20,192 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Marcello Tiseo · 2010 · Drug Design Development and Therapy
Most patients with non-small-cell lung cancer (NSCLC) present with advanced disease and their long-term prognosis remains poor. Epidermal growth factor receptor (EGFR)-targeted therapies, such as gefitinib, have been subjected to…
View details →Juliano Rodrigues Sangalli, Marcos Roberto Chiaratti, Tiago Henrique Camara De et al. · 2014 · PLoS ONE
Cloning of mammals by somatic cell nuclear transfer (SCNT) is still plagued by low efficiency. The epigenetic modifications established during cellular differentiation are a major factor determining this low efficiency as they act as epigenetic barriers restricting reprogramming of somatic nuclei. In this regard, most factors that promote chromatin decondensation, including histone deacetylase inhibitors (HDACis), have been found to increase nuclear reprogramming efficiency, making their use common to improve SCNT rates. Herein we used valproic acid (VPA) in SCNT to test whether the treatment
View details →Witoon Purahong, Dolaya Sadubsarn, Benjawan Tanunchai et al. · 2019 · Microorganisms
Mangrove forest trees play important ecological functions at the interface between terrestrial and marine ecosystems. However, despite playing crucial roles in plant health and productivity, there is little information on microbiomes of the tree species in mangrove ecosystems. Thus, in this study we aimed to characterize the microbiome in soil (rhizosphere) and plant (root, stem, and leaf endosphere) compartments of the widely distributed mangrove tree Rhizophora stylosa. Surprisingly, bacterial operational taxonomic units (OTUs) were only confidently detected in rhizosphere soil, while fungal
View details →Hamzah Abu‐Sbeih, Cynthia N. Tran, Phillip S. Ge et al. · 2019 · Journal for ImmunoTherapy of Cancer
BACKGROUND: Immune checkpoint inhibitors (ICIs) represent a promising novel class of cancer therapy, but immune-mediated adverse events can complicate ICI treatment. Acute cholecystitis in patients receiving ICI therapy has not been characterized. We aimed to describe the clinical features of patients who developed ICI-related cholecystitis. METHODS: We evaluated a case series of patients at a tertiary cancer center who received ICI therapy and developed cholecystitis, diagnosed by clinical presentation and diagnostic imaging, during 2010-2018. Patients with a history of chronic cholecystitis
View details →Andrea Botticelli, Silvia Mezi, Giulia Pomati et al. · 2020 · Frontiers in Immunology
Backgrounds. Clinical trials showed that only a subset of patients benefits from immunotherapy suggesting the need to identify new predictive biomarker of resistance.. Indolamine 2,3-dioxygenase (IDO) has been proposed as a mechanism of resistance to anti-PD1 treatment and serum kyn/trp ratio represent a possible marker of IDO activity. Methods. Metastatic NSCLC, RCC and HNSCC treated in second line with nivolumab were included in this prospective study. Baseline serum kynurenine and tryptophan levels were measured by high-performance liquid chromatography to define the kyn/trp ratio. The 2–t
View details →Brian J. Anderson, Carolyn S. Calfee, Kathleen D. Liu et al. · 2019 · Critical Care
BACKGROUND: Enrichment strategies improve therapeutic targeting and trial efficiency, but enrichment factors for sepsis trials are lacking. We determined whether concentrations of soluble tumor necrosis factor receptor-1 (sTNFR1), interleukin-8 (IL8), and angiopoietin-2 (Ang2) could identify sepsis patients at higher mortality risk and serve as prognostic enrichment factors. METHODS: In a multicenter prospective cohort study of 400 critically ill septic patients, we derived and validated thresholds for each marker and expressed prognostic enrichment using risk differences (RD) of 30-day mortal
View details →Matias Lindgren · 2020 · Aaltodoc (Aalto University)
This thesis applies deep learning based classification techniques to identify natural languages from speech. The primary motivation behind this thesis is to implement accurate techniques for segmenting multimedia materials by the languages…
View details →M.P.L. Calus, Michael E. Goddard, Yvonne C. J. Wientjes et al. · 2018 · Journal of Dairy Science
Genomic prediction is applicable to individuals of different breeds. Empirical results to date, however, show limited benefits in using information on multiple breeds in the context of genomic prediction. We investigated a multitask…
View details →Daniel Skupski, John Owen, Sungduk Kim et al. · 2017 · Obstetrics and Gynecology
OBJECTIVE: To compare the accuracy of a new formula with one developed in 1984 (and still in common use) and to develop and compare racial and ethnic-specific and racial and ethnic-neutral formulas. METHODS: The Eunice Kennedy Shriver…
View details →Andrew Orton, Jonathan Frandsen, Randy L. Jensen et al. · 2017 · Journal of neurosurgery
OBJECTIVE Anaplastic meningiomas represent 1%-2% of meningioma diagnoses and portend a poor prognosis. Limited information is available on practice patterns and optimal management. The purpose of this study was to define treatment patterns…
View details →Changhee Park, Tae Min Kim, Jeong Mo Bae et al. · 2020 · Cancer Research and Treatment
PURPOSE: The treatment outcomes and genomic profiles of diffuse midline glioma (DMG) in adult patients are rarely characterized. We performed a retrospective study to evaluate the clinicogenomic profiles of adult patients with brain DMG.…
View details →Tácia Tavares Aquinas Liguori, Gabriel Romero Liguori, Luíz Felipe Pinho Moreira et al. · 2018 · Scientific Reports
Transforming growth factor-β1 (TGF-β1) is a potent inducer of fibroblast to myofibroblast differentiation and contributes to the pro-fibrotic microenvironment during cardiac remodeling. Fibroblast growth factor-2 (FGF-2) is a growth factor secreted by adipose tissue-derived stromal cells (ASC) which can antagonize TGF-β1 signaling. We hypothesized that TGF-β1-induced cardiac fibroblast to myofibroblast differentiation is abrogated by FGF-2 and ASC conditioned medium (ASC-CMed). Our experiments demonstrated that TGF-β1 treatment-induced cardiac fibroblast differentiation into myofibroblasts, as
View details →Loes F.M. van der Zanden, Iris A.L.M. van Rooij, Wout Feitz et al. · 2010 · The Journal of Clinical Endocrinology & Metabolism
CONTEXT: Hypospadias is a common congenital malformation of the male external genitalia with a multifactorial etiology. Little is known about the genes involved in hypospadias. A few genetic associations have been reported but mainly in…
View details →Valentina Lanteri, Gianguido Cossellu, Marco Farronato et al. · 2020 · Scientific Reports
The Palatal Rugae are considered a useful human identification marker for both orthodontists and forensic personnel. The principal aim of the present study was to evaluate the stability of palatal rugae with a 3D-3D superimposition procedure following Slow Maxillary Expansion (SME), in order to assess whether they kept their uniqueness and validity for human identification, even after a specific dental treatment. For this purpose, a sample of 27 digital dental models - belonging to growing patients (13 males and 14 females), aged between 8.5 and 15 years, who underwent SME therapy - was retros
View details →Troy MacAvelia, Meisam Salahi, Michael Olsen et al. · 2012 · Journal of Biomechanical Engineering
Few experimental studies have examined surgical drilling in human bone, and no studies have inquired into this aspect for a popular commercially-available artificial bone used in biomechanical studies. Sixteen fresh-frozen human femurs and…
View details →Samuel Murray, Nathan Liang, Nicholaus P. Brosowsky et al. · 2021 · Psychology of Aesthetics Creativity and the Arts
A primary aim of mind-wandering research has been to understand its influence on task performance. While this research has typically highlighted the costs of mind wandering, a handful of studies have suggested that mind wandering may be…
View details →Kristin M. Burkart, Tamar Sofer, Stephanie J. London et al. · 2018 · American Journal of Respiratory and Critical Care Medicine
Abstract Rationale Lung function and chronic obstructive pulmonary disease (COPD) are heritable traits. Genome-wide association studies (GWAS) have identified numerous pulmonary function and COPD loci, primarily in cohorts of European ancestry. Objectives Perform a GWAS of COPD phenotypes in Hispanic/Latino populations to identify loci not previously detected in European populations. Methods GWAS of lung function and COPD in Hispanic/Latino participants from a population-based cohort. We performed replication studies of novel loci in independent studies. Measurements and Main Results Among 11,
View details →Dajana Radujković, Erik Verbruggen, Bjarni D. Sigurðsson et al. · 2017 · FEMS Microbiology Ecology
Global change is expected to affect soil microbial communities through their responsiveness to temperature. It has been proposed that prolonged exposure to elevated temperatures may lead to progressively larger effects on soil microbial…
View details →Bahaaldin Alsoufi, Cedric Manlhiot, Bahaa M. Fadel et al. · 2010 · European Journal of Cardio-Thoracic Surgery
OBJECTIVES: The Ross procedure is the aortic valve-replacement procedure of choice in children. Nonetheless, late autograft re-operation for dilatation and/or valve regurgitation is of concern. We examined whether preoperative haemodynamic…
View details →Josh Kinsler · 2012 · Quantitative Economics
Value-added models of teacher effectiveness yield consistent estimates of teacher quality under the assumption that students are randomly assigned to classrooms conditional on ability. Rothstein (2010) tested and rejected this underlying…
View details →Nolwazi Z. Khumalo, Melusi Sibanda · 2019 · Sustainability
Regardless of the steady increase in the economic growth of South Africa, poverty levels and food insecurity have not declined as one would have anticipated. Urban and peri-urban agriculture (UPA) presents an opportunity as a livelihood strategy to alleviate poverty and ensure household food security within the urban and peri-urban spheres. However, less research has been done in this area to discover the contribution of UPA on households’ food security. This paper assesses the food security status of households that practised any form of UPA activities (later on referred to the rest of this p
View details →Mieke Metzemaekers, Seppe Cambier, Marfa Blanter et al. · 2021 · Clinical & Translational Immunology
OBJECTIVES: Emerging evidence of dysregulation of the myeloid cell compartment urges investigations on neutrophil characteristics in coronavirus disease 2019 (COVID-19). We isolated neutrophils from the blood of COVID-19 patients receiving…
View details →Brittany I Davidson, Heather Shaw, David A. Ellis · 2022 · Computers in Human Behavior
The mass adoption of digital technologies raises questions about how they impact people and society. Associations between technology use and negative correlates (e.g., depression and anxiety) remain common. However, pre-registered studies have failed to replicate these findings. Regardless of direction, many designs rely on psychometric scales that claim to define and quantify a construct associated with technology engagement. These often suggest clinical manifestations present as disorders or addictions. Given their importance for research integrity, we consider what these scales might be mea
View details →Sharmin Akter, Rajesh Madhuvilakku, Anik Kumar Kar et al. · 2026 · Signal Transduction and Targeted Therapy
Reactive oxygen species (ROS) act as critical secondary messengers in various intracellular signaling pathways that regulate cellular proliferation, differentiation, and survival under normal physiological conditions. However, dysregulation of redox signaling-driven by genetic mutations, epigenetic alterations, and posttranscriptional or posttranslational modifications-plays a central role in malignant transformation and cancer progression. Cancer cells typically exhibit elevated basal ROS levels due to increased metabolic activity, mitochondrial dysfunction, and oncogene activation. This mode
View details →Michael W. Topping, Dan Stark, Peter Senchyna et al. · 2025 · The Astrophysical Journal
Abstract JWST has recently discovered a subset of reionization era galaxies with ionized gas that is metal-poor in oxygen and carbon but heavily enriched in nitrogen. This abundance pattern is almost never seen in lower-redshift galaxies but is commonly observed in globular cluster stars. We have recently demonstrated that this peculiar abundance pattern appears in a compact (≃20 pc) metal-poor galaxy undergoing a strong burst of star formation. This galaxy was originally selected based on strong C iv emission, indicating a hard radiation field rarely seen locally. In this paper, we present JW
View details →Anders Alm, AM. Hornmark, Per-Arne Fall et al. · 2026 · Acta Dermato Venereologica
An occlusive hydrocolloid dressing (Comfeel Ulcus) was compared with a conventional wet saline gauze dressing regarding the effect on ulcer cleansing and healing processes, experience of pain and the consumption of nursing time, in a…
View details →Seo‐Young Park, Jong‐Mu Sun, Yoon‐La Choi et al. · 2022 · ESMO Open
•The adjuvant durvalumab therapy failed to demonstrate the survival benefit in ESCC who underwent neoadjuvant CCRT.•This is the first report on the role of adjuvant immunotherapy in both pathologic complete response (ypCR) and…
View details →Alexander Mihaescu, Mikaeel Valli, Carme Uribe et al. · 2022 · Molecular Brain
Abstract The accumulation of beta amyloid in the brain has a complex and poorly understood impact on the progression of Parkinson’s disease pathology and much controversy remains regarding its role, specifically in cognitive decline symptoms. Some studies have found increased beta amyloid burden is associated with worsening cognitive impairment in Parkinson’s disease, especially in cases where dementia occurs, while other studies failed to replicate this finding. To better understand this relationship, we examined a cohort of 25 idiopathic Parkinson’s disease patients and 30 healthy controls f
View details →Zhen Wang, Shuangshan Wang, Qingmin Wu · 2014 · FEMS Microbiology Letters
Brucella melitensis is a facultative intracellular pathogen that mainly resides within macrophages. The mechanisms employed by Brucella to adapt to harsh intracellular environments and survive within host macrophages are not clearly…
View details →Jacob Schewe, Anders Levermann · 2012 · Environmental Research Letters
Abstract Indian monsoon rainfall is vital for a large share of the world’s population. Both reliably projecting India’s future precipitation and unraveling abrupt cessations of monsoon rainfall found in paleorecords require improved…
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