Negative / Null Result ReportOpen accessEngineering
Peter D. Dunning · 2020 · Structural and Multidisciplinary Optimization
Abstract This paper investigates the application of the co-rotational method to solve geometrically nonlinear topology optimization problems. The main benefit of this approach is that the tangent stiffness matrix is naturally positive definite, which avoids some numerical issues encountered when using other approaches. Three different methods for constructing the tangent stiffness matrix are investigated: a simplified method, where the linear elastic stiffness matrix is simply rotated; the consistent method, where the tangent stiffness is derived by differentiating residual forces by displacem
View details →DOI: 10.1007/s00158-020-02605-4Cited by 18 Negative / Null Result Report
Kristina B Beck, Ben C Sheldon, Josh A Firth · 2023 · eLife
The emergence and spread of novel behaviours via social learning can lead to rapid population-level changes whereby the social connections between individuals shape information flow. However, behaviours can spread via different mechanisms…
View details →DOI: 10.7554/elife.85703Cited by 18 Negative / Null Result ReportOpen accessPsychology
Hubertus Himmerich, Jörg-Egbert Wolf, Peter Zimmermann et al. · 2016 · Chinese Medical Journal
To the Editor: With great interest we read the original article of Chen et al.[1] published in the Chinese Medical Journal comparing serum concentrations of cytokines in patients of Han and Li ethnicity with posttraumatic stress disorder…
View details →DOI: 10.4103/0366-6999.178039Cited by 18 Negative / Null Result ReportOpen accessMedicine
Charanpreet Singh, Sanjay Jain, Veena Dhawan et al. · 2020 · Archives of Endocrinology and Metabolism
OBJECTIVE: We conducted a study to examine the association of endothelial dysfunction and oxidative stress with uric acid levels in patients of metabolic syndrome. METHODS: One hundred and two patients of Metabolic Syndrome (International Diabetes Federation definition) were included in the study. Anthropometric measurements, serum uric acid levels, fasting blood sugar levels and lipid levels, as well as malondialdehyde and reactive nitrogen intermediates were measured after an 8-hour fasting period. Flow mediated vasodilation (FMD) of the brachial artery was measured and endothelial dysfuncti
View details →DOI: 10.20945/2359-3997000000298Cited by 18 Negative / Null Result ReportOpen accessNeuroscience
Marcello Sartarelli · 2016 · PLoS ONE
Evidence showing that on average left-handed (L), who are 10% in a population, tend to earn less than others is solely based on survey data. This paper is the first to test the relationship between handedness and earnings experimentally and also to assess whether the mechanism underlying it is predominantly cognitive or psychological. Data on 432 undergraduate students show that L do not obtain significantly different payoffs, a proxy for earnings, in a stylised labour market with multiple principals and agents. Similarly, scores in the Cognitive Reflection Test are not significantly different
View details →DOI: 10.1371/journal.pone.0164412Cited by 18 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Diego Chemello, Luís Eduardo Paim Rohde, Kátia Gonçalves dos Santos et al. · 2010 · EP Europace
AIMS: We investigated whether the combination of beta(1)-Gly389Arg and GNB3 C825T, two genetic polymorphisms strictly related to adrenergic system modulation, could act as predictors of appropriate therapies in patients with heart failure…
View details →DOI: 10.1093/europace/euq040Cited by 18 Negative / Null Result ReportOpen accessMedicine
Mary A.M. Rogers, Kathleen Ward, Tanya R. Gure et al. · 2011 · Diabetes Care
OBJECTIVE: The goals of this study were to examine trajectories of blood pressure (BP) in adults with diabetes and investigate the association of trajectory patterns with mortality. RESEARCH DESIGN AND METHODS: A nonconcurrent longitudinal…
View details →DOI: 10.2337/dc11-0441Cited by 18 Negative / Null Result ReportOpen accessMedicine
Mark Seow Khoon Chong, Jing Lim, Junwei Goh et al. · 2014 · Molecular Pharmaceutics
In spite of recognized limitations in capturing species-specific responses and high costs, rodent models remain commonly used in prostate cancer metastasis research, due largely to the lack of available alternatives. We aim to develop an…
View details →DOI: 10.1021/mp500141bCited by 18 Negative / Null Result ReportOpen accessMathematics
Abigail Bradshaw, Dorothy Bishop, Zoe Woodhead · 2019 · Quarterly Journal of Experimental Psychology
A deficit in interhemispheric transfer has been proposed as a neuropsychological theory of dyslexia. Interactions between the hemispheres during word recognition can be studied using the visual half-field paradigm. The well-established…
View details →DOI: 10.1177/1747021819895472Cited by 18 Negative / Null Result ReportOpen accessPsychology
Emily P. Taylor, Rachel Couper, Carolyn Maeve Butler · 2017 · Psychology and Psychotherapy Theory Research and Practice
OBJECTIVES: Perfectionism is recognized as a significant risk factor for psychopathology. Emerging research links attachment to perfectionism in adult and college-age samples. The Frost Multidimensional Perfectionism Scale (FMPS) has been…
View details →DOI: 10.1111/papt.12133Cited by 18 Negative / Null Result ReportOpen accessMedicine
Lijun Lu, Youqing Deng, Renshi Xu · 2024 · Frontiers in Neurology
Amyotrophic lateral sclerosis (ALS) is a debilitating motor neurological disorder for which there is still no cure. The disease seriously jeopardizes the health and lifespan of adult populations. The authors extensively retrieved the current literature about clinical and experimental ALS treatments. Based on them, this review primarily focused on summarizing the current potential clinical usage and trialing therapeutics of ALS. Currently, the clinical ALS treatments have focused primarily on relieving symptoms to improve the quality of life yet. There are a number of therapeutic approaches suc
View details →DOI: 10.3389/fneur.2024.1402962Cited by 18 Negative / Null Result ReportPsychology
Youjia Hua, Chengan Yuan, Kristin V. Monroe et al. · 2016 · Developmental Neurorehabilitation
OBJECTIVE: Reread-Adapt and Answer-Comprehend (RAAC) + Goal Setting intervention is a reading intervention that addresses both oral reading fluency (ORF) and reading comprehension while supporting persistence and motivation for learners…
View details →DOI: 10.3109/17518423.2016.1139011Cited by 18 Negative / Null Result ReportComputer Science
Akhil Arora, Mayank Sachan, Arnab Bhattacharya · 2014
The steady growth of graph data in various applications has resulted in wide-spread research in finding significant sub-structures in a graph. In this paper, we address the problem of finding statistically significant connected subgraphs…
View details →DOI: 10.1145/2588555.2588574Cited by 18 Negative / Null Result Report
Annelise Mennicke, Heather M. Bush, Candace J. Brancato et al. · 2021 · Journal of Family Violence
Abstract Youth who witness parental intimate partner violence (IPV) are at increased risk of teen dating violence (DV). This analysis of secondary data investigated whether a bystander intervention program, Green Dot, was effective at…
View details →DOI: 10.1007/s10896-021-00297-yCited by 18 Negative / Null Result ReportOpen accessMedicine
Robert S. Wallis · 2014 · Open Forum Infectious Diseases
OBJECTIVES: There is increasing interest in the potential role of adjunctive anti-inflammatory therapy to accelerate tuberculosis (TB) treatment. Sputum culture conversion is an important biomarker predictor of durable TB cure. METHODS:…
View details →DOI: 10.1093/ofid/ofu020Cited by 18 Negative / Null Result ReportOpen accessNeuroscience
Aung Naing, Alain P. Algazi, Gerald S. Falchook et al. · 2022 · Cancer
BACKGROUND: Targeting programmed cell death protein 1 (PD-1) and indoleamine 2,3-dioxygenase (IDO1) pathways is an appealing option for cancer treatment. METHODS: The open-label, phase 1/2 ECHO-203 study evaluated the safety, tolerability,…
View details →DOI: 10.1002/cncr.34512Cited by 18 Negative / Null Result ReportOpen accessMedicine
Lucy Brazil, Angela Swampillai, Ka Man Mak et al. · 2020 · Neuro-Oncology Advances
BACKGROUND: Effective treatment for patients at least 70 years with newly diagnosed glioblastoma remains challenging and alternatives to conventional cytotoxics are appealing. Autophagy inhibition has shown promising efficacy and safety in small studies of glioblastoma and other cancers. METHODS: We conducted a randomized phase II trial to compare radiotherapy with or without hydroxychloroquine (2:1 allocation). Patients aged at least 70 years with newly diagnosed high-grade glioma deemed suitable for short-course radiotherapy with an ECOG performance status of 0-1 were included. Radiotherapy
View details →DOI: 10.1093/noajnl/vdaa046Cited by 18 Negative / Null Result ReportOpen accessPsychology
Ana R. Sepúlveda, Dimitra Anastasiadou, Yolanda de Pellegrin et al. · 2016 · Men and Masculinities
The aim of this study was to examine the factor structure of the Male Body Attitudes Scale (MBAS) among a sample of 212 adolescent males by conducting a confirmatory factor analysis. The data revealed that while muscularity and low body fat factors were appropriate for the male sample, the height factor was not supported. The composite MBAS-Spanish version (MBAS-S) and its two factors had high internal consistency and were not significantly related to the traditionally used measure of body image (Eating Disorder Inventory–Body Dissatisfaction [BD]), confirming that this subscale only appears t
View details →DOI: 10.1177/1097184x16634798Cited by 18 Negative / Null Result ReportOpen accessPharmacology, Toxicology and Pharmaceutics
Michael Schütt, Konstantinos Stamatopoulos, Hannah Batchelor et al. · 2022 · European Journal of Pharmaceutical Sciences
The performance of colon-targeted solid dosage forms is commonly assessed using standardised pharmacopeial dissolution apparatuses like the USP II or the miniaturised replica, the mini-USP II. However, these fail to replicate the hydrodynamics and shear stresses in the colonic environment, which is crucial for the tablet's drug release process. In this work, computer simulations are used to create a digital twin of a dissolution apparatus and to develop a method to create a digital twin of a tablet that behaves realistically. These models are used to investigate the drug release profiles and s
View details →DOI: 10.1016/j.ejps.2022.106310Cited by 18 Negative / Null Result Report
Margarida Arrobas, João V. Decker, Bruna L. Feix et al. · 2021 · Soil Use and Management
Abstract Soil conditioners, such as biochar and zeolites, may play an important role in agriculture if they increase nutrient use efficiency, in particular, that of phosphorus (P), due to the depletion of phosphate rocks from which…
View details →DOI: 10.1111/sum.12704Cited by 18 Negative / Null Result Report
RuoLi Chen, Mohammad Alkataan Ahmed, Nicholas Robert Forsyth · 2022 · Biomolecules
Cells respond to reduced oxygen availability predominately by activation of the hypoxia-inducible factor (HIF) pathway. HIF activation upregulates hundreds of genes that help cells survive in the reduced oxygen environment. The aim of this…
View details →DOI: 10.3390/biom12040541Cited by 18 Negative / Null Result Report
Christopher W. Belter, Neal K. Kaske · 2016 · College & Research Libraries
Although cited reference studies are common in the library and information science literature, they are rarely performed in nonacademic institutions or in the atmospheric and oceanic sciences. In this paper, we analyze more than 400,000…
View details →DOI: 10.5860/crl.77.4.410Cited by 18 Negative / Null Result Report
Aidan E. Gilchrist, Brendan A. C. Harley · 2022 · Advanced Healthcare Materials
Abstract Hematopoietic stem cells are the progenitors of the blood and immune system and represent the most widely used regenerative therapy. However, their rarity and limited donor base necessitate the design of ex vivo systems that…
View details →DOI: 10.1002/adhm.202102130Cited by 18 Negative / Null Result Report
Thomas Perneger, Angèle Gayet-Ageron · 2023 · JAMA
Importance Many randomized clinical trials yield statistically nonsignificant results. Such results are difficult to interpret within the dominant statistical framework. Objective To estimate the strength of evidence in favor of the null…
View details →DOI: 10.1001/jama.2023.8549Cited by 18 Negative / Null Result ReportOpen accessNeuroscience
Barbara Schmidt, Luisa Keßler, Clay B. Holroyd et al. · 2019 · Psychophysiology
A recent study claims that participants wearing a bike helmet behave riskier in a computer-based risk task compared to control participants without a bike helmet. We hypothesized that wearing a bike helmet reduces cognitive control over risky behavior. To test our hypothesis, we recorded participants' EEG brain responses while they played a risk game developed in our laboratory. Previously, we found that, in this risk game, anxious participants showed greater levels of cognitive control as revealed by greater frontal midline theta power, which was associated with less risky decisions. Here, we
View details →DOI: 10.1111/psyp.13458Cited by 18 Negative / Null Result ReportOpen accessMedicine
Mark B. Stoddard, Hui Li, Shuyi Wang et al. · 2015 · mBio
UNLABELLED: Hepatitis C virus (HCV) infection is characterized by persistent replication of a complex mixture of viruses termed a "quasispecies." Transmission is generally associated with a stringent population bottleneck characterized by infection by limited numbers of "transmitted/founder" (T/F) viruses. Characterization of T/F genomes of human immunodeficiency virus type 1 (HIV-1) has been integral to studies of transmission, immunopathogenesis, and vaccine development. Here, we describe the identification of complete T/F genomes of HCV by single-genome sequencing of plasma viral RNA from a
View details →DOI: 10.1128/mbio.02518-14Cited by 18 Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology
Da‐Tian Bau · 2011 · The Chinese Journal of Physiology
Many articles have reported the caveolin-1 gene to be down-regulated thus suggesting that it might be a candidate tumor suppressor gene in many tumors. However, its involvement in bladder cancer is not clear and may be depending on…
View details →DOI: 10.4077/cjp.2011.amm009Cited by 18 Negative / Null Result ReportOpen accessNeuroscience
Brett Mercier, Dylan Wiwad, Paul K. Piff et al. · 2020 · Collabra Psychology
Does belief in free will increase support for economic inequality? Five studies using diverse measures and methods tested this question. Study 1 finds belief in free will is associated with increased support for inequality. Study 2 manipulates belief in free will and does not find evidence that this changes support for inequality. Studies 3 and 4 find that people are more willing to support inequality in a hypothetical universe where free will exists compared to one where it does not (dz = 0.10–0.13), indicating that people believe the existence of free will justifies inequality. However, a be
View details →DOI: 10.1525/collabra.303Cited by 18 Negative / Null Result ReportMedicine
Jinling Li, Carol J. Cardona · 2010 · Avian Diseases
Mutations in a wild duck isolate of avian influenza virus were detected in isolates shed by chickens within 1 day after inoculation. The newly adapted virus was transmitted to naïve chickens in direct contact and sharing food and water.…
View details →DOI: 10.1637/8806-040109-resnote.1Cited by 18 Negative / Null Result ReportOpen accessImmunology and Microbiology
Micah J. McCauley, Ioulia Rouzina, Jasmine Li et al. · 2020 · Viruses
Retroviral nucleocapsid (NC) proteins are nucleic acid chaperones that play distinct roles in the viral life cycle. During reverse transcription, HIV-1 NC facilitates the rearrangement of nucleic acid secondary structures, allowing the transactivation response (TAR) RNA hairpin to be transiently destabilized and annealed to a complementary RNA hairpin. In contrast, during viral assembly, NC, as a domain of the group-specific antigen (Gag) polyprotein, binds the genomic RNA and facilitates packaging into new virions. It is not clear how the same protein, alone or as part of Gag, performs such d
View details →DOI: 10.3390/v12050484Cited by 18 