A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19814 results in Negative / Null Result Report · page 134 of 661
Lujia Wang, Chenchen Feng, Guanxiong Ding et al. · 2017 · Scientific Reports
Abstract In this study, we aimed to validate the association of 8 reported significant loci at 5q35.3, 7p14.3, 13q14.1 and 16p12.3 with urolithiasis in Chinese Han population. We performed case-control association analysis using 624…
A. Nanditha, C. Snehalatha, J. Ram et al. · 2016 · Diabetic Medicine
Abstract Aim To investigate whether the effectiveness of lifestyle interventions on the incidence of diabetes was influenced by the baseline age and BMI of the Asian‐Indian participants with prediabetes. Methods Pooled data, obtained from…
Jennifer M. Yentes, Jessie M. Huisinga, Sara A. Myers et al. · 2012 · Journal of Applied Biomechanics
Peripheral arterial disease (PAD) is a manifestation of atherosclerosis resulting in intermittent claudication (IC) or leg pain during physical activity. Two drugs (cilostazol and pentoxifylline) are approved for treatment of IC. Our…
Robert Massey, Yu Chen, Marina Panova‐Noeva et al. · 2024 · Cardiovascular Diabetology
BACKGROUND: BMI variability has been associated with increased cardiovascular disease risk in individuals with type 2 diabetes, however comparison between clinical studies and real-world observational evidence has been lacking. Furthermore, it is not known whether BMI variability has an effect independent of HbA1c variability. METHODS: We investigated the association between BMI variability and 3P-MACE risk in the Harmony Outcomes trial (n = 9198), and further analysed placebo arms of REWIND (n = 4440) and EMPA-REG OUTCOME (n = 2333) trials, followed by real-world data from the Tayside Bioreso
Jeremiasz Jagiełła, Efthimios Dardiotis, Jerzy Gąsowski et al. · 2014 · Neurologia i Neurochirurgia Polska
BACKGROUND AND PURPOSE: Spontaneous intracerebral haemorrhage (ICH) is the most fatal form of stroke with the highest morbidity and disability rate of all stroke types. Recent data suggest that the genetic background has a sizeable and…
Elizabeth Taylor, Kelsey C. Hewitt, Robert A. Reeves et al. · 2013 · Procedia Technology
Previously, in the field to solve complex problems, we had found that majority rule (MR) decision-making out-performed consensus rule (CR) by making decisions that were quicker, more practical, and of better quality. This is an important…
Todd W. Arnold, Alan D. Afton, Michael J. Anteau et al. · 2017 · Journal of Wildlife Management
ABSTRACT We recently analyzed long‐term (1951–2011) continental band‐recovery data from lesser scaup ( Aythya affinis ) and demonstrated that harvest rates declined through time, but annual survival rates exhibited no such trends;…
Uraiwan Buatoom, Muhammad Usman Jamil · 2023 · Applied Sciences
In image classification, various techniques have been developed to enhance the performance of principal component analysis (PCA) dimension reduction techniques with guiding weighting features to remove redundant and irrelevant features.…
Ross D. Pollock, Caroline J. Jolley, N. Abid et al. · 2021 · Aerospace Medicine and Human Performance
Abstract BACKGROUND: Members of the public will soon be taking commercial suborbital spaceflights with significant G x (chest-to-back) acceleration potentially reaching up to 6 G x . Pulmonary physiology is gravity-dependent and is likely…
James W. Price · 2014 · Journal of Addictive Diseases
Although the decriminalization of recreational marijuana and medical marijuana laws provide a compassionate answer for treatment-related issues in patients' lives, they leave questions open as to the impact on other realms of life, such as…
Katherine A. Rawson, Kathryn T. Wissman, Kalif E. Vaughn · 2015 · Journal of Experimental Psychology Learning Memory and Cognition
Recent research on testing effects (i.e., practice tests are more effective than restudy for enhancing subsequent memory) has focused on explaining when and why testing enhances memory. Of particular interest for present purposes, Zaromb…
Samuel Kyle Jones, Jodie Davies-Thompson, Jeremy Tree · 2021 · Frontiers in Human Neuroscience
Bilingualism has been identified as a potential cognitive factor linked to delayed onset of dementia as well as boosting executive functions in healthy individuals. However, more recently, this claim has been called into question following…
Enzo M. Scutigliani, Edwin R. Scholl, Anita E. Grootemaat et al. · 2018 · Frontiers in Microbiology
Tuberculosis is once again a major global threat, leading to more than 1 million deaths each year. Treatment options for tuberculosis patients are limited, expensive and characterized by severe side effects, especially in the case of multi-drug resistant forms. Uncovering novel vulnerabilities of the pathogen is crucial to generate new therapeutic strategies. Using high resolution microscopy techniques, we discovered one such vulnerability of Mycobacterium tuberculosis. We demonstrate that the DNA of M. tuberculosis can condense under stressful conditions such as starvation and antibiotic trea
Anne Gast, Jasmin Richter, Borys Ruszpel · 2019 · Cognition & Emotion
In three experiments we investigated whether memory-independent evaluative conditioning (EC) and other memory-independent contingency learning (CL) effects occur in the valence contingency task (VCT). In the VCT, participants respond to…
James P. Reynolds, Milica Vasiljevic, Mark Pilling et al. · 2020 · International Journal of Environmental Research and Public Health
Public support for numerous obesity policies is low, which is one barrier to their implementation. One reason for this low support is the tendency to ascribe obesity to failings of willpower as opposed to the environment. Correlational evidence supports this position. However, the experimental evidence is mixed. In two experimental studies, participants were randomised to receive no message, messages about the environment’s influence on obesity (Study 1 & 2), or messages about the environment’s influence on human behaviour (Study 1). We investigated whether communicating these messages cha
Yi‐Ping Phoebe Chen, Ulrich Kirk, Suzanne Dikker · 2022 · Frontiers in Psychology
In recent years, the possible benefits of mindfulness meditation have sparked much public and academic interest. Mindfulness emphasizes cultivating awareness of our immediate experience and has been associated with compassion, empathy, and various other prosocial traits. However, neurobiological evidence pertaining to the prosocial benefits of mindfulness in social settings is sparse. In this study, we investigate neural correlates of trait mindful awareness during naturalistic dyadic interactions, using both intra-brain and inter-brain measures. We used the Muse headset, a portable electroenc
Johan Jirholt, Bengt Åsling, Paul Hammond et al. · 2011 · PLoS ONE
Gastro-esophageal reflux disease (GERD) is partly caused by genetic factors. The underlying susceptibility genes are currently unknown, with the exception of COL3A1. We used three independent GERD patient cohorts to identify GERD susceptibility genes. Thirty-six families, demonstrating dominant transmission of GERD were subjected to whole genome microsatellite genotyping and linkage analysis. Five linked regions were identified. Two families shared a linked region (LOD 3.9 and 2.0) on chromosome 16. We used two additional independent GERD patient cohorts, one consisting of 219 trios (affected
James Alex Bonus, Judy Watts, C. Joseph Francemone · 2022 · Journal of Communication
Abstract Integrating predictions derived from the self-memory system and biographic resonance theory, the current project investigated the relationship between media-induced reminiscence and appreciation. In two experiments, undergraduates…
Sera Wiechert, Leonie Hannah Shoshana Loewy, Ineke Wessel et al. · 2023 · Memory
Post-traumatic stress disorder is characterised by recurring memories of a traumatic experience despite deliberate attempts to forget (i.e., suppression). The Think/No-Think (TNT) task has been used widely in the laboratory to study…
Taeyong Kwon, Jessie D. Trujillo, Mariano Carossino et al. · 2025 · Emerging Microbes & Infections
Since the first emergence of highly pathogenic avian influenza (HPAI) H5N1 viruses in dairy cattle, the virus has continued to spread, reaching 17 states and at least 1000 dairy herds in the United States. Subsequently, spillovers of the…
Tonia C. Carter, Scott J. Hebbring, Jixia Liu et al. · 2017 · Journal of Medical Virology
Host response to influenza is highly variable, suggesting a potential role of host genetic variation. To investigate the host genetics of severe influenza in a targeted fashion, 32 single nucleotide polymorphisms (SNPs) within viral immune…
Leonardo Calza, Isabella Bon, Marco Borderi et al. · 2020 · JAIDS Journal of Acquired Immune Deficiency Syndromes
Calza, Leonardo MD; Bon, Isabella PhD; Borderi, Marco MD; Colangeli, Vincenzo MD; Viale, Pierluigi MD Author Information
Muhammad Jasim Uddin, Willy W. Suen, Angela M. Bosco‐Lauth et al. · 2016 · Veterinary Research
West Nile virus (WNV) is one of the most common causes of epidemic viral encephalitis in horses worldwide. Peripheral blood mononuclear cells (PBMCs) are amongst the first to encounter the virus following a mosquito bite. This study aimed to elucidate the transcription kinetics of cytokine, Toll-like receptor (TLRs) and TLRs-associated genes following WNV challenge of equine PBMCs. PBMCs were challenged with an Australian strain of WNV (WNVNSW2011) and transcriptomes were quantified at 2, 6, 12 and 24 h post-infection (pi) using qRT-PCR. Type I and II interferons (IFNα, β and γ) mRNA transcrip
Ornella Zollo, Neal Sondheimer · 2017 · Transcription
In vitro studies of mitochondrial transcription often use linear templates that fail to replicate key features of transcription on a circular genome. We developed a plasmid-based system for the analysis of heavy-strand promoters that…
Tyler Colasante, Katie Faulkner, Dana Kharbotli et al. · 2024 · Affective Science
Abstract Public discourse and empirical studies have predominantly focused on the negative repercussions of social media on adolescents’ mental health. However, pervasive social media use is a relatively new phenomenon—its apparent harms have been widely accepted before sufficient longitudinal and experimental research has been conducted. The present study used an intensive longitudinal design (four assessments/day × 14 days; N = 154 12- to 15-year-olds ( M age = 13.47, SD = 0.58); N = 6,240 valid measurement occasions) to test the directionality of social media–negative emotion links in early
Nathan Leggett, Nicole A. Thomas, Michael E. R. Nicholls · 2015 · Cognition & Emotion
Approach motivation leads to greater left hemisphere activation, whereas an avoidant motivational state activates the right hemisphere. Recent research, which served as the basis for the current experiment, suggests line bisection provides…
Sarah N. Rigby, Lorna S. Jakobson, Pauline M. Pearson et al. · 2020 · Frontiers in Psychology
Alexithymia is a personality trait characterized by difficulties identifying and describing feelings (DIF and DDF) and an externally-oriented thinking style (EOT). The primary aim of the present study was to investigate links between alexithymia and the evaluation of emotional scenes. We also investigated whether viewers’ evaluations of emotional scenes were better predicted by specific alexithymic traits or by individual differences in sensory processing sensitivity (SPS). Participants (N = 106) completed measures of alexithymia and SPS along with a task requiring speeded judgments of the ple
Sreeram V Ramagopalan, Andrew P. Skingsley, Lahiru Handunnetthi et al. · 2015 · F1000Research
Background : We and others have shown a significant proportion of interventional trials registered on ClinicalTrials.gov have their primary outcomes altered after the listed study start and completion dates. The objectives of this study…
Rui Perdigão · 2018 · Entropy
The information shared among observables representing processes of interest is traditionally evaluated in terms of macroscale measures characterizing aggregate properties of the underlying processes and their interactions. Traditional…
Giannis Penloglou, Alexandros Pavlou, Costas Kiparissides · 2023 · Fermentation
The intended circular economy for plastics envisages that they will be partially replaced by bio-based polymers in the future. In this work, the natural polyester polyhydroxybutyrate (PHB) was produced by Azohydromonas lata using cheese…