Null Result Report

Another Brick to Confirm the Efficacy of Rigosertib as Anticancer Agent

Alessio Malacrida, Marie Deschamps-Wright, Roberta Rigolio et al. · 2023 · International Journal of Molecular Sciences

Rigosertib is a small molecule in preclinical development that, due to its characteristics as a dual PLK1 and PI3K inhibitor, is particularly effective in counteracting the advance of different types of tumors. In this work, we evaluated…

View details →DOI: 10.3390/ijms24021721Cited by 6
Negative / Null Result Report

Association between Intraoperative Blood Pressure Drop and Clinically Significant Hypoperfusion in Abdominal Surgery: A Cohort Study

Zbigniew Putowski, Szymon Czajka, Łukasz J. Krzych · 2021 · Journal of Clinical Medicine

The recent consensus by the Perioperative Quality Initiative (POQI) on intraoperative hypotension (IOH) stated that mean arterial pressure (MAP) below 60–70 mmHg is associated with myocardial infarction (MI), acute kidney injury (AKI),…

View details →DOI: 10.3390/jcm10215010Cited by 6
Negative / Null Result Report

Significant liver histological change is common in HBeAg-positive chronic hepatitis B with normal ALT

Menghui Duan, Huanming Xiao, Meijie Shi et al. · 2024 · BMC Infectious Diseases

Abstract Background and aims Numerous HBeAg-positive chronic hepatitis B (CHB) patients with persistently normal ALT have significant liver histopathology. It is imperative to identify true “immune tolerant” patients. We aimed to evaluate…

View details →DOI: 10.1186/s12879-024-09617-1Cited by 6
Negative / Null Result Report

50 Years of Cumulative Open-Source Data Confirm Stable and Robust Biodiversity Distribution Patterns for Macrofungi

Haili Yu, Tiejun Wang, Andrew Skidmore et al. · 2022 · Journal of Fungi

Fungi are a hyper-diverse kingdom that contributes significantly to the regulation of the global carbon and nutrient cycle. However, our understanding of the distribution of fungal diversity is often hindered by a lack of data, especially…

View details →DOI: 10.3390/jof8090981Cited by 6
Negative / Null Result Report

Calcium and magnesium supplementation of ewes grazing pasture did not improve lamb survival

Susan M. Robertson, Shawn R. McGrath, Samuel Scarlett et al. · 2022 · Animal Production Science

Context Clinical deficiencies of calcium and magnesium may result in the metabolic disorders hypocalcaemia and hypomagnesaemia, resulting in ewe and lamb mortality. However, the contribution of subclinical deficiencies to perinatal lamb…

View details →DOI: 10.1071/an22113Cited by 6
Negative / Null Result Report

An attachment‐based program for parents of youth with clinically significant mental health problems: Scaling up and drilling down to mechanisms of change

Marlene M. Moretti, Sebastian P. Dys, Stephanie G. Craig et al. · 2024 · JCPP Advances

Abstract Background Given the prevalence and recent increases in youth mental health problems, there is a pressing need for interventions that target transdiagnostic protective factors that could be targeted as mechanisms of change in…

View details →DOI: 10.1002/jcv2.12248Cited by 6
Negative / Null Result Report

Significant association of nicotine reinforcement and cue reactivity: a translational study in humans and rats

Kevin Butler, Benoît Forget, Stephen J. Heishman et al. · 2021 · Behavioural Pharmacology

Relapse is common amongst smokers attempting to quit and tobacco cue-induced craving is an important relapse mechanism. Preclinical studies commonly use cue-induced reinstatement of nicotine seeking to investigate relapse neurobiology.…

View details →DOI: 10.1097/fbp.0000000000000607Cited by 6