19,878 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Ott A, Gül AZ, Löber U et al. · 2026 · Brain research bulletin
High-fat diet (HFD) consumption contributes to obesity, yet its impact on females of (pre)reproductive age and the effects of dietary modification after adolescence remain underexplored. This study examined how continuous HFD exposure or…
View details →Lagacé JC, St-Martin P, Avino M et al. · 2026 · Experimental physiology
Prolonged bed rest and immobilization have deleterious effects on skeletal muscle mass and function, especially in older adults. These can lead to reduced physical capacity and quality of life. Previous experiments in younger individuals…
View details →Stadie N, Heinzer R, Marques-Vidal P · 2026 · European journal of nutrition
PURPOSE: Many individuals turn to supplements like magnesium, believing them to offer a natural way to improve sleep quality. Yet, research on magnesium’s effects has produced inconsistent results. We assessed the relationships between…
View details →Thomas S, Ben-Davies R, Cetinkaya-Fisgin A et al. · 2026 · Journal of the peripheral nervous system : JPNS
Background and aims Recent preclinical studies have shown that nicotinamide adenine dinucleotide (NAD + ) plays a critical role in molecular mechanisms of axon degeneration, and reductions in NAD + levels are associated with axonal…
View details →Battistelli LS, Moraes RM, Santos YC et al. · 2026 · Journal of periodontology
Background Recent findings have associated alveolar bone loss (ABL) with the presence of senescent cells. Aging and the accumulation of senescent cells are associated with a pro-inflammatory environment which may exacerbate tissue damage.…
View details →Spormann S, Lebre M, Moutinho-Pereira J et al. · 2026 · Journal of plant physiology
Wild tomato species (WTS) have long been attracting the attention of plant researchers due to their ability to tolerate harsh environmental conditions in their natural habitats. In this context, their use in grafting procedures, where they…
View details →Espelta JM, Viana‐Soto A, Molowny‐Horas R et al. · 2026 · Journal of Applied Ecology.
While disturbances are essential for biodiversity, their escalation driven by climate change may threaten forest ecosystems. Contrasting approaches to adapt forests to disturbances-intensifying management versus encouraging natural…
View details →Ruocco-Vetucci V, Chaves RAC, Ballan ACF et al. · 2026 · General dentistry
Considering that osteonecrosis of the jaw may be due to the antiangiogenic effect of bisphosphonates and that leukocyte- and platelet-rich fibrin (L-PRF) releases proangiogenic factors, this study hypothesized that L-PRF could prevent…
View details →Al-Haddad C, Kobeissi H, Wehbi Z et al. · 2026 · Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus
Purpose To assess the driving performance and visual attention of amblyopic drivers using a driving simulator integrated with eye tracking technology in an urban setting. Methods A total of 30 participants were enrolled: 14 amblyopic…
View details →Cao X, Francisco CO, TaghiBeyglou B et al. · 2026 · Sleep & breathing = Schlaf & Atmung
PURPOSE: The recumbent posture during sleep increases small airway narrowing and nocturnal asthma despite optimal asthma treatment. Fluid accumulation in the chest can narrow the airway lumen, contributing to small airway narrowing. We…
View details →Lu X, Han Y, Song J et al. · 2025 · Frontiers in endocrinology
Background Recent studies have focused on investigating the role of cellular senescence in ovarian aging. Targeting cellular senescence has been proposed as a potential strategy to improve ovarian aging. p16 and p21 are classical molecules…
View details →He M, Wang L, Zhang S et al. · 2025 · Preprint
Abstract Purpose To investigate the effect of nightly 0.01% atropine eye drops on choroidal thickness (ChT) in pre-myopic children (at risk of myopia). Methods A 12-month randomized, double-blind, placebo-controlled trial was conducted in…
View details →Rodríguez-Arias M, Malaguarnera M, Ribes-Catalá M et al. · 2026 · Behavioral neuroscience
Social defeat (SD) is a well established model that increases addiction vulnerability accompanied by depressive- and anxiety-like behaviors. Environmental enrichment (EE) has been shown to enhance resilience and mitigate stress-induced…
View details →Leitão EPT, Del Rosario H, Hernández I et al. · 2026 · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
By 2030, the incidence of new cases of cancer worldwide is expected to have increased by 18.1%, with a 22% increase in mortality. Leukaemia is the most common childhood cancer, and drug resistance remains a major therapeutic challenge.…
View details →Zhang H, Patton HN, Nagahawatte ND et al. · 2026 · Neurogastroenterology and motility
Background Stomach contractions are coordinated in part by bioelectric slow waves (SW). Dysfunctional SWs are associated with motility disorders. Electrical pacing is a potential strategy for managing motility disorders but remains poorly…
View details →Song JH, Kim SY, Lee YJ et al. · 2026 · Surgery
Background The use of postoperative antibiotics in patients with nonperforated appendicitis remains controversial, with limited evidence supporting routine administration. However, certain intraoperative findings, such as gangrenous,…
View details →Barbarot S, Aubert H, Boivin M et al. · 2026 · The British journal of dermatology
Background New primary preventive therapeutic strategies for atopic dermatitis (AD) are needed. Atopic diseases are associated with disrupted gut microbial balance in early life, suggesting that optimizing microflora through intervention…
View details →Altvater EE, Kojh D, Huang R et al. · 2025 · Preprint
ABSTRACT In metabolic dysfunction-associated steatotic liver disease (MASLD), liver fibrosis is the most important prognostic factor, and fibrosis can lead to hepatic cirrhosis and cancer. In the liver toll-like receptor 4 (TLR4) signaling…
View details →Battaglia-Vieni A, Marchant V, Tejedor-Santamaria L et al. · 2025 · Preprint
Background: /Objectives: Acute kidney injury (AKI) remains an unsolved medical problem due to the lack of effective treatments, high mortality and increased susceptibility to progression to chronic kidney disease (CKD), especially in the…
View details →Amthor L, Jaeckle A, Kampmeier J et al. · 2025 · Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
Sitagliptin, an inhibitor of dipeptidyl peptidase-4 widely used in type 2 diabetes therapy, impairs the barrier formed by retinal endothelial cells (REC) during prolonged exposure. Because diabetic macular edema is treated with inhibitors…
View details →Villard M, Espinosa-Carrasco G, Hernandez J · 2025 · Preprint
ABSTRACT Lymphodepletion, which is currently used as adjuvant for adoptive cytotoxic T cell immunotherapy in cancer, promotes the breakdown of peripheral CD8 + T cell tolerance. Under lymphopenic conditions, naive T cells proliferate due…
View details →Kalafut KC, Cormerais Y, Cissé MY et al. · 2025 · Preprint
The nutrient-sensing mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway controls cellular and organismal growth and metabolism, while aberrant activation is linked to human disease, including metabolic disease. Cellular…
View details →Jordhani M, Ruci D, Jordhani P et al. · 2025 · Preprint
Background: Hydroxychloroquine (HCQ) is a disease-modifying antirheumatic drug used in rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and other autoimmune diseases. Although HCQ reduces SARS-CoV-2 replication in vitro at…
View details →Ryan BC, Griffith KE, Geczi CN et al. · 2025 · Preprint
Stargardt disease (STGD1) is the most common inherited macular dystrophy, caused by loss-of-function mutations in ABCA4 that result in bisretinoid-containing lipofuscin accumulation in the retinal pigment epithelium (RPE), and progressive…
View details →Caltabiano A, Voruganti A, Nesi J et al. · 2026 · JMIR serious games
Background Exposure and response prevention is a first-line intervention for obsessive-compulsive disorder (OCD), yet many individuals with contamination concerns do not access care. Virtual reality exposure-based therapy (VRET) may…
View details →Rau KK, Harrison BJ, Venkat G et al. · 2025 · Preprint
Pain resulting from tissue damage, including surgical incision, is often only partially responsive to standard treatments focusing on inflammation, suggesting additional mechanisms are involved. Tissue damage leads to expression in dorsal…
View details →Heller DT, Benites NM, Amick EM et al. · 2025 · Preprint
Pre-sensory (ps), peripherally-generated spontaneous activity (SA) is important for establishing basic topography of central components of sensory pathways. However, roles for psSA in sculpting connections at the single neuron level and in…
View details →Kik OE, Zaviska F, Lesage G et al. · 2026 · Water research
This study investigated the electro-oxidation (EO) of three priority micropollutants: carbamazepine (CBZ), diuron (DIU), and perfluorooctane sulfonate (PFOS), in secondary-treated wastewater using boron-doped diamond (BDD) anodes. Although…
View details →Bidon M, Saito T, Skjaerven KH et al. · 2026 · Aquatic toxicology (Amsterdam, Netherlands)
Methylmercury (MeHg) is a pervasive neurotoxicant threatening aquatic ecosystems. Selenium (Se) has been reported to protect fish against the adverse MeHg toxicity, yet molecular investigations of their interaction in the brain remain…
View details →Birsen I, Erdogan K, Ozsoy O et al. · 2026 · Tissue & cell
Inflammatory bowel disease (IBD) is a systemic condition that can also lead to extraintestinal complications, including liver damage. Disruptions in the gut-liver axis and inflammatory mediators play a key role in this process. Apelin, a…
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