A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
422 results in Replication Failure · page 10 of 15
Levy MM · 2013 · Critical care (London, England)
During the past 50 years, caring for the critically ill has become increasingly complex and the need for an intensivist has become more evident. Management by intensivists has become a quality indicator for many ICUs. Numerous small…
Rodrigue JR, Fleishman A, Fitzpatrick S et al. · 2015 · Progress in transplantation (Aliso Viejo, Calif.)
Context Since nearly all registered organ donors in the United States signed up via a driver's license transaction, motor vehicle (MV) offices represent an important venue for organ donation education. Objective To evaluate the impact of…
Kim JK, Karp JM, Gerber NK · 2023 · Clinical and translational radiation oncology
Background/purpose The optimal management of residual micrometastases and isolated tumor cells (ITC) in patients with invasive breast cancer who undergo neoadjuvant chemotherapy (NAC) followed by definitive surgery is not well-studied. We…
Ünal F, Gülhan B, Yüksek SK et al. · 2026 · Diagnostic microbiology and infectious disease
Background This study aimed to evaluate the diagnostic performance of serum galactomannan for invasive fungal infections in children with hematologic malignancies and to assess the impact of mold-active antifungal prophylaxis on test…
Schouten CS, Guarda V, Stadler TM et al. · 2026 · Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Background Human papillomavirus (HPV)-16 is the most commonly found HPV-type in HPV-induced oropharyngeal squamous cell carcinomas (OPSCC). The serological response to HPV oncoproteins could be a way to detect HPV-driven OPSCC early. A…
Khan A, Jaynes A, Ali F et al. · 2025 · Journal of translational gastroenterology
Background and objectives Guaiac fecal occult blood test (gFOBT) is often used to evaluate evidence of food protein-induced allergic proctocolitis (FPIAP) in children in primary care and gastroenterology settings; however, it has not been…
Kumar S, Sahu S, Sharma S · 2025 · Phlebology
ObjectivesAn open label, single-centric, post market clinical study was undertaken to evaluate the safety and efficacy of a new antimicrobial wound dressing (VELVERT) as an adjuvant therapy in the treatment of venous leg ulcer…
Wang Y, Li L, Song C et al. · 2026 · Journal of virus eradication
Background The incidence of low-level viremia (LLV) in chronic hepatitis B (CHB) patients receiving first-line nucleos(t)ide analogue (NAs) therapy with negative results on conventional HBV DNA testing is unknown. Methods A total of 557…
McCavitt DG, Culler MW, Palmer RC et al. · 2026 · The Journal of arthroplasty
Background The utility of synovial C-reactive protein (CRP) in diagnosing periprosthetic joint infection (PJI) remains controversial. This study examined the performance of synovial CRP for PJI diagnosis following total knee arthroplasty…
Koh SJ, Liou WL, Gan S et al. · 2026 · Cureus
Hepatitis C virus (HCV) screening is routinely performed in patients undergoing haemodialysis (HD) to detect incident infections. Currently, patients undergoing HD are screened using enzyme immunoassays (EIA) that detect hepatitis C…
Mura T, Aso M, Kawamura K et al. · 2025 · Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
Rapid diagnostic tests like the Xpert MRSA/SA BC assay are valuable for the early detection of Staphylococcus aureus (SA) and methicillin-resistant S. aureus (MRSA) in positive blood cultures. However, genetic variations in target regions…
Li X, Ou X, Liu X et al. · 2025 · BMC infectious diseases
BACKGROUND: In China, most health facilities for Tuberculosis(TB) prevention and treatment are not TB-designated. Underdiagnosis in non-TB-designated health facilities(NTDHFs) is a major cause of under-detection and underdiagnosis of…
Guleria S, Dutta U, Mewara A et al. · 2026 · Diagnostic microbiology and infectious disease
Background Giardia duodenalis is globally distributed intestinal protozoan parasite responsible for giardiasis causing various clinical manifestations ranging from asymptomatic to chronic diarrhea and malabsorption. Accurate diagnosis is…
Wang D, Huang D, Shen H et al. · 2026 · Nature human behaviour
Human-machine partnerships are increasingly used to address grand societal challenges, yet knowledge of the comparative strengths of humans and machines to innovate is nascent. Here we compare the ability of humans (N = 9,198) and large…
Hajkowicz K, Woodford J, Pillai ES et al. · 2025 · Emerging infectious diseases
Using metatranscriptomics, we identified Trubanaman virus in cerebrospinal fluid from a severely immunocompromised man who died of encephalitis in Queensland, Australia. Virus sequences were related to orthobunyaviruses previously detected…
Painter C, Phommasone K, Mayxay M et al. · 2026 · BMJ public health
Introduction In many low- and middle-income countries, there is widespread use of point-of-care tests (POCTs) to diagnose a variety of infectious diseases, even in hospitals due to weak laboratory capacity. Often, POCT use is unregulated…
Sitter TM, Savinen S, Andiné P et al. · 2026 · BMJ mental health
Background Patients in forensic psychiatric care (FPC) are often treated with various psychotropic medications. However, evidence regarding their effectiveness in this setting is lacking. Objective The study aimed to estimate how different…
Juárez Sarrión C, Armas IR, Torrano Guillamón A et al. · 2026 · Animals : an open access journal from MDPI
Objectives To describe the clinical, clinicopathological and ultrasonographic characteristics of dogs with an acute pancreatitis (AP) and to identify prognostic markers associated with short-term mortality in a referral population. Methods…
Allfelt A, Bendahl PO, Alkner S et al. · 2026 · Preprint
Abstract Background Invasive lobular carcinoma (ILC) is a risk factor for positive margins after breast-conserving surgery (BCS). This retrospective observational study examined whether the presence of residual cancer cells in re-excision…
Alija B, Bolas T, Vithiananthan S · 2026 · The Journal of surgical research
Introduction Over one million hernia repairs are performed annually in the United States, with more than 20 million worldwide. Although randomized trials support watchful waiting in select cases, delayed repair can lead to strangulation,…
Aarhus M, Netteland DF, Tverdal C et al. · 2026 · Acta neurochirurgica
Purpose Traumatic brain injury (TBI) in patients ≥ 80 years poses major clinical challenges, with limited evidence to guide neurosurgical decision-making. We evaluated mortality, functional outcomes, and prognostic factors in patients…
Fisayo T, Evans C, Mutasa K et al. · 2026 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Background Cytomegalovirus (CMV) co-infection is associated with mortality in adults with HIV, but whether CMV is associated with mortality in children with HIV remains uncertain. Methods In 498 children (median age 6.3 years,…
Castillo F, Tafur M, Lin C et al. · 2026 · Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes
Introduction Nondiagnostic results after thyroid fine-needle aspiration (FNA) are common and may delay diagnosis. Purpose To identify demographic and sonographic predictors of nondiagnostic cytology at repeat thyroid FNA and to report…
Rotevatn AØ, Eagan TM, McCann A et al. · 2026 · BMC pulmonary medicine
Background and aim Short-chain fatty acids (SCFAs) are metabolites largely produced by the gut microbiota, except for formate, which is also produced by the host. SCFAs may influence COPD development by modulating the immune system. This…
Soler-Blasco R, Lozano M, González-Safont L et al. · 2026 · Environmental research
Prenatal cadmium (Cd) exposure may impair placental function and disrupt biological processes relevant to foetal neurodevelopment, including oxidative stress and metal homeostasis, but epidemiological evidence linking Cd to childhood…
Eryılmaz T, Gayretli TK, Şefik SÖ et al. · 2026 · Preprint
Abstract Background Postpartum hemorrhage remains a major cause of maternal morbidity, and cesarean delivery is associated with greater blood loss than vaginal birth. This study compared prophylactic oxytocin and carbetocin for…
Fusar-Poli L, Prachason T, Brondino N et al. · 2026 · CNS spectrums
Objective Autistic traits (ATs) are associated with difficulties in social functioning, but their impact on the quantity and the quality of daily-life social interactions is not yet fully understood. Hereby, we examined the relationship…
Yiğit N, Nazlıgül AS, Ülgen NK et al. · 2026 · Geriatric orthopaedic surgery & rehabilitation
Background Distal radius fractures are common among elderly patients and frequently pose management challenges due to advanced age, multiple comorbidities, and increased anesthesia-related risks. In high-risk individuals with limited…
Rogalska E, Stenka W, Kupcewicz E et al. · 2026 · Frontiers in public health
Introduction Breast cancer is the most common malignancy among women worldwide. Mastectomy, often accompanied by breast reconstruction, plays a key role in treatment and prevention among high-risk patients; however, psychological outcomes…
Nowell S, Fantini O, Roman A et al. · 2026 · Veterinary dermatology
Fluorescent light energy (FLE; Phovia, Vetoquinol) is a photobiomodulation therapy that promotes healing and reduces inflammation. Cutaneous epitheliotropic lymphoma (CTCL) is a neoplastic skin disease with limited treatment options.…