e-ISSN: Pending
WASTE Journal
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

AllReplication FailureNegative / Null Result ReportFailed Experiment ReportAbandoned HypothesisMethods Dead-EndShort NoteNull DatasetProtocol

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

By fieldMedicine 12,218Computer Science 744Biochemistry, Genetics and Molecular Biology 414Social Sciences 302Psychology 299Physics 280Neuroscience 244Economics, Econometrics and Finance 196Environmental Science 172Mathematics 155Agricultural and Biological Sciences 138Engineering 135

750 results in Failed Experiment Report · page 14 of 25

Failed Experiment ReportMedicine

Impact of Dam Lactation Number on Colostrum Quality, Calf Growth, and Economic Performance in Holstein Cows.

García-Mendoza A, González-Hernández M, Vega-Manriquez DX et al. · 2026 · Veterinary sciences

This study investigated the associations among dam lactation number, passive immunity transfer, internal parasite burden, and weaning performance in female calves. Early consumption of high-quality colostrum is critical for effective…

View details →DOI: 10.3390/vetsci13060600
Failed Experiment Report

Cold-Shock-Mediated Inhibition of Silk Extrusion in Galleria mellonella (Lepidoptera: Pyralidae) for Improved Handling in Infection Studies: Effects on Developmental Traits and Pathogen Susceptibility

Matiya DJ, Tutt K, Wakefield JG et al. · 2026 · Preprint

The greater wax moth, Galleria mellonella , is an increasingly important invertebrate model for infection biology, yet silk extrusion during handling complicates larval injections and hampers survival assessment. Here, we develop and…

View details →DOI: 10.64898/2026.01.20.700541
Failed Experiment Report

Acute Effect of Photobiomodulation Therapy in Quadriceps Strength, Fatigue and Pain of Patients With Chronic Kidney Failure: A Randomized, Double-blind, Placebo Controlled Crossover Clinical Trial

Barbosa APO, Santos LM, Catelli AM et al. · 2026 · Preprint

Abstract Background Patients with chronic kidney failure (CKF) present changes in physical capacity and low exercise tolerance. Photobiomodulation therapy (PBMT) has shown an ergogenic effect on exercise in studies with different…

View details →DOI: 10.21203/rs.3.rs-8149683/v1
Failed Experiment ReportMedicine

Site-specific role of CRF<sub>1</sub> receptors along the rostrocaudal axis of the insular cortex in cardiovascular responses evoked by acute and repeated restraint stress in rats.

Reis-Silva LL, Tomeo RA, Barreto-de-Souza L et al. · 2026 · Autonomic neuroscience : basic & clinical

The present study investigated the contribution of corticotropin-releasing factor (CRF) neurotransmission acting through local CRF₁ receptors in the anterior (aIC), rostral-posterior (rpIC), and caudal-posterior (cpIC) subregions of the…

View details →DOI: 10.1016/j.autneu.2026.103403
Failed Experiment ReportMedicine

Histomorphometric Evaluation of Socket Preservation Healing Using Xenogeneic Bone Substitute Combined with Statin: A Prospective Split-Mouth Clinical Pilot Study.

Katanec T, Šimunović L, Likić R et al. · 2026 · Acta stomatologica Croatica

Objective Statins exhibit pleiotropic effects on bone metabolism, including osteogenic and angiogenic activity. The aim of this pilot study was to evaluate whether local application of simvastatin combined with a bovine-derived xenogeneic…

View details →DOI: 10.15644/asc60/2/6
Failed Experiment ReportMedicine

Can machine learning predict vessels that encapsulates tumor cluster ptterns and histological differentiation in solitary small (< 5 cm) hepatocellular carcinoma?

Toshida K, Sugitani Y, Itoh S et al. · 2026 · Surgery today

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality. Machine learning (ML) may enable the noninvasive prediction of histopathological features using clinical and imaging data. This study evaluated the utility of…

View details →DOI: 10.1007/s00595-026-03317-w
Failed Experiment ReportOpen accessMedicine

Promotion of recovery from Traumatic Brain Injury (TBI) by Granulocyte Colony-Stimulating Factor (G-CSF) treatment requires cannabinoid receptor type 2 activity.

Song S, Wang B, Kong X et al. · 2025 · Journal of cannabis research

Granulocyte colony-stimulating factor (G-CSF) has the capacity to enhance brain repair following various injuries to brain. G-CSF treatment after TBI in rodents has been reported to promote brain repair, hippocampal neurogenesis, and…

View details →DOI: 10.1186/s42238-025-00305-8
Failed Experiment ReportOpen accessMedicine

Effect of Short-Anchored PEGylated Lipids on Lipid Nanoparticle Characterization Profiles, Stability, and Efficacy.

Souleyrette CER, West PC, Kirkpatrick SS et al. · 2026 · Biomedicines

Background/Objectives : RNA interference (RNAi) is a promising strategy for mitigating diseases at the molecular level. However, RNAi is limited by its instability in biological fluids and impermeability to cellular membranes. In response,…

View details →DOI: 10.3390/biomedicines14051002
Failed Experiment ReportOpen accessMedicine

High-dose beta-alanine supplementation for two weeks did not enhance intermittent endurance or sprint performance in trained futsal players.

Miraftabi H, Berjisian E, Nouri Dizicheh M et al. · 2025 · Journal of the International Society of Sports Nutrition

Background This study aimed to investigate the effects of a high-dose beta-alanine (BA) supplementation on physical performance, blood lactate concentration, and ratings of perceived exertion (RPE) in trained futsal players. Methods…

View details →DOI: 10.1080/15502783.2025.2564245
Failed Experiment ReportMedicine

Application of High-Performance Liquid Chromatography to Quantify Formaldehyde Release From the Chemical Interaction of Sodium Hypochlorite and EDTA.

Ioannidis K, Katmerou I, Nikolaidis A et al. · 2026 · Journal of endodontics

Introduction The aim of this study was to examine, in vitro, the formation of formaldehyde with the aid of high performance liquid chromatography (HPLC), following the interaction of sodium hypochlorite (NaOCl) 2% w/v and…

View details →DOI: 10.1016/j.joen.2026.06.001
Failed Experiment ReportOpen accessMedicine

The Causal Effects of Inflammation and Coagulation-Related Biomarkers on Sepsis-Related Complications: A Mendelian Randomization Study.

Yao Q, Yao Y, Liao Z et al. · 2026 · Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis

BackgroundSepsis and its complications pose a major global health burden. Mendelian randomization (MR) provides a genetic approach to assess causality.MethodsWe conducted a two-sample Mendelian randomization (MR) study using data from…

View details →DOI: 10.1177/10760296261438237
Failed Experiment ReportOpen accessMedicine

Nudging accurate scientific communication.

Allard A, Clavien C · 2023 · PloS one

The recent replicability crisis in social and biomedical sciences has highlighted the need for improvement in the honest transmission of scientific content. We present the results of two studies investigating whether nudges and soft social…

View details →DOI: 10.1371/journal.pone.0290225
Failed Experiment ReportMedicine

A study of the effects of age on the dynamics of RSV in animal models.

Khan S, Dobrovolny HM · 2021 · Virus research

Respiratory syncytial virus can cause severe illness and even death, particularly in infants. The increased severity of disease in young children is thought to be due to a lack of previous exposure to the virus as well as the limited…

View details →DOI: 10.1016/j.virusres.2021.198524
Failed Experiment ReportOpen accessMedicine

Effects of transcutaneous electrical stimulation on peripheral nerve regeneration after digital neurorrhaphy: A randomized clinical trial.

de Mattos ESR, Guedes A, Zana Y et al. · 2025 · F1000Research

Background Sensory recovery following digital nerve neurorrhaphy is often incomplete, and strategies to enhance regeneration remain under investigation. Low-frequency transcutaneous electrical stimulation has been proposed as a potential…

View details →DOI: 10.12688/f1000research.169801.3
Failed Experiment ReportMedicine

Is exergaming a viable exercise option for obese black women?

Hicks J, Dash C, Smith D et al. · 2025 · Contemporary clinical trials

Background Physical inactivity and obesity, which are disproportionately higher in Black women, are known risk factors of breast cancer. Novel methods to address this public health concern involve leveraging screen-viewing activities to…

View details →DOI: 10.1016/j.cct.2025.107846
Failed Experiment ReportOpen accessMedicine

Inhibition of p38α MAPK increases short-term astrocyte reactivity: the exploratory VIP trial in early Alzheimer's disease.

Gouilly D, Da-Costa A, Vrillon A et al. · 2025 · Journal of neuroinflammation

BACKGROUND: Neuro-inflammation is an early mechanistic target in Alzheimer’s disease (AD). However, the effect of anti-inflammatory drugs on biomarkers of neuro-inflammation has yet to be described. Biomarkers of neuro-inflammation showed…

View details →DOI: 10.1186/s12974-025-03625-x
Failed Experiment ReportOpen accessMedicine

Synthesis and intramolecular singlet fission properties of ortho -phenylene linked oligomers of diphenylhexatriene.

Millington O, Sharma A, Montanaro S et al. · 2023 · Chemical science

In molecular dimers that undergo intramolecular singlet fission (iSF), efficient iSF is typically accompanied by triplet pair annihilation at rates which prohibit effective triplet harvesting. Collisional triplet pair separation and…

View details →DOI: 10.1039/d3sc03665k
Failed Experiment ReportMedicine

A mixed methods evaluation of a motivational enhancement intervention to increase SARS-CoV-2 testing among people experiencing houselessness and people who inject drugs.

Mauricio AM, Cioffi CC, Sanders AM et al. · 2025 · Psychological services

This explanatory sequential mixed methods hybrid Type 1 study examined the efficacy and implementation of Connect2Test, a brief motivational enhancement intervention to increase SARS-CoV-2 testing among people experiencing houselessness…

View details →DOI: 10.1037/ser0000939
Failed Experiment ReportOpen accessMedicine

Covert-attention shifting superseded: Simple visual search explained by a computational cognitive architecture with early vision limitations, eye movements, and task strategies.

Kieras DE, Meyer DE · 2026 · Psychonomic bulletin & review

This article concerns simple visual-search tasks that require people to respond "yes" or "no" about whether a specified target object is present in stimulus displays containing relatively small numbers of typically simple objects. The…

View details →DOI: 10.3758/s13423-025-02772-9
Failed Experiment Report

Interpreting clinical trial outcomes marred by placebo response with an assessment of false-negative and true-negative clinical trials in depression using propensity-weighting

Gomeni R, Hopkins S, Bressolle-Gomeni F et al. · 2023 · Preprint

Abstract The objective of this study was to evaluate the performances of the propensity score weighted (PSW) methodology in a post-hoc re-analysis of a failed and a negative RCTs in major depressive disorders. The conventional study…

View details →DOI: 10.21203/rs.3.rs-3309369/v1