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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

AllReplication FailureNegative / Null Result ReportFailed Experiment ReportAbandoned HypothesisMethods Dead-EndShort NoteNull DatasetProtocol

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

By fieldMedicine 12,218Computer Science 744Biochemistry, Genetics and Molecular Biology 414Social Sciences 302Psychology 299Physics 280Neuroscience 244Economics, Econometrics and Finance 196Environmental Science 172Mathematics 155Agricultural and Biological Sciences 138Engineering 135

750 results in Failed Experiment Report · page 15 of 25

Failed Experiment ReportMedicine

Cardiovascular benefit of continuous positive airway pressure according to high-risk obstructive sleep apnoea: a multi-trial analysis.

Azarbarzin A, Vena D, Esmaeili N et al. · 2026 · European heart journal

Background and aims Randomized trials of continuous positive airway pressure (CPAP) treatment for obstructive sleep apnoea (OSA) in patients with cardiovascular disease have not detected reduced risk of major adverse cardiovascular and…

View details →DOI: 10.1093/eurheartj/ehaf447
Failed Experiment ReportOpen accessMedicine

Survival, neurocognitive function, and health-related quality of life outcomes after rituximab-methotrexate, BCNU, teniposide, and prednisolone for primary CNS lymphoma: Final results of the HOVON 105/ALLG NHL 24 study.

Bromberg JEC, Issa S, van der Holt B et al. · 2024 · Neuro-oncology

Background Studies on the efficacy of rituximab in primary CNS lymphoma (PCNSL) reported conflicting results. Our international randomized phase 3 study showed that the addition of rituximab to high-dose methotrexate, BCNU, teniposide, and…

View details →DOI: 10.1093/neuonc/noad224
Failed Experiment ReportOpen accessMedicine

Interpreting clinical trial outcomes complicated by placebo response with an assessment of false-negative and true-negative clinical trials in depression using propensity-weighting.

Gomeni R, Hopkins S, Bressolle-Gomeni F et al. · 2023 · Translational psychiatry

The objective of this study was to evaluate the performances of the propensity score weighted (PSW) methodology in a post-hoc re-analysis of a failed and a negative RCTs in depressive disorders. The conventional study designs,…

View details →DOI: 10.1038/s41398-023-02685-y
Failed Experiment ReportOpen accessMedicine

The Nail in the Coffin?: Examining the KEYNOTE-789 Clinical Trial's Impact.

Arter ZL, Nagasaka M · 2024 · Lung Cancer (Auckland, N.Z.)

Targeted therapies, such as epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), have revolutionized the treatment landscape for EGFR-mutant non-small cell lung cancer (NSCLC). However, the emergence of resistance to…

View details →DOI: 10.2147/lctt.s443099
Failed Experiment ReportOpen accessMedicine

Conventional versus advanced imaging selection for endovascular treatment of basilar artery occlusion strokes.

Chen H, Colasurdo M, Matsukawa H et al. · 2025 · European stroke journal

Introduction Endovascular thrombectomy (EVT) is an effective treatment for basilar artery occlusion (BAO) stroke in select patients. While there is a growing body of literature suggesting that advanced imaging modalities such as computed…

View details →DOI: 10.1177/23969873251364973
Failed Experiment ReportMedicine

Targeting the SHIP1 Pathway Fails to Show Treatment Benefit in Interstitial Cystitis/Bladder Pain Syndrome: Lessons Learned from Evaluating Potentially Effective Therapies in This Enigmatic Syndrome.

Nickel JC, Moldwin R, Hanno P et al. · 2019 · The Journal of urology

Purpose In this 12-week, randomized, double-blind, placebo controlled, multicenter, 3-arm, parallel group, phase 3 trial we assessed the effects of a novel SHIP1 activator on bladder pain and urinary symptoms in patients with interstitial…

View details →DOI: 10.1097/ju.0000000000000192
Failed Experiment ReportOpen accessMedicine

Virome drift in ulcerative colitis patients: faecal microbiota transplantation results in minimal phage engraftment dominated by microviruses.

Jansen D, Deleu S, Caenepeel C et al. · 2025 · Gut microbes

Ulcerative colitis (UC) is an inflammatory bowel disease characterized by recurrent colonic inflammation. Standard treatments focus on controlling inflammation but remain ineffective for one-third of patients. This underscores the need for…

View details →DOI: 10.1080/19490976.2025.2499575
Failed Experiment ReportOpen accessMedicine

A phase II, open-label, single-arm trial of pembrolizumab for recurrent meningioma and solitary fibrous tumor.

Limon D, Amiel A, Even Haim S et al. · 2024 · Neuro-oncology advances

Background Atypical and anaplastic meningiomas account for 20% of all meningioma cases. Solitary fibrous tumor (SFT) is a type of soft tissue sarcoma with similar attributes to meningioma. For patients with refractory or recurrent disease…

View details →DOI: 10.1093/noajnl/vdae154
Failed Experiment ReportMedicine

A randomized phase II/III study of paclitaxel/carboplatin/metformin versus paclitaxel/carboplatin/placebo as initial therapy for measurable stage III or IVA, stage IVB, or recurrent endometrial cancer: An NRG oncology/GOG study.

Bae-Jump VL, Sill MW, Gehrig PA et al. · 2025 · Gynecologic oncology

Introduction We evaluated the efficacy of the addition of the anti-diabetic drug metformin to standard-of-care paclitaxel and carboplatin (PC) in patients with advanced and recurrent endometrial cancer (EC). Methods In this phase II/III…

View details →DOI: 10.1016/j.ygyno.2025.03.003
Failed Experiment ReportMedicine

A critical question for cancer therapy: what new targets exist?

Rosell R, Karachaliou N, Codony J et al. · 2014 · Translational lung cancer research

Designing molecular targeted therapy with high specificity based on novel tumor biomarkers is a high priority in lung cancer research. Several molecular aberrations have been already identified in non-small cell lung cancer (NSCLC), with…

View details →DOI: 10.3978/j.issn.2218-6751.2014.08.10
Failed Experiment ReportMedicine

Tolerability of bevacizumab and chemotherapy in a phase 3 clinical trial with human epidermal growth factor receptor 2-negative breast cancer: A trajectory analysis of adverse events.

Ip EH, Saldana S, Miller KD et al. · 2021 · Cancer

Background E5103 was a study designed to evaluate the efficacy and safety of bevacizumab. It was a negative trial for the end points of invasive disease-free survival and overall survival. The current work examines the tolerability of…

View details →DOI: 10.1002/cncr.33992
Failed Experiment ReportMedicine

Clinical experience with ramucirumab : outcomes in breast cancer.

O'Sullivan Coyne G, Burotto M · 2014 · Expert opinion on biological therapy

Introduction Monoclonal antibodies and small molecules targeting the VEGF pathway are part of the arsenal to treat malignant tumors. Antiangiogenesis therapies has been studied in breast cancer with partial success, reflected by the…

View details →DOI: 10.1517/14712598.2014.939069
Failed Experiment ReportMedicine

Severe COVID-19 in a patient with chronic graft-versus-host disease after hematopoietic stem cell transplant successfully treated with ruxolitinib.

Saraceni F, Scortechini I, Mancini G et al. · 2021 · Transplant infectious disease : an official journal of the Transplantation Society

Graft-versus-host disease (GVHD) is a common complication of hematopoietic stem cell transplant, which is known to be mediated by cytotoxic T-cell effectors and dysregulated inflammatory cytokines. Similarly, the lung injury observed in…

View details →DOI: 10.1111/tid.13401
Failed Experiment ReportMedicine

Phase 2 Trial of Atezolizumab in Bacillus Calmette-Guérin-unresponsive High-risk Non-muscle-invasive Bladder Cancer: SWOG S1605.

Black PC, Tangen CM, Singh P et al. · 2023 · European urology

Background Although radical cystectomy (RC) is the standard of care for patients with bacillus Calmette-Guérin (BCG)-unresponsive high-risk non-muscle-invasive bladder cancer (NMIBC), many patients are ineligible for surgery or elect…

View details →DOI: 10.1016/j.eururo.2023.08.004
Failed Experiment ReportOpen accessMedicine

Timing of Exposure to ICU Diaries and Its Impact on Mental Health, Memories, and Quality of Life: A Double-Blind Randomized Control Trial.

Tripathy S, Acharya SP, Sahoo AK et al. · 2022 · Critical care explorations

Optimal time for ICU diary delivery and impact on mental health (MH), anxiety-depression, post-traumatic stress symptoms (PTSS), quality of life (QOL), and memories is unclear. We evaluated the effect of ICU diaries, dispatched at…

View details →DOI: 10.1097/cce.0000000000000742
Failed Experiment ReportOpen accessMedicine

Angina and left ventricular dysfunction: can we 'reduce' it?

Biscaglia S, Tebaldi M, Mele D et al. · 2019 · European heart journal supplements : journal of the European Society of Cardiology

Despite the evolution in pharmacology and devices, recurrent and persistent angina still represent a frequent issue in clinical practice. A 69-year-old Caucasian female patient has history of surgical aortic valve replacement with a…

View details →DOI: 10.1093/eurheartj/suz045
Failed Experiment ReportOpen accessMedicine

The Effect of Live-Virus Vaccines on Tests for Tuberculosis Infection During the US Immigration Medical Examination: Are Vaccines Causing False-Negative Results?

Regan JJ, Wang Z, Phares CR · 2025 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Background It is not recommended to perform tuberculin skin tests (TSTs) or interferon-γ release assays (IGRAs) in the 4 weeks following live-virus vaccination because these vaccines are thought to increase the risk of false-negative…

View details →DOI: 10.1093/cid/ciaf129
Failed Experiment ReportOpen accessMedicine

Four Consecutive False Negative Newborn Screens in a Patient with Classical Congenital Adrenal Hyperplasia: A Case Report

Rizzuto P, Gangat M, Khattab A et al. · 2026 · Journal of clinical research in pediatric endocrinology

21-hydroxylase deficiency is the most common cause of congenital adrenal hyperplasia (CAH). Salt-wasting CAH can present with life-threatening salt-wasting crises, underscoring the importance of universal newborn screening. We present a…

View details →DOI: 10.4274/jcrpe.galenos.2025.2024-10-16
Failed Experiment ReportMedicine

Industry promotion of oncology drugs with accelerated approval that failed confirmatory trials.

Mooghali M, Ramachandran R, Mohammad A et al. · 2026 · Journal of the National Cancer Institute

Industry payments to physician's influence prescribing, raising concern for drugs granted accelerated approval that failed confirmatory studies. We measured industry payments for oncology drugs granted accelerated approval before and after…

View details →DOI: 10.1093/jnci/djaf241
Failed Experiment ReportOpen accessMedicine

Factors associated with false-negative results from the rapid molecular test for pulmonary tuberculosis in the state of São Paulo, Brazil.

Bruce ATI, Faria MGBF, Andrade RLP et al. · 2026 · Revista brasileira de epidemiologia = Brazilian journal of epidemiology

Objective To analyze the factors associated with the frequency of false negative results for the RMT-TB test for the diagnosis of pulmonary tuberculosis in the state of São Paulo. Methods Cross-sectional study using pulmonary tuberculosis…

View details →DOI: 10.1590/1980-549720260012