e-ISSN: Pending
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19808 results in Negative / Null Result Report · page 115 of 661

Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology

ASSA: Fast identification of statistically significant interactions between long RNAs

Ivan Antonov, Andrey V. Marakhonov, Maria A. Zamkova et al. · 2018 · Journal of Bioinformatics and Computational Biology

The discovery of thousands of long noncoding RNAs (lncRNAs) in mammals raises a question about their functionality. It has been shown that some of them are involved in post-transcriptional regulation of other RNAs and form inter-molecular…

View details →DOI: 10.1142/s0219720018400012Cited by 17
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Analysis of Genome-Wide Association Study (GWAS) data looking for replicating signals in Alzheimer's disease (AD).

Hui Shi, Christopher Medway, James M. Bullock et al. · 2010 · PubMed

We have performed cross-platform comparisons of output from 4 GWAS in late-onset Alzheimer's disease (LOAD) - Reiman et al., 2007; Li et al., 2008; Beecham et al., 2008 and Carrasquillo et al., 2009 to search for new association signals.…

View details →Cited by 17
Negative / Null Result ReportOpen accessMedicine

Impact of the Glucagon Assay When Assessing the Effect of Chronic Liraglutide Therapy on Glucagon Secretion

Caroline K. Kramer, Bernard Zinman, Haysook Choi et al. · 2017 · The Journal of Clinical Endocrinology & Metabolism

Context: Glucagon-like peptide-1 agonists acutely lower serum glucagon. However, in the Liraglutide and β-Cell Repair (LIBRA) Trial, 48-week treatment with liraglutide yielded lower/unchanged fasting glucagon but, surprisingly, enhanced…

View details →DOI: 10.1210/jc.2017-00928Cited by 16
Negative / Null Result ReportPsychology

The money priming debate revisited: A review, meta‐analysis, and extension to organizations

Alexander D. Stajković, Jessica M. Greenwald, Kayla Stajkovic · 2022 · Journal of Organizational Behavior

Summary The effects of primed money have received widespread attention in social psychology but not in the organizational literature. This research examines whether priming money causes people to think and behave in ways consistent with…

View details →DOI: 10.1002/job.2619Cited by 16
Negative / Null Result Report

Significant DBSCAN+: Statistically Robust Density-based Clustering

Yiqun Xie, Xiaowei Jia, Shashi Shekhar et al. · 2021 · ACM Transactions on Intelligent Systems and Technology

Cluster detection is important and widely used in a variety of applications, including public health, public safety, transportation, and so on. Given a collection of data points, we aim to detect density-connected spatial clusters with…

View details →DOI: 10.1145/3474842Cited by 16
Negative / Null Result Report

Case studies to demonstrate challenges of driven piles on rock

Kam Ng, Todd Sullivan · 2017 · Geotechnical Research

In Wyoming, pile foundations for bridges are often driven on rock materials because of the state’s shallow bedrock stratigraphy. Unfortunately, no static analysis methods are currently available for estimating the resistance of these…

View details →DOI: 10.1680/jgere.16.00015Cited by 16
Negative / Null Result ReportSocial Sciences

Psychometric Properties of the Institutional Betrayal Questionnaire, Version 2: Evidence for a Two-Factor Model

Anthony N. Reffi, Caitlin M. Pinciotti, Holly K. Orcutt · 2018 · Journal of Interpersonal Violence

Institutional betrayal reflects the failings of a trusted institution to prevent or respond appropriately to negative experiences. Following sexual assault, survivors who encounter institutional betrayal may experience greater distress and…

View details →DOI: 10.1177/0886260518805771Cited by 16
Negative / Null Result ReportOpen accessComputer Science

The Meta-Science of Adult Statistical Word Segmentation: Part 1

Joshua K. Hartshorne, Lauren Skorb, Sven L. Dietz et al. · 2019 · Collabra Psychology

We report the first set of results in a multi-year project to assess the robustness – and the factors promoting robustness – of the adult statistical word segmentation literature. This includes eight total experiments replicating six different experiments. The purpose of these replications is to assess the reproducibility of reported experiments, examine the replicability of their results, and provide more accurate effect size estimates. Reproducibility was mixed, with several papers either lacking crucial details or containing errors in the description of method, making it difficult to ascert

View details →DOI: 10.1525/collabra.181Cited by 16
Negative / Null Result Report

Assessment of Statistically Significant Command-Following in Pediatric Patients with Disorders of Consciousness, Based on Visual, Auditory and Tactile Event-Related Potentials

Marian Dovgialo, Anna Chabuda, Anna Duszyk et al. · 2019 · International Journal of Neural Systems

Disorders of consciousness (DOC) are among the major challenges of contemporary medicine, mostly due to the high rates of misdiagnoses in clinical assessment, based on behavioral scales. This turns our attention to potentially objective…

View details →DOI: 10.1142/s012906571850048xCited by 16
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

VEGF receptors mediate hypoxic remodeling of adult ovine carotid arteries

Olayemi O. Adeoye, Vincent Bouthors, Margaret C. Hubbell et al. · 2014 · Journal of Applied Physiology

Recent studies suggest that VEGF contributes to hypoxic remodeling of arterial smooth muscle, although hypoxia produces only transient increases in VEGF that return to normoxic levels despite sustained changes in arterial structure and…

View details →DOI: 10.1152/japplphysiol.00012.2014Cited by 16
Negative / Null Result ReportBusiness, Management and Accounting

Towards geographically robust statistically significant regional colocation pattern detection

Subhankar Ghosh, Jayant Gupta, Arun Sharma et al. · 2022

Given a set S of spatial feature-types, its feature-instances, a study area, and a neighbor relationship, the goal is to find pairs such that C is a statistically significant regional colocation pattern in region rg. For example Caribou…

View details →DOI: 10.1145/3557989.3566158Cited by 16
Negative / Null Result ReportOpen accessNeuroscience

Host genetic predictors of the kynurenine pathway of tryptophan catabolism among treated HIV-infected Ugandans

Sulggi A. Lee, Joel Mefford, Yong Huang et al. · 2016 · AIDS

OBJECTIVE: Plasma kynurenine/tryptophan ratio, a biomarker of indoleamine 2,3-dioxygenase-1 (IDO) activity, is a strong independent predictor of mortality in HIV-infected Ugandans initiating antiretroviral therapy (ART) and may play a key…

View details →DOI: 10.1097/qad.0000000000001124Cited by 16
Negative / Null Result ReportOpen accessMedicine

Comparison of the Physical Demands of Friendly Matches and Different Types On-Field Integrated Training Sessions in Professional Soccer Players

Jesús Giménez, Julen Castellano, Patrycja Lipińska et al. · 2020 · International Journal of Environmental Research and Public Health

The aim of this study was to investigate the relationships among physical demands of two friendly matches (FMs) and three task training sessions (TS1,2,3) combining in a different way: a Small-Sided Game (SSG), Mini-Goals (MG), a ball Circuit Training (CT) and a Large-Sided Game (LSG): SSG+MG+LSG (TS1), SSG+CT+LSG (TS2) and MG+CT+LSG (TS3). The TS and match demands in running intensities were monitored in fourteen professional soccer players (age = 23.2 ± 2.7 years, height = 178 ± 6 cm, body mass = 73.2 ± 6.9 kg, mean and SD, respectively) using 10-Hz global positioning system devices, and pla

View details →DOI: 10.3390/ijerph17082904Cited by 16
Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology

Replication of plasmids derived from Shiga toxin-converting bacteriophages in starved Escherichia coli

Bożena Nejman-Faleńczyk, Beata Nadratowska-Wesołowska, Agnieszka Szalewska-Pałasz et al. · 2010 · Microbiology

The pathogenicity of Shiga toxin-producing Escherichia coli (STEC) depends on the expression of stx genes that are located on lambdoid prophages. Effective toxin production occurs only after prophage induction, and one may presume that…

View details →DOI: 10.1099/mic.0.042820-0Cited by 16
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Genome-wide association study of treatment-related toxicity two years following radiotherapy for breast cancer

Harkeran K. Jandu, Colin Veal, Laura Fachal et al. · 2023 · Radiotherapy and Oncology

Background and purpose Up to a quarter of breast cancer patients treated by surgery and radiotherapy experience clinically significant toxicity. If patients at high risk of adverse effects could be identified at diagnosis, their treatment could be tailored accordingly. This study was designed to identify common single nucleotide polymorphisms (SNPs) associated with toxicity two years following whole breast radiotherapy. Materials and Methods A genome-wide association study (GWAS) was performed in 1,640 breast cancer patients with complete SNP, clinical, treatment and toxicity data, recruited a

View details →DOI: 10.1016/j.radonc.2023.109806Cited by 16
Negative / Null Result ReportOpen accessNeuroscience

Amygdala and nucleus accumbens involvement in appetitive extinction

Onno Kruse, S. Klein, Isabell Tapia León et al. · 2020 · Human Brain Mapping

Extinction of appetitive conditioning is regarded as an important model for the treatment of psychiatric disorders like addiction. However, very few studies have investigated its neural correlates. Therefore, we investigated neural…

View details →DOI: 10.1002/hbm.24915Cited by 16
Negative / Null Result ReportNeuroscience

Does contextual diversity affect serial recall?

Dominic Guitard, Leonie M. Miller, Ian Neath et al. · 2019 · Journal of Cognitive Psychology

People are better at recalling lists of high- than low-frequency words but as Parmentier, Comesãna, and Soares [(2017). Disentangling the effects of word frequency and contextual diversity on serial recall performance. Quarterly Journal of…

View details →DOI: 10.1080/20445911.2019.1626401Cited by 16
Negative / Null Result ReportOpen accessNeuroscience

Vulnerability to Distraction in Schizophrenia

Chieffi S Iavarone A · 2015 · African Journal of Psychiatry

Attentional processes enhancing relevant information and attenuating competing irrelevant information are required for coherent and effective action. One of deficits that may characterize schizophrenia is the impairment of the ability in focusing on relevant information while inhibiting the irrelevant. The intrusion of irrelevant stimuli during information processing may impair cognitive and behavioral functioning. In this paper we review studies that investigated the vulnerability to distracting stimuli in schizophrenia by using visual interference paradigms, namely flanker, Stroop, and negat

View details →DOI: 10.4172/psychiatry.1000228Cited by 16
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Pharmacoepigenetics of hypertension: genome-wide methylation analysis of responsiveness to four classes of antihypertensive drugs using a double-blind crossover study design

Marja-Liisa Nuotio, Heini Sánez Tähtisalo, Alexandra Lahtinen et al. · 2022 · Epigenetics

Essential hypertension remains the leading risk factor of global disease burden, but its treatment goals are often not met. We investigated whether DNA methylation is associated with antihypertensive responses to a diuretic, a beta-blocker, a calcium channel blocker or an angiotensin receptor antagonist. In addition, since we previously showed an SNP at the transcription start site (TSS) of the catecholamine biosynthesis-related ACY3 gene to associate with blood pressure (BP) response to beta-blockers, we specifically analysed the association of methylation sites close to the ACY3 TSS with BP

View details →DOI: 10.1080/15592294.2022.2038418Cited by 16
Negative / Null Result ReportMedicine

No Significant Effect of Ginkgo Biloba Special Extract EGb 761 in the Treatment of Primary Raynaud Phenomenon

S.J.H. Bredie, Miek C. Jong · 2011 · Journal of Cardiovascular Pharmacology

BACKGROUND: Medicinal treatment of vasospastic Raynaud phenomenon is limited to primarily vasodilator medicines. OBJECTIVE: To explore the possible beneficial effects and tolerability of 120 mg two times a day of Ginkgo Biloba special…

View details →DOI: 10.1097/fjc.0b013e31823c0bedCited by 16
Negative / Null Result ReportOpen accessMedicine

Bioinspired Intervertebral Disc with Multidirectional Stiffness Prepared via Multimaterial Additive Manufacturing

Guangsheng Song, Zhihui Qian, Xiangyu Liu et al. · 2023 · Advanced Functional Materials

Abstract Degenerative disc disease (DDD) has become a significant public health issue worldwide. This can result in loss of spinal function affecting patient health and quality of life. Artificial total disc replacement (A‐TDR) is an…

View details →DOI: 10.1002/adfm.202300298Cited by 16
Negative / Null Result ReportOpen accessSocial Sciences

ROLE OF NEUTRAL EVOLUTION IN WORD TURNOVER DURING CENTURIES OF ENGLISH WORD POPULARITY

Damian J. Ruck, R. Alexander Bentley, Alberto Acerbi et al. · 2017 · Advances in Complex Systems

Here, we test Neutral models against the evolution of English word frequency and vocabulary at the corpus scale, as recorded in annual word frequencies from three centuries of English language books. Against these data, we test both static…

View details →DOI: 10.1142/s0219525917500126Cited by 16
Negative / Null Result ReportOpen accessMathematics

A SIMULATION STUDY ON TESTS FOR ONE-WAY ANOVA UNDER THE UNEQUAL VARIANCE ASSUMPTION

Esra Yiğit, Fikri Gökpınar · 2010 · Communications Faculty Of Science University of Ankara Series A1Mathematics and Statistics

The classical F-test to compare several population means depends on the assumption of homogeneity of variance of the population and the normality. When these assumptions especially the equality of variance is dropped, the classical F-test fails to reject the null hypothesis even if the data actually provide strong evidence for it. This can be considered a serious problem in some applications, especially when the sample size is not large. To deal with this problem, a number of tests are available in the literature. In this study, the Brown-Forsythe, Weerahandiís Generalized F, Parametric Bootst

View details →DOI: 10.1501/commua1_0000000660Cited by 16
Negative / Null Result Report

Towards integrated oncogenic marker recognition through mutual information‐based statistically significant feature extraction: an association rule mining based study on cancer expression and methylation profiles

Saurav Mallik, Zhongming Zhao · 2017 · Quantitative Biology

Background Marker detection is an important task in complex disease studies. Here we provide an association rule mining (ARM) based approach for identifying integrated markers through mutual information (MI) based statistically significant…

View details →DOI: 10.1007/s40484-017-0119-0Cited by 16
Negative / Null Result Report

No statistically significant kinematic difference found between a cruciate-retaining and posterior-stabilised Triathlon knee arthroplasty

N. C. Hunt, K. M. Ghosh, A. P. Blain et al. · 2015 · The Bone & Joint Journal

The aim of this study was to compare the maximum laxity conferred by the cruciate-retaining (CR) and posterior-stabilised (PS) Triathlon single-radius total knee arthroplasty (TKA) for anterior drawer, varus–valgus opening and rotation in…

View details →DOI: 10.1302/0301-620x.97b5.34999Cited by 16
Negative / Null Result ReportOpen accessSocial Sciences

Does governance matter to ensure significant effect of foreign direct investment on poverty reduction? Evidence from developing and emerging countries

Zouhaier Aloui, Mekki Hamdaoui, Samir Maktouf · 2024 · Transnational Corporation Review

This paper examines the moderating role of governance in the effect of Foreign Direct Investment (FDI) on poverty using simultaneous equations models for sub-Saharan African, Asian, Latin American and Eastern European countries over the…

View details →DOI: 10.1016/j.tncr.2024.200058Cited by 16
Negative / Null Result Report

Cyclic thrombocytopenia with statistically significant neutrophil oscillations

Gabriel P. Langlois, Donald M. Arnold, Jayson Potts et al. · 2018 · Clinical Case Reports

Key Clinical Message Cyclic thrombocytopenia is often misdiagnosed as immune thrombocytopenia due to similar clinical features, a fact of significance because cyclic thrombocytopenia generally responds poorly to treatments used…

View details →DOI: 10.1002/ccr3.1611Cited by 16
Negative / Null Result ReportAgricultural and Biological Sciences

Superiority of extra-pair offspring: maternal but not genetic effects as revealed by a mixed cross-fostering design

Miloš Krist, Pavel Munclinger · 2011 · Molecular Ecology

Extra-pair copulations (EPC) are the rule rather than an exception in socially monogamous birds, but despite widespread occurrences, the benefits of female infidelity remain elusive. Most attention has been paid to the possibility that…

View details →DOI: 10.1111/j.1365-294x.2011.05337.xCited by 16
Negative / Null Result ReportOpen accessPsychology

Accuracy and transportability of machine learning models for adolescent suicide prediction with longitudinal clinical records

Chengxi Zang, Yu Hou, Daoming Lyu et al. · 2024 · Translational Psychiatry

Machine Learning models trained from real-world data have demonstrated promise in predicting suicide attempts in adolescents. However, their transportability, namely the performance of a model trained on one dataset and applied to…

View details →DOI: 10.1038/s41398-024-03034-3Cited by 16