Negative / Null Result ReportOpen accessComputer Science
Xinsong Du, John Novoa-Laurentiev, Joseph M. Plasek et al. · 2024 · EBioMedicine
BACKGROUND: Large language models (LLMs) have shown promising performance in various healthcare domains, but their effectiveness in identifying specific clinical conditions in real medical records is less explored. This study evaluates LLMs for detecting signs of cognitive decline in real electronic health record (EHR) clinical notes, comparing their error profiles with traditional models. The insights gained will inform strategies for performance enhancement. METHODS: This study, conducted at Mass General Brigham in Boston, MA, analysed clinical notes from the four years prior to a 2019 diagn
View details →Negative / Null Result ReportOpen accessMedicine
Karin Bammann, Nicola K. Thomson, Birte Marie Albrecht et al. · 2021 · PLoS ONE
The study of physical activity in older adults is becoming more and more relevant. For evaluation of physical activity recommendations, intensity-specific accelerometer cut-points are utilized. However, research on accelerometer cut-points for older adults is still scarce. The aim of the study was to generate placement-specific cut-points of ActiGraph GT3X+ activity counts and raw measures of acceleration to determine physical activity intensity in older adults. A further aim was to compare the validity of the generated cut-points for a range of different physical activities. The study was a s
View details →Negative / Null Result ReportMedicine
Soenke Böettger, David García Núñez, Rafael Meyer et al. · 2017 · Palliative & Supportive Care
BACKGROUND: In the intensive care setting, delirium is a common occurrence that comes with subsequent adversities. Therefore, several instruments have been developed to screen for and detect delirium. Their validity and psychometric…
View details →Negative / Null Result ReportOpen accessComputer Science
Zongyao Li, Kazuhiro Kitajima, Kenji Hirata et al. · 2021 · EJNMMI Research
Abstract Background To improve the diagnostic accuracy of axillary lymph node (LN) metastasis in breast cancer patients using 2-[ 18 F]FDG-PET/CT, we constructed an artificial intelligence (AI)-assisted diagnosis system that uses deep-learning technologies. Materials and methods Two clinicians and the new AI system retrospectively analyzed and diagnosed 414 axillae of 407 patients with biopsy-proven breast cancer who had undergone 2-[ 18 F]FDG-PET/CT before a mastectomy or breast-conserving surgery with a sentinel lymph node (LN) biopsy and/or axillary LN dissection. We designed and trained a
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Rajesh R. Shrestha, Daniel L. Peters, Markus A. Schnorbus · 2013 · Hydrological Processes
Abstract It is a common practice to employ hydrologic models for assessing alterations to streamflow as a result of anthropogenically driven changes, such as riverine, land use, and climate change. However, the ability of the models to…
View details →Negative / Null Result ReportOpen accessMedicine
Michael Mullerad, Jonatan R. A. Aguinaga, Tareq Aro et al. · 2017 · Rambam Maimonides Medical Journal
OBJECTIVE: High-power Holmium Laser (120H) has a unique modulated pulse mode, Moses™ technology. Moses technology modulates the laser pulse to separate the water (vapor bubble), then deliver the remaining energy through the bubble. Proprietary laser fibers were designed for the Moses technology. Our aim was to compare stone lithotripsy with and without the Moses technology. METHODS: We designed a questionnaire for the urologist to fill immediately after each ureteroscopy in which the Lumenis 120H was used. We compared procedures with (n=23) and without (n=11) the use of Moses technology. Surge
View details →Negative / Null Result ReportOpen accessMedicine
Phitsinee Thipubon, Chairat Uthaipibull, Sumalee Kamchonwongpaisan et al. · 2015 · Malaria Journal
BACKGROUND: Iron is an essential micronutrient required by all living organisms including malaria parasites (Plasmodium spp.) for many biochemical reactions, especially growth and multiplication processes. Therefore, malaria parasite needs to take up the iron from outside or/and inside the parasitized red blood cells (PRBC). Iron chelators are widely used for the treatment of thalassaemia-related iron overload and also inhibit parasite growth at levels that are non-toxic to mammalian cells. METHODS: Inhibitory effect of 1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methylpyridin-4-one (CM1) and green
View details →Negative / Null Result ReportOpen accessSocial Sciences
Mary Burns · 2013 · International Journal of Emerging Technologies in Learning (iJET)
The question of whether computers have positively or negatively impacted student learning is still hotly contested in educational technology circles, particularly in the area of international development, by proponents and critics of technology in education. Overall, research still provides conflicting answers to this question. Nonetheless, the abundant research on effective school change and innovation implementation points to practices which those who promote technology in schools should tap. This paper outlines the long-term structural conditions that can lead to the deep change technology
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Andreas Billich, Thomas Baumruker, Christian Beerli et al. · 2013 · PLoS ONE
BACKGROUND: Sphingosine-1-phosphate (S1P) regulates the egress of T cells from lymphoid organs; levels of S1P in the tissues are controlled by S1P lyase (Sgpl1). Hence, Sgpl1 offers a target to block T cell-dependent inflammatory processes. However, the involvement of Sgpl1 in models of disease has not been fully elucidated yet, since Sgpl1 KO mice have a short life-span. METHODOLOGY: We generated inducible Sgpl1 KO mice featuring partial reduction of Sgpl1 activity and analyzed them with respect to sphingolipid levels, T-cell distribution, and response in models of inflammation. PRINCIPAL FIN
View details →Negative / Null Result ReportOpen accessNursing
Gisele P. Oliveira, Cristina Márcia Dias, Paolo Pelosi et al. · 2010 · Anais da Academia Brasileira de Ciências
Glutamine (Gln) is an important energy source and has been used as a supplementary energy substrate. Furthermore, Gln is an essential component for numerous metabolic functions, including acid-base homeostasis, gluconeogenesis, nitrogen…
View details →Negative / Null Result ReportOpen accessMedicine
Florence T.H. Wu, Ping Xu, Annabelle Chow et al. · 2018 · British Journal of Cancer
There are phase 3 clinical trials underway evaluating anti-PD-L1 antibodies as adjuvant (postoperative) monotherapies for resectable renal cell carcinoma (RCC) and triple-negative breast cancer (TNBC); in combination with antiangiogenic VEGF/VEGFR2 inhibitors (e.g., bevacizumab and sunitinib) for metastatic RCC; and in combination with chemotherapeutics as neoadjuvant (preoperative) therapies for resectable TNBC. This study investigated these and similar clinically relevant drug combinations in highly translational preclinical models of micro- and macro-metastatic disease that spontaneously de
View details →Negative / Null Result ReportOpen accessEarth and Planetary Sciences
George B. McManus, Donald M. Schoener, Katharine Haberlandt · 2012 · Frontiers in Microbiology
Simultaneous use of both heterotrophic and autotrophic metabolism ("mixotrophy") is common among protists. Strombidium rassoulzadegani is a planktonic mixotrophic marine ciliate that saves chloroplasts from its algal food and obtains a nutritional subsidy via photosynthesis. Cultures from the northeast, northwest, and southwest Atlantic Ocean show similar numerical response parameters (maximum growth rate, food concentration at which growth is half its maximum, and threshold food concentration for growth), and some isolates have been maintained in vitro for over 3 years. This ciliate grows equ
View details →Negative / Null Result ReportOpen accessMaterials Science
Elisabet Martí Coma-Cros, Alexandre Lancelot, María San Anselmo et al. · 2019 · Biomaterials Science
Biomaterials for antimalarial drug transport still need to be investigated in order to attain nanocarriers that can tackle essential issues related to malaria treatment, e.g. complying with size requirements and targeting specificity for their entry into Plasmodium-infected red blood cells (pRBCs), and limiting premature drug elimination or drug resistance evolution. Two types of dendritic macromolecule that can form vehicles suitable for antimalarial drug transport are herein explored. A new hybrid dendritic-linear-dendritic block copolymer based on Pluronic® F127 and amino terminated 2,2'-bi
View details →Negative / Null Result ReportMedicine
Larisa I. Labzin, Keng Yih Chew, Kathrin Eschke et al. · 2023 · Science Signaling
Macrophages are key cellular contributors to the pathogenesis of COVID-19, the disease caused by the virus SARS-CoV-2. The SARS-CoV-2 entry receptor ACE2 is present only on a subset of macrophages at sites of SARS-CoV-2 infection in…
View details →Negative / Null Result ReportOpen accessMedicine
Christoph Rochlitz, Martin Bigler, Roger von Moos et al. · 2016 · BMC Cancer
BACKGROUND: Adding bevacizumab to chemotherapy improves response rates and progression-free survival (PFS) in metastatic breast cancer (mBC). We aimed to demonstrate decreased toxicity with metronomic chemotherapy/bevacizumab compared with paclitaxel/bevacizumab. METHODS: This multicenter, randomized phase III trial compared bevacizumab with either paclitaxel (arm A) or daily oral capecitabine-cyclophosphamide (arm B) as first-line treatment in patients with HER2-negative advanced breast cancer. The primary endpoint was the incidence of selected grade 3-5 adverse events (AE) including: febrile
View details →Negative / Null Result ReportOpen accessSocial Sciences
David Brady, Agnes Blome, Julie A. Kmec · 2018 · Socio-Economic Review
Abstract Prominent research has claimed that work–family reconciliation policies trigger ‘tradeoffs’ and ‘paradoxes’ in terms of gender equality with adverse labor market consequences for women. These claims have greatly influenced debates…
View details →Negative / Null Result ReportOpen accessMedicine
Huajun Zhang, Shawn Todd, Mary Tachedjian et al. · 2012 · Journal of Virology
Herpesviruses or herpesviral sequences have been identified in various bat species. Here, we report the isolation, cell tropism, and complete genome sequence of a novel betaherpesvirus from the bat Miniopterus schreibersii (MsHV). In…
View details →Negative / Null Result ReportOpen accessMedicine
Qinfeng Huang, Junjie Shao, Shuiyun Lan et al. · 2015 · Journal of Virology
UNLABELLED: Arenaviruses cause severe hemorrhagic fever diseases in humans, and there are limited preventative and therapeutic measures against these diseases. Previous structural and functional analyses of arenavirus nucleoproteins (NPs)…
View details →Negative / Null Result ReportPsychology
Irene M. Pepperberg, Leigh Ann Hartsfield · 2014 · Journal of comparative psychology
Linking specific cognitive abilities of nonhuman species on a laboratory task to their evolutionary history-ecological niche can be a fruitful exercise in comparative psychology. Crucial issues, however, are the choice of task, the…
View details →Negative / Null Result ReportOpen accessMedicine
Jessica J. Harrison, David Warrilow, Breeanna J. McLean et al. · 2016 · Viruses
The discovery and characterisation of new mosquito-borne viruses provides valuable information on the biodiversity of vector-borne viruses and important insights into their evolution. In this study, a broad-spectrum virus screening system, based on the detection of long double-stranded RNA in inoculated cell cultures, was used to investigate the presence of novel viruses in mosquito populations of northern Australia. We detected and isolated a new virus (tentatively named Parry's Lagoon virus, PLV) from Culex annulirostris, Culex pullus, Mansonia uniformis and Aedes normanensis mosquitoes that
View details →Negative / Null Result ReportOpen accessSocial Sciences
Adam K. Fetterman, Kai Sassenberg · 2015 · PLoS ONE
Scientists are dedicating more attention to replication efforts. While the scientific utility of replications is unquestionable, the impact of failed replication efforts and the discussions surrounding them deserve more attention. Specifically, the debates about failed replications on social media have led to worry, in some scientists, regarding reputation. In order to gain data-informed insights into these issues, we collected data from 281 published scientists. We assessed whether scientists overestimate the negative reputational effects of a failed replication in a scenario-based study. Sec
View details →Negative / Null Result ReportOpen accessSocial Sciences
Janina Molina Dargo, Michelle Dimas · 2021 · JETL (Journal Of Education Teaching and Learning)
Due to Covid-19 pandemic, schools, particularly in the rural areas employed Modular Distance Learning (MDL) to ensure education continuity. This study seeks to investigate the effects of MDL in the academic performance of learners whether…
View details →Negative / Null Result ReportOpen accessEarth and Planetary Sciences
Kaustubh Thirumalai, Julie N. Richey, Terrence M. Quinn et al. · 2014 · Scientific Reports
Planktic foraminifer Globigerinoides ruber (G. ruber), due to its abundance and ubiquity in the tropical/subtropical mixed layer, has been the workhorse of paleoceanographic studies investigating past sea-surface conditions on a range of…
View details →Negative / Null Result ReportMathematics
W. Trey Hill, Gary L. Brase · 2012 · Quarterly Journal of Experimental Psychology
The thesis that the mind is better prepared to process frequencies-as compared to other numerical formats-continues to be debated. A recent aspect of this issue is the role of numeracy (numerical literacy; one's ability to understand and…
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Mary Garvey · 2023 · Infectious Disease Reports
The antimicrobial resistance crisis is an ongoing major threat to public health safety. Low- and middle-income countries are particularly susceptible to higher fatality rates and the economic impact of antimicrobial resistance (AMR). As an…
View details →Negative / Null Result ReportOpen accessEngineering
Seong Ki Yoo, Simon L. Cotton, Robert W. Heath et al. · 2017 · IEEE Wireless Communications Letters
In this letter, we report the results of a series of experiments which were performed to examine the impact of terminal handling and movement upon the user equipment (UE) to evolved NodeB (eNB) communications channel at 60 GHz. Three key utilization scenarios, in which a user imitated making a voice call, sending a text message or simply carrying the device in a pocket, are investigated. Each of these three user cases were studied under line of sight (LOS) and non-LOS (NLOS) channel conditions when the user was mobile in a range of different indoor and outdoor small cell scenarios. It is shown
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Linda M. Polfus, Jennifer A. Smith, Lawrence C. Shimmin et al. · 2013 · PLoS ONE
Many GWAS have identified novel loci associated with common diseases, but have focused only on main effects of individual genetic variants rather than interactions with environmental factors (GxE). Identification of GxE interactions is particularly important for coronary heart disease (CHD), a major preventable source of morbidity and mortality with strong non-genetic risk factors. Atherosclerosis is the major cause of CHD, and coronary artery calcification (CAC) is directly correlated with quantity of coronary atherosclerotic plaque. In the current study, we tested for genetic variants influe
View details →Negative / Null Result ReportOpen accessMedicine
L. Kavalieris, P.J. O’Sullivan, James M. Suttie et al. · 2015 · BMC Urology
BACKGROUND: Hematuria can be symptomatic of urothelial carcinoma (UC) and ruling out patients with benign causes during primary evaluation is challenging. Patients with hematuria undergoing urological work-ups place significant clinical and financial burdens on healthcare systems. Current clinical evaluation involves processes that individually lack the sensitivity for accurate determination of UC. Algorithms and nomograms combining genotypic and phenotypic variables have largely focused on cancer detection and failed to improve performance. This study aimed to develop and validate a model inc
View details →Negative / Null Result ReportOpen accessDecision Sciences
Chris Lu, Cong Lu, R. T. Lange et al. · 2026 · Nature
Abstract The automation of science is a long-standing ambition in artificial intelligence (AI) research 1,2 . Although the community has made substantial progress in automating individual components of the scientific process, a system that autonomously navigates the entire research life cycle—from conception to publication—has remained out of reach. Here we present a pipeline for automating the entire scientific process end to end. We present The AI Scientist, which creates research ideas, writes code, runs experiments, plots and analyses data, writes the entire scientific manuscript, and perf
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Klaudia Jomová, Suliman Yousef Alomar, Richard Valko et al. · 2025 · Archives of Toxicology
Abstract Cellular systems responsible for the formation and removal of reactive oxygen species (ROS), functioning within physiological limits, are essential for maintaining intracellular redox balance. This state is known as oxidative eustress. Key redox signaling molecules, such as superoxide anion radical (O 2 •— ) and hydrogen peroxide (H 2 O 2 ), operate at nanomolar concentrations and are produced by NADPH oxidases (regulated by various factors), the mitochondrial electron transport chain (ETC), and numerous enzymes. In addition, cell signaling is influenced by nitric oxide (NO • ) and re
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