A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20217 results in Negative / Null Result Report · page 142 of 674
Stefania Piscopo, Euan R. Brown · 2018 · Small
Abstract Membrane–nanoparticle interactions are important in determining the effects of manufactured nanomaterials on cell physiology and pathology. Here, silica, titanium, zinc, and magnesium oxide nanoparticles are screened against human…
Chang Yu, Ning Zhang, Weikang Zhu et al. · 2019 · Evidence-based Complementary and Alternative Medicine
Objectives . To evaluate the safety of moxa smoke, especially to provide quantitative information and details for the occupational prevention of acupuncturists. Methods . We combined the questionnaire-based cross-sectional survey and lung function testing-based historical retrospective cohort research to investigate the safety of moxa smoke exposure (MSE) among acupuncturists. A mathematical regression model was established to quantitatively evaluate the relationship between moxa smoke exposure and the respiratory health of the acupuncturist. The smoke exposure time of the acupuncturist and th
Jennifer Zou, Jinjing Zhou, Sarah Faller et al. · 2022 · G3 Genes Genomes Genetics
Genome-wide association studies (GWAS) have identified thousands of genetic variants associated with complex human traits, but only a fraction of variants identified in discovery studies achieve significance in replication studies. Replication in genome-wide association studies has been well-studied in the context of Winner's Curse, which is the inflation of effect size estimates for significant variants due to statistical chance. However, Winner's Curse is often not sufficient to explain lack of replication. Another reason why studies fail to replicate is that there are fundamental difference
Linda Liu, Zachary Burchill, Michael K. Tanenhaus et al. · 2017 · eScholarship (California Digital Library)
Sentence understanding is affected by recent experience. Animportant open question is whether this reflects adaptationto the statistics of the input. Support for this hypothesiscomes from the recent finding that listeners can…
Zofia Strojny, Rafał Rutkowski, Alina Kanikowska et al. · 2021 · Nutrients
Background: Chronotype is the pattern of the circadian rhythm that allows an individual to optimize times of sleep and activity. It has been observed that chronotypes may associate with some conditions and diseases, including obesity. It is not known, however, whether chronotypes determine the effectiveness of weight loss regimens. Therefore, in the present study, we compared the outcomes of a 3-week moderate calorie restriction undertaken by individuals with obesity under the same controlled hospital conditions. Methods: A total of 131 participants with obesity (median BMI 40.0) were studied.
Wan Azani Mustafa, Haniza Yazid, Hiam Alquran et al. · 2024 · PLoS ONE
Weld defect inspection is an essential aspect of testing in industries field. From a human viewpoint, a manual inspection can make appropriate justification more difficult and lead to incorrect identification during weld defect detection. Weld defect inspection uses X-radiography testing, which is now mostly outdated. Recently, numerous researchers have utilized X-radiography digital images to inspect the defect. As a result, for error-free inspection, an autonomous weld detection and classification system are required. One of the most difficult issues in the field of image processing, particu
Shanshan Jiang, Jaka Sunarso, Wei Zhou et al. · 2013 · Journal of Materials Chemistry A
Layered oxides of Sr4Fe4Co2O13 (SFC2) which contains alternating perovskite oxide octahedral and polyhedral oxide double layers are attractive for their mixed ionic and electronic conducting and oxygen reduction reaction properties. In…
Loet Leydesdorff, Caroline S. Wagner, Lin Zhang · 2021 · Journal of Data and Information Science
Abstract Purpose Building on Leydesdorff, Bornmann, and Mingers (2019), we elaborate the differences between Tsinghua and Zhejiang University as an empirical example. We address the question of whether differences are statistically…
Dapeng Liu, Heinz Roland Weistroffer · 2020 · Journal of Computer Information Systems
Trust, such as trust in a technology or believing that a technology has trustworthy utility, manifests its importance by affecting user behaviors toward information systems (IS). There is no dearth of evidence showing that the effect of…
Michael Benatar, Christopher McDermott, Martin R. Turner et al. · 2024 · Brain
There is a long history in amyotrophic lateral sclerosis (ALS) of promoting therapies based on phase 2 data, which then fail in phase 3 trials. Experience suggests that studies of 6 months in duration are too short, especially with…
Kaylin Ratner, Anthony L. Burrow, Felix Thoemmes · 2016 · Royal Society Open Science
Having a sense of meaning in life (MIL) has been acknowledged as a catalyst to psychological flourishing. As such, understanding ways to promote MIL represents a worthy goal for those interested in bolstering positive outcomes. This study sought to replicate the findings of Heintzelman, Trent & King (2013 Psychol. Sci. 24 , 991–998 ( doi:10.1177/0956797612465878 )), who found that MIL could be influenced by external stimulation. Their findings suggest that exposure to coherent stimuli produces significantly higher MIL scores than exposure to incoherent stimuli. Using materials and methodol
Luisa Hopp, Barbara Glaser, Julian Klaus et al. · 2019 · Hydrological Processes
Abstract The occurrence of preferential flow in the subsurface has often been shown in field experiments. However, preferential flow is rarely included in models simulating the hydrological response at the catchment scale. If it is…
Qian Xu, Shi Chen, Lida Safarnejad · 2020 · Health Communication
By taking the 2016 Zika outbreak as a case study, this research examines how information veracity (true information vs. misinformation) interacted with message frames to influence the dissemination of information about Zika through retweet…
Santosh Lohumi, Lalit Mohan Kandpal, Young Wook Seo et al. · 2016 · Journal of Biosystems Engineering
Purpose: Fusel oil is a potent volatile aroma compound found in many alcoholic beverages. At low concentrations, it makes an essential contribution to the flavor and aroma of fermented alcoholic beverages, while at high concentrations, it…
Camille Zaug, John D. Carter · 2021 · Studies in Applied Mathematics
Abstract Ocean swell plays an important role in the transport of energy across the ocean, yet its evolution is not well understood. In the late 1960s, the nonlinear Schrödinger (NLS) equation was derived as a simplified model for the…
Pertti Vakkari · 2011 · Online Information Review
Purpose This paper seeks to evaluate to what extent Google retrieved correct answers to queries inferred from factual and topical requests in a digital Ask‐a‐Librarian service. Design/methodology/approach In total, 100 factual and 100…
Jacobien H. F. Oosterhoff, Anne de Hond, Rinne M Peters et al. · 2024 · Clinical Orthopaedics and Related Research
BACKGROUND: Estimating the risk of revision after arthroplasty could inform patient and surgeon decision-making. However, there is a lack of well-performing prediction models assisting in this task, which may be due to current conventional…
C. Elizabeth Shaaban, Caterina Rosano, Xiaonan Zhu et al. · 2023 · The Journals of Gerontology Series A
BACKGROUND: Older adults with discordant biological and chronological ages (BA and CA) may vary in cognitive and physical function from those with concordant BA and CA. METHODS: To make our approach clinically accessible, we created…
Cedric Popa, Karel Holvoet, Tessa Van Montfort et al. · 2018 · Frontiers in Pharmacology
Background: Profits in the biopharmaceutical industry have been scrutinized in social debate. However, drawing conclusions based on industry profitability only is inappropriate as such an analysis does not account for risks faced by investors. This study aims to measure risks and returns in the biopharmaceutical industry and investigates whether risk-adjusted return on investment in the biopharmaceutical industry is higher than that in other industries. Methods: To enable appropriate comparison, we identified six benchmark industries with characteristics that match those of the biopharmaceutic
Carlos González‐Alayón, Esteban Porrini, Sergio Luis‐Lima et al. · 2021 · Liver International
BACKGROUND & AIMS: In cirrhosis, the reliability of formulas that estimate renal function, either those specifically developed in this population or the classic equations, has not been properly quantified. We studied the agreement between…
Eun-Ju Kim, Chan Kyo Kim, Hyun Soo Kim et al. · 2020 · British Journal of Radiology
Objective: To evaluate the usefulness of histogram analysis of stretched exponential model (SEM) on diffusion-weighted imaging in evaluating clinically significant prostate cancer (CSC). Methods: A total of 85 patients with prostate cancer…
Yumei Luo, Quan Chen, Fan Liu et al. · 2023 · Frontiers in Ecology and Evolution
Introduction Plant richness is thought to improve the function of constructed wetlands (CWs), but most CWs are planted with monocultures, with only a few employed polycultures, which have drawn contradictory conclusions. We suppose functional diversity is the key to better performance of plant communities and hypothesize that CWs planted with diverse growth forms are superior in plant growth and nutrient removal. Methods In this study, six emergent plant species categorized into slender type ( Schoenoplectus tabernaemontani, Typha orientalis ), fan type ( Iris sibirica, Acorus calamus ) and la
Liza Van der Laan, Kyle Parmley, Mojdeh Saadati et al. · 2025 · The Plant Genome
Developments in genomics and phenomics have provided valuable tools for use in cultivar development. Genomic prediction (GP) has been used in commercial soybean [Glycine max L. (Merr.)] breeding programs to predict grain yield and seed…
Peipei Ma, Mogens Sandø Lund, Xiangdong Ding et al. · 2014 · Journal of Animal Breeding and Genetics
This study investigated the effect of including Nordic Holsteins in the reference population on the imputation accuracy and prediction accuracy for Chinese Holsteins. The data used in this study include 85 Chinese Holstein bulls genotyped…
Geri R. Donenberg, Jessica Fitts, Charles Ingabire et al. · 2022 · PubMed
BACKGROUND: Adolescents living with HIV have elevated mental distress and suboptimal antiretroviral therapy (ART) adherence. SETTING: Two urban clinics in Kigali, Rwanda. METHODS: A 2-arm individual randomized controlled trial compared…
David Giguere, Daniel J. Dickson, Michelle K. Tulloch et al. · 2021 · Journal of Experimental Child Psychology
Evidence is mixed regarding whether and why bilingual children might be advantaged in the development of executive functions. Five preregistered hypotheses regarding sources of a bilingual advantage were tested with data from 102 Spanish-English bilingual children and 25 English monolingual children who were administered a test of executive attention, the flanker task, at 7, 8, and 9 years of age. Measures of the children's early and concurrent bilingual exposure and their concurrent English and Spanish skill were available from a larger longitudinal study in which these children participated.
Jan Reinhard, Melanie Schindler, Franziska Leiss et al. · 2023 · Archives of Orthopaedic and Trauma Surgery
Abstract Introduction Enhanced recovery after surgery (ERAS) leads to less morbidity, faster recovery, and, therefore, shorter hospital stays. The expected increment of primary total hip arthroplasty (THA) in the U.S. highlights the need…
C Länger, P Ernst, M Bender et al. · 2021 · New Journal of Physics
Abstract Hydrogen-covered Si(001) surfaces were exposed to swift heavy ions (SHI) and slow highly charged ions (HCI). Using scanning tunneling microscopy as analysis tool, the ion-induced modifications on the surface were resolved on the…
Youn-Goo Kang, Taeyoung Lee, Jaeyoung Ro et al. · 2023 · Nutrients
Obesity is a major global health problem which is associated with various diseases and psychological conditions. Increasing understanding of the relationship between obesity and gut microbiota has led to a worldwide effort to use…
Li Wang, Jiting Zhang, Li Zhang et al. · 2022 · Frontiers in Cellular and Infection Microbiology
Background Sepsis is regarded as a life-threatening organ dysfunction syndrome that responds to infection. Pyroptosis, a unique form of programmed cell death, is characterized by inflammatory cytokine secretion. Recently, an increasing…