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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

422 results in Replication Failure · page 11 of 15

Replication FailureOpen accessMedicine

RETRACTION: Spliceosomal Protein E Regulates Neoplastic Cell Growth by Modulating Expression of Cyclin E/CDK2 and G2/M Checkpoint Proteins.

· 2026 · Journal of cellular and molecular medicine

Retraction Z. Li and B. M. Pützer, "Spliceosomal Protein E Regulates Neoplastic Cell Growth by Modulating Expression of Cyclin E/CDK2 and G2/M Checkpoint Proteins," Journal of Cellular and Molecular Medicine 12, no. 6a (2008): 2427-2438.…

View details →DOI: 10.1111/jcmm.71228
Replication FailureMedicine

Clinical practice recommendations for the management of Alport syndrome: a joint statement of the Korean Society of Nephrology and the Korean Society of Pediatric Nephrology.

Kim JH, Hwang YH, Kang E et al. · 2026 · Kidney research and clinical practice

Background Alport syndrome (AS) is a hereditary kidney disorder characterized by progressive hematuria, proteinuria, and kidney failure, frequently accompanied by hearing loss and ocular abnormalities. Although blockade of the…

View details →DOI: 10.23876/j.krcp.25.452
Replication FailureMedicine

Botulinum toxin type A for subacute/chronic neck pain.

Gross AR, Lee H, Chacko N et al. · 2026 · The Cochrane database of systematic reviews

Rationale Botulinum toxin type A (BoNT-A) intramuscular injections are commonly administered for neck pain unresponsive to other therapies, but the benefit-harm profile remains uncertain. Objectives To assess the benefits and harms of…

View details →DOI: 10.1002/14651858.cd008626.pub4
Replication FailureMedicine

Postoperative pain after low-pressure versus standard-pressure laparoscopic surgery in children. A randomized clinical trial.

Neeser HR, Gerwinn T, Forschbach VC et al. · 2026 · Journal of pediatric surgery

Background Children still suffer from substantial pain after laparoscopic surgery. It has been hypothesized that low-pressure pneumoperitoneum reduces postoperative pain after laparoscopic surgery. However, this has not yet been studied in…

View details →DOI: 10.1016/j.jpedsurg.2026.163233
Replication FailureMedicine

What's the Rush? Challenging the Early Surgery Paradigm for Older Adults in Emergency General Surgery.

Rice WM, Shaw AP, Britt RC et al. · 2026 · Journal of the American College of Surgeons

Background Rising patient volumes and an aging population are leading to difficulties in providing timely surgical intervention in emergency general surgery (EGS). With decreased resilience and greater comorbidity burden, we hypothesized…

View details →DOI: 10.1097/xcs.0000000000001749
Replication FailureMedicine

Locomotor play behavior evolves by random genetic drift but not as a correlated response to selective breeding for high voluntary wheel-running behavior.

Whitehead NN, Kelly SA, Demes JS et al. · 2023 · Behavioural processes

Locomotor play is vigorous and seemingly purposeless behavior, commonly observed in young mammals. It can be costly in terms of energy expenditure, increased injury risk, and predator exposure. The main hypothesized benefit of locomotor…

View details →DOI: 10.1016/j.beproc.2023.104973
Replication Failure

Exploring the moderation role of corporate sustainability disclosure in the relationship between board-level committees and firm performance: The perspective of Sub-Saharan Africa

Moyini AAM, Tahir M, Farah M et al. · 2025 · Preprint

Abstract This study explores the moderating role of corporate sustainability disclosure (ESG) in the relationship between board-level committees and firm performance (FP) in Sub-Saharan Africa (SSA). While prior research has extensively…

View details →DOI: 10.21203/rs.3.rs-7251993/v1
Replication FailureMedicine

Ambivalent sexism and opposition toward public breastfeeding.

Jedinger A, Feldhausen M · 2025 · The Journal of social psychology

The study examines the impact of hostile and benevolent sexism on attitudes toward public versus private breastfeeding. According to ambivalent sexism theory, we hypothesized that hostile sexism would result in disapproval of public…

View details →DOI: 10.1080/00224545.2025.2523279
Replication FailureOpen accessMedicine

Development of an Immunohistochemical Assay to Detect the Ataxia-Telangiectasia Mutated (ATM) Protein in Gastric Carcinoma.

Miller RM, Nworu C, McKee L et al. · 2020 · Applied immunohistochemistry & molecular morphology : AIMM

Ataxia-telangiectasia mutated (ATM), a key activator of DNA damage response mechanisms, represents a potential biomarker for targeted gastric carcinoma therapies. A phase II study (Study 39; NCT01063517) designed to investigate the…

View details →DOI: 10.1097/pai.0000000000000786
Replication Failure

Neonatal fecal abundance of Bifidobacterium longum subspecies infantis is not associated with anthropometric outcomes up to 6 months of age in Bangladeshi infants

Heasley CK, Stefanova V, Funk C et al. · 2025 · Preprint

Background Bifidobacterium longum subspecies infantis ( B. infantis ) abundance in the infant gut may be associated with growth and health outcomes. However, these relationships have not been widely studied in settings where B. infantis is…

View details →DOI: 10.1101/2025.07.07.25329844
Replication FailureOpen accessMedicine

Lack of Association Between <i>Histoplasma</i> Urine Antigen Values and Clinical Response in Persons Without HIV.

Miceli MH, Dalton LM, Pasqualotto AC et al. · 2025 · Open Forum Infectious Diseases

Background Histoplasma urine antigen detection, a valuable diagnostic tool, is often used to monitor response to antifungal therapy, but persistently positive antigen values, even when the infection has resolved, often present a clinical…

View details →DOI: 10.1093/ofid/ofaf448
Replication FailureOpen accessMedicine

Serum magnesium levels of children living with sickle cell anaemia at the Lagos University Teaching Hospital: a comparative cross-sectional study.

Akowundu PK, Salako AO, Akinsete AM et al. · 2025 · BMC pediatrics

Background Sickle cell anaemia (SCA) is a lifelong, chronic haemolytic disorder with episodic vaso-occlusive crises (VOC) and chronic end-organ damage. Red cell dehydration during a VOC changes permeability with loss of potassium and…

View details →DOI: 10.1186/s12887-025-06079-5
Replication FailureOpen accessMedicine

Lack of association between loneliness, social isolation and inflammation in people living with HIV aged ≥50 years: Results from the sub-study "No One Alone-Gesida Study".

Blanco JR, Albendin-Iglesias H, Negredo-Puigmal E et al. · 2025 · PloS one

Introduction Inflammation is linked to multiple health conditions. Emerging evidence suggest it may play a role in the association between social isolation - loneliness and health outcomes. People living with HIV (PLWH) exhibit chronic…

View details →DOI: 10.1371/journal.pone.0335949
Replication FailureOpen accessMedicine

Prevalence and concomitance of diabetic peripheral sensory neuropathy and lower limb peripheral arterial disease in type II diabetics and its correlation with obesity.

Solanki JD, Shah AP, Lalwani N et al. · 2025 · Journal of family medicine and primary care

Introduction Among type 2 diabetics (T2D), macrovascular complication lower limb Peripheral Arterial Disease (PAD) and microvascular complication Diabetic Peripheral Sensory Neuropathy (DPSN) have scarcely studied concordance and their…

View details →DOI: 10.4103/jfmpc.jfmpc_1168_24
Replication FailureOpen accessMedicine

Lack of association between <i>MALAT1</i> rs591291 and rs3200401 polymorphisms and venous malformation risk in the Chinese pediatric population.

Lin X, Ou J, Wu G et al. · 2025 · Biochemistry and biophysics reports

Introduction Venous malformations are the most common congenital vascular anomaly, accounting for 65 % of all congenital vascular abnormalities. This study aims to investigate the correlation between genetic polymorphisms of MALAT1 and the…

View details →DOI: 10.1016/j.bbrep.2025.102209
Replication FailureOpen accessMedicine

Longitudinal Assessment of Area of Reticular Pseudodrusen in Eyes with Age-Related Macular Degeneration.

Velaga SB, Alagorie AR, Nittala MG et al. · 2025 · Ophthalmology science

Purpose To evaluate the change in the area of reticular pseudodrusen (RPD) and choroidal thickness over 2 years in eyes with age-related macular degeneration (AMD). Design Longitudinal cohort study. Subjects The study reviewed 1332 eyes…

View details →DOI: 10.1016/j.xops.2025.100881
Replication FailureMedicine

Impact of Vitamin D Supplementation on IVF Outcomes in Vitamin D-Deficient Poor Responders: a Randomized Controlled Trial.

Mirsharifi MS, Shirdel S, Ghaderi E et al. · 2026 · Reproductive sciences (Thousand Oaks, Calif.)

OBJECTIVE: This study aimed to evaluate the effect of vitamin D supplementation on in vitro fertilization (IVF) outcomes in poor responder women with vitamin D deficiency, focusing on fertilization rates, oocyte quality, and pregnancy…

View details →DOI: 10.1007/s43032-025-02022-2
Replication FailureMedicine

Partial rebreathing is not effective for early treatment of migraine with aura attacks: Results of a double-blind, randomized, controlled trial (PAREMA1).

Gaul C, Ferreira S, Johansen T · 2026 · Headache

Objective Evaluate the efficacy and safety of a novel partial rebreathing device for early treatment of acute attacks of migraine with aura. Background Earlier clinical studies have indicated a potential for CO 2 -enriched gas to be…

View details →DOI: 10.1111/head.15090
Replication FailureMedicine

Association between cognitive adverse effects of anticholinergic medication and development of dementia in Parkinson's disease.

Ha SH, Kim S, Lee S et al. · 2026 · Parkinsonism & related disorders

Introduction Approximately one-third of patients with Parkinson's disease (PD) develop dementia, and anticholinergic use has been implicated as a risk factor, particularly with prolonged exposure. This study examined whether short-term…

View details →DOI: 10.1016/j.parkreldis.2025.108136
Replication FailureOpen accessMedicine

Lack of effect of a parent-delivered early language intervention: Evidence from a randomised controlled trial completed during COVID-19.

Burgoyne K, Hargreaves S, Akhter N et al. · 2025 · JCPP advances

Background Parents play a key role in their child's early development but evidence that parental engagement strategies are effective is unclear. The current study evaluated a parent-delivered early language teaching programme that aimed to…

View details →DOI: 10.1002/jcv2.12279
Replication Failure

Perceived Psychological Stress and Fecundability among Women Planning Pregnancy: Evidence from a Large Preconception Cohort Study from China

Lan T, Ming J, Liu J et al. · 2026 · Preprint

Objective: Evidence on the stress–fecundability relationship is mixed, and both the population heterogeneity and the effects of moderate stress remain understudied. We aimed to investigate the association of stress with fecundability in…

View details →DOI: 10.22541/au.177095736.68250416/v1