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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

AllReplication FailureNegative / Null Result ReportFailed Experiment ReportAbandoned HypothesisMethods Dead-EndShort NoteNull DatasetProtocol

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

By fieldMedicine 12,218Computer Science 744Biochemistry, Genetics and Molecular Biology 414Social Sciences 302Psychology 299Physics 280Neuroscience 244Economics, Econometrics and Finance 196Environmental Science 172Mathematics 155Agricultural and Biological Sciences 138Engineering 135

403 results in Replication Failure · page 12 of 14

Replication FailureMedicine

Mean Platelet Volume Shows Distinct Patterns Between Mitral and Aortic Valve Replacement Patients but Does Not Predict Anticoagulation Quality in Mechanical Heart Valves.

Can V, Polat F, Kaya AF et al. · 2026 · Journal of cardiovascular pharmacology

Abstract Mechanical heart valve replacement necessitates long-term warfarin anticoagulation to prevent thromboembolic complications, yet achieving adequate anticoagulation control remains challenging. This study evaluated whether mean…

View details →DOI: 10.1097/fjc.0000000000001830
Replication FailureMedicine

Imaging correlates of disease activity and patient-reported symptoms in primary Sjögren's disease: an ultrasonographic and scintigraphic study.

Vukšić J, Kustić D · 2026 · Rheumatology international

To examine whether salivary gland ultrasonography (SGUS) and scintigraphy (SGS) reflect systemic disease activity (ESSDAI) and patient-reported index (ESSPRI) in primary Sjögren's disease (PSD). We retrospectively enrolled 118 patients…

View details →DOI: 10.1007/s00296-026-06132-1
Replication FailureMedicine

Efficacy of abdominal drainage in perforated appendicitis: a retrospective single-center study using AAST grading and inverse probability treatment weighting analysis.

Wang C, Li S, Lu H et al. · 2026 · BMC gastroenterology

Background While routine use of abdominal drainage in cases of perforated appendicitis is not generally recommended, there exists a paucity of evidence regarding the detailed stratification of its necessity based on varying degrees of…

View details →DOI: 10.1186/s12876-026-05025-8
Replication FailureOpen accessMedicine

Tranexamic acid use for the prevention of postpartum hemorrhage in high-income countries: a review of recent literature.

Baxi SM, Igbinosa II, Main EK et al. · 2026 · AJOG global reports

Background Postpartum hemorrhage (PPH) is the leading global cause of maternal morbidity and mortality. Tranexamic acid (TXA), an antifibrinolytic agent that has been shown to reduce hemorrhage-related mortality in trauma, is used…

View details →DOI: 10.1016/j.xagr.2026.100651
Replication FailureMedicine

Management of the Clinically Node-Negative Neck in Intermediate-Grade Mucoepidermoid Carcinoma of the Head and Neck: A Single-Institution Retrospective Study.

Lin MC, Jiang X, Qiu ZC et al. · 2026 · Head & neck

Background Management of the clinically node-negative (cN0) neck in intermediate-grade mucoepidermoid carcinoma (MEC) of the head and neck remains controversial. Methods We retrospectively reviewed patients with cN0 intermediate-grade MEC…

View details →DOI: 10.1002/hed.70304
Replication FailureMedicine

TFPI2 expression predicts resistance to immunotherapy plus tyrosine kinase inhibitor and informs first-line therapy selection in metastatic renal cell carcinoma.

Wang J, Du L, Wang Y et al. · 2026 · Cellular oncology (Dordrecht, Netherlands)

Purpose Combinations of anti-PD-1/PD-L1 immunotherapy (IO) and anti-VEGF tyrosine kinase inhibitor (TKI) are recommended as first-line therapy for metastatic renal cell carcinoma (RCC). We aimed to evaluate the predictive value of tissue…

View details →DOI: 10.1007/s13402-026-01224-3
Replication FailureMedicine

Prophylactic antibiotic in pubertal testicular torsion: Is it Justified?

Arenas Hoyos J, Dalela D, Schlomer BJ et al. · 2026 · Journal of pediatric urology

Background There is insufficient evidence to support the effectiveness of preoperative antibiotic prophylaxis in reducing surgical site infections (SSI) during urgent testicular torsion (TT) surgeries. Objective The primary objective was…

View details →DOI: 10.1016/j.jpurol.2026.105844
Replication FailureMedicine

Treatment of Melasma Using Low-Fluence QS Nd: YAG (1064 nm) Laser: A Blind, Randomized, Placebo-Controlled Trial.

Sadeghpour M, Laughter M, Rizzo SI et al. · 2026 · Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]

Background Despite evidence supporting efficacy of low-fluence Q-switched (QS) neodymium-doped yttrium aluminum garnet (Nd:YAG) 1,064-nm lasers, treatment protocols are not standardized and limited to mostly retrospective, observational,…

View details →DOI: 10.1097/dss.0000000000004846
Replication FailureMedicine

Does Orthosis Improve Outcomes of Conservative Treatment in Trigger Fingers? A 3-Arm Prospective Randomized Controlled Trial.

Minkhorst K, Munn A, MacDermid J et al. · 2025 · Archives of physical medicine and rehabilitation

Objective To evaluate whether the addition of an orthosis improved the efficacy of cortisone injection for the nonoperative management of trigger finger. Design Block randomized controlled trial. Setting Outpatient hand clinic.…

View details →DOI: 10.1016/j.apmr.2025.05.015
Replication FailureMedicine

Implementation of a mentored scholarly project and corresponding research course at University of Maryland School of Medicine: 10 years of data showing improved scholarly productivity.

Silva SJ, Romero F, Magder LS et al. · 2026 · Academic medicine : journal of the Association of American Medical Colleges

Purpose Interest in research careers among medical graduates is decreasing, and fewer physicians report research as their primary work activity. This study examines the implementation of a required scholarly research course at the…

View details →DOI: 10.1093/acamed/wvag166
Replication FailureMedicine

Comparative clinical effects of extraoral photobiomodulation using laser and LED on pain, swelling, and quality of life following impacted mandibular third molar surgery: a randomized split-mouth trial.

Albayrak D, Bulut E, Singer EA · 2026 · Lasers in medical science

This study aimed to compare the clinical effectiveness of extraoral photobiomodulation using laser and light-emitting diode (LED) in reducing postoperative pain, swelling, and improving oral health-related quality of life following…

View details →DOI: 10.1007/s10103-025-04796-y
Replication FailureMedicine

BDNF rs6265 polymorphism is not associated with the occurrence of overactive bladder and its response to intradetrusor injection of botulinum neurotoxin type A in female patients.

Ciećwież SM, Lewandowska K, Boroń A et al. · 2026 · Scientific reports

Reports suggest increased urinary excretion of Brain-Derived Neurotrophic Factor in patients with Overactive Bladder (OAB). The rs6265 (c.196G > A, p.Val66Met) polymorphism in the BDNF gene was previously associated with impaired secretion…

View details →DOI: 10.1038/s41598-026-58792-5
Replication FailureMedicine

Chemotherapy-free combination of ibrutinib and obinutuzumab for untreated advanced follicular lymphoma: results of a phase II study from the German Lymphoma Alliance.

Schmidt C, Scheubeck G, Jurinovic V et al. · 2025 · Haematologica

Immunochemotherapy induces long-term responses in patients with follicular lymphoma. However, the toxicity of chemotherapy remains a relevant challenge. The Bruton tyrosine kinase inhibitor ibrutinib has shown significant activity in…

View details →DOI: 10.3324/haematol.2024.287162
Replication FailureMedicine

The Secondary Pulmonary Hypertension Diagnosis is Not Useful in Lung Allocation.

Sonnick MA, Laothamatas K, Furfaro D et al. · 2024 · Transplantation proceedings

Background In lung transplant, the United Network for Organ Sharing (UNOS) contains a diagnosis of secondary pulmonary hypertension (SPH). SPH and pulmonary arterial hypertension are treated the same in the allocation scoring system. It is…

View details →DOI: 10.1016/j.transproceed.2024.08.025
Replication FailureMedicine

Dyslipidemia and heart failure: current evidence and perspectives of use of statins.

Pradhan A, Bhandari M, Vishwakarma P et al. · 2024 · European review for medical and pharmacological sciences

Heart failure (HF) is a condition with growing morbidity and mortality. Dyslipidemia in HF is not concentrated around hypercholesterolemia as in coronary artery disease. As a corollary, the robust benefits seen with statins across the…

View details →DOI: 10.26355/eurrev_202404_35929
Replication FailureOpen accessMedicine

Clinical outcome following best medical management in acute stroke with a proximal isolated occlusion of the anterior cerebral artery: an international multicentre study.

Sabben C, Charbonneau F, Obadia M et al. · 2026 · European stroke journal

Introduction Acute ischaemic strokes (AIS) due to proximal anterior cerebral artery (ACA) occlusions are rare. Their clinical outcomes following medical management alone have been scarcely described. Patients and methods We conducted a…

View details →DOI: 10.1093/esj/aakag014
Replication FailureMedicine

Safety and efficacy of decompressive craniectomy versus standard craniotomy for large acute epidural haematoma with tentorial herniation in China (PREDICT-AEDH): a nationwide, multicentre, open-label, parallel-group, randomised controlled trial.

Feng J, Yang C, Xie L et al. · 2026 · The Lancet. Neurology

Background Decompressive craniectomy has been widely evaluated across heterogeneous types of brain injury but its effect in patients with large acute epidural haematoma complicated by tentorial herniation remains unclear. We aimed to…

View details →DOI: 10.1016/s1474-4422(26)00143-2
Replication FailureMedicine

Impact of Persistent Hypogonadism on Overall Survival After Androgen Deprivation Therapy in Localized Prostate Cancer Patients: Long-Term Prospective Data.

Nabid A, Carrier N, Vigneault É et al. · 2026 · International journal of radiation oncology, biology, physics

Purpose The impact of persistent hypogonadism post-androgen deprivation therapy (ADT) on overall survival (OS) of patients with prostate cancer (PCa) is poorly documented. We compared OS between patients who recovered testosterone and…

View details →DOI: 10.1016/j.ijrobp.2025.09.062
Replication FailureMedicine

No evidence in favor of the existence of "intentional" binding.

Kong G, Aberkane C, Desoche C et al. · 2024 · Journal of experimental psychology. Human perception and performance

Intentional binding refers to the subjective temporal compression between a voluntary action and its subsequent sensory outcome. Despite some studies challenging the link between temporal compression and intentional action, intentional…

View details →DOI: 10.1037/xhp0001204
Replication FailureMedicine

Targeted Temperature Management After Pediatric Cardiac Arrest: A Quality Improvement Program With Multidisciplinary Implementation in the PICU.

McMullin MP, Cadotte NB, Fuchs EM et al. · 2025 · Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Objectives We aimed to implement a post-cardiac arrest targeted temperature management (TTM) bundle to reduce the percent of time with a fever from 7% to 3.5%. Design A prospective, quality improvement (QI) initiative utilizing the Method…

View details →DOI: 10.1097/pcc.0000000000003640