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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19808 results in Negative / Null Result Report · page 107 of 661

Negative / Null Result ReportOpen accessMathematics

Representation of numerical magnitude in math-anxious individuals

Àngels Colomé · 2018 · Quarterly Journal of Experimental Psychology

Larger distance effects in high math-anxious individuals (HMA) performing comparison tasks have previously been interpreted as indicating less precise magnitude representation in this population. A recent study by Dietrich, Huber, Moeller, and Klein limited the effects of math anxiety to symbolic comparison, in which they found larger distance effects for HMA, despite equivalent size effects. However, the question of whether distance effects in symbolic comparison reflect the properties of the magnitude representation or decisional processes is currently under debate. This study was designed t

View details →DOI: 10.1177/1747021817752094Cited by 20
Negative / Null Result ReportOpen accessMedicine

Radioactive Iodine Therapy Did Not Significantly Increase the Incidence and Recurrence of Subsequent Breast Cancer

Hwa Young Ahn, Hye Sook Min, Yohwan Yeo et al. · 2015 · The Journal of Clinical Endocrinology & Metabolism

CONTEXT: Previous studies on the extent to which radioactive iodine (RAI) therapy for thyroid cancer increases the risk of subsequently developing breast cancer have given conflicting results. OBJECTIVE: This study aimed to evaluate the…

View details →DOI: 10.1210/jc.2014-2896Cited by 20
Negative / Null Result ReportOpen accessPsychology

How bad is the mere presence of a phone? A replication of Przybylski and Weinstein (2013) and an extension to creativity

Claire Linares, Anne-Laure Sellier · 2021 · PLoS ONE

A 2013 article reported two experiments suggesting that the mere presence of a cellphone (vs. a notebook) can impair the relationship quality between strangers. The purpose of the present research is twofold: (1) closely replicate this article's findings, and (2) examine whether there may be an impact of the mere presence of a phone on creativity, whether at a group- or an individual- level. In two experiments (N = 356 participants, 136 groups), we followed the original procedure in the 2013 article. In particular, groups of participants who had never seen each other before the study had a con

View details →DOI: 10.1371/journal.pone.0251451Cited by 20
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Replication of the Association of a MET Variant with Autism in a Chinese Han Population

Xue Zhou, Yang Xu, Jia Wang et al. · 2011 · PLoS ONE

BACKGROUND: Autism is a common, severe and highly heritable neurodevelopmental disorder in children, affecting up to 100 children per 10,000. The MET gene has been regarded as a promising candidate gene for this disorder because it is located within a replicated linkage interval, is involved in pathways affecting the development of the cerebral cortex and cerebellum in ways relevant to autism patients, and has shown significant association signals in previous studies. PRINCIPAL FINDINGS: Here, we present new ASD patient and control samples from Heilongjiang, China and use them in a case-contro

View details →DOI: 10.1371/journal.pone.0027428Cited by 20
Negative / Null Result ReportOpen accessEnvironmental Science

Developmental psychologists should adopt citizen science to improve generalization and reproducibility

Wei Li, Laura Germine, Samuel A. Mehr et al. · 2022 · Infant and Child Development

Widespread failures of replication and generalization are, ironically, a scientific triumph, in that they confirm the fundamental metascientific theory that underlies our field. Generalizable and replicable findings require testing large…

View details →DOI: 10.1002/icd.2348Cited by 20
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Genome-Wide Association Study of Serum Fructosamine and Glycated Albumin in Adults Without Diagnosed Diabetes: Results From the Atherosclerosis Risk in Communities Study

Stephanie Loomis, Man Li, Nisa M. Maruthur et al. · 2018 · Diabetes

Fructosamine and glycated albumin are potentially useful alternatives to hemoglobin A1c (HbA1c) as diabetes biomarkers. The genetic determinants of fructosamine and glycated albumin, however, are unknown. We performed genome-wide…

View details →DOI: 10.2337/db17-1362Cited by 20
Negative / Null Result ReportMedicine

Intensive Care Unit Educators: A Multicenter Evaluation of Behaviors Residents Value in Attending Physicians

Lekshmi Santhosh, Snigdha Jain, Anna K. Brady et al. · 2017 · Annals of the American Thoracic Society

RATIONALE: It is important for attending physicians to know which behaviors influence learner perceptions. To date, two studies focusing on general medicine attending physicians have been published addressing internal medicine residents'…

View details →DOI: 10.1513/annalsats.201612-996bcCited by 20
Negative / Null Result ReportOpen accessMedicine

Combination of Olanzapine and Samidorphan Has No Clinically Significant Effect on the Pharmacokinetics of Lithium or Valproate

Lei Sun, Sergey Yagoda, Baiyun Yao et al. · 2019 · Clinical Drug Investigation

BACKGROUND AND OBJECTIVE: Olanzapine is an atypical antipsychotic indicated for the treatment of schizophrenia and, either as monotherapy or as an adjunct to lithium or valproate, for bipolar I disorder. Multiple daily doses of olanzapine…

View details →DOI: 10.1007/s40261-019-00860-yCited by 20
Negative / Null Result ReportSocial Sciences

The Impact of Teach for America on Non-Test Academic Outcomes

Ben Backes, Michael Hansén · 2017 · Education Finance and Policy

Recent evidence on teacher productivity suggests that teachers meaningfully influence non-test academic student outcomes that are commonly overlooked by narrowly focusing on test scores. Despite a large number of studies investigating the…

View details →DOI: 10.1162/edfp_a_00231Cited by 20
Negative / Null Result ReportBusiness, Management and Accounting

Molecular Genetics and Hormones: New Frontiers in Entrepreneurship Research

Matthijs van der Loos · 2011 · Data Archiving and Networked Services (DANS)

Recent studies suggest that entrepreneurship is partly heritable, but are unable to pinpoint the specific genes involved. This thesis presents results from novel research aiming to identify genes associated with entrepreneurship using…

View details →Cited by 20
Negative / Null Result ReportOpen accessMedicine

Reexamining the “brain drain” effect: A replication of Ward et al. (2017)

Ana C. Ruiz Pardo, John Paul Minda · 2022 · Acta Psychologica

The present study was a pre-registered direct replication of Ward et al.'s (2017) second experiment (OSF pre-registration found at: https://osf.io/5fq4r). This replication assigned both smartphone location (on desk, in pocket/bag, or outside of the testing room) and smartphone power (on, or off) for a total of six conditions. Participants completed an automated operation span (OSpan) task, a Cue-Dependent Go/No-Go task, and the smartphone attachment and dependency inventory. It was hypothesized that performance on an attention-demanding task (i.e., the OSpan task) would be worse for those in c

View details →DOI: 10.1016/j.actpsy.2022.103717Cited by 20
Negative / Null Result ReportPsychology

Simulating semantics: Are individual differences in motor imagery related to sensorimotor effects in language processing?

Emiko J. Muraki, Penny M. Pexman · 2021 · Journal of Experimental Psychology Learning Memory and Cognition

In embodied theories of semantic representation, the processes and mechanisms of modal simulations that are engaged during semantic processing have tended to be underspecified. We investigated the possibility that motor imagery may be a…

View details →DOI: 10.1037/xlm0001039Cited by 20
Negative / Null Result ReportMedicine

Development of a Chimeric Replicon System for Phenotypic Analysis of Ns3 Protease Sequences from HCV Clinical Isolates

Amy K. Sheaffer, Min S. Lee, Dennis Hernandez et al. · 2011 · Antiviral Therapy

BACKGROUND: To support clinical development of HCV non-structural protein (NS) 3 protease inhibitors (PIs), phenotypic monitoring of patient isolates is a prerequisite for understanding the emergence of resistance. HCV isolates typically…

View details →DOI: 10.3851/imp1825Cited by 20
Negative / Null Result ReportOpen accessMedicine

Variants Associated with the Ankle Brachial Index Differ by Hispanic/Latino Ethnic Group: a genome-wide association study in the Hispanic Community Health Study/Study of Latinos

Tamar Sofer, Leslie S. Emery, Deepti Jain et al. · 2019 · Scientific Reports

Abstract Lower extremity peripheral artery disease (PAD) burden differs by race/ethnicity. Although familial aggregation and heritability studies suggest a genetic basis, little is known about the genetic susceptibility to PAD, especially in non-European descent populations. Genome-wide association studies (GWAS) of the ankle brachial index (ABI) and PAD (defined as an ABI < 0.90) have not been conducted in Hispanics/Latinos. We performed a GWAS of PAD and the ABI in 7,589 participants aged >45 years from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). We also performed

View details →DOI: 10.1038/s41598-019-47928-5Cited by 20
Negative / Null Result ReportOpen accessMedicine

Replication and Heritability of Prostate Cancer Risk Variants: Impact of Population-Specific Factors

Victor Virlogeux, Rebecca E. Graff, Thomas J. Hoffmann et al. · 2015 · Cancer Epidemiology Biomarkers & Prevention

BACKGROUND: Prostate cancer incidence and mortality rates vary across populations, with African American men exhibiting the highest rates. To date, genome-wide association studies have identified 104 SNPs independently associated with…

View details →DOI: 10.1158/1055-9965.epi-14-1372Cited by 20
Negative / Null Result ReportPharmacology, Toxicology and Pharmaceutics

Menthol concentration in topical cold gel does not have significant effect on skin cooling

Roope Lasanen, Petro Julkunen, Olavi Airaksinen et al. · 2015 · Skin Research and Technology

BACKGROUND: Topical menthol gels are used in the treatment of various pain conditions. However, the effect of the menthol concentration to skin cooling or cooling sensation is not clear. We hypothesized that increasing menthol…

View details →DOI: 10.1111/srt.12226Cited by 20
Negative / Null Result ReportNeuroscience

The Relationship Between Immorality and Cleansing

Jedidiah Siev, Shelby E. Zuckerman, Joseph J. Siev · 2018 · Social Psychology

Abstract. In a widely publicized set of studies, participants who were primed to consider unethical events preferred cleansing products more than did those primed with ethical events ( Zhong & Liljenquist, 2006 ). This tendency to…

View details →DOI: 10.1027/1864-9335/a000349Cited by 20
Negative / Null Result ReportSocial Sciences

Benefits of power posing: effects on dominance and social sensitivity

Lukas Klaschinski, Konrad Schnabel, Michela Schröder–Abé · 2017 · Comprehensive Results in Social Psychology

The current study attempted to replicate results by Cuddy, Wilmuth, Yap, and Carney (2015) who showed that adopting high-power poses prior to a demanding job interview improved dominant behavior and overall hireability judgments. We…

View details →DOI: 10.1080/23743603.2016.1248080Cited by 20
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Gut Microbiota Modulation through Akkermansia spp . Supplementation Increases CAR T-cell Potency

Laura Marcos-Kovandzic, Michele Avagliano, Myriam Ben Khelil et al. · 2025 · Cancer Discovery

This study investigates the clinical relevance of the gut microbiome at taxonomic and metabolic levels in anti-CD19 chimeric antigen receptor (CAR) T-cell therapy, both in patients and in a preclinical syngeneic tumor model. Patients with…

View details →DOI: 10.1158/2159-8290.cd-24-1230Cited by 20
Negative / Null Result ReportOpen accessMedicine

Nutritional and Microbial Strategies for Treating Acne, Alopecia, and Atopic Dermatitis

Alejandro Borrego-Ruiz, Juan J. Borrego · 2024 · Nutrients

BACKGROUND/OBJECTIVES: Diet is one of the major determinants of the composition and function of the gut microbiome, and diverse studies have established directional connections between gut microbiome dysbiosis and skin dyshomeostasis. Furthermore, a significant link between the gut and certain skin-related disorders has been reported. This work reviews the mechanisms underlying the relationship between nutritional factors, gut microbiome, and certain skin diseases such as acne vulgaris, alopecia, and atopic dermatitis. In addition, it explores how the modulation of the gut microbiome and human

View details →DOI: 10.3390/nu16203559Cited by 20
Negative / Null Result ReportOpen accessBusiness, Management and Accounting

Corporate Environmental Performance Leading Financial Performance: Impacts of Social Media Sentiment and Corporate Reputation

Tiasha Islam, Murugesh Arunachalum, Nirosha Hewa Wellalage et al. · 2025 · Business Strategy and the Environment

ABSTRACT This study examines the interplay between social media sentiment (SMS) and corporate reputation (CR) in shaping the relationship between corporate environmental performance (CEP) and corporate financial performance (CFP). Using a…

View details →DOI: 10.1002/bse.4201Cited by 20
Negative / Null Result ReportOpen accessMedicine

Treatment of Relapsed/Refractory AML—Novel Treatment Options Including Immunotherapy

Catherine Gutierrez, Anthony S. Stein, Amir T. Fathi et al. · 2025 · American Journal of Hematology

Acute myeloid leukemia is a molecularly heterogenous disease caused by the rapid expansion and impaired differentiation of malignant myeloid progenitors. Overall, outcomes remain poor, and more than half of patients develop relapsed or…

View details →DOI: 10.1002/ajh.27584Cited by 20
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

An unbiased comparison of 14 epigenetic clocks in relation to 174 incident disease outcomes

Christos Mavrommatis, Daniel W. Belsky, Kejun Ying et al. · 2025 · Nature Communications

Epigenetic Clocks have been trained to predict chronological age, healthspan and lifespan. Such clocks are often analysed in relation to disease outcomes - typically using small datasets and a limited number of clocks. Here, we present a large-scale (n = 18,859), unbiased comparison of 14 widely used clocks as predictors of 174 incident disease outcomes and all-cause mortality over 10-years of follow up. Second- and third-generation clocks significantly outperform first-generation clocks, which have limited applications in disease settings. Of the 176 Bonferroni significant (P 1%. However, the

View details →DOI: 10.1038/s41467-025-66106-yCited by 20
Negative / Null Result ReportOpen accessMedicine

Primary Sjögren’s Disease: a review of unmet need, outcome measures, therapeutic advances and health economic impacts. Lessons from the NEw Clinical Endpoints in primary Sjögren’s Syndrome: an Interventional Trial based on stratifYing patients (NECESSITY) Innovative Health Initiative (IHI)

Simon Bowman, Raphaèle Séror, Raphaël Porcher et al. · 2025 · Annals of the Rheumatic Diseases

Primary Sjögren's disease (pSjD) is an autoimmune rheumatic disease involving exocrine glands and associated with high symptom burden (dryness, fatigue, pain), systemic features and salivary gland dysfunction. B-cell hyperactivity is common, with an increased risk of mucosa-associated lymphoid tissue lymphoma. This review describes the unmet need, scientific validity of outcome measures, optimisation of clinical trial design, therapeutic advances and how clinical improvement relates to health-related quality of life, additional quality-adjusted life years and economic benefit in pSjD. It deriv

View details →DOI: 10.1016/j.ard.2025.05.004Cited by 20
Negative / Null Result ReportOpen accessPsychology

Journal N-Pact Factors From 2011 to 2019: Evaluating the Quality of Social/Personality Journals With Respect to Sample Size and Statistical Power

R. Chris Fraley, Jia Y. Chong, Kyle A. Baacke et al. · 2022 · Advances in Methods and Practices in Psychological Science

Scholars and institutions commonly use impact factors to evaluate the quality of empirical research. However, a number of findings published in journals with high impact factors have failed to replicate, suggesting that impact alone may…

View details →DOI: 10.1177/25152459221120217Cited by 20
Negative / Null Result ReportOpen accessImmunology and Microbiology

A triad of somatic mutagenesis converges in self-reactive B cells to cause a virus-induced autoimmune disease

Clara Young, Mandeep Singh, Katherine Jackson et al. · 2025 · Immunity

The unexplained association between infection and autoimmune disease is strongest for hepatitis C virus-induced cryoglobulinemic vasculitis (HCV-cryovas). To analyze its origins, we traced the evolution of pathogenic rheumatoid factor (RF) autoantibodies in four HCV-cryovas patients by deep single-cell multi-omic analysis, revealing three sources of B cell somatic mutation converged to drive the accumulation of a large disease-causing clone. A method for quantifying low-affinity binding revealed recurring antibody variable domain combinations created by V(D)J recombination that bound self-immu

View details →DOI: 10.1016/j.immuni.2024.12.011Cited by 20
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Lipid nanoparticle screening in nonhuman primates with minimal loss of life

Ryan Zenhausern, Bora Jang, Elisa Schrader Echeverri et al. · 2025 · Nature Biotechnology

Understanding how well delivery in mice predicts delivery in nonhuman primates (NHPs) could make lipid nanoparticle (LNP) discovery more efficient. Yet, few LNP-mRNA drug candidates are tested in NHPs, in part because the experiments…

View details →DOI: 10.1038/s41587-025-02711-yCited by 20
Negative / Null Result ReportOpen accessPsychology

Motivational Computing: Transformer-Based Automation of Implicit Motive Coding

Joyce S. Pang, Hiram Ring, Kate Y Huang et al. · 2026 · Journal of Personality Assessment

Implicit motives have a clear relation to observed behavior but are time-consuming to measure. Automating the content coding of implicit motives has been a pursuit since the 1960s, but has not been widely adopted due to limitations with…

View details →DOI: 10.1080/00223891.2026.2630930Cited by 19
Negative / Null Result ReportOpen accessMedicine

Obeticholic Acid and Other Farnesoid-X-Receptor (FXR) Agonists in the Treatment of Liver Disorders

Stefano Fiorucci, Ginevra Urbani, Eleonora Distrutti et al. · 2025 · Pharmaceuticals

The Farnesoid-X-receptor (FXR) is a bile sensor involved in the regulation of bile acid homeostasis, fibrosis, inflammation, and metabolism. Obeticholic acid (OCA), a semisynthetic derivative of chenodeoxycholic acid (CDCA), initially named 6-ethyl-CDCA or INT-747, is the first in a class of FXR ligands that have been approved for clinical use for the treatment of patients with primary biliary cholangitis (PBC) who are unresponsive or intolerant to ursodeoxycholic acid. In this narrative review, we will examine the current status and future perspective of clinical use of OCA. Based on results

View details →DOI: 10.3390/ph18091424Cited by 19