A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19808 results in Negative / Null Result Report · page 108 of 661
Jamal T. Maalouf, James Combs, William E. Gillis et al. · 2020 · Journal of Knowledge Management
Purpose The purpose of this paper is to introduce strategy as a factor that explains when franchisors – through the franchisees they select – seek to replicate routines exactly versus allow local adaptation of routines.…
Christoph Alexander Rüst, Romuald Lepers, Thomas Rosemann et al. · 2014 · SpringerPlus
Abstract This study investigated the change in sex differences across years in ultra-distance swimming performances at the 36-km ‘Maratona del Golfo Capri-Napoli’ race held from 1954 to 2013. Changes in swimming performance of 662 men and…
Carlo Russo, Mariarosaria Simeone, Maria Angela Perito · 2020 · Sustainability
In this paper, we investigated educated millennials’ evaluation of credence attributes in food products containing genetically modified organisms (GMO products). Our goal is to assess whether beliefs about GMO products are determined by scientific knowledge alone or if they are affected by other factors such as trust in information providers and use of social media. The focus on millennials is motivated by the increasing relevance of this social group in the public debate and by their extensive use of social media. We surveyed a sample of 215 Italian college students, confronting them with que
Adeyemi Ogundipe, Opeyemi Akınyemi, Oluwatomisin Ogundipe · 2016 · Covenant University Repository (Covenant University)
The study examines the relationship between electricity consumption and economic development using an extended neoclassical model for the period 1970-2013. The study incorporates the uniqueness of the Nigerian economy by controlling for…
Muhammad Bilal, Muhammad Aslam Mirza, Muhammad Kaleem et al. · 2016 · Journal of Animal Physiology and Animal Nutrition
The response of broiler chickens to 3 levels of sunflower meal and 2 levels of NSP-ase enzyme combination (with and without) was investigated in 3 × 2 factorial arrangement under complete randomized design (CRD). A total of 240 Hubbard…
Weitao Zhou, Xiaoyong Li, Daochao Huang et al. · 2015 · Current Alzheimer Research
It is reported that 7,8-dihydroxyflavone (DHF), a TrkB agonist, has beneficial effects on neuronal excitotoxicity, stroke, and Parkinson disease in animal models by enhancing axon regeneration, muscle reinnervation and neuromuscular…
Federico Serpe, Carlo Massimo Casciola, Giancarlo Ruocco et al. · 2024 · International Journal of Bioprinting
Microfluidics is rapidly revolutionizing the scientific panorama, providing unmatched high-throughput platforms that find application in numerous areas of physics, chemistry, biology, and materials science. Recently, microfluidic chips have been proposed, in combination with bioactive materials, as promising tools for spinning cell-laden fibers with on-demand characteristics. However, cells encapsulated in filaments produced via microfluidic spinning technology are confined in a quasi-three-dimensional (3D) environment that fails to replicate the intricate 3D architecture of biological tissues
Louisa Chan, Christine T. H. Bui, Chris Ka Pun Mok et al. · 2016 · Scientific Reports
Novel avian H7N9 virus emerged in China in 2013 resulting in a case fatality rate of around 39% and continues to pose zoonotic and pandemic risk. Amino acid substitutions in PB2 protein were shown to influence the pathogenicity and transmissibility of H7N9 following experimental infection of ferrets and mice. In this study, we evaluated the role of amino acid substitution PB2-627K or compensatory changes at PB2-591K and PB2-701N, on the tropism and replication competence of H7N9 viruses for human and swine respiratory tracts using ex vivo organ explant cultures. Recombinant viruses of A/Shangh
Kenneth H. Mayer, Douglas Krakower · 2012 · Annals of Internal Medicine
During the past 2 years, several pivotal clinical trials have proven that the use of antiretrovirals by HIV-infected and at-risk uninfected persons can decrease the probability of HIV being transmitted sexually. The initial…
Satoru Taniguchi, Kohei Ninomiya, Itaru Kushima et al. · 2019 · Psychiatry and Clinical Neurosciences
AIMS: Recent studies have revealed that the interplay between polygenic risk scores (PRS) and large copy number variants (CNV; >500kb) is essential for the etiology of schizophrenia (SCZ). To replicate previous findings, including those for smaller CNV (>10kb), the PRS between SCZ patients with and without CNV were compared. METHODS: The PRS were calculated for 724 patients with SCZ and 1178 healthy controls (HC), genotyped using array-based comparative genomic hybridization and single nucleotide polymorphisms chips, and comparisons were made between cases and HC, or between subjects with and
Caitlin Mills, Jennifer Wu, Sidney K. D’Mello · 2017 · Discourse Processes
We investigated how affective states influence expository text comprehension and whether text valence moderates the effects (i.e., mood congruency). In Experiment 1 participants were randomly assigned to a happy or sad affective state…
Tobias Kopp, Marco Baumgartner, Steffen Kinkel · 2023 · International Journal of Human-Computer Studies
An appropriate level of human-robot trust is widely acknowledged as a crucial factor for successful human-robot interaction (HRI). Previous research has addressed anthropomorphic design but mostly neglected linguistic framing as a means to…
Chris Skurka, Rainer Romero‐Canyas, Helen H. Joo et al. · 2021 · Human Communication Research
Abstract There is much need to verify the robustness of published findings in the field of communication—particularly regarding the effects of persuasive emotional appeals about social issues. To this end, we present the results from a…
Lidia Y. X. Wong, Stephen J. Gray, David A. Gallo · 2018 · Cognitive Neuroscience
We report 4 experiments aiming to replicate and extend the finding that anodal transcranial direct current stimulation (tDCS) over dorsolateral prefrontal cortex after encoding and just prior to retrieval improves accuracy on an episodic…
Cheng Peng, Martijn den Dekker, Andrés Cárdenas et al. · 2018 · Environmental Health Perspectives
BACKGROUND: Epigenetic variability is hypothesized as a regulatory pathway through which prenatal exposures may influence child development and health. OBJECTIVE: We sought to examine the associations of residential proximity to roadways at birth and epigenome-wide DNA methylation. We also assessed associations of differential methylation with child cognitive outcomes. METHODS: We estimated residential proximity to roadways at birth using a geographic information system (GIS) and cord blood methylation using Illumina's HumanMethylation450-array in 482 mother-child pairs in Project Viva. We ide
Roland Imhoff, Jens Lange, Markus Germar · 2018 · Cognition & Emotion
Spatial cueing paradigms are popular tools to assess human attention to emotional stimuli, but different variants of these paradigms differ in what participants' primary task is. In one variant, participants indicate the location of the…
Mohammed Al-Asadi, Michelle Sherren, Hassaan Abdel Khalik et al. · 2024 · The American Journal of Sports Medicine
Background: Evidence-based care relies on robust research. The fragility index (FI) is used to assess the robustness of statistically significant findings in randomized controlled trials (RCTs). While the traditional FI is limited to…
Pau Ribó-Molina, Stefan van Nieuwkoop, Anna Z. Mykytyn et al. · 2024 · mSphere
ABSTRACT Human metapneumovirus (HMPV), a member of the Pneumoviridae family, causes upper and lower respiratory tract infections in humans. In vitro studies with HMPV have mostly been performed in monolayers of undifferentiated epithelial cells. In vivo studies in cynomolgus macaques and cotton rats have shown that ciliated epithelial cells are the main target of HMPV infection, but these observations cannot be studied in monolayer systems. Here, we established an organoid-derived bronchial culture model that allows physiologically relevant studies on HMPV. Inoculation with multiple prototype
Gongxun Zhong, Shufang Fan, Masato Hatta et al. · 2019 · Journal of Virology
Bats are reservoirs for several severe zoonotic pathogens. The genomes of influenza A viruses of the H17N10 and H18N11 subtypes have been identified in bats, but no live virus has been isolated. The characterization of artificially…
Lyndsay Gavin, Jenna McChesney, Anson Tong et al. · 2022 · Technology Mind and Behavior
The spread of misinformation has generated confusion and uncertainty about how to behave with respect to protective actions during the COVID-19 pandemic, such as social distancing and getting vaccinated. garnered significant press…
Melissa K. Crocker, Paul B. Kaplowitz · 2010 · Clinical Endocrinology
OBJECTIVE: Thyroid hormones are involved in metabolic regulation, but the degree to which they affect body weight and body mass index (BMI) in children is unclear. We examined the effect of hypo- and hyperthyroidism on weight and BMI at…
Annie Gott, Clare Andrews, María Larriva et al. · 2018 · PeerJ
) found that a marker of biological age predicted the strength of the stress response even in individuals of the same chronological age. Specifically, birds that had experienced greater developmental telomere attrition (DTA) showed a lower peak corticosterone (CORT) response to an acute stressor, and more rapid recovery of CORT levels towards baseline. Here, we performed a follow-up study using the same capture-handling-restraint stressor in a separate cohort of starlings that had been subjected to a developmental manipulation of food availability and begging effort. We measured the CORT respo
Akio Kôyama, Toshiro Fujita, Fumitake Gejyo et al. · 2015 · BMC Nephrology
BACKGROUND: Evidence increasingly points to the importance of chronic hypoxia in the tubulointerstitium as a final common pathway to end-stage renal disease (ESRD). Beraprost sodium (BPS) is an orally active prostacyclin (PGI2) analogue demonstrating prevention of the progression of chronic kidney disease (CKD) in various animal models by maintaining renal blood flow and attenuating renal ischemic condition. METHODS: This multicenter, randomized, double-blind, placebo-controlled, phase II trial was designed to determine the recommended dose of the sustained-release form of BPS (TRK-100STP 120
Noel D. Campbell, David Mitchell, Tammy M. Rogers · 2013 · Journal of Entrepreneurship and Public Policy
Purpose The purpose of this paper is to provide a robustness check of the relationship between entrepreneurial activity and economic freedom. As a deliberate “robustness check,” the authors estimated various spatial measures of…
Travis J. Matics, Nadia Khan, Priti Jani et al. · 2019 · Pediatric Critical Care Medicine
Objectives: The Fragility Index measures the number of events on which the statistical significance of a result depends and has been suggested as an adjunct statistical assessment for interpretation of trial results. This study aimed to…
Haotian Zhang, Wen‐Yong Guo, Wenting Wang · 2023 · Ecology and Evolution
How to effectively obtain species-related low-dimensional data from massive environmental variables has become an urgent problem for species distribution models (SDMs). In this study, we will explore whether dimensionality reduction on environmental variables can improve the predictive performance of SDMs. We first used two linear (i.e., principal component analysis (PCA) and independent components analysis) and two nonlinear (i.e., kernel principal component analysis (KPCA) and uniform manifold approximation and projection) dimensionality reduction techniques (DRTs) to reduce the dimensionali
Takatsugu Aihara, Takeshi OGAWA, Takeaki Shimokawa et al. · 2017 · PLoS ONE
Humans often utilize past experience to solve difficult problems. However, if past experience is insufficient to solve a problem, solvers may reach an impasse. Insight can be valuable for breaking an impasse, enabling the reinterpretation or re-representation of a problem. Previous studies using between-subjects designs have revealed a causal relationship between the anterior temporal lobes (ATLs) and non-verbal insight, by enhancing the right ATL while inhibiting the left ATL using transcranial direct current stimulation (tDCS). In addition, neuroimaging studies have reported a correlation be
Jiaying Liu, Weixi Zhang, Chao Teng et al. · 2024 · Frontiers in Microbiology
Introduction: Enhancing the planning of the forest-agricultural composite model and increasing the efficiency with which forest land is utilized could benefit from a thorough understanding of the impacts of intercropping between forests and agriculture on soil physicochemical properties and microbial communities. Methods: intercrop soils, along with their corresponding monocrops, were used in this study's llumina high-throughput sequencing analysis to determine the composition and diversity of soil bacterial and fungal communities. Results: The findings indicated that intercropping considerabl
Dipender Gill, Marios Arvanitis, Paul Carter et al. · 2020 · Royal Society Open Science
Angiotensin-converting enzyme 2 (ACE2) and serine protease TMPRSS2 have been implicated in cell entry for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19). The expression of ACE2 and TMPRSS2 in the lung epithelium might have implications for the risk of SARS-CoV-2 infection and severity of COVID-19. We use human genetic variants that proxy angiotensin-converting enzyme (ACE) inhibitor drug effects and cardiovascular risk factors to investigate whether these exposures affect lung ACE2 and TMPRSS2 gene expression and circ
Natalie A. Prow, Marcus G. Mah, Joshua M. Deerain et al. · 2018 · Journal of General Virology
Liao ning virus (LNV) was first isolated in 1996 from mosquitoes in China, and has been shown to replicate in selected mammalian cell lines and to cause lethal haemorrhagic disease in experimentally infected mice. The first detection of…