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750 real negative results, null findings, and replication failures · Failed Experiment Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Failed Experiment ReportOpen accessComputer Science

Token-Efficient RL for LLM Reasoning

Alan Lee, Harry Tong · 2025 · arXiv

We propose reinforcement learning (RL) strategies tailored for reasoning in large language models (LLMs) under strict memory and compute limits, with a particular focus on compatibility with LoRA fine-tuning. Building on early policy gradient methods with baseline subtraction, we design critic-free methods that operate on a small, informative subset of output tokens to reduce memory usage and stabilize training. We introduce S-GRPO, a stochastic variant of Group Relative Policy Optimization, and T-SPMO, a token-level prefix matching approach for fine-grained credit assignment. Applied to Qwen2

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Failed Experiment ReportOpen accessComputer Science

How to Fine-Tune a Reasoning Model? A Teacher-Student Cooperation Framework to Synthesize Student-Consistent SFT Data

Zixian Huang, Kaichen Yang, Xu Huang et al. · 2026 · arXiv

A widely adopted strategy for model enhancement is to use synthetic data generated by a stronger model for supervised fine-tuning (SFT). However, for emerging reasoning models like Qwen3-8B, this approach often fails to improve reasoning capabilities and can even lead to a substantial drop in performance. In this work, we identify substantial stylistic divergence between teacher generated data and the distribution of student as a major factor impacting SFT. To bridge this gap, we propose a Teacher-Student Cooperation Data Synthesis framework (TESSY), which interleaves teacher and student model

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Failed Experiment ReportOpen accessComputer Science

Granularity Noise Limit in Atomic-Ensemble-Based Metrology

Chen-Rong Liu, Chuang Li, Runxia Tao et al. · 2026 · arXiv

Conventional noise analysis in atomic-ensemble sensing assumes a continuous-medium approximation, thereby treating the atomic system as a deterministic dielectric. Here, we demonstrate that this assumption breaks down due to the discrete, particulate nature of the ensemble, giving rise to an intrinsic "atomic granularity noise" (AGN) that fundamentally competes with the optical measurement noise (OMN, typically photon shot noise). By introducing a discrete-atom statistical framework, we derive a unified noise-scaling law governed by a single dimensionless resource ratio, $\mathcal{R} = \bar{N}

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Failed Experiment ReportMedicine

Endovascular management of a ruptured pancreaticoduodenal artery pseudoaneurysm using a stent-graft: a case report and literature review.

Abukhalaf, Al-Ihribat, Sabarna et al. · 2026 · International journal of surgery case reports

Pancreaticoduodenal artery (PDA) pseudoaneurysms are rare vascular complications, accounting for approximately 2% of all visceral artery aneurysms. They are often associated with chronic pancreatitis and have a high risk of rupture, which…

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Failed Experiment ReportMedicine

Failed air enema reduction leading to the diagnosis of small-bowel intussusception secondary to Meckel's diverticulum with ectopic gastric mucosa in a 5-month-old infant: A case report.

Wang, Yu · 2026 · SAGE open medical case reports

A 5-month-old infant presented with paroxysmal crying and vomiting for more than 4 h. Ultrasonography confirmed intussusception in the right abdomen, but intraluminal gas limited precise classification. On the assumption of…

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Failed Experiment ReportMedicine

Transposition of the right renal artery to gastroduodenal artery for management of acute, symptomatic renovascular hypertension.

Ellis, Perry, Tabbara et al. · 2026 · Journal of vascular surgery cases and innovative techniques

Renovascular hypertension can be clinically challenging to diagnose. The most common etiology remains atherosclerotic disease. When medical management fails, renal artery revascularization is considered. Since the advent of endovascular…

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Failed Experiment ReportMedicine

Managing post-laminoplasty deformity after resection in of a cervical intramedullary hemangioblastoma in a 36-year-old male: a case report.

Versyck, Tollenaere, Schelfaut et al. · 2026 · Journal of spine surgery (Hong Kong)

Cervical kyphotic deformity is a recognized complication following posterior cervical spine surgery, particularly after laminectomy. However, post-laminoplasty kyphosis remains an underreported entity. We present a case of progressive…

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Failed Experiment ReportMedicine

Loureirin B Attenuates Methotrexate-Induced Liver Injury Associated with Oxidative Stress, SIRT1 Alterations, and TGF-β/SMAD3-Related Profibrotic Responses.

Hengirmen Acu, Erbaş · 2026 · Pharmaceuticals (Basel, Switzerland)

Background: Methotrexate-induced oxidative stress is mechanistically linked not only to hepatocellular injury but also to DNA damage, indicating that oxidative stress, hepatotoxicity, and genotoxicity represent interconnected…

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Failed Experiment ReportMedicine

Pediatric Lateral Condyle Fractures Pins or Screw?

White AB, Reid R, Graham GD et al. · 2026 · Journal of pediatric orthopedics

Background This prospective observational cohort study evaluates the clinical, radiographic, and functional differences between pins and screw fixation for displaced pediatric lateral condyle fractures of the elbow. Methods Skeletally…

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Failed Experiment ReportOpen accessMedical physics. Medical radiology. Nuclear medicine

Value of renal resistive index in hepatitis C virus related liver cirrhosis and its response to midodrine

Sameh Ahmed Abdel-bary, Eslam Safwat, Hany Ali Hussein et al. · 2014 · The Egyptian Journal of Radiology and Nuclear Medicine

Background: Hyperdynamic circulatory state in liver cirrhosis is characterized by increased splanchnic blood flow and renal vasoconstriction. Aim: To evaluate the relationship between renal resistive indices (RI) and HCV liver cirrhosis severity and RI value in predicting 6 month survival of those patients. Also we aimed to assess the effect of midodrine on RI. Patients and methods: 120 patients with HCV liver cirrhosis and 40 healthy controls were enrolled in the study. INR, total bilirubin, albumin, creatinine and sodium were measured in all patients. Both patients and controls underwent abd

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Failed Experiment ReportOpen accessMedicine (General)

Preemptive Propofol Administration in Spinal Cord Injury: Effects on Pain‐Induced Hypertension, Neuroinflammation, and Functional Recovery in Rats

Qun Cheng, Xiang‐Yu Fang, Rong‐En Qiu · 2025 · Kaohsiung Journal of Medical Sciences

ABSTRACT Spinal cord injury (SCI) triggers secondary damage, including pain‐induced hypertension, inflammation, and hemorrhage, impairing recovery. This study evaluated the efficacy of general anesthesia with preemptive propofol administration in mitigating secondary damage in SCI rats. SCI was induced in rats using a contusion model. Propofol (100 mg/kg) was administered intraperitoneally either 30 min before (preemptive) or 30 min after intermittent tail shock. Systolic blood pressure (SBP), body weight, food intake, inflammatory markers (interleukin‐1 beta [IL‐1β], interleukin‐6 [IL‐6]), he

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Failed Experiment ReportOpen accessPublic aspects of medicine

Feasibility and Usability of a Post-Hospital Behavioral Intervention to Improve Mobility in Veterans

Jacqueline A. Benson MPH, Matthew Wilson MS, Aidan J. Flynn MS et al. · 2025 · Inquiry: The Journal of Health Care Organization, Provision, and Financing

The strongest risk factor for readmission to the hospital is impaired physical function. We sought to determine the usability and feasibility of a post-hospital behavioral intervention to improve mobility in older adults with significant morbidity and functional impairment. We conducted a two-arm pragmatic pilot randomized trial of a behavioral economics-informed intervention to increase daily steps in Veterans, age 60 or older, receiving home health (HH) services post-discharge. The intervention group received a multicomponent behavioral economics-informed intervention, including daily step c

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Failed Experiment ReportOpen accessMedicine

Genetic variants associated with sepsis-associated acute kidney injury.

Nicholas J Douville, Lisa Bastarache, Emily Bertucci-Richter et al. · 2024 · PLoS ONE

Background Kidney dysfunction is a common complication in septic patients. Studies have identified numerous risk factors for sepsis-associated acute kidney injury (S-AKI), yet there is wide variability in the incidence even among patients with similar risk factors, suggesting the presence of additional uncharacterized risk factors, including genetic differences. The expansion of biobanks, advances in genotyping, and standardized diagnostic criteria have enabled large-scale, hypothesis-generating studies into the genetic mechanisms underlying S-AKI. We hypothesize that the genetic pathway behin

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Failed Experiment ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry

5′-upstream variants of CRHR1 and MAPT genes associated with age at onset in progressive supranuclear palsy and cortical basal degeneration

Carlos Cruchaga, Jose M. Vidal-Taboada, Mario Ezquerra et al. · 2009 · Neurobiology of Disease

Two different H1 sub-haplotypes at chromosome 17q21, H1C and H1E′A, have been associated with progressive supranuclear palsy (PSP) and cortical basal degeneration (CBD). We analyzed the SNPs included in the H1C and H1E′A haplotypes in a large Spanish PSP/CBD series and their interaction with age at onset (AAO). Survival analysis of rs1880753 marker was consistently associated with disease risk and with an earlier age at onset under an additive model. Its location at 160 kb and 50 kb upstream of tau and CRHR1 genes, respectively, suggests that it might act as a cis-element that regulates gene e

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Failed Experiment ReportOpen accessPsychology

Working Memory Load Effects on the Tilt Aftereffect

Gaoxing Mei, Mofen Cen, Xu Luo et al. · 2021 · Frontiers in Psychology

Prolonged exposure to an oriented stimulus causes a subsequent test stimulus to be perceived as tilted in the opposite direction, a phenomenon referred to as the tilt aftereffect (TAE). Previous studies have demonstrated that high-level cognitive functions such as attention can modulate the TAE, which is generally well-known as a low-level perceptual process. However, it is unclear whether working memory load, another high-level cognitive function, could modulate the TAE. To address this issue, here we developed a new paradigm by combining a working memory load task with a TAE task. Participan

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