Genome-Wide Association Study of Gene by Smoking Interactions in Coronary Artery Calcification
Linda M. Polfus; Jennifer A. Smith; Lawrence C. Shimmin; Lawrence F. Bielak; Alanna C. Morrison; Sharon L.R. Kardia; Patricia A. Peyser; James E. Hixson · 2013 · PLoS ONE
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Many GWAS have identified novel loci associated with common diseases, but have focused only on main effects of individual genetic variants rather than interactions with environmental factors (GxE). Identification of GxE interactions is particularly important for coronary heart disease (CHD), a major preventable source of morbidity and mortality with strong non-genetic risk factors. Atherosclerosis is the major cause of CHD, and coronary artery calcification (CAC) is directly correlated with quantity of coronary atherosclerotic plaque. In the current study, we tested for genetic variants influe
Abstract by Linda M. Polfus; Jennifer A. Smith; Lawrence C. Shimmin; Lawrence F. Bielak; Alanna C. Morrison; Sharon L.R. Kardia; Patricia A. Peyser; James E. Hixson, PLoS ONE (2013) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1371/journal.pone.0074642