A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19814 results in Negative / Null Result Report · page 142 of 661
Wändi Bruine de Bruin, Laurel Kruke, Gale M. Sinatra et al. · 2024 · Climatic Change
Abstract The terms “global warming,” “climate crisis,” “climate emergency,” and “climate justice” each draw attention to different aspects of climate change. Psychological theories of attitude formation suggest that people’s attitudes can…
Annie McCluskey, Sally Bennett, Tammy Hoffmann et al. · 2010 · Health Information & Libraries Journal
Abstract Background: Research is essential for evidence‐based practice yet many health professionals do not have enough time to find research. Studies relevant to occupational therapists can be particularly difficult to find. Most search…
Qiang Tang, Yanwei Liu, Yingfeng Fu et al. · 2021 · Scientific Reports
The 2019 Coronavirus Disease (COVID-19) has become an unprecedented public crisis. We retrospectively investigated the clinical data of 197 COVID-19 patients and identified 88 patients as disease aggravation cases. Compared with patients without disease aggravation, the aggravation cases had more comorbidities, including hypertension (25.9%) and diabetes (20.8%), and presented with dyspnoea (23.4%), neutrophilia (31.5%), and lymphocytopenia (46.7%). These patients were more prone to develop organ damage in liver, kidney, and heart (P < 0.05). A multivariable regression analysis showed that adv
Zhongwei Liu, Shuang Shi, Haitao Zhu et al. · 2018 · International Heart Journal
The phenotype shifting of vascular smooth muscle cells (VSMCs) was indicated to play a role during the initial stage of atherosclerotic plaque formation by facilitating extracellular matrix deposition. This study was aimed at investigating…
Lien Anh Ha Do, Zheng Quan Toh, Paul Vincent Licciardi et al. · 2021 · The Lancet Global Health
Measles virus and respiratory syncytial virus (RSV) are two important global health pathogens causing substantial morbidity and mortality worldwide. The current measles vaccination schedule has the first dose given at 9-12 months of age…
Michal Mego, Barbora Judita Kasperová, Jozef Chovanec et al. · 2024 · Frontiers in Oncology
Background: Probiotics could decrease irinotecan-induced diarrhea due to the reduction of intestinal beta-d-glucuronidase activity. This study included a combined analysis of two clinical trials aimed to determine the effectiveness of the probiotics in the prophylaxis of irinotecan-induced diarrhea in metastatic colorectal cancer (CRC) patients. Methods: This combined analysis included 46 patients with CRC enrolled in the Probio-SK-003 (NCT01410955) and 233 patients from Probio-SK-005 (NCT02819960) starting a new line of irinotecan-based therapy with identical eligibility criteria. Patients we
Ciara Conduit, Ian D. Davis, Jeffrey C. Goh et al. · 2023 · British Journal of Urology
OBJECTIVE: To evaluate the efficacy of sequential treatment with ipilimumab and nivolumab following progression on nivolumab monotherapy in individuals with advanced, non-clear-cell renal cell carcinoma (nccRCC). MATERIALS AND METHODS:…
Silvia Park, Emma Langley, Jong‐Mu Sun et al. · 2015 · Oncotarget
// Silvia Park 1, * , Emma Langley 2, * , Jong-Mu Sun 1 , Steve Lockton 2 , Jin Seok Ahn 1 , Anjali Jain 2 , Keunchil Park 1 , Sharat Singh 2 , Phillip Kim 2 , Myung-Ju Ahn 1 1 Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea 2 Prometheus Laboratories Inc, A Nestlé Health Science Company, Department of Research and Development, San Diego, CA, USA * These authors have contributed equally to this work Correspondence to: Myung-Ju Ahn, e-mail: silkahn@skku.edu Phillip Kim, e-mail: pkim@prometheuslabs.co
Christopher A. Tait, Abtin Parnia, Nishan Zewge-Abubaker et al. · 2020 · BMC Public Health
Abstract Background Child mortality has been reduced by more than 50 % over the past 30 years. A range of secular economic and social developments have been considered to explain this phenomenon. In this paper, we examine the association…
Naicheng Wu, Guohao Liu, Min Zhang et al. · 2022 · Animals
One of the key targets of community ecology and biogeography concerns revealing the variability and underlying drivers of biodiversity. Most current studies understand biodiversity based on taxonomic information alone, but few studies have…
Gamze Durhan, Ahmet Gürkan Erdemir, Sezin Yuce Sari et al. · 2020 · Breast Care
Objective: Lymphatic irradiation in breast cancer improves locoregional control and has been shown to decrease distant metastasis. However, irradiation also accelerates the formation of atherosclerosis and can cause stenosis,…
B. WIELSTRA, J. W. ARNTZEN · 2014 · Zootaxa
We collected nuclear DNA data (52 markers) with next-generation sequencing for nine Triturus newt specimens, including the holotype and two of the paratypes of T. arntzeni, from the type locality at Vrtovać in eastern Serbia. We compare…
Marlies Oostendorp, Christine H. ten Hove, Miranda van Berkel et al. · 2023 · Archives of Pathology & Laboratory Medicine
Context.— Total serum bilirubin (TSB) analysis is pivotal for diagnosing neonatal hyperbilirubinemia. Because of a routine change in laboratory equipment, our TSB assay changed from a diazo to a vanadate oxidase method. Upon…
Huanhuan Chang, Jiao Li · 2022 · Journal of Clinical Laboratory Analysis
Abstract Background At present, there is a new variant Omicron BA.2 of SARS‐CoV‐2. In some previous studies, it was found that CBC, NLR, CRP, SAA, etc. in patients with SARS‐CoV‐2 had a series of changes, which were significantly…
Ping Yue, Xiaoan Zuo, Kaihui Li et al. · 2021 · Land Degradation & Development
Abstract As the third most important greenhouse gas, nitrous oxide (N 2 O) poses a significant threat to global warming and the ozone layer. However, the effects of precipitation changes on N 2 O emissions in arid areas remain unclear,…
Barton J. Mann, Taco Gosens, Stephen Lyman · 2012 · The American Journal of Sports Medicine
Treatment outcome researchers in orthopaedics frequently report only tests of statistical significance between group means to evaluate the effectiveness of a given intervention. Although important in establishing that mean differences are…
Haoran Zhou, Jung-Min Ji, Min Kim et al. · 2018 · Nanomaterials
The rational design of porphyrin sensitizers is always crucial for dye-sensitized solar cells (DSSCs), since the change of only a single atom can have a significant influence on the photovoltaic performance. We incorporated the…
Joshua Fisher, Poonam Arora, Sophia Rhee · 2018 · Sustainability
The viability of conservation efforts, including protected areas and buffer zones, depends on finding ways to make those strategies more attractive and viable for local populations. This paper presents a pilot study utilizing a rapid rural…
Geoffrey L. Dickens, Laura E. O'Shea · 2017 · International Journal of Forensic Mental Health
Outcomes measures are commonly derived from post-discharge recidivism, readmission, and mortality rates but information about common outcomes across admission is scant. We determined whether reliable and clinically significant change in…
Seo-Ha Jeong, Yeon Gyo Nam · 2024 · Healthcare
Background/Objectives: Globally, life expectancy has been increasing with South Korea focusing on improving health to enhance quality of life. The COVID-19 pandemic further emphasized the need for digital transformation in healthcare,…
Wenhua Wan, Petra Döll, Hang Zheng · 2022 · Water Resources Research
Abstract To support the implementation of China's carbon neutrality target, this study assesses the impact of future climate change on hydroelectricity production (HP) in China. We developed a hydropower database for mainland China, which…
Joon Young Choi, Jeong Uk Lim, Ho Jung Jeong et al. · 2020 · BMC Pulmonary Medicine
Abstract Background We investigated the association between a combination of two markers, peripheral (PEC) and bronchoalveolar lavage (BAL) eosinophil percentage (BEP), and oxygen requirements in patients with acute eosinophilic pneumonia…
Karina Gutiérrez-Moreno, Ana Isabel Olguín-Martínez, Amelia C. Montoya-Martínez et al. · 2025 · Diversity
Fungi from the genus Trichoderma have been extensively studied and used as biological control agents (BCAs) because of their versatile mechanisms of action. These include triggering systemic resistance, directly inhibiting pathogens, promoting plant growth, enhancing tolerance to abiotic stress, and producing auxins. However, the widespread application of the most studied Trichoderma strains has been limited by discrepancies between their potential results observed in controlled environments and the outcomes in greenhouses and field conditions. These differences are associated with context dep
Abdulaziz Alfahed · 2024 · Biology
The migration-proliferation dichotomy (MPD) has long been observed in cultured cancer cells. This phenomenon is not only relevant to tumour progression but may also have therapeutic significance in clinical cancer. However, MPD has rarely been investigated in primary cancer. This study aimed to either confirm or disprove the existence of MPD in primary cancer. Using primary gastric, colorectal and prostate cancer (GC, CRC and PCa) cohorts from the Cancer Genome Atlas and Memorial Sloan Kettering Cancer Center, this study interrogated the MPD phenomenon by utilising RNA-Seq-based proliferation
A. Giordano, Cristina Romero-Mascarell, Begoña González-Suárez et al. · 2025 · Digestive Diseases and Sciences
The integration of artificial intelligence (AI) into capsule endoscopy is transforming gastrointestinal diagnostics by enhancing lesion detection and optimizing reading efficiency. This review focuses on the clinical applications of…
Holly Overton, Michail Vafeiadis, Pratiti Diddi et al. · 2025 · Corporate Communications An International Journal
Purpose As companies continue to engage in CSA, they continue to struggle with determining what issues they should speak out about and how they can create compelling messages that inspire action. Guided by arguments from issue ownership theory, this study examines CSA message content effects related to two different social-political issues on advocacy behavioral intentions, megaphoning, brand preference and purchase intention. Specifically, the level of advocacy in a CSA message is examined, as well as the manner in which the message is written (narrative vs informational). Furthermore, this s
Zachary J. Williams, Hannah Barnett, Balázs Szigeti · 2026 · JAMA Psychiatry
Importance: Psychedelic-assisted therapy (PAT) trials have high levels of functional unblinding, which biases results when comparing PAT with blinded interventions. Because PAT is effectively always open label, treatment results should be…
Ewelina Młynarska, Wiktoria Lisińska, Katarzyna Hossa et al. · 2025 · Pharmaceuticals
Vitamin D, long recognized for its essential role in calcium-phosphate balance and bone health, has increasingly been identified as a pleiotropic regulator of metabolic, cardiovascular, and renal function. Deficiency of vitamin D is widespread worldwide and has been linked to a higher risk of insulin resistance, type 2 diabetes, atherosclerosis, hypertension, and chronic kidney disease. Meta-analyses suggest that each 10 nmol/L (≈4 ng/mL) increase in serum 25-hydroxyvitamin D [25(OH)D] is associated with about a 4% lower risk of type 2 diabetes, whereas other analyses indicate an approximately
Junyi Yin, Jie Zhu, Shaolei Wang et al. · 2026 · Nature Communications
One-dimensional (1D) multifunctional fibers have garnered significant attention due to their advantageous geometry properties, which allows conformal interfacing with soft biological tissues and efficient charge transport. Here, we…
Judith Charbit, Jean‐Sébastien Vidal, Olivier Hanon · 2025 · Nutrients
Cognitive aging is a complex, multifactorial process influenced by genetic, metabolic, and environmental factors. Among modifiable risk factors, nutrition has emerged as a promising target to preserve cognitive function. This review provides a comprehensive overview of the impact of dietary interventions-including specific nutrients and dietary patterns-on cognitive domains (memory, executive function, global cognition) and mental health. Recent findings: multinutrient supplementation, particularly combinations of B vitamins and omega-3 fatty acids, appears beneficial for episodic memory, espe