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19,850 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessGeriatrics

Postoperative Complications of Hip Fractures Patients on Chronic Coumadin: A Comparison Based on Operative International Normalized Ratio

Michael S. Kain, David Saper, Kyle Lybrand et al. · 2020 · Geriatrics

In current clinical practice, orthopedic surgeons often delay the surgery intervention on geriatric hip fracture patients to optimize the international normalized ratio (INR), in order to decrease the risk of postoperative hematological complications. However, some evidence suggests that full reversal protocols may not be necessary, especially for patients with prior thromboembolic history. Our study aims to compare the surgical outcomes of patients with normal versus elevated INR values. We conducted a retrospective chart review on 217 patients who underwent surgeries on hip fractures at two

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Negative / Null Result ReportOpen accessAnimal culture

Effects of the physical form of starter feed on the intake, performance, and health of female Holstein calves

Í.R.R. Castro, G.B.C. Leite, I.F. Carrari et al. · 2025 · Animal

Available literature on the effect of various physical forms of starter feed (PFSF) on calf performance is conflicting. Thus, this study aimed to investigate the effect of the PFSF on feed intake, growth performance, blood metabolites, and the health of dairy calves. Twenty-four female Holstein calves (5-d-old; 40.4 ± 3.86 kg BW; mean ± SD) were used in a completely randomized block design. Calves were individually housed and randomly assigned to the treatments (n = 12 calves/treatment): (1) textured starter feed (TSF, a mix of pelleted ingredients and whole-kernel corn) and (2) pelleted start

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Negative / Null Result ReportOpen accessMedicine

Contribution of model organism phenotypes to the computational identification of human disease genes

Sarah M. Alghamdi, Paul N. Schofield, Robert Hoehndorf · 2022 · Disease Models & Mechanisms

Computing phenotypic similarity helps identify new disease genes and diagnose rare diseases. Genotype–phenotype data from orthologous genes in model organisms can compensate for lack of human data and increase genome coverage. In the past decade, cross-species phenotype comparisons have proven valuble, and several ontologies have been developed for this purpose. The relative contribution of different model organisms to computational identification of disease-associated genes is not fully explored. We used phenotype ontologies to semantically relate phenotypes resulting from loss-of-function mu

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Negative / Null Result ReportOpen accessMedical physics. Medical radiology. Nuclear medicine

Phase I and II trial on infusional 5-fluorouracil and gefitinib in combination with preoperative radiotherapy in rectal cancer: 10-years median follow-up

Maria Antonietta Gambacorta, Antonino De Paoli, Marco Lupattelli et al. · 2018 · Clinical and Translational Radiation Oncology

Purpose: The aim of this study is to evaluate the long term survival of the addition of gefitinib to chemoradiotherapy (CRT) in locally advanced rectal cancer (LARC). Methods and materials: This previously published multicentre, open-label, phase I-II study, enrolled patients (pts) with LARC to receive CRT with concurrent 5-fluorouracil continuous intravenous infusion and a dose escalation of orally administered gefitinib, followed 6–8 weeks later by surgery. An intra-operative radiotherapy boost of 10 Gy was planned. Adjuvant chemotherapy was administrated in ypN1-2 pts. After a median f/u of

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Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens

Daratumumab Plus Atezolizumab in Previously Treated Advanced or Metastatic NSCLC: Brief Report on a Randomized, Open-Label, Phase 1b/2 Study (LUC2001 JNJ-54767414)

Rathi N. Pillai, MD, Suresh S. Ramalingam, MD, Meena Thayu, MD et al. · 2021 · JTO Clinical and Research Reports

Introduction: The programmed death-ligand 1 inhibitor atezolizumab improves progression-free survival (PFS) and overall survival (OS) for patients with previously treated advanced NSCLC. Preclinical studies indicate that targeting CD38-positive cells with daratumumab may synergistically enhance atezolizumab’s antitumor activity by increasing the effector T-cell activity. Methods: This phase 1b-2 study included a safety run-in (one cycle of daratumumab plus atezolizumab) and randomized phases (daratumumab plus atezolizumab versus atezolizumab alone). The primary objective of the randomized phas

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Negative / Null Result ReportOpen accessVeterinary medicine

Modification of albendazole pharmacokinetics by menbutone administration in calves

E. Milena Vazquez, Beatriz Romero, Raquel Diez et al. · 2026 · Frontiers in Veterinary Science

Optimizing the use of the existing anthelmintics has become a priority, as resistance is a growing concern worldwide and the development of novel antiparasitic drugs slow. The paper describes the pharmacokinetic interaction between the antiparasitic albendazole (ABZ) and the choleretic drug menbutone (MEN) in calves, when ABZ was administered orally (7.5 mg/kg) alone or with intramuscular MEN (10 mg/kg) (1 or 2 doses 24 h apart) to 12 animals. Blood samples were collected at 14 sampling points over 72 h, and plasma concentrations of ABZ, albendazole sulfoxide (ABZSO, active metabolite), and al

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Negative / Null Result ReportOpen accessVeterinary medicine

Clinical utility of fungal culture and antifungal susceptibility in cats and dogs with histoplasmosis

Andrew S. Hanzlicek, Kate S. KuKanich, Audrey K. Cook et al. · 2023 · Journal of Veterinary Internal Medicine

Abstract Background Culture can be used for diagnosis and antifungal susceptibility testing in animals with fungal infections. Limited information is available regarding the diagnostic performance of culture and the susceptibility patterns of Histoplasma spp. isolates. Hypothesis/Objectives Describe the clinical utility of culture and the susceptibility patterns of Histoplasma spp. isolates causing histoplasmosis in cats and dogs. Animals Seventy‐one client‐owned animals, including 33 cats and 19 dogs with proven or probable histoplasmosis. Methods Culture was attempted from tissue or fluid sa

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Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system

The Effect of Spinal Tap Test on Different Sensory Modalities of Postural Stability in Idiopathic Normal Pressure Hydrocephalus

Katrin Abram, Silvia Bohne, Peter Bublak et al. · 2016 · Dementia and Geriatric Cognitive Disorders Extra

Background/Aims: Postural instability in patients with normal pressure hydrocephalus (NPH) is a most crucial symptom leading to falls with secondary complications. The aim of the current study was to evaluate the therapeutic effect of spinal tap on postural stability in these patients. Methods: Seventeen patients with clinical symptoms of NPH were examined using gait scale, computerized dynamic posturography (CDP), and neuropsychological assessment. Examinations were done before and after spinal tap test. Results: The gait score showed a significant improvement 24 h after spinal tap test in al

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Negative / Null Result ReportOpen accessMedicine

Availability of volunteer-led home-based care system and baseline factors as predictors of clinical outcomes in HIV-infected patients in rural Zambia.

Christopher B Estopinal, Janneke H van Dijk, Stanley Sitali et al. · 2012 · PLoS ONE

Background We assessed the impact of home-based care (HBC) for HIV+ patients, comparing outcomes between two groups of Zambians receiving antiretroviral therapy (ART) who lived in villages with and without HBC teams. Methods We conducted a retrospective cohort study using medical charts from Macha Mission Hospital, a hospital providing HIV care in Zambia's rural Southern Province. Date of birth, date of ART initiation, place of residence, sex, body mass index (BMI), CD4+ cell count, and hemoglobin (Hgb) were abstracted. Logistic regression was used to test our hypothesis that HBC was associate

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Negative / Null Result ReportOpen accessMedicine

Challenges and strategies in the soluble expression of CTA1-(S14P5)4-DD and CTA1-(S21P2)4-DD fusion proteins as candidates for COVID-19 intranasal vaccines.

Simson Tarigan, Gita Sekarmila, Apas et al. · 2024 · PLoS ONE

Developing intranasal vaccines against pandemics and devastating airborne infectious diseases is imperative. The superiority of intranasal vaccines over injectable systemic vaccines is evident, but developing effective intranasal vaccines presents significant challenges. Fusing a protein antigen with the catalytic domain of cholera toxin (CTA1) and the two-domain D of staphylococcal protein A (DD) has significant potential for intranasal vaccines. In this study, we constructed two fusion proteins containing CTA1, tandem repeat linear epitopes of the SARS-CoV-2 spike protein (S14P5 or S21P2), a

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Negative / Null Result Report

Comparative Assessment of Efficiency and Productivity in Implant Crown Design Generated by Artificial Intelligence, Digital Designers, and Dental Students

Naydenov A, Uzunov T, Kostadinov G et al. · 2026 · Preprint

Abstract Objectives . This study aimed to compare the efficiency and productivity of a three-dimensional Generative Adversarial Network (3DGAN) with experienced digital operators and dental students in the design of screw-retained implant…

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Negative / Null Result ReportMedicine

Statins May Not Reduce Reoperation Rates in Chronic Subdural Hematoma, Regardless of the Use of Antithrombotic Medication.

Klein J, Carl B, Schackert G · 2026 · Journal of neurological surgery. Part A, Central European neurosurgery

Objective Various studies have shown a beneficial effect of statins in patients with chronic subdural hematoma (cSDH) who do not require surgery. In surgical cohorts, however, the results of statin treatment in cSDH have been inconsistent,…

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Negative / Null Result ReportMedicine

Determination of the First Aid Knowledge Level of Teachers Working in Special Education and Rehabilitation Centers Regarding Tooth Avulsion.

Yabaş ŞM, Gümüşboğa ZŞ · 2026 · Dental traumatology : official publication of International Association for Dental Traumatology

Aim Tooth avulsion is among the traumatic dental injuries that require immediate intervention during childhood, and children are often with teachers or parents at the time of such incidents. This situation highlights the need to evaluate…

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Negative / Null Result ReportMedicine

Nociception-guided opioid administration within multimodal analgesia for laparoscopic endometriosis surgery: a randomized controlled trial.

Buis HT, Berger-Estilita J, Zirngast S et al. · 2026 · Journal of clinical monitoring and computing

Women with endometriosis are at increased risk of severe postoperative pain due to nociceptive sensitization. While multimodal analgesia reduces opioid use, the added value of objective nociception monitoring remains unclear. This study…

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Negative / Null Result ReportMedicine

Influence of Cavity Design, Bonding-Banding Sequence, and Thermomechanical Loading on the Marginal Adaptation of Class II Resin Composite Restorations.

Ismail HS, Ali AI, Soliman HAN · 2026 · Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]

Objective To evaluate whether differences exist in marginal adaptation among beveled and non-beveled cavity designs, different bonding-banding sequences, and before and after thermomechanical loading. Methods Forty molars received…

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Negative / Null Result ReportMedicine

Causal Impact of Primary Care and Publicly Funded Health Insurance on Catastrophic Health Spending From Climate-Sensitive Diseases in India.

Chaudhary D, Mukhopadhyay I · 2026 · Applied health economics and health policy

Background Universal health coverage has become central to health policy debates, particularly as a strategy to protect households from financial hardship and impoverishment related to out-of-pocket (OOP) spending. Many low- and…

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Negative / Null Result ReportOpen accessMedicine

The mediating role of job and life satisfaction in the effect of psychological resilience on employee performance: evidence from the February 6 Kahramanmaraş (Türkiye) earthquakes.

Amırlı H, Gurbanli E · 2026 · BMC psychology

The purpose of this study is to investigate the mediating roles of job satisfaction (JS) and life satisfaction (LS) in the relationship between psychological resilience (PR) and employee performance (EP). Data for this study, which…

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Negative / Null Result ReportMedicine

The combined and independent influence of food texture and a 'mindful eating' instruction on eating rate and food intake among Dutch primary schoolchildren.

Jager G, de Wild VWT, Camps G et al. · 2026 · Appetite

Eating rate (ER), the amount of food consumed per unit of time, is a key determinant of food intake, with faster ER associated with larger meal size. Research in adults has shown that both sensory properties like texture, and instructions…

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