A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
403 results in Replication Failure · page 11 of 14
A. Bühler, Johannes Thrul, Evelin Strüber et al. · 2015 · Health Promotion International
Because of scarce research, the effectiveness of substance abuse prevention in leisure settings remains unclear. In this study, we evaluated the effectiveness of a peer-led educational prevention measure with adolescent groups in…
Elsiaulavita Gracia, S. Nurohman, I. Wilujeng · 2024 · Jurnal Penelitian Pendidikan IPA
This study aims to analyze the impact of applying the STEAM (Science, Technology, Engineering, Arts, Mathematics) approach in science education on students' creative thinking skills. The STEAM approach offers an integration of various…
Ela Miranda, Iriani Iriani, I. Nasution · 2022 · JRMB (Jurnal Riset Manajemen & Bisnis)
The high income tax expense causes the company to carry out earnings management. Decreased earnings management tends to result in high tax planning. The company's ability to pay off short-term liabilities by using good current assets…
· 2021 · Indonesian Treasury Review: Jurnal Perbendaharaan, Keuangan Negara dan Kebijakan Publik
This study examines the effects of fiscal decentralization, internal audit capability, bureaucratic reform, and performance accountability on corruption that occur in local governments. Corruption in this research was measured by the…
The CMS collaboration, A. Hayrapetyan, A. Tumasyan et al. · 2025 · Journal of High Energy Physics
Abstract Results are presented for a test of the compositeness of the heaviest charged lepton, τ, using data collected by the CMS experiment in proton-proton collisions at a center-of-mass energy of 13 TeV at the CERN LHC. The data were collected in 2016–2018 and correspond to an integrated luminosity of 138 fb −1. This analysis searches for tau lepton pair production in which one of the tau leptons is produced in an excited state and decays to a ground state tau lepton and a photon. The event selection consists of two isolated tau lepton decay candidates and a high-energy photon. The mass of
J. Ming, M. A. Papa, H.-B. Eggenstein et al. · 2024 · The Astrophysical Journal
We perform a search for continuous nearly monochromatic gravitational waves from the central compact objects associated with the supernova remnants Vela Jr. and G347.3. Over 10 ^18 different waveforms are considered, covering signal frequencies between 20 and 1300 Hz (20 and 400 Hz) for G347.3-0.5 (Vela Jr.) and a very broad range of frequency derivatives. The data set used for this first search is from the second observing run of LIGO (O2). Thousands of volunteers donating compute cycles through the computing project Einstein@Home have made this endeavor possible. Following the Einstein@Home
N. V. Dmitrieva, M. V. Eidelshtein, V. V. Aginova et al. · 2019 · Сибирский онкологический журнал
The purpose of the study was to evaluate the frequency of isolation of multi-resistant Pseudomonas aeruginosa and identify the mechanisms of resistance to carbapenems.Material and methods. We analyzed 866 strains of Pseudomonos aeruginosaisolated from clinical samples from cancer patients in the period 2014–2016. the level of resistance to piperacillin/tazobactam, ceftazidime, cefepime, imipenem, meropenem, ciprofloxacin, amikacin in dynamics was determined. carbapenem-resistant (car-R) strains were examined for the presence of enzymes.Results. Between 2014 and 2016, the number of strains resi
Ben-Gang Zhou, Ming-Wen Guo, Li-Juan Zhang et al. · 2024 · Therapeutic Advances in Gastroenterology
Background: The efficacy of the 14-day esomeprazole–amoxicillin (EA) dual therapy in eradicating Helicobacter pylori ( H. pylori ) has been widely discussed previously. Vonoprazan, a novel potassium-competitive acid blocker, presents rapid, potent, and long-lasting acid inhibitory effects compared to esomeprazole. However, there is currently a scarcity of direct comparisons between the 10-day vonoprazan–amoxicillin (VA) and the 14-day EA dual therapy for H. pylori eradication. Objectives: This study aimed to compare the efficacy and safety of the 10-day VA and the 14-day EA dual therapy for H.
Hassan Rezvanian, Ali Kachuei, Ali Mirzapour · 2011 · مجله دانشکده پزشکی اصفهان
Background: Milk thistle has antioxidative effects and may improve renal performance. Our study investigated whether Milk thistle improve renal performance in patients with type II diabetes mellitus nephropathy. Methods: In this clinical trial study, after ethics committee approval, 65 Patients with type II diabetes mellitus were enrolled into a randomized simple sampling, prospective, double-blinded study. In the case group, was gave Milk thistle and control group was given placebo. We measured urine albumin/cratinine (A/C) ratio and eGFR before and after intervention. The gathered data were
Quoc Huy Hoang, Hung Sy Ho, Huong Thuy Do et al. · 2021 · Reproductive Medicine and Biology
Abstract Purpose This study compared the therapeutic effects of transdermal testosterone gel (TTG) application at 4 and 6 weeks before controlled ovarian hyperstimulation (COH) in women with poor ovarian response (POR). Methods In this randomized control trial, infertile women with POR who underwent in vitro fertilization (IVF) were recruited and randomly classified into 4 week (n = 42) and 6 week (n = 38) TTG treatment groups and control group (n = 42). The primary outcome was total number of retrieved mature oocytes. The secondary outcomes were the biochemical pregnancy rate, clinical pregna
Parsa Mohammadi, Elaheh Karimi, Adeleh Maleki et al. · 2022 · Acta Medica Iranica
Accumulating evidence suggests the potential use of chloroquine, an anti-malaria medication, as a neuroprotective agent. Moreover, several studies have reported that the endogenous opioids and nitric oxide (NO) may mediate the chloroquine’s effects. In the present study, effects of chloroquine on hyoscine-induced memory impairment were assessed. Furthermore, the possible involvements of opioids and NO were evaluated. Chloroquine was administered intraperitonially (i.p.) at doses of 0.1, 0.5, 1, 3, 10, and 20 mg/kg to hyoscine-treated (1mg/kg, i.p.) mice, and the spatial and fear memories were
Pooja Budhiraja, Rocio Lopez, Rocio Lopez et al. · 2025 · Transplant International
This study compares outcomes between Simultaneous Pancreas-Kidney Transplantation (SPKT) and Deceased Donor Kidney Transplantation (DDKT) in recipients with diabetes, assessing survival benefits against surgical and immunological risks. We analyzed Scientific Registry of Transplant Recipients data (2014–2023) to assess patient and kidney graft survival. Overlap propensity score weighting was applied to adjust for group differences. Kaplan-Meier and Cox proportional hazards models were used to estimate survival outcomes in unadjusted, covariate-adjusted, and weighted analyses. Among 22,545 reci
Tatsuya Nagano, Masashi Hashimoto, Shintaro Izumi et al. · 2024 · Scientific Reports
Abstract Previously reported oropharyngeal exercises are long and difficult to perform. Therefore, we created a 10-min daily oropharyngeal exercise program and conducted a study to confirm its effectiveness. Twenty-five participants whose apnoea–hypopnoea index (AHI) values were greater than 5 were enrolled. All of the participants performed 10 min of exercise per day for 12 weeks and were evaluated for AHI values, tongue pressure, lip closure pressure, snoring, and Mallampati scores before and after the exercise. Twenty-two participants (88% of all participants) completed the oropharyngeal ex
Alba Massolo, Mariel Traversi, Matías Alfonso · 2024 · Europe's Journal of Psychology
In this paper, we investigate whether collaborative group performance is better than individual performance in solving a syllogism evaluation task. We hypothesise that collaborative group settings will outperform individual settings and that the belief bias effect will be mitigated in a group setting. Two empirical studies were conducted with Argentinian undergraduate students. Study 1 (N = 239) used a between-subjects design with two conditions: individual resolution and interactive group resolution. Overall, the group condition performed better than the individual condition, but there were n
Karina da Silva, Cristino Carneiro Oliveira, Leandro Ferracini Cabral et al. · 2023 · PLoS ONE
Pulmonary expansion manoeuvres are therapeutic techniques used to prevent and reverse atelectasis; however, no randomized controlled trials have provided evidence supporting the use of this intervention among individuals on mechanical ventilation. Objective To evaluate the effects of chest compression-decompression and chest block manoeuvres compared to usual care among patients on mechanical ventilation. Methods The current study was a randomized clinical trial of adult subjects on mechanical ventilation for 12 to 48 hours. The control group received usual care (passive or active mobilization
Ziqi Sang, Ziqi Sang, Han Wang et al. · 2025 · Frontiers in Nutrition
BackgroundHepatic fibrosis and the fatty liver index (FLI) are critical indicators for assessing the progression and severity of metabolic dysfunction-associated steatotic liver disease (MASLD) and serve as valuable reference markers for predicting MASLD-related risks. The Dietary Inflammation Index (DII) quantifies the inflammatory effects of dietary intake and has been extensively utilized in nutritional and epidemiological studies. Although studies have been conducted to confirm the correlation between dietary quality and MASLD in the general population, this study sought to further explore
Edlin Brian R, Yeager Meredith, Xiao Nianqing et al. · 2008 · BMC Infectious Diseases
Abstract Background Genetic variations in MBL2 that reduce circulating levels and alter functional properties of the mannose binding lectin (MBL) have been associated with many autoimmune and infectious diseases. We examined whether MBL2 variants influence the outcome of hepatitis C virus (HCV) infection. Methods Participants were enrolled in the Urban Health Study of San Francisco Bay area injection drug users (IDU) during 1998 through 2000. Study subjects who had a positive test for HCV antibody were eligible for the current study. Participants who were positive for HCV RNA were frequency ma
Md Habibul Ghani, Md. Shahed Morshed, Tahniyah Haq et al. · 2023 · Bangabandhu Sheikh Mujib Medical University Journal
Hypovitaminosis D (<20 ng/mL) is thought to increase insulin resistance and meta-inflammation contributing to the pathogenesis of diabetes mellitus (DM). Correcting vitamin D deficiency in people with prediabetes might halt its progression to DM. The aim of this study was to examine the effect of vitamin D supplementation on insulin resistance, glycemic status, and inflammation in prediabetic adults with vitamin D deficiency. This doubleblind randomized placebo-controlled trial was done among 27 newly detected prediabetic adults with hypovitaminosis D randomly assigned to 60,000 IU of vitamin
Nozomi Maniwa, Samuel Porfirio Xavier, Sergio Luis Scombatti de Souza et al. · 2024 · Journal of Functional Biomaterials
Background: A comprehensive investigation to associate the use of polynucleotides and hyaluronic acid with bovine bone in maxillary sinus lift procedures in rabbits has not been performed yet. The aim was to evaluate the influence of this novel association on the processes of bone regeneration in maxillary sinus augmentation. Methods: In this prospective, randomized, within-animal model, maxillary sinus augmentation was performed bilaterally in 12 rabbits. Deproteinized bovine bone material (DBBM) was used as filler material. A hyaluronic acid–polynucleotide gel was aggregated at the test site
Xiao Y, Li Z, Hu B et al. · 2025 · Neurologia medico-chirurgica
For resectable malignant peripheral nerve sheath tumors, the additional benefits of radiotherapy remain controversial. This study aims to investigate whether there is an additional benefit of radiotherapy for resectable malignant…
Stazi F · 2026 · European heart journal supplements : journal of the European Society of Cardiology
Despite the use of oral anticoagulants, the residual risk of recurrent ischaemic stroke in patients with atrial fibrillation (AF) is ∼4% per year; however, in patients who experience a stroke despite oral anticoagulant therapy (OAT), this…
Florens N, Demiselle J · 2026 · Kidney360
Iodinated contrast media have long been feared for causing contrast-induced AKI (CI-AKI), a concern rooted in early reports with high-osmolar agents. Experimental data suggest potential nephrotoxic mechanisms, yet clinical evidence from…
Eroğlu AS, Demirtaş OK · 2026 · Acta neurochirurgica
Objectives This study aims to retrospectively analyze the factors affecting implant failure in patients who underwent anterior cervical plating (ACP) following anterior cervical discectomy and fusion (ACDF). Methods Data from 332 patients…
Gkantidis N, Tsikouriadou E, Halazonetis D et al. · 2026 · Scientific reports
The present study investigated the association between facial shape and self-perceived personality and psychosocial traits. The study population consisted of 613 young adults (399 females and 214 males) aged 21-35 years, with similar…
van der Linden C, Trapp P, Dembek TA et al. · 2026 · Preprint
Background Deep brain stimulation (DBS) of the ventral intermediate nucleus and posterior subthalamic area (VIM/PSA) in Essential Tremor (ET) and the subthalamic nucleus (STN) in Parkinson’s disease (PD) are established treatment for…
Webster E, Ng L, Prendergast K et al. · 2026 · Journal of insect physiology
Climate change and urbanisation are major drivers of global insect pollinator decline. However, the combined effects of these stressors remain poorly understood, particularly in relation to pollinator behaviour. Understanding how these…
Sheng YC, Chen X, Zhang YF et al. · 2026 · Huan jing ke xue= Huanjing kexue
Achieving ecological protection and high-quality development is the fundamental goal of sustainable development in the Yellow River Basin， and it is also an inevitable choice for the practice of the concept of Chinese-style modernization.…
Cheng WJ, Kao CL, Hung IY · 2026 · Frontiers in nutrition
Background Hearing impairment is associated with an elevated risk of depression, yet modifiable risk factors in this population remain poorly characterized. Although vitamin D deficiency (VDD) has been linked to depression in general…
Amuji DN, Iweala EEJ · 2026 · BMC cancer
BACKGROUND: Breast cancer (BC) is a major cause of cancer-related mortality among women worldwide. Genetic polymorphisms, such as those in the Mesenchymal Epithelial Transition factor (MET) proto-oncogene, may influence cancer risk and…
Liu Y, Zhong S, Zhong K et al. · 2026 · Frontiers in endocrinology
Aim To investigate the association between history of gestational diabetes mellitus (GDM) and the risk of hypertensive disorders of pregnancy in subsequent pregnancy (s-HDP). Methods A retrospective cohort of 5, 928 women with two…