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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20211 results in Negative / Null Result Report · page 107 of 674

Negative / Null Result ReportPsychology

Simulating semantics: Are individual differences in motor imagery related to sensorimotor effects in language processing?

Emiko J. Muraki, Penny M. Pexman · 2021 · Journal of Experimental Psychology Learning Memory and Cognition

In embodied theories of semantic representation, the processes and mechanisms of modal simulations that are engaged during semantic processing have tended to be underspecified. We investigated the possibility that motor imagery may be a…

View details →DOI: 10.1037/xlm0001039Cited by 20
Negative / Null Result ReportOpen accessMedicine

Potential Influence of Anesthetic Interventions on Breast Cancer Early Recurrence According to Estrogen Receptor Expression: A Sub-Study of a Randomized Trial

Mohan Li, Yuelun Zhang, Lijian Pei et al. · 2022 · Frontiers in Oncology

Background Effects of anesthetic interventions on cancer prognosis remain controversial. There is evidence that estrogen receptor (ER)-negative breast cancer patients have an early recurrence peak. We aimed to assess the potential benefit of regional anesthesia-analgesia versus general anesthesia regarding early recurrence in breast cancer according to ER expression. Methods Based on a multicenter randomized controlled trial (clinicaltrials.gov, NCT00418457), we included all the patients from Peking Union Medical College Hospital research center in this study. The primary outcome was breast ca

View details →DOI: 10.3389/fonc.2022.837959Cited by 20
Negative / Null Result ReportOpen accessEnvironmental Science

Developmental psychologists should adopt citizen science to improve generalization and reproducibility

Wei Li, Laura Germine, Samuel A. Mehr et al. · 2022 · Infant and Child Development

Widespread failures of replication and generalization are, ironically, a scientific triumph, in that they confirm the fundamental metascientific theory that underlies our field. Generalizable and replicable findings require testing large…

View details →DOI: 10.1002/icd.2348Cited by 20
Negative / Null Result ReportOpen accessMedicine

Significant Differences in the Bacterial Microbiome of the Pharynx and Skin in Patients with Psoriasis Compared with Healthy Controls

Malin Assarsson, Jan Söderman, Olaf Dienus et al. · 2020 · Acta Dermato Venereologica

Studies have shown differences in the skin and gut bacterial microbiomes in patients with psoriasis, but the pharyngeal microbiome has not been studied previously. The aim of this study was to investigate differences in the bacterial…

View details →DOI: 10.2340/00015555-3619Cited by 20
Negative / Null Result ReportOpen accessMedicine

Reexamining the “brain drain” effect: A replication of Ward et al. (2017)

Ana C. Ruiz Pardo, John Paul Minda · 2022 · Acta Psychologica

The present study was a pre-registered direct replication of Ward et al.'s (2017) second experiment (OSF pre-registration found at: https://osf.io/5fq4r). This replication assigned both smartphone location (on desk, in pocket/bag, or outside of the testing room) and smartphone power (on, or off) for a total of six conditions. Participants completed an automated operation span (OSpan) task, a Cue-Dependent Go/No-Go task, and the smartphone attachment and dependency inventory. It was hypothesized that performance on an attention-demanding task (i.e., the OSpan task) would be worse for those in c

View details →DOI: 10.1016/j.actpsy.2022.103717Cited by 20
Negative / Null Result ReportOpen accessMedicine

Are three weeks hypofractionated radiation therapy (HFRT) comparable to six weeks for newly diagnosed glioblastoma patients? Results of a phase II study

Pierina Navarria, Federico Pessina, Stefano Tomatis et al. · 2017 · Oncotarget

// Pierina Navarria 1, * , Federico Pessina 2, * , Stefano Tomatis 1 , Riccardo Soffietti 3 , Marco Grimaldi 4 , Egesta Lopci 5 , Arturo Chiti 5, 7 , Antonella Leonetti 9 , Alessandra Casarotti 2 , Marco Rossi 2 , Luca Cozzi 1 , Anna Maria Ascolese 1 , Matteo Simonelli 6, 7 , Simona Marcheselli 8 , Armando Santoro 6, 7 , Elena Clerici 1 , Lorenzo Bello 2 and Marta Scorsetti 1, 7 1 Radiotherapy and Radiosurgery Department, Humanitas Cancer Center and Research Hospital, Rozzano, Italy 2 Neurosurgical Oncology Department, Humanitas Cancer Center and Research Hospital, Rozzano, Italy 3 Consultant

View details →DOI: 10.18632/oncotarget.18809Cited by 20
Negative / Null Result ReportPsychology

Small-Group, Emergent Literacy Intervention Under Two Implementation Models: Intent-to-Treat and Dosage Effects for Preschoolers at Risk for Reading Difficulties

Shayne B. Piasta, Jessica A. R. Logan, Cynthia M. Zettler‐Greeley et al. · 2022 · Journal of Learning Disabilities

Preschool-age children identified as at risk for later reading difficulties can benefit from supplemental, small-group emergent literacy intervention. As such interventions become commercially available and marketed to preschool programs,…

View details →DOI: 10.1177/00222194221079355Cited by 20
Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

Modified cyclodextrin type and dehydration methods exert a significant effect on the antimicrobial activity of encapsulated carvacrol and thymol

Santiago López‐Miranda, Daniel Berdejo, Elisa Pagán et al. · 2020 · Journal of the Science of Food and Agriculture

Abstract BACKGROUND The antimicrobial activity of essential oils and their constituents has led to increasing interest in using them as natural preservative agents. However, their high sensitivity to light and oxygen, their volatility and…

View details →DOI: 10.1002/jsfa.11017Cited by 20
Negative / Null Result ReportOpen accessMedicine

Little evidence for an effect of the rubber hand illusion on basic movement

Arran T. Reader, Victoria S. Trifonova, H. Henrik Ehrsson · 2021 · European Journal of Neuroscience

Body ownership refers to the distinct sensation that our observed body belongs to us, which is believed to stem from multisensory integration. This is commonly shown through the rubber hand illusion (RHI), which induces a sense of ownership over a false limb. Whilst the RHI may interfere with object-directed action and alter motor cortical activity, it is not yet clear whether a sense of ownership over an artificial hand has functional consequences for movement production per se. As such, we performed two motion-tracking experiments (n = 117) to examine the effects of the RHI on the reaction t

View details →DOI: 10.1111/ejn.15444Cited by 20
Negative / Null Result ReportMedicine

Development of a Chimeric Replicon System for Phenotypic Analysis of Ns3 Protease Sequences from HCV Clinical Isolates

Amy K. Sheaffer, Min S. Lee, Dennis Hernandez et al. · 2011 · Antiviral Therapy

BACKGROUND: To support clinical development of HCV non-structural protein (NS) 3 protease inhibitors (PIs), phenotypic monitoring of patient isolates is a prerequisite for understanding the emergence of resistance. HCV isolates typically…

View details →DOI: 10.3851/imp1825Cited by 20
Negative / Null Result ReportOpen accessNeuroscience

Anodal tDCS and High-Frequency tRNS Targeting the Occipitotemporal Cortex Do Not Always Enhance Face Perception

Megan Willis, Andrea I. Costantino, Michael A. Nitsche et al. · 2019 · Frontiers in Neuroscience

There has been increasing interest in the utility of transcranial electrical stimulation as a tool to enhance cognitive abilities. In the domain of face perception, enhancements have been reported for both transcranial direct current stimulation (tDCS) and high-frequency transcranial random noise stimulation (tRNS) targeting the occipitotemporal cortex. In a series of two experiments, we attempted to replicate these findings for face identity perception, and extend on previous studies, to determine if similar enhancements are also observed for object and facial expression perception. In Experi

View details →DOI: 10.3389/fnins.2019.00078Cited by 20
Negative / Null Result ReportOpen accessMedicine

A randomized phase 2 study of temsirolimus and cetuximab versus temsirolimus alone in recurrent/metastatic, cetuximab‐resistant head and neck cancer: The MAESTRO study

Tanguy Y. Seiwert, Sara Kochanny, Kevin Wood et al. · 2020 · Cancer

BACKGROUND: Patients with cetuximab-resistant, recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) have poor outcomes. This study hypothesized that dual blockade of mammalian target of rapamycin and epidermal growth factor…

View details →DOI: 10.1002/cncr.32929Cited by 20
Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology

Significant Differences in Capsid Properties and Potency Between Adeno-Associated Virus Vectors Produced in Sf9 and HEK293 Cells

April R. Giles, Martin Lock, Shu‐Jen Chen et al. · 2023 · Human Gene Therapy

For successful vector-based gene therapy manufacturing, the selected adeno-associated virus (AAV) vector production system must produce vector at sufficient scale. However, concerns have arisen regarding the quality of vector produced…

View details →DOI: 10.1089/hum.2022.116Cited by 20
Negative / Null Result ReportOpen accessEngineering

Channel Characteristics of Dynamic Off-Body Communications at 60 GHz Under Line-of-Sight (LOS) and Non-LOS Conditions

Seong Ki Yoo, Simon L. Cotton, Young Jin Chun et al. · 2017 · IEEE Antennas and Wireless Propagation Letters

This letter investigates the first-order characteristics of dynamic off-body communications channels at 60 GHz. In particular, we have studied signal propagation from a chest-worn millimeter-wave transmitter as an adult male walked toward and then away from a hypothetical base station. The mobile line-of-sight (LOS) and non-LOS (NLOS) channel measurements have been conducted in a diverse range of environments, including a hallway, an open office, an anechoic chamber, and an outdoor car park. In this study, we have decomposed the received signal into its path loss, large-scale, and small-scale

View details →DOI: 10.1109/lawp.2017.2650863Cited by 20
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Replication of the Association of a MET Variant with Autism in a Chinese Han Population

Xue Zhou, Yang Xu, Jia Wang et al. · 2011 · PLoS ONE

BACKGROUND: Autism is a common, severe and highly heritable neurodevelopmental disorder in children, affecting up to 100 children per 10,000. The MET gene has been regarded as a promising candidate gene for this disorder because it is located within a replicated linkage interval, is involved in pathways affecting the development of the cerebral cortex and cerebellum in ways relevant to autism patients, and has shown significant association signals in previous studies. PRINCIPAL FINDINGS: Here, we present new ASD patient and control samples from Heilongjiang, China and use them in a case-contro

View details →DOI: 10.1371/journal.pone.0027428Cited by 20
Negative / Null Result ReportNeuroscience

The Relationship Between Immorality and Cleansing

Jedidiah Siev, Shelby E. Zuckerman, Joseph J. Siev · 2018 · Social Psychology

Abstract. In a widely publicized set of studies, participants who were primed to consider unethical events preferred cleansing products more than did those primed with ethical events ( Zhong & Liljenquist, 2006 ). This tendency to…

View details →DOI: 10.1027/1864-9335/a000349Cited by 20
Negative / Null Result ReportOpen accessMedicine

Cost–Utility Analysis of Deferiprone for the Treatment of β-Thalassaemia Patients with Chronic Iron Overload: A UK Perspective

Anthony Bentley, Samantha Gillard, Michael Spino et al. · 2013 · PharmacoEconomics

BACKGROUND: Patients with β-thalassaemia major experience chronic iron overload due to regular blood transfusions. Chronic iron overload can be treated using iron-chelating therapies such as desferrioxamine (DFO), deferiprone (DFP) and…

View details →DOI: 10.1007/s40273-013-0076-zCited by 20
Negative / Null Result ReportOpen accessMedicine

Functional co-activation of the default mode network in APOE ε4-carriers: A replication study

Lara J. Mentink, Joao Guimaraes, Myrthe Faber et al. · 2021 · NeuroImage

Structural and functional alterations of the brain in persons genetically at-risk for Alzheimer's disease (AD) are crucial in unravelling AD development. Filippini et al. found that the default mode network (DMN) is already affected in young APOE ε4-carriers, with increased co-activation of the DMN during rest and increased hippocampal task activation. We aimed to replicate the early findings of Filippini et al, using the APOE gene, still the principal AD risk gene, and extended this with a polygenic risk score (PRS) analysis for AD, using the Human Connectome Project dataset (HCP). We include

View details →DOI: 10.1016/j.neuroimage.2021.118304Cited by 20
Negative / Null Result ReportOpen accessMedicine

Replication and Heritability of Prostate Cancer Risk Variants: Impact of Population-Specific Factors

Victor Virlogeux, Rebecca E. Graff, Thomas J. Hoffmann et al. · 2015 · Cancer Epidemiology Biomarkers & Prevention

BACKGROUND: Prostate cancer incidence and mortality rates vary across populations, with African American men exhibiting the highest rates. To date, genome-wide association studies have identified 104 SNPs independently associated with…

View details →DOI: 10.1158/1055-9965.epi-14-1372Cited by 20
Negative / Null Result ReportOpen accessPsychology

How bad is the mere presence of a phone? A replication of Przybylski and Weinstein (2013) and an extension to creativity

Claire Linares, Anne-Laure Sellier · 2021 · PLoS ONE

A 2013 article reported two experiments suggesting that the mere presence of a cellphone (vs. a notebook) can impair the relationship quality between strangers. The purpose of the present research is twofold: (1) closely replicate this article's findings, and (2) examine whether there may be an impact of the mere presence of a phone on creativity, whether at a group- or an individual- level. In two experiments (N = 356 participants, 136 groups), we followed the original procedure in the 2013 article. In particular, groups of participants who had never seen each other before the study had a con

View details →DOI: 10.1371/journal.pone.0251451Cited by 20
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Genome-Wide Association Study of Serum Fructosamine and Glycated Albumin in Adults Without Diagnosed Diabetes: Results From the Atherosclerosis Risk in Communities Study

Stephanie Loomis, Man Li, Nisa M. Maruthur et al. · 2018 · Diabetes

Fructosamine and glycated albumin are potentially useful alternatives to hemoglobin A1c (HbA1c) as diabetes biomarkers. The genetic determinants of fructosamine and glycated albumin, however, are unknown. We performed genome-wide…

View details →DOI: 10.2337/db17-1362Cited by 20
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Significant association between renal function and amyloid-positive area in renal biopsy specimens in AL amyloidosis

Takeshi Kuroda, Naohito Tanabe, Daisuke Kobayashi et al. · 2012 · BMC Nephrology

BACKGROUND: The kidney is a major target organ for systemic amyloidosis that often affects the kidney including proteinura, and elevated serum creatinine (Cr). The correlation between amount of amyloid deposits and clinical parameters is not known. The aim of this study was to clarify correlation the amyloid area in all renal biopsy specimen and clinical parameters. METHODS: Fifty-eight patients with an established diagnosis of AL amyloidosis participated in the study. All patients showed amyloid deposits in renal biopsies. We retrospectively investigated the correlation between clinical data

View details →DOI: 10.1186/1471-2369-13-118Cited by 20
Negative / Null Result ReportOpen accessMedicine

Mortality in HIV and tuberculosis patients following implementation of integrated HIV-TB treatment: Results from an open-label cluster-randomized trial

Kogieleum Naidoo, Santhanalakshmi Gengiah, Nonhlanhla Yende‐Zuma et al. · 2022 · EClinicalMedicine

Background HIV-TB treatment integration reduces mortality. Operational implementation of integrated services is challenging. This study assessed the impact of quality improvement (QI) for HIV-TB integration on mortality within primary…

View details →DOI: 10.1016/j.eclinm.2022.101298Cited by 20
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Phylogenomics Illuminates the Evolutionary History of Wild Silkmoths in Space and Time (Lepidoptera: Saturniidae)

Rodolphe Rougerie, Astrid Cruaud, Pierre Arnal et al. · 2026 · Systematic Biology

Wild silkmoths (Saturniidae) are one of the most emblematic and well-studied families of moths. Yet, the absence of a robust phylogenetic framework based on a comprehensive taxonomic sampling impedes our understanding of their evolutionary…

View details →DOI: 10.1093/sysbio/syag056Cited by 20
Negative / Null Result Report

The dog that failed to bark

Tom Burns · 2010 · The Psychiatrist

Summary UK mental healh services have been distinguished by their continuity of care but recently there has been a move to separating consultant responsibility for in-patient and out-patient care. Local examples of the success of this…

View details →DOI: 10.1192/pb.bp.110.030254Cited by 20
Negative / Null Result Report

Did Noise Pollution Really Improve during COVID-19? Evidence from Taiwan

Rezzy Eko Caraka, Yusra Yusra, Toni Toharudin et al. · 2021 · Sustainability

Background and objectives: The impacts of COVID-19 are like two sides of one coin. During 2020, there were many research papers that proved our environmental and climate conditions were improving due to lockdown or large-scale restriction…

View details →DOI: 10.3390/su13115946Cited by 20
Negative / Null Result ReportOpen accessMedicine

Combination of Olanzapine and Samidorphan Has No Clinically Significant Effect on the Pharmacokinetics of Lithium or Valproate

Lei Sun, Sergey Yagoda, Baiyun Yao et al. · 2019 · Clinical Drug Investigation

BACKGROUND AND OBJECTIVE: Olanzapine is an atypical antipsychotic indicated for the treatment of schizophrenia and, either as monotherapy or as an adjunct to lithium or valproate, for bipolar I disorder. Multiple daily doses of olanzapine…

View details →DOI: 10.1007/s40261-019-00860-yCited by 20
Negative / Null Result Report

Assessment and Comparison of the Overall Analytical Potential of Capillary Electrophoresis and High-Performance Liquid Chromatography Using the RGB Model: How Much Can We Find Out?

Paweł Mateusz Nowak, Edyta Sekuła, Paweł Kościelniak · 2020 · Chromatographia

Abstract The choice between capillary electrophoresis (CE) and high-performance liquid chromatography (HPLC) is not easy and depends on many factors. An attempt to facilitate this choice is this work, in which both techniques have been…

View details →DOI: 10.1007/s10337-020-03933-9Cited by 20
Negative / Null Result ReportBusiness, Management and Accounting

Molecular Genetics and Hormones: New Frontiers in Entrepreneurship Research

Matthijs van der Loos · 2011 · Data Archiving and Networked Services (DANS)

Recent studies suggest that entrepreneurship is partly heritable, but are unable to pinpoint the specific genes involved. This thesis presents results from novel research aiming to identify genes associated with entrepreneurship using…

View details →Cited by 20
Negative / Null Result ReportOpen accessMedicine

New treatment options for lupus – a focus on belimumab

Laurent Chiche · 2012 · Therapeutics and Clinical Risk Management

Belimumab is the first biologic approved for patients with systemic lupus erythematosus (SLE). Belimumab is the first of a new class of drug targeting B cell-stimulating factors or their receptors to reach the market. Its target, BLyS,…

View details →DOI: 10.2147/tcrm.s19819Cited by 20