403 real negative results, null findings, and replication failures · Replication Failure. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Guo G, Yan W, Zhou R et al. · 2026 · Frontiers in nutrition
Background Early-life nutritional factors play a crucial role in child health, but their association with palatine tonsil grading is not well understood. This study aimed to investigate the relationship between early-life nutrition and…
View details →Yi K, Zhan Y, Wei A et al. · 2026 · Drug design, development and therapy
Background The optimal analgesia regimen for patients undergoing laparoscopic gastrectomy is still unclear. This study evaluated the efficacy of ultrasound-guided rectus sheath block (RSB) with liposomal bupivacaine in providing sustained…
View details →Wenzel M, Rowland Z · 2024 · Preprint
Research on emotion regulation (ER) has shifted from focusing on the static to the flexible use of ER strategies in response to environmental demands, emphasizing the importance of strategy-situation fit. Despite the growing theoretical…
View details →Barker J, Sau A, Bajaj N et al. · 2024 · Preprint
Background Pulmonary vein isolation (PVI) is the mainstay of ablation for atrial fibrillation (AF). Adjunctive posterior wall isolation (PWI) has not demonstrated convincing additional benefit. To provide mechanistic underpinnings as to…
View details →Lopez DS, Polychronopoulou E, Abdelgadir O et al. · 2025 · Cancers
Background/Objectives: Metformin is one of the most frequently used concomitant medications among prostate cancer (PCa) patients. However, the effects of metformin on all-cause and PCa-specific mortality among men diagnosed with…
View details →Gass JC, Tonkin S, Maguin E et al. · 2024 · Translational behavioral medicine
Ecological Momentary Assessment (EMA) methods are increasingly used by translational scientists to study real-world behavior and experience. The ability to draw meaningful conclusions from EMA research depends upon participant compliance…
View details →Shelton RC, Pizzagalli DA, Cohen EA et al. · 2025 · The Journal of clinical psychiatry
Objective: To assess proof-of-concept (PoC) for efficacy, tolerability, and safety of TRPC4/5 inhibitor BI 1358894 vs placebo in patients with major depressive disorder (MDD) with inadequate response to ongoing antidepressants. Methods: In…
View details →Khan A, Khan H, Hughes GK et al. · 2024 · Cancer medicine
Objective This study aims to evaluate published clinical trials of ramucirumab to assess the risk/benefit profile and burden over time for patients. Background The burden of oncologic drug development on patients paired with increasing…
View details →Kendall C, Swaminathan A, Borichevsky GM et al. · 2026 · JGH open : an open access journal of gastroenterology and hepatology
Background Fecal calprotectin (fCal) and fecal myeloperoxidase (fMPO) have been proposed as biomarkers for monitoring inflammatory bowel disease (IBD); however, their reliability is not fully established. This study investigated clinical…
View details →Meyers DE, Jenei K, Chisamore TM et al. · 2021 · JAMA internal medicine
Importance Cancer drugs approved by the US Food and Drug Administration have come under scrutiny for marginal clinical benefits; however, the clinical benefits of cancer drugs recommended for reimbursement in Canada have not been…
View details →Levy MM · 2013 · Critical care (London, England)
During the past 50 years, caring for the critically ill has become increasingly complex and the need for an intensivist has become more evident. Management by intensivists has become a quality indicator for many ICUs. Numerous small…
View details →Rodrigue JR, Fleishman A, Fitzpatrick S et al. · 2015 · Progress in transplantation (Aliso Viejo, Calif.)
Context Since nearly all registered organ donors in the United States signed up via a driver's license transaction, motor vehicle (MV) offices represent an important venue for organ donation education. Objective To evaluate the impact of…
View details →Kim JK, Karp JM, Gerber NK · 2023 · Clinical and translational radiation oncology
Background/purpose The optimal management of residual micrometastases and isolated tumor cells (ITC) in patients with invasive breast cancer who undergo neoadjuvant chemotherapy (NAC) followed by definitive surgery is not well-studied. We…
View details →Ünal F, Gülhan B, Yüksek SK et al. · 2026 · Diagnostic microbiology and infectious disease
Background This study aimed to evaluate the diagnostic performance of serum galactomannan for invasive fungal infections in children with hematologic malignancies and to assess the impact of mold-active antifungal prophylaxis on test…
View details →Schouten CS, Guarda V, Stadler TM et al. · 2026 · Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Background Human papillomavirus (HPV)-16 is the most commonly found HPV-type in HPV-induced oropharyngeal squamous cell carcinomas (OPSCC). The serological response to HPV oncoproteins could be a way to detect HPV-driven OPSCC early. A…
View details →Khan A, Jaynes A, Ali F et al. · 2025 · Journal of translational gastroenterology
Background and objectives Guaiac fecal occult blood test (gFOBT) is often used to evaluate evidence of food protein-induced allergic proctocolitis (FPIAP) in children in primary care and gastroenterology settings; however, it has not been…
View details →Kumar S, Sahu S, Sharma S · 2025 · Phlebology
ObjectivesAn open label, single-centric, post market clinical study was undertaken to evaluate the safety and efficacy of a new antimicrobial wound dressing (VELVERT) as an adjuvant therapy in the treatment of venous leg ulcer…
View details →Wang Y, Li L, Song C et al. · 2026 · Journal of virus eradication
Background The incidence of low-level viremia (LLV) in chronic hepatitis B (CHB) patients receiving first-line nucleos(t)ide analogue (NAs) therapy with negative results on conventional HBV DNA testing is unknown. Methods A total of 557…
View details →McCavitt DG, Culler MW, Palmer RC et al. · 2026 · The Journal of arthroplasty
Background The utility of synovial C-reactive protein (CRP) in diagnosing periprosthetic joint infection (PJI) remains controversial. This study examined the performance of synovial CRP for PJI diagnosis following total knee arthroplasty…
View details →Koh SJ, Liou WL, Gan S et al. · 2026 · Cureus
Hepatitis C virus (HCV) screening is routinely performed in patients undergoing haemodialysis (HD) to detect incident infections. Currently, patients undergoing HD are screened using enzyme immunoassays (EIA) that detect hepatitis C…
View details →Mura T, Aso M, Kawamura K et al. · 2025 · Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
Rapid diagnostic tests like the Xpert MRSA/SA BC assay are valuable for the early detection of Staphylococcus aureus (SA) and methicillin-resistant S. aureus (MRSA) in positive blood cultures. However, genetic variations in target regions…
View details →Li X, Ou X, Liu X et al. · 2025 · BMC infectious diseases
BACKGROUND: In China, most health facilities for Tuberculosis(TB) prevention and treatment are not TB-designated. Underdiagnosis in non-TB-designated health facilities(NTDHFs) is a major cause of under-detection and underdiagnosis of…
View details →Guleria S, Dutta U, Mewara A et al. · 2026 · Diagnostic microbiology and infectious disease
Background Giardia duodenalis is globally distributed intestinal protozoan parasite responsible for giardiasis causing various clinical manifestations ranging from asymptomatic to chronic diarrhea and malabsorption. Accurate diagnosis is…
View details →Wang D, Huang D, Shen H et al. · 2026 · Nature human behaviour
Human-machine partnerships are increasingly used to address grand societal challenges, yet knowledge of the comparative strengths of humans and machines to innovate is nascent. Here we compare the ability of humans (N = 9,198) and large…
View details →Hajkowicz K, Woodford J, Pillai ES et al. · 2025 · Emerging infectious diseases
Using metatranscriptomics, we identified Trubanaman virus in cerebrospinal fluid from a severely immunocompromised man who died of encephalitis in Queensland, Australia. Virus sequences were related to orthobunyaviruses previously detected…
View details →Painter C, Phommasone K, Mayxay M et al. · 2026 · BMJ public health
Introduction In many low- and middle-income countries, there is widespread use of point-of-care tests (POCTs) to diagnose a variety of infectious diseases, even in hospitals due to weak laboratory capacity. Often, POCT use is unregulated…
View details →Sitter TM, Savinen S, Andiné P et al. · 2026 · BMJ mental health
Background Patients in forensic psychiatric care (FPC) are often treated with various psychotropic medications. However, evidence regarding their effectiveness in this setting is lacking. Objective The study aimed to estimate how different…
View details →Juárez Sarrión C, Armas IR, Torrano Guillamón A et al. · 2026 · Animals : an open access journal from MDPI
Objectives To describe the clinical, clinicopathological and ultrasonographic characteristics of dogs with an acute pancreatitis (AP) and to identify prognostic markers associated with short-term mortality in a referral population. Methods…
View details →Allfelt A, Bendahl PO, Alkner S et al. · 2026 · Preprint
Abstract Background Invasive lobular carcinoma (ILC) is a risk factor for positive margins after breast-conserving surgery (BCS). This retrospective observational study examined whether the presence of residual cancer cells in re-excision…
View details →Alija B, Bolas T, Vithiananthan S · 2026 · The Journal of surgical research
Introduction Over one million hernia repairs are performed annually in the United States, with more than 20 million worldwide. Although randomized trials support watchful waiting in select cases, delayed repair can lead to strangulation,…
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