A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20211 results in Negative / Null Result Report · page 116 of 674
Mark Nieuwenstein, Hedderik van Rijn · 2012 · Judgment and Decision Making
Abstract According to the deliberation without attention (DWA) hypothesis, people facing a difficult choice will make a better decision after a period of distraction than after an equally long period of conscious deliberation, an effect…
Kayla M. Quinnies, Paul J. Bonthuis, Erin P. Harris et al. · 2015 · Biology of Sex Differences
BACKGROUND: Sex differences in pituitary growth hormone (GH) are well documented and coordinate maturation and growth. GH and its receptor are also produced in the brain where they may impact cognitive function and synaptic plasticity, and estradiol produces Gh sex differences in rat hippocampus. In mice, circulating estradiol increases Gh mRNA in female but not in male medial preoptic area (mPOA); therefore, additional factors regulate sexually dimorphic Gh expression in the brain. Thus, we hypothesized that sex chromosomes interact with estradiol to promote sex differences in GH. Here, we as
Ludmila Pawlikowska, Jeffrey Nelson, Diana E. Guo et al. · 2018 · Molecular Genetics & Genomic Medicine
BACKGROUND: Hereditary hemorrhagic telangiectasia (HHT) is caused by mutations in TGFβ/BMP9 pathway genes and characterized by vascular malformations (VM) including arteriovenous malformations (AVM) in lung, liver, and brain, which lead to severe complications including intracranial hemorrhage (ICH) from brain VM. The clinical heterogeneity of HHT suggests a role for genetic modifier effects. Common variants in loci that modify phenotype severity in Tgfb knockout mice were previously reported as associated with lung AVM in HHT. Common variants in candidate genes were reported as associated wit
Liang He, Janne Pitkäniemi, Kauko Heikkilä et al. · 2016 · Brain and Behavior
BACKGROUND: Various pivotal stages in smoking behavior can be identified, including initiation, conversion from experimenting to established use, development of tolerance, and cessation. Previous studies have shown high heritability for age of smoking initiation and cessation; however, time-to-event genome-wide association studies aiming to identify underpinning genes that accelerate or delay these transitions are missing to date. METHODS: We investigated which single nucleotide polymorphisms (SNPs) across the whole genome contribute to the hazard ratio of transition between different stages o
Paul Montgomery, Thees F. Spreckelsen, Alice Burton et al. · 2018 · PLoS ONE
BACKGROUND: Omega-3 fatty acids are central to brain-development of children. Evidence from clinical trials and systematic reviews demonstrates the potential of long-chain Omega-3 supplementation for learning and behavior. However, findings are inconclusive and in need of robust replication studies since such work is lacking. OBJECTIVES: Replication of the 2012 DOLAB 1 study findings that a dietary supplementation with the long-chain omega-3 docosahexaenoic acid (DHA) had beneficial effects on the reading, working memory, and behavior of healthy schoolchildren. DESIGN: Parallel group, fixed-do
Caitlin E. Hill, Danika M. Brodak, Mary Bartlett Bunge · 2012 · Journal of Neurotrauma
Several recent studies suggest that predegenerated nerves (PDNs) or dissociated PDNs (dPDNs) can improve behavioral and histological outcomes following transplantation into the injured rat spinal cord. In the current study we tested the…
Roberta Marino, Viola Tanganelli, Annalisa Pietrobelli et al. · 2020 · American Journal of Physical Anthropology
OBJECTIVES: Sex estimation in subadult skeletal remains is still considered highly problematic. The aim of this research is to test the reliability of the method of subadult sex assessment proposed by Luna and co-workers in 2017, based on…
Toby Prike, Phoebe Blackley, Briony Swire‐Thompson et al. · 2023 · Cognitive Research Principles and Implications
Corrections are a frequently used and effective tool for countering misinformation. However, concerns have been raised that corrections may introduce false claims to new audiences when the misinformation is novel. This is because boosting the familiarity of a claim can increase belief in that claim, and thus exposing new audiences to novel misinformation-even as part of a correction-may inadvertently increase misinformation belief. Such an outcome could be conceptualized as a familiarity backfire effect, whereby a familiarity boost increases false-claim endorsement above a control-condition or
Hieab H.H. Adams, Vincentius J.A. Verlinden, Michele L. Callisaya et al. · 2015 · The Journals of Gerontology Series A
Human gait is a complex neurological and musculoskeletal function, of which the genetic basis remains largely unknown. To determine the influence of common genetic variants on gait parameters, we studied 2,946 participants of the Rotterdam…
Olga Stavrova, Lena Haarmann · 2019 · Motivation and Emotion
Abstract Although perceptions of subjective well-being (SWB) in unacquainted others have been shown to play a major role in impression formation, little is known about how accurate such perceptions are. In two original studies and one pre-registered replication, we explored the accuracy of life satisfaction and happiness judgments from texts and its underlying mechanisms (use of linguistic cues). Participants filled in life satisfaction and happiness measures and completed a brief writing task. Another sample of participants judged the targets’ life satisfaction and happiness from the obtained
Saranya Chitturi, Venkata Gopich, Talatam et al. · 2013 · Der pharmacia lettre
Recently, many studies have been oriented towards improving methods and efficiency of recovery from different fruit industry wastes. The investigations carried out were mainly aimed at evaluating Pectin content, Protease activity, Protein…
Burney, Saira, Muhammad Wasif Saif, Saif, Muhammad Wasif et al. · 2013 · PubMed
CONTEXT: Pancreatic cancer is the fourth leading cause of cancer mortality in the United States. Most of the patients are diagnosed in the metastatic staging. Consolidated risk factors include chronic pancreatitis, smoking and family…
Ivan Antonov, Andrey V. Marakhonov, Maria A. Zamkova et al. · 2018 · Journal of Bioinformatics and Computational Biology
The discovery of thousands of long noncoding RNAs (lncRNAs) in mammals raises a question about their functionality. It has been shown that some of them are involved in post-transcriptional regulation of other RNAs and form inter-molecular…
Hui Shi, Christopher Medway, James M. Bullock et al. · 2010 · PubMed
We have performed cross-platform comparisons of output from 4 GWAS in late-onset Alzheimer's disease (LOAD) - Reiman et al., 2007; Li et al., 2008; Beecham et al., 2008 and Carrasquillo et al., 2009 to search for new association signals.…
Caroline K. Kramer, Bernard Zinman, Haysook Choi et al. · 2017 · The Journal of Clinical Endocrinology & Metabolism
Context: Glucagon-like peptide-1 agonists acutely lower serum glucagon. However, in the Liraglutide and β-Cell Repair (LIBRA) Trial, 48-week treatment with liraglutide yielded lower/unchanged fasting glucagon but, surprisingly, enhanced…
Alexander D. Stajković, Jessica M. Greenwald, Kayla Stajkovic · 2022 · Journal of Organizational Behavior
Summary The effects of primed money have received widespread attention in social psychology but not in the organizational literature. This research examines whether priming money causes people to think and behave in ways consistent with…
Yiqun Xie, Xiaowei Jia, Shashi Shekhar et al. · 2021 · ACM Transactions on Intelligent Systems and Technology
Cluster detection is important and widely used in a variety of applications, including public health, public safety, transportation, and so on. Given a collection of data points, we aim to detect density-connected spatial clusters with…
Kam Ng, Todd Sullivan · 2017 · Geotechnical Research
In Wyoming, pile foundations for bridges are often driven on rock materials because of the state’s shallow bedrock stratigraphy. Unfortunately, no static analysis methods are currently available for estimating the resistance of these…
Anthony N. Reffi, Caitlin M. Pinciotti, Holly K. Orcutt · 2018 · Journal of Interpersonal Violence
Institutional betrayal reflects the failings of a trusted institution to prevent or respond appropriately to negative experiences. Following sexual assault, survivors who encounter institutional betrayal may experience greater distress and…
Joshua K. Hartshorne, Lauren Skorb, Sven L. Dietz et al. · 2019 · Collabra Psychology
We report the first set of results in a multi-year project to assess the robustness – and the factors promoting robustness – of the adult statistical word segmentation literature. This includes eight total experiments replicating six different experiments. The purpose of these replications is to assess the reproducibility of reported experiments, examine the replicability of their results, and provide more accurate effect size estimates. Reproducibility was mixed, with several papers either lacking crucial details or containing errors in the description of method, making it difficult to ascert
Marian Dovgialo, Anna Chabuda, Anna Duszyk et al. · 2019 · International Journal of Neural Systems
Disorders of consciousness (DOC) are among the major challenges of contemporary medicine, mostly due to the high rates of misdiagnoses in clinical assessment, based on behavioral scales. This turns our attention to potentially objective…
Olayemi O. Adeoye, Vincent Bouthors, Margaret C. Hubbell et al. · 2014 · Journal of Applied Physiology
Recent studies suggest that VEGF contributes to hypoxic remodeling of arterial smooth muscle, although hypoxia produces only transient increases in VEGF that return to normoxic levels despite sustained changes in arterial structure and…
Subhankar Ghosh, Jayant Gupta, Arun Sharma et al. · 2022
Given a set S of spatial feature-types, its feature-instances, a study area, and a neighbor relationship, the goal is to find pairs such that C is a statistically significant regional colocation pattern in region rg. For example Caribou…
Sulggi A. Lee, Joel Mefford, Yong Huang et al. · 2016 · AIDS
OBJECTIVE: Plasma kynurenine/tryptophan ratio, a biomarker of indoleamine 2,3-dioxygenase-1 (IDO) activity, is a strong independent predictor of mortality in HIV-infected Ugandans initiating antiretroviral therapy (ART) and may play a key…
Jesús Giménez, Julen Castellano, Patrycja Lipińska et al. · 2020 · International Journal of Environmental Research and Public Health
The aim of this study was to investigate the relationships among physical demands of two friendly matches (FMs) and three task training sessions (TS1,2,3) combining in a different way: a Small-Sided Game (SSG), Mini-Goals (MG), a ball Circuit Training (CT) and a Large-Sided Game (LSG): SSG+MG+LSG (TS1), SSG+CT+LSG (TS2) and MG+CT+LSG (TS3). The TS and match demands in running intensities were monitored in fourteen professional soccer players (age = 23.2 ± 2.7 years, height = 178 ± 6 cm, body mass = 73.2 ± 6.9 kg, mean and SD, respectively) using 10-Hz global positioning system devices, and pla
Bożena Nejman-Faleńczyk, Beata Nadratowska-Wesołowska, Agnieszka Szalewska-Pałasz et al. · 2010 · Microbiology
The pathogenicity of Shiga toxin-producing Escherichia coli (STEC) depends on the expression of stx genes that are located on lambdoid prophages. Effective toxin production occurs only after prophage induction, and one may presume that…
Harkeran K. Jandu, Colin Veal, Laura Fachal et al. · 2023 · Radiotherapy and Oncology
Background and purpose Up to a quarter of breast cancer patients treated by surgery and radiotherapy experience clinically significant toxicity. If patients at high risk of adverse effects could be identified at diagnosis, their treatment could be tailored accordingly. This study was designed to identify common single nucleotide polymorphisms (SNPs) associated with toxicity two years following whole breast radiotherapy. Materials and Methods A genome-wide association study (GWAS) was performed in 1,640 breast cancer patients with complete SNP, clinical, treatment and toxicity data, recruited a
Onno Kruse, S. Klein, Isabell Tapia León et al. · 2020 · Human Brain Mapping
Extinction of appetitive conditioning is regarded as an important model for the treatment of psychiatric disorders like addiction. However, very few studies have investigated its neural correlates. Therefore, we investigated neural…
Dominic Guitard, Leonie M. Miller, Ian Neath et al. · 2019 · Journal of Cognitive Psychology
People are better at recalling lists of high- than low-frequency words but as Parmentier, Comesãna, and Soares [(2017). Disentangling the effects of word frequency and contextual diversity on serial recall performance. Quarterly Journal of…
Chieffi S Iavarone A · 2015 · African Journal of Psychiatry
Attentional processes enhancing relevant information and attenuating competing irrelevant information are required for coherent and effective action. One of deficits that may characterize schizophrenia is the impairment of the ability in focusing on relevant information while inhibiting the irrelevant. The intrusion of irrelevant stimuli during information processing may impair cognitive and behavioral functioning. In this paper we review studies that investigated the vulnerability to distracting stimuli in schizophrenia by using visual interference paradigms, namely flanker, Stroop, and negat