Replication Failure
Kalapuj Y, Perassolo M, Rodrïguez JM et al. · 2026 · Preprint
Abstract Anthraquinones (AQs) are specialized metabolites produced by Rubia tinctorum that have traditionally been used as dyes, but also have important biological activities. The present research studied the effects of the addition of…
View details →DOI: 10.21203/rs.3.rs-8650732/v1 Replication Failure
Zeng Q, Zhang W, Peng X et al. · 2026 · Preprint
Abstract Background Congenital disorders of glycosylation (CDG) are a group of inherited metabolic diseases caused by defects in genes involved in protein and lipid glycosylation. The conserved oligomeric Golgi (COG) complex plays a…
View details →DOI: 10.21203/rs.3.rs-9327009/v1 Replication FailureOpen accessComputer Science
Supriyo Maji · 2017 · arXiv
Spin transfer torque oscillators (STOs) based on magnetic tunnel junction (MTJ) devices are emerging as a possible replacement for complementary metal-oxide semiconductors for radio-frequency (RF) signal generation. Advantages include low power consumption, small device area, and large frequency tunability. But such a single device cannot achieve the necessary noise performance for RF applications. It has been reported lately that a network of globally coupled STOs achieves significant improvement in phase noise. The study here is to propose use of such coupled STOs as self-oscillating RF mixe
Replication FailureOpen accessComputer Science
Zhichao Fan, Yanhang Li, Zexin Zhuang · 2026 · arXiv
Forced chain-of-thought (CoT) is widely assumed to make vision-language models more reliable on video question answering. We propose a small three-probe evaluation recipe to test that assumption: paired accuracy across direct, CoT, answer-first, and no-video conditions; a counterfactual video-swap diagnostic over the CoT chains; and a four-rung visual-degradation ladder. Each probe is reported under both a strict and a permissive regex scorer, with multiplicity correction over a manuscript-declared primary family. Applied to Qwen2.5-VL on Video-MME subsets, the recipe returns a two-part findin
Replication FailureOpen accessComputer Science
Xiqi Hao, Zengqing Wu, Yu-Xuan Qiu et al. · 2026 · arXiv
Multi-agent debate (MAD) is a promising strategy for improving LLM reasoning, but when agents converge on a shared answer, it is unclear whether that convergence reflects genuine deliberation or social compliance. We show that the conventional answer flip rate conflates three distinct mechanisms: spontaneous instability, stance-induced conformity, and reasoning-induced persuasion. Our three-source decomposition framework isolates each through controlled counterfactual conditions. In the primary MMLU-Pro setting, 37% of agent-question observations change under self-reflection alone, while robus
Replication FailureOpen accessComputer Science
J. Jon Ryu, Pavan Yeddanapudi, Xiangxiang Xu et al. · 2025 · arXiv
The InfoNCE objective, originally introduced for contrastive representation learning, has become a popular choice for mutual information (MI) estimation, despite its indirect connection to MI. In this paper, we demonstrate why InfoNCE should not be regarded as a valid MI estimator, and we introduce a simple modification, which we refer to as InfoNCE-anchor, for accurate MI estimation. Our modification introduces an auxiliary anchor class, enabling consistent density ratio estimation and yielding a plug-in MI estimator with significantly reduced bias. Beyond this, we generalize our framework us
Replication FailureOpen accessMathematics
Natesh Pillai, Aaron Smith · 2026 · arXiv
In Diaconis and Saloff-Coste (1996), the authors introduced the simple ``transvection" walk on $\mathrm{GL}_n(\mathbb F_2)$: at each step, choose two distinct rows and add one to the other. In Ben-Hamou (2025), the author recently proved that this walk has mixing time $O(n^2\log n)$. Inspired by applications in cryptography (see Sotiraki (2016)), Ben-Hamou and Peres (2018) conjectured that the first $k$ columns of this walk mixed in $O(nk \log(n))$ steps. Our main result is a proof of this conjecture uniformly in $n$ and $k.$ Our proof is based on a local-to-global entropy estimate, in the spi
Replication Failure
· 2019 · Journal of Gynecology & Reproductive Medicine
Karyotyping is a technique to examine the chromosomes-abnormality or structural defects. Karyotyping can be used to detect a variety of genetic disorders. For example, a woman who has premature ovarian failure may have a chromosomal defect…
View details →DOI: 10.33140/jgrm.03.06.02 Replication FailureOpen accessGynecology and obstetrics
Fereshteh Vaziri Nezamdoust, Hossein Hadinedoushan, Nasrin Ghasemi · 2023 · International Journal of Reproductive BioMedicine
Abstract Background: A large proportion of cases of recurrent pregnancy loss (RPL) are associated with immunological factors. Objective: This study investigated the association between single nucleotide polymorphisms of cytotoxic T-lymphocyte-associated protein (CTLA)-4 gene in women with a history of RPL compared to healthy women. Materials and Methods: A case-control study was performed on 2 groups consisting of 120 healthy women with no history of abortion and at least one delivery (control) and 120 women with a history of 2 or more primary RPLs (case). In addition, 5 mL of peripheral blood
View details →DOI: 10.18502/ijrm.v21i1.12664 Replication Failure
Haoyu Lian, Siyuan Zhou, Huanyang He et al. · 2026 · Frontiers in Oncology
Objective The purpose of this study was to reveal the genetic correlation of RANKL polymorphisms with bone metastasis in breast cancer patients. Methods In this study, 139 bone metastasis patients and 152 no metastasis were included as the…
View details →DOI: 10.3389/fonc.2026.1788455 Replication FailureOpen access
Robert H. Biggerstaff · 1973
The study of the Carabelli trait among 199 monozygotic and dizygotic twin pairs failed to demonstrate a high degree of heritability. Analyses of antimere differences in individuals indicated a lack of mirroring and no sexual dimorphism.…
View details →DOI: 10.1177/00220345730520013301 Replication FailureOpen access
John H. Strickler · 2018
Abstract Summary: Anti-EGFR therapies have failed to improve survival for unselected patients with metastatic gastroesophageal cancer, but in a subset of patients, EGFR amplification may predict treatment benefit. Maron and colleagues…
View details →DOI: 10.1158/2159-8290.cd-18-0191 Replication FailureOpen accessVeterinary medicine
Şakir Doğan TUNCER, Behiç COŞKUN, Rıfat CANTORAY et al. · Eurasian Journal of Veterinary Sciences
This experiment was carried out to investigate the effects of Na -lasalocid that was added into concentrate mixtures in 25, 50 and 75 g per ton on growth performance and against the possible coccidia infection of lambs. In the experiment, 40 Akkaraman male lambs with 3.5 - 4 months old were used. The research works were conducted as 4 groups for the period of 84 days. The ratian of the control group did not contain any Na-lasalocid. The average of final weights of lambs in the groups were 47.41; 48.91; 49.98 and 49.96 kg respectively, (P>0.05). Average daily weight gain was found to be 260 g i
Replication FailureOpen accessInternal medicine
Kraemer Rachel, Claas Steven A, Devereux Richard B et al. · 2009 · BMC Medical Genetics
Abstract Background We conducted a genome-wide association study (GWAS) and validation study for left ventricular (LV) mass in the Family Blood Pressure Program – HyperGEN population. LV mass is a sensitive predictor of cardiovascular mortality and morbidity in all genders, races, and ages. Polymorphisms of candidate genes in diverse pathways have been associated with LV mass. However, subsequent studies have often failed to replicate these associations. Genome-wide association studies have unprecedented power to identify potential genes with modest effects on left LV mass. We describe here a
View details →DOI: 10.1186/1471-2350-10-43 Replication FailureMedicine
Ramphul R, McCurdy SA, Lee J et al. · 2026 · Drug and alcohol dependence
Background In 2023, an estimated 39.6 million adults aged ≥ 18 years had a substance use disorder (SUD) and 94.7 % did not seek treatment. Recovery residences provide essential support for individuals recovering from SUD, yet their…
View details →DOI: 10.1016/j.drugalcdep.2026.113044 Replication FailureMedicine
Pieracci FM, Doben A, Eriksson E et al. · 2026 · The journal of trauma and acute care surgery
Abstract The use of surgical stabilization of rib fractures (SSRF) for non-flail fracture patterns continues to rise. However, multiple, recent randomized controlled trials in this patient population have failed to show a clear benefit to…
View details →DOI: 10.1097/ta.0000000000004723 Replication FailureOpen accessMedicine
Glynatsis MN, Economou M, Papadopoulou K et al. · 2024 · Cureus
This report presents a rare case of a central retinal artery occlusion in an eight-year-old girl attributed to an undiagnosed patent ductus arteriosus (PDA). Despite intensive treatment, the patient's eyesight failed to improve. Cases of…
View details →DOI: 10.7759/cureus.61083 Replication FailureMedicine
Novik AV, Protsenko SA, Baldueva IA et al. · 2021 · The oncologist
Lessons learned Melatonin did not increase the efficacy of systemic chemotherapy in melanoma. Metformin did not increase the efficacy of systemic chemotherapy in melanoma. Background Current data support the possibility of antitumor…
View details →DOI: 10.1002/onco.13761 Replication FailureMedicine
Roth MT, Cardin DB, Borazanci EH et al. · 2020 · The oncologist
Lessons learned This trial evaluating a novel plant extract, PBI-05204, did not meet its primary endpoint of overall survival but did show signals of efficacy in heavily pretreated mPDA. PBI-05204 was generally well tolerated, with the…
View details →DOI: 10.1634/theoncologist.2020-0440 Replication FailureMedicine
Appleman LJ, Kim SE, Harris WB et al. · 2024 · Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Purpose Patients with no evidence of disease (NED) after metastasectomy for renal cell carcinoma are at high risk of recurrence. Pazopanib is an inhibitor of vascular endothelial growth factor receptor and other kinases that improves…
View details →DOI: 10.1200/jco.23.01544 Replication Failure
Reverberi S, Cuypers K, King BR et al. · 2026 · Preprint
The availability of a pre-existing cognitive-motor schema accelerates the learning of novel motor information. The encoding of a novel schema-compatible, compared to -incompatible, motor sequence was recently shown to be supported by the…
View details →DOI: 10.64898/2026.03.12.711304 Replication FailureOpen accessMathematics
Georg Ostrovski · 2011 · arXiv
Let X and Y be compact, simply connected and locally connected subsets of R^2, and let f : X -> Y be a homeomorphism isotopic to the identity on X. Generalizing Brouwer's plane translation theorem for self-maps of the plane, we prove that f has no recurrent (in particular, no periodic) points if it has no fixed points.
Replication Failure
C C Colling, T R Reents, M K Kottmaier et al. · 2024 · European Heart Journal
Abstract Introduction Radiofrequency (RF) current is the classic ablation technology in the EP lab. Underlying RF ablation parameters, such as RF power, impedance, duration and contact force are used to calculate expected lesion size.…
View details →DOI: 10.1093/eurheartj/ehae666.394 Replication FailureOpen accessComputer Science
Frank Meier, Hans Walliser · 1996 · arXiv
We present a procedure to calculate 1-loop graphs in the soliton sector of chiral Lagrangians and use it to calculate quantum corrections to certain baryon observables in Skyrme-type models. Results generally show an improvement over the values obtained in tree approximation except for the case of the axial coupling g_A.
Replication FailureMedicine
Kerkeni, Chamari, Kerkeni et al. · 2026 · Biology of sport
We explored how Ramadan fasting (RF) influences GPS-derived time-motion metrics and psychophysiological responses in soccer players during small-sided games (SSG). Twelve semi-professional male players (mean age 21.1 ± 0.7 y;…
View details →DOI: 10.5114/biolsport.2026.156231 Replication FailureMedicine
Moses K, Kamaraj, Konda Ramachary Subramanian · 2026 · Drug delivery
Ustekinumab is approved for treating moderate to severe plaque psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis. The Bmab 1200 autoinjector is a simple, two-step device for subcutaneous ustekinumab biosimilar…
View details →DOI: 10.1080/10717544.2026.2680354 Replication FailureMedicine
Deveci Koçbilek Z, Karayurt Ö, Bilik Ö et al. · 2026 · Computers, informatics, nursing : CIN
This single-blind, randomized controlled design study aims to examine the effect of a mobile-based Lymphedema Self-care Support Program on self-care, the quality of life, and lymphedema symptoms in women with breast cancer-related…
View details →DOI: 10.1097/cin.0000000000001336 Replication FailureMedicine
Ye C, Sheng Y, Zhang X et al. · 2026 · Plant Science.
Gene editing has emerged as a powerful tool in crop breeding, particularly for rice, enabling the creation of germplasm and trait improvement. A thorough understanding of gene functions is essential for precise and efficient crop…
Replication FailureOpen accessGeriatrics
Anum Zahra, Maarten van Smeden, Petra J. M. Elders et al. · 2025 · BMC Geriatrics
Abstract Background During the COVID-19 pandemic, nursing home (NH) residents faced the highest risk of severe COVID-19 disease and mortality. Due to their frailty status, comorbidity burden can serve as a useful predictive indicator of vulnerability in this frail population. However, the prognostic value of these cumulative comorbidity scores like the Charlson comorbidity index (CCI) remained unclear in this population. We evaluated the incremental predictive value of the CCI for predicting 28-day mortality in NH residents with COVID-19, compared to prediction using age and sex only. Methods
View details →DOI: 10.1186/s12877-025-05721-2 Replication FailureOpen accessDiseases of the genitourinary system. Urology
Wanqing Huang, Jiuxu Bai, Yanping Zhang et al. · 2024 · Renal Failure
Background Elderly hemodialysis (HD) patients have a high risk of death. The effect of different types of HD membranes on survival is still controversial. The purpose of this study was to determine the relationship between the use of low-flux or high-flux membranes and all-cause and cardiovascular mortality in elderly hemodialysis patients.Methods This was a retrospective clinical study involving maintenance hemodialysis patients which were categorized into low-flux and high-flux groups according to the dialyzer they were using. Propensity score matching was used to balance the baseline data o
View details →DOI: 10.1080/0886022x.2024.2338217 