A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19815 results in Negative / Null Result Report · page 148 of 661
Hannah R. Spaulding, Tiffany Quindry, Kayleen Hammer et al. · 2019 · Journal of Applied Physiology
Progressive muscle injury and weakness are hallmarks of Duchenne muscular dystrophy. We showed previously that quercetin (Q) partially protected dystrophic limb muscles from disease-related injury. As quercetin activates PGC-1α through…
Sue M Hudson, Kathie Binysh, Stephen W Duffy · 2022 · Journal of Medical Screening
Objective The Covid-19 pandemic created a backlog of women awaiting an invitation for breast screening in the UK. To recover in a timely fashion, the National Health Service programme opted to issue open invitations (OI) to women rather…
Breanne Cuddington, Meghan L. Verschoor, Ali A. Ashkar et al. · 2015 · Molecular Therapy — Oncolytics
Oncolytic viruses selectively replicate in cancer cells by exploiting biochemical differences between normal and tumor cells. Treatment with epigenetic modifiers such as 5-Azacytidine, a DNA methyltransferase inhibitor, increases the…
Sam J. Griffiths, Dan E. Browne · 2024 · Physical Review Research
The union-find decoder is a leading algorithmic approach to the correction of quantum errors on the surface code, achieving code thresholds comparable to minimum-weight perfect matching (MWPM) with amortized computational time scaling…
Padma Kaul, Dat T. Tran, Roopinder K. Sandhu et al. · 2020 · Journal of the American College of Emergency Physicians Open
STUDY OBJECTIVE: Patients with syncope are frequently admitted to the hospital, but whether this improves outcome is unknown. We tested whether hospitalization reduced mortality in patients who presented to emergency departments (EDs) with…
Jung Hyun Yoon, Jin Young Kwak, Hee Jung Moon et al. · 2019 · Ultrasound Quarterly
Abstract In this study, we evaluated the role of ultrasonography-guided core needle biopsy (US-CNB) in deciding upon management for prior atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS)…
Dana Lengel, Paul J. Kenny · 2023 · Addiction Neuroscience
Diseases associated with nicotine dependence in the form of habitual tobacco use are a major cause of premature death in the United States. The majority of tobacco smokers will relapse within the first month of attempted abstinence.…
Wei Tang, Yuwei Qiu, Huijie Lu et al. · 2021 · Frontiers in Surgery
Study Objective: This study aimed to investigate whether stroke volume variation (SVV)-guided goal-directed therapy (GDT) can improve postoperative outcomes in elderly patients undergoing minimally invasive esophagectomy (MIE) compared…
Ecaterina E. Dumbrava, Thomas E. Stinchcombe, Mrinal M. Gounder et al. · 2025 · Clinical Cancer Research
PURPOSE: Mouse double minute 2 (MDM2) is an E3 ubiquitin ligase that degrades the tumor suppressor p53. In cancers, MDM2 amplification (MDM2amp) leads to overexpression of MDM2, inducing p53 degradation and a p53-null phenotype even in the…
James M. Barron, Nathan R. Jensen, Paul J. Anders et al. · 2013 · North American Journal of Aquaculture
Abstract The survival and percentage of North American Burbot Lota lota maculosa larvae and metamorphosing larvae presumed to have been cannibalized during a 15-d period immediately following a size-grading event were compared with those of fish in nongraded control groups. In larvae (mean TL, 11.8 mm), grading immediately produced a size distinction, as the group that passed the grader was significantly narrower and shorter than the group retained by the grader. The mean coefficient of variation of the length of larvae in the retained group was significantly lower than that of the control gro
Divya Narayanan, John David Rodriguez, Garrick Wallstrom et al. · 2020 · BMC Ophthalmology
BACKGROUND: To prevent irreversible vision loss in age-related macular degeneration (AMD), it is critical to detect retinal dysfunction before permanent structural loss occurs. In the current study we evaluated a series of visual function tests to identify potential endpoints to detect visual dysfunction in non-advanced AMD. METHODS: A series of visual function tests were performed on 23 non-advanced AMD subjects (AREDS grade 1-4 on simplified scale) and 34 age-matched normals (AREDS grade 0). Tests included some commonly used endpoints such as ETDRS visual acuity (VA), low luminance (LL) 2.0N
Marcin A. Sowa, Haoyu Sun, Tricia T. Wang et al. · 2024 · JACC Basic to Translational Science
We investigated the impact of antiplatelet therapy on the megakaryocyte (MK) and platelet transcriptome. RNA-sequencing was performed on MKs treated with aspirin or P2Y12 inhibitor, platelets from healthy volunteers receiving aspirin or…
Jianbo Wang, Hussein A. Tawbi · 2021 · Neuro-Oncology Advances
Brain metastases from solid tumors are increasing in incidence, especially as outcomes of systemic therapies continue to extend patients' overall survival. The long-held notion that the brain is an immune sanctuary has now been largely…
Justin J. Robert, Sarah M. Larocque, Steven J. Cooke · 2012 · North American Journal of Fisheries Management
Abstract Catch and release is a common practice among recreational anglers. In instances when fish are deeply hooked, the proper techniques for promoting survival are poorly understood, although evidence suggests that the fishing line…
Zeev Elkoshi · 2021 · Frontiers in Immunology
A binary model for the classification of chronic diseases has formerly been proposed. The model classifies chronic diseases as “high Treg” or “low Treg” diseases according to the extent of regulatory T cells (Treg) activity (frequency or function) observed. The present paper applies this model to severe acute respiratory syndrome coronavirus 2 (SARS - CoV - 2) infection. The model correctly predicts the efficacy or inefficacy of several immune-modulating drugs in the treatment of severe coronavirus disease 2019 (COVID-19) disease. It also correctly predicts the class of pathogens mostly associ
Sami Saeed Binyamin · 2026 · Edinburgh Napier Research Repository (Edinburgh Napier University)
Learning management systems (LMS), which allow education at the student’s choice of place and time, have been widely adopted in higher education worldwide. In the case of Saudi Arabia, LMS have been recently introduced in Saudi…
Bin Liu, Changfeng Yan, Ming Lv et al. · 2026 · Computers in Industry
Domain adaptation-based methods are extensively applied to predict the Remaining Useful Life (RUL) of rolling bearings under complex operating conditions. However, the nonlinear degradation process of bearings gives rise to markedly…
Chen Ding, Dize Li, Linzhu Su et al. · 2026 · International Journal of Oral Science
Nanotechnology has provided thousands of novel nano-antimicrobials possessing features uncommon in clinically available antimicrobials. Here, nanocarriers loaded with conventional antimicrobials and responding to environmental changes upon…
Bianca Menzani, Priscille De Gea, Xavier Gidrol et al. · 2026 · Lab on a Chip
models for studying human physiology, development and disease. Their potential is very important and they have broad applications, but their impact is currently limited by persistent challenges such as incomplete maturation, batch…
Amalie Kjær Andresen, Mathilde Sophie Felding, Margarida M. A. Sacramento et al. · 2025 · Journal of Controlled Release
Bacterial biofilms pose a significant clinical challenge due to their intrinsic resistance to antibiotics and immune clearance. Traditional systemic antibiotic therapies are often ineffective against the structured microbial communities, emphasizing the urgent need for localized and targeted drug delivery systems. Hydrogels are three-dimensional, water-rich polymeric networks, and have emerged as a versatile platform for localized delivery of antimicrobial agents, offering controlled release, biocompatibility and the potential for functionalization with bioactive components. This review explor
Cao Zhengzheng, Guo Fangxu, Rong Tao et al. · 2026 · Scientific Reports
Floor aquifers are responsible for approximately 55% of water inrush incidents in coal mines. As mining depths increase, the risk posed by confined floor aquifers becomes more severe. Grouting reinforcement and the sealing of water…
Sathish Babu Vasamsetti, Samreen Sadaf, Mohammad A. Uddin et al. · 2026 · Nature Communications
How cellular metabolism facilitates tissue-resident macrophage maintenance remains elusive. Here we show that visceral adipose tissue (VAT)-resident macrophages, unlike monocyte-derived macrophages, are enriched with mitochondrial-specific antioxidant enzymes restraining inflammation and promoting VAT homeostasis and insulin sensitivity. Additionally, VAT resident macrophages express high levels of plasminogen activator inhibitor type 2, encoded by SerpinB2, which is involved in the blood coagulation cascade. SerpinB2 promotes adipose resident macrophage survival by regulating mitochondrial ox
Florian Missey, Emma Acerbo, Adam S. Dickey et al. · 2025 · Brain stimulation
INTRODUCTION: Medication-refractory focal epilepsy creates a significant clinical challenge, with approximately 30 % of patients deemed ineligible for surgery due to involvement of eloquent cortical regions within the epileptogenic network. For these patients, electrical neuromodulation represents a promising alternative therapy. We investigated the potential of non-invasive temporal interference (TI) electrical stimulation in reducing epileptic biomarkers in patients with mesiotemporal epilepsy (MTLE) MATERIAL AND METHOD: Thirteen patients implanted with stereoelectroencephalography (sEEG) de
Anna Barton, Maciej Jaśkiewicz, Anna Więch -Walów et al. · 2025 · Cell Communication and Signaling
Abstract The cellular and tissue response to acute hypoxia is mediated by a complex adaptive response initiated by hypoxia-inducible factors (HIF) 1 and 2. HIF proteins are key transcription factors that modulate gene expression to adapt cells to the low oxygen tension. Cellular studies of hypoxia have used the low oxygen model by using hypoxia chambers to monitor the gene expression changes, while others have utilized hypoxia mimetics in normoxic conditions. Here, we provide a comparison of the utility and limitations of two hypoxia mimetics by studying the changes in the miRNA and mRNA expre
Yi Zhang, Yanqi Han, Ying Sun et al. · 2026 · Signal Transduction and Targeted Therapy
Osteoarthritis (OA) is a debilitating joint disorder that causes chronic pain, inflammation, and detrimental bone alterations. Despite significant advances in understanding OA pathogenesis, current therapeutic strategies remain inadequate in halting disease progression or providing effective pain relief, highlighting unmet clinical needs. Recent insights into OA nociceptive pathways, inflammatory mediators, and organelle dysfunction have revealed promising therapeutic targets. Specifically, OA progression is driven by mitochondrial dysfunction (marked by accumulated damaged mitochondria with e
Sterling Williams-Ceci, Maurice Jakesch, Advait Bhat et al. · 2026 · Science Advances
Artificial intelligence (AI) writing assistants powered by large language models (LLMs) are increasingly used to make autocomplete suggestions to people as they write text. Can these AI writing assistants affect people’s attitudes in this…
S. H. Suyu, Ana Acebrón, C. Grillo et al. · 2026 · Astronomy and Astrophysics
Robust mass modeling of strong-lensing galaxy clusters is crucial for studying cosmology and galaxy evolution. We present and compare seven mass models of the galaxy cluster MACS J0138−2155, constructed using six independent modeling software programs, including parametric and free-form approaches. By conducting a blind analysis where all the mass-modeling teams constructed their models independently without exchanging results, we quantified uncertainties arising from modeling software and assumptions. MACS J0138−2155 is unique as the only cluster found to strongly lens two supernovae (SNe), R
F Visalli, Matteo Capobianco, F. Cappellani et al. · 2026 · International Journal of Molecular Sciences
Mitochondrial dysfunction represents a central hallmark of aging and a broad spectrum of chronic diseases, ranging from metabolic to neurodegenerative and ocular disorders. Nicotinamide riboside (NR), a vitamin B3 derivative and efficient precursor of NAD+ (nicotinamide adenine dinucleotide), and berberine (BBR), an isoquinoline alkaloid widely investigated in metabolic regulation, have independently emerged as promising mitochondrial modulators. NR enhances cellular NAD+ pools, thereby activating sirtuin-dependent pathways, stimulating PGC-1α–mediated mitochondrial biogenesis, and triggering
Rafael Scaf de Molon, João Paulo Steffens, Érica Dorigatti de Ávila et al. · 2026 · Journal of Periodontal Research
Periodontitis is a chronic, host-mediated inflammatory disease in which microbial dysbiosis and dysregulated immune responses drive the destruction of tooth-supporting tissues. Although conventional therapy remains centered on mechanical biofilm control, persistent inflammation and alveolar bone loss in susceptible individuals underscore the need for adjunctive strategies. Translating preclinical discoveries into predictable clinical outcomes, however, remains a major challenge in periodontal research. This narrative review integrates two interrelated themes, translational research methodology
Fiyinfoluwa Demilade Ojeniyi, Adeola Oluwakemi Ayoola, Olajumoke Ibitoye et al. · 2025 · Scientific Reports
Rapid diagnostic tests (RDTs) have revolutionized malaria diagnosis, playing a crucial role in improving timely treatment and supporting surveillance efforts, especially in resource-limited settings. However, the performance of RDTs can…