Negative / Null Result ReportOpen accessMedicine
Olga V. Bocharova, Aidan Fisher, Narayan Pandit et al. · 2022 · Brain Pathology
The possibility that the etiology of late onset Alzheimer's disease is linked to viral infections of the CNS has been actively debated in recent years. According to the antiviral protection hypothesis, viral pathogens trigger aggregation…
View details →DOI: 10.1111/bpa.13116Cited by 14 Negative / Null Result ReportOpen accessEngineering
Rianne Haumann, John Bianco, Piotr Waranecki et al. · 2022 · Translational Medicine Communications
Abstract Background Diffuse intrinsic pontine glioma (DIPG) is a notoriously difficult tumor to treat, with an overall survival of DIPG patients being only 11 months. One of the major obstacles for the effective treatment of DIPG is the blood–brain barrier (BBB). In order to circumvent the BBB, drug delivery methods are needed that target the pontine area. One such approach is microbubble-mediated focused ultrasound (FUS)—a non-invasive method that can temporarily and locally open the BBB. Previously, it was shown that FUS is safe with minimal side effects and rapid recovery times in preclinic
View details →DOI: 10.1186/s41231-022-00115-7Cited by 14 Negative / Null Result ReportOpen accessMedicine
Tomoyoshi Tamura, Hiromichi Narumiya, Koichiro Homma et al. · 2024 · Critical Care Medicine
OBJECTIVE: The Efficacy of Inhaled Hydrogen on Neurologic Outcome Following Brain Ischemia During Post-Cardiac Arrest Care (HYBRID) II trial (jRCTs031180352) suggested that hydrogen inhalation may reduce post-cardiac arrest brain injury…
View details →DOI: 10.1097/ccm.0000000000006395Cited by 14 Negative / Null Result ReportOpen accessMedicine
Martin Scharffenberg, Thomas G. Weiss, Jakob Wittenstein et al. · 2022 · BMC Anesthesiology
Abstract Background Oxygen is one of the most commonly used drugs by anesthesiologists. The World Health Organization (WHO) gave recommendations regarding perioperative oxygen administration, but the practice of oxygen use in anesthesia, critical emergency, and intensive care medicine remains unclear. Methods We conducted an online survey among members of the European Society of Anaesthesiology and Intensive Care (ESAIC). The questionnaire consisted of 46 queries appraising the perioperative period, emergency medicine and in the intensive care, knowledge about current recommendations by the WH
View details →DOI: 10.1186/s12871-022-01884-2Cited by 14 Negative / Null Result ReportOpen accessImmunology and Microbiology
Chad A. Baumwart, Tom J. Doherty, James Schumacher et al. · 2011 · American Journal of Veterinary Research
OBJECTIVE: To determine the effectiveness of preinduction hyperbaric oxygen treatment (HBOT) in ameliorating signs of experimentally induced endotoxemia in horses. ANIMALS: 18 healthy adult horses. PROCEDURES: Horses were randomly assigned…
View details →DOI: 10.2460/ajvr.72.9.1266Cited by 14 Negative / Null Result ReportOpen accessMedicine
Nesli Ersoy, İlker Taşçı, Taner Özgürtaş et al. · 2018 · Nutrition Research and Practice
BACKGROUND/OBJECTIVES: Available data suggest that seasonal changes may influence the nutritional status and overall health of elderly individuals. Therefore, this study was conducted to investigate the effects of seasonal changes and…
View details →DOI: 10.4162/nrp.2018.12.4.315Cited by 14 Negative / Null Result ReportOpen accessMedicine
Aaron Simpson, Renata Krowka, Jennifer Kerrigan et al. · 2013 · BMJ Open
OBJECTIVE: To determine the potential of opportunistic glycated haemoglobin (HbA1c) testing of pathology samples to detect previously unknown diabetes. DESIGN: Pathology samples from participants collected for other reasons and suitable…
View details →DOI: 10.1136/bmjopen-2013-003411Cited by 14 Negative / Null Result ReportOpen accessMedicine
Bai Wei, Se-Yeoun Cha, Min Kang et al. · 2015 · Journal of Ethnic Foods
Chongkukjang is a traditional Korean fermented product prepared from soybeans and reported to have multiple biological functions, including antidiabetic, antiinflammatory, and neuroprotective effects. Influenza is a respiratory disease caused by influenza viruses and continues to be a worldwide threat with a high potential to cause pandemics. Besides vaccination, only two classes of drugs are available for antiviral treatment against these pathogens. We tested the inhibitory activity of an ethyl acetate extract from Chongkukjang toward influenza A virus neuraminidase. All 10 compounds extracte
View details →DOI: 10.1016/j.jef.2015.04.001Cited by 14 Negative / Null Result ReportOpen accessMedicine
Xiao Li, Maierhaba Maitiyaer, Qing Tan et al. · 2024 · Frontiers in Pharmacology
Primary Sjögren's Syndrome (pSS) is a complex autoimmune disorder characterized by exocrine gland dysfunction, leading to dry eyes and mouth. Despite growing interest in biologic therapies for pSS, FDA approval has proven challenging due to trial complications. This review addresses the absence of a molecular-target-based approach to biologic therapy development and highlights novel research on drug targets and clinical trials. A literature search identified potential pSS treatment targets and recent advances in molecular understanding. Overlooking extraglandular symptoms like fatigue and depr
View details →DOI: 10.3389/fphar.2024.1377055Cited by 14 Negative / Null Result ReportOpen accessMedicine
Dejan Georgiev, Harith Akram, Marjan Jahanshahi · 2021 · Psychoradiology
Following the established application of deep brain stimulation (DBS) in the treatment of movement disorders, new non-neurological indications have emerged, such as for obsessive-compulsive disorders, major depressive disorder, dementia, Gilles de la Tourette Syndrome, anorexia nervosa, and addictions. As DBS is a network modulation surgical treatment, the development of DBS for both neurological and psychiatric disorders has been partly driven by advances in neuroimaging, which has helped explain the brain networks implicated. Advances in magnetic resonance imaging connectivity and electrophy
View details →DOI: 10.1093/psyrad/kkab012Cited by 14 Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Courtney Davis, Anita K. Wagner, Maximilian Salcher‐Konrad et al. · 2023 · BMJ
OBJECTIVE: To evaluate the frequency with which relevant and accurate information about the benefits and related uncertainties of anticancer drugs are communicated to patients and clinicians in regulated information sources in Europe. DESIGN: Document content analysis. SETTING: European Medicines Agency. PARTICIPANTS: Anticancer drugs granted a first marketing authorisation by the European Medicines Agency, 2017-19. MAIN OUTCOME MEASURES: Whether written information on a product addressed patients' commonly asked questions about: who and what the drug is used for; how the drug was studied; typ
View details →DOI: 10.1136/bmj-2022-073711Cited by 14 Negative / Null Result ReportOpen accessMedicine
Tyler Beck, Elena Wilson, Erik Wilkes et al. · 2023 · Itch
Chronic pruritus is a debilitating condition affecting 23-44 million Americans. Recently, kappa opioid agonists (KOAs) have emerged as a novel class of potent antipruritic agents. In 2021, the Food and Drug Administration approved…
View details →DOI: 10.1097/itx.0000000000000072Cited by 14 Negative / Null Result ReportOpen accessEngineering
Gábor Szabó, András Ágoston, Gábor Csató et al. · 2021 · Sensors
As demonstrated by earlier studies, pre-hospital triage with trans-telephonic electrocardiogram (TTECG) and direct referral for catheter therapy shows great value in the management of out-of-hospital chest pain emergencies. It does not only improve in-hospital mortality in ST-segment elevation myocardial infarction, but it has also been identified as an independent predictor of higher in-hospital survival rate. Since TTECG-facilitated triage shortens both transport time and percutaneous coronary intervention (PCI)-related procedural time intervals, it was hypothesized that even high-risk patie
View details →DOI: 10.3390/s21030969Cited by 14 Negative / Null Result Report
A Ovental, R Marom, E Botzer et al. · 2014 · Acta Paediatrica
Abstract Aim The US Food and Drug Administration has said that oral preparations containing benzocaine should only be used in infants under strict medical supervision, due to the rare, but potentially fatal, risk of methemoglobinemia. This…
View details →DOI: 10.1111/apa.12654Cited by 14 Negative / Null Result ReportMedicine
Thomas Kubiszyn, Sarah S. Mire, Sonia Dutt et al. · 2012 · School Psychology Quarterly
Some side effects (SEs) of increasingly prescribed psychotropic medications can impact student performance in school. SE risk varies, even among drugs from the same class (e.g., antidepressants). Knowing which SEs occur significantly more…
View details →DOI: 10.1037/a0027419Cited by 14 Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Carlos Morales, Percy Marquina Feldman · 2013 · Journal of CENTRUM Cathedra (JCC) The Business and Economics Research Journal
An extensive literature review reveals various authors acknowledge skills have an impact on entrepreneurial success. However, a lack of consensus regarding the main skills an entrepreneur needs is apparent. In this study, a contribution is made to the debate with empirical data and analysis, in two steps: by testing mean differences and reducing data with a principal components analysis. A sample of 394 potential entrepreneurs was administered the SAT-ECENT questionnaire, testing four skills: readiness to change, learning capacity, impact on people, and stress tolerance. The questionnaires wer
View details →DOI: 10.7835/jcc-berj-2013-0085Cited by 14 Negative / Null Result ReportOpen accessMedicine
Hadgu Gerensea, Rajalakshmi Murugan · 2016 · Advances in Nursing
Background . Children’s decisions concerning investigation and treatment may be based on the results of temperature alone. Although the accuracy of axillary temperature measurement is affected by a number of factors, device dwell time and device type are common. Objective . Compare body temperature between glass mercury thermometer (GMT) and digital thermometer (DT). Method . Comparative descriptive study was used. A total of 101 samples were taken with convenient sampling technique, but 98 were analyzed. Statistical significance (p<0.01) and clinical significance (MD≥0.2°C) were used in th
View details →DOI: 10.1155/2016/3474503Cited by 14 Negative / Null Result Report
Daniel R. Principe · 2022 · Scientific Reports
Abstract Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy and are now the preferred treatment for several tumor types. Though ICIs have shown remarkable efficacy in several cancer histologies, in many cases providing…
View details →DOI: 10.1038/s41598-022-15714-5Cited by 14 Negative / Null Result Report
Nikola Vučinić, R. Shane Tubbs, Mirela Erić et al. · 2019 · Clinical Anatomy
The appearance of the face is one of the most important factors influencing our perception of beauty. However, few studies have attempted to quantitate what one perceives as beauty. Therefore, this study was conducted with the goal of…
View details →DOI: 10.1002/ca.23455Cited by 14 Negative / Null Result ReportPsychology
Zifei Fay Chen, Weiting Tao · 2020 · International Journal of Strategic Communication
This study investigates whether hybrid strategy would be more effective than corporate social responsibility (CSR) strategy in boosting CSR information recall and company evaluation. Informed by the corporate ability (CA)-CSR-hybrid…
View details →DOI: 10.1080/1553118x.2020.1730378Cited by 14 Negative / Null Result Report
Travis A. Smith, Eliza M. Mojduszka, Shun Chen · 2020 · Applied Economic Perspectives and Policy
Abstract School meal programs represent the second largest form of food assistance in the United States. Schools receive federal reimbursements, totaling $17 billion in 2018, provided they meet certain nutritional standards. The Healthy…
View details →DOI: 10.1002/aepp.13074Cited by 14 Negative / Null Result ReportAgricultural and Biological Sciences
Xiao Hui Gu, Hao Lin, Jun Hong Xia · 2018 · Aquaculture Research
Identifying candidate genes involved into osmoregulation provides a basis for developing molecular markers for breeding of saline tilapia. In this study, we characterized and conducted a functional analysis of the Enhancer of Polycomb…
View details →DOI: 10.1111/are.13625Cited by 14 Negative / Null Result ReportOpen accessEnergy
Jeong‐Mi Do, Ji Won Hong, Ho‐Sung Yoon · 2025 · Frontiers in Microbiology
Traditional nanoparticle synthesis relies on chemical and physical methods that often involve hazardous reagents, high energy consumption, and environmental toxicity. As a sustainable alternative, biological synthesis utilizes biomolecules in an eco-friendly manner to form nanoparticles. This study explores the green synthesis of silver nanoparticles (AgNPs) using extracellular polymeric substances (EPS) secreted by the microalga Graesiella emersonii KNUA204, highlighting the potential of microalgal biomolecules in nanotechnology. EPS-rich supernatant from G. emersonii enabled AgNP formation u
View details →DOI: 10.3389/fmicb.2025.1589285Cited by 14 Negative / Null Result ReportOpen accessPsychology
Yvonne Stikkelbroek, Gerko Vink, Maaike H. Nauta et al. · 2020 · Scientific Reports
We examined if manualized cognitive behavioral therapy (CBT) was more effective than Treatment As Usual (TAU) for clinically depressed adolescents within routine care. This multisite Randomized controlled trail included 88 clinically depressed adolescents (aged 12-21 years) randomly assigned to CBT or TAU. Multiple assessments (pre-, post treatment and six-month follow-up) were done using semi-structured interviews, questionnaires and ratings and multiple informants. The primary outcome was depressive or dysthymic disorder based on the KSADS. Completers, CBT (n = 19) and TAU (n = 26), showed a
View details →DOI: 10.1038/s41598-020-71160-1Cited by 14 Negative / Null Result Report
Vaiva Petrylė · 2017 · Ekonomika
The concept of a country’s competitiveness still does not have a clear and straightforward meaning and remains ambiguous. Different economists stress various aspects of the concept and use a number of different methods to evaluate how…
View details →DOI: 10.15388/ekon.2016.3.10326Cited by 14 Negative / Null Result ReportEnvironmental Science
Mollie E. Herget, Kristina M. Hufford, Daniel L. Mummey et al. · 2015 · Restoration Ecology
When landscapes are heavily impacted by biological invasion, local populations of native plant species may no longer be adapted to altered environmental conditions. In these cases, it is useful to investigate alternative sources of…
View details →DOI: 10.1111/rec.12177Cited by 14 Negative / Null Result ReportMedicine
Janine Stein, Melanie Luppa, Hanna Kaduszkiewicz et al. · 2015 · Psychological Assessment
The aim of the study was to investigate the psychometric properties of a Short Form of the Mini-Mental State Examination (SMMSE) for the screening of dementia in older primary care patients. Data were obtained from a large longitudinal…
View details →DOI: 10.1037/pas0000076Cited by 14 Negative / Null Result ReportComputer Science
Nima Jamalian, Marco Gillies, Frédéric Fol Leymarie et al. · 2022
Until recently, Virtual Reality (VR) applications relied on controllers to enable user interaction in virtual environments. With advances in tracking technology, HMDs are now able to track the movements of users’ hands in real-time with…
View details →DOI: 10.1109/ismar55827.2022.00095Cited by 14 Negative / Null Result ReportOpen accessPsychology
Ghuzayyil Mohammed Al-Otaibi · 2019 · Journal of language and Education
English as a Foreign Language (EFL) learners find some phrasal verbs problematic because of their idiomatic and polysemous nature. They are frequently used in spoken English and textbooks suggest an arbitrary way in teaching them. Cognitive linguists proposed that the particle plays a major role in determining the meaning of such phrasal verbs. This study investigated the effectiveness of a cognitive approach (i.e., Rudzka-Ostyn’s Model) in teaching taught and new phrasal verbs including metaphorical ones. Using a list of frequent phrasal verbs, a quasi-experimental design was used in which an
View details →DOI: 10.17323/jle.2019.8170Cited by 14 Negative / Null Result ReportComputer Science
Arvinder Kaur, Kamaldeep Kaur, Shilpi Jain · 2016
The objective of this paper is to study the relationship between different types of object-oriented software metrics, code smells and actual changes in software code that occur during maintenance period. It is hypothesized that code smells…
View details →DOI: 10.1109/icacci.2016.7732136Cited by 14 