SAKK 24/09: safety and tolerability of bevacizumab plus paclitaxel vs. bevacizumab plus metronomic cyclophosphamide and capecitabine as first-line therapy in patients with HER2-negative advanced stage breast cancer - a multicenter, randomized phase III trial
Christoph Rochlitz; Martin Bigler; Roger von Moos; Jürg Bernhard; Klazien Matter‐Walstra; Andreas Wicki; Khalil Zaman; Sandro Anchisi · 2016 · BMC Cancer
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: Adding bevacizumab to chemotherapy improves response rates and progression-free survival (PFS) in metastatic breast cancer (mBC). We aimed to demonstrate decreased toxicity with metronomic chemotherapy/bevacizumab compared with paclitaxel/bevacizumab. METHODS: This multicenter, randomized phase III trial compared bevacizumab with either paclitaxel (arm A) or daily oral capecitabine-cyclophosphamide (arm B) as first-line treatment in patients with HER2-negative advanced breast cancer. The primary endpoint was the incidence of selected grade 3-5 adverse events (AE) including: febrile
Abstract by Christoph Rochlitz; Martin Bigler; Roger von Moos; Jürg Bernhard; Klazien Matter‐Walstra; Andreas Wicki; Khalil Zaman; Sandro Anchisi, BMC Cancer (2016) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1186/s12885-016-2823-y