Failed Experiment ReportOpen accessEngineering
Kaustav A. Gopinathan, Avanish Mishra, Baris R. Mutlu et al. · 2023 · Nature
Abstract Microfluidics have enabled notable advances in molecular biology 1,2 , synthetic chemistry 3,4 , diagnostics 5,6 and tissue engineering 7 . However, there has long been a critical need in the field to manipulate fluids and suspended matter with the precision, modularity and scalability of electronic circuits 8–10 . Just as the electronic transistor enabled unprecedented advances in the automatic control of electricity on an electronic chip, a microfluidic analogue to the transistor could enable improvements in the automatic control of reagents, droplets and single cells on a microflui
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Troy C. Sutton, Elaine W. Lamirande, Kevin W. Bock et al. · 2017 · Journal of Virology
ABSTRACT Influenza viruses of the H1N1, H2N2, and H3N2 subtypes have caused previous pandemics. H2 influenza viruses represent a pandemic threat due to continued circulation in wild birds and limited immunity in the human population. In…
View details →Failed Experiment ReportOpen accessEarth and Planetary Sciences
K. V. Cashman · 2020 · Frontiers in Earth Science
Studies of magmatic systems have long used the textures of erupted samples to infer processes that control the location and duration of magma storage and drive volcanic eruptions from these storage regions. Models of volcanic processes and magmatic systems have evolved substantially over the past decades, in large part because of advances in analytical and experimental techniques. Cooling- and decompression-experiments have greatly enhanced our understanding of crystal textures produced by crystallization associated with volcanic eruptions, while advances in compositional mapping, isotopic ana
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Nicole Armbruster, Annalisa Lattanzi, M. Jeavons et al. · 2016 · Molecular Therapy — Methods & Clinical Development
Spinal muscular atrophy (SMA) is an autosomal recessive disease of variable severity caused by mutations in the SMN1 gene. Deficiency of the ubiquitous SMN function results in spinal cord α-motor neuron degeneration and proximal muscle…
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Arafat Tfayli, Majd Al Assaad, Ghina Fakhri et al. · 2020 · Cancer Medicine
Multiple randomized studies have shown that combination of chemotherapy and immune checkpoint inhibitors (ICIs) leads to better response rates and survival as compared to chemotherapy alone in the advanced stage of NSCLC. Data suggesting a benefit to using ICIs in the neoadjuvant therapy of patients with early stage NSCLC are emerging. Eligible subjects were treatment naïve patients with stage IB, II, and resectable IIIA NSCLC. Patients received three cycles of neoadjuvant chemotherapy with four doses of avelumab every 2 weeks. Patients with squamous cell cancer received cisplatin or carboplat
View details →Failed Experiment ReportPhysics and Astronomy
V. K. Dixit, S. Porwal, S. D. Singh et al. · 2014 · Journal of Physics D Applied Physics
Temperature dependence of the photoluminescence (PL) peak energy of bulk and quantum well (QW) structures is studied by using a new phenomenological model for including the effect of localized states. In general an anomalous S-shaped…
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Christian Theilacker, Andrea Kropec, Felix Hammer et al. · 2012 · The Journal of Infectious Diseases
Type 1 lipoteichoic acid (LTA) is present in many clinically important gram-positive bacteria, including enterococci, streptococci, and staphylococci, and antibodies against LTA have been shown to opsonize nonencapsulated Enterococcus…
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Kristen Starbuck, Linah Al-Alem, David A. Eavarone et al. · 2018 · Oncotarget
// Kristen Starbuck 1, 4 , Linah Al-Alem 1, 4 , David A. Eavarone 2 , Silvia Fatima Hernandez 1, 4 , Chiara Bellio 1, 4 , Jillian M. Prendergast 2 , Jenna Stein 2 , Daniel T. Dransfield 2 , Bianca Zarrella 1 , Whitfield B. Growdon 1, 3, 4 , Jeff Behrens 2 , Rosemary Foster 1, 3, 4, * and Bo R. Rueda 1, 3, 4, * 1 Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA, USA 2 Siamab Therapeutics, Inc., Newton, MA, USA 3 Division of Gynecologic Oncology, Vincent Department of Obstetrics and Gynecology, Massachusetts General Hosp
View details →Failed Experiment ReportOpen accessBiochemistry, Genetics and Molecular Biology
Michel Michaelides, Cagri G. Besirli, Yesa Yang et al. · 2024 · American Journal of Ophthalmology
PURPOSE: To assess the safety and efficacy of AAV5-hRKp.RPGR in participants with retinitis pigmentosa GTPase regulator (RPGR)-associated X-linked retinitis pigmentosa (XLRP). DESIGN: Open-label, phase 1/2 dose escalation/expansion study (ClinicalTrials.gov Identifier: NCT03252847). METHODS: vg/ml) was administered to the poorer-seeing eye (n = 10). Dose confirmation (intermediate dose) was carried out in 3 pediatric participants. In the dose expansion phase, 36 participants were randomized 1:1:1 to immediate (low or intermediate dose) or deferred (control) treatment. The primary outcome was s
View details →Failed Experiment ReportOpen accessBiochemistry, Genetics and Molecular Biology
Shobana Raghunath, Siba K. Samal, Subbiah Elankumaran · 2013 · Journal of Virology
Oncolytic virus (OV) therapies of cancer are based on the use of replication-competent, tumor-selective viruses with limited toxicity. Newcastle disease virus (NDV), an avian paramyxovirus, is a promising OV and is inherently tumor…
View details →Failed Experiment ReportOpen accessBiochemistry, Genetics and Molecular Biology
Emily J. Mockford, Rupert C. Marshall, Torben Dabelsteen · 2011 · PLoS ONE
Acoustic signals play a fundamental role in avian territory defence and mate attraction. Several studies have now shown that spectral properties of bird song differ between urban and rural environments. Previously this has been attributed to competition for acoustic space as a result of low-frequency noise present in cities. However, the physical structure of urban areas may have a contributory effect. Here we investigate the sound degradation properties of woodland and city environments using both urban and rural great tit song. We show that although urban surroundings caused significantly le
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Huyen Tran, Tim Brighton, Andrew Grigg et al. · 2014 · British Journal of Haematology
The efficacy of a fixed-dose rituximab schedule was prospectively explored in primary/acute refractory, relapsed or chronic (platelet count >10 × 10(9) /l and ≤50 × 10(9) /l) idiopathic thrombocytopenic purpura (ITP). Patients received two…
View details →Failed Experiment ReportComputer Science
Jihan Yang, Shusheng Yang, Anjali Gupta et al. · 2025
Humans possess the visual-spatial intelligence to remember spaces from sequential visual observations. However, can Multimodal Large Language Models (MLLMs) trained on million-scale video datasets also "think in space" from videos? We…
View details →Failed Experiment ReportOpen accessComputer Science
Nitin Chitranshi, Ashutosh Kumar, Samran Sheriff et al. · 2021 · Cells
Amyloid precursor protein (APP), upon proteolytic degradation, forms aggregates of amyloid β (Aβ) and plaques in the brain, which are pathological hallmarks of Alzheimer's disease (AD). Cathepsin B is a cysteine protease enzyme that catalyzes the proteolytic degradation of APP in the brain. Thus, cathepsin B inhibition is a crucial therapeutic aspect for the discovery of new anti-Alzheimer's drugs. In this study, we have employed mixed-feature ligand-based virtual screening (LBVS) by integrating pharmacophore mapping, docking, and molecular dynamics to detect small, potent molecules that act a
View details →Failed Experiment ReportOpen accessImmunology and Microbiology
Carl Christoph Schimanski, Stefan Kasper, Susanna Hegewisch‐Becker et al. · 2020 · OncoImmunology
= .2141), respectively. Cox regression models revealed no dependence of RFS or OS on MUC1 expression. The most common tecemotide-related grade 3/4 adverse events were diarrhea, injection site reaction, intestinal perforation, peritonitis…
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Vitória Piai, Kristoffer Dahlslätt, Eric Maris · 2014 · Psychophysiology
Abstract When making statistical comparisons, the temporal dimension of the EEG signal introduces problems. Guthrie and Buchwald (1991) proposed a formally correct statistical approach that deals with these problems: comparing waveforms by…
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Lukas Ernstbrunner, Torsten Pastor, Manuel Waltenspül et al. · 2021 · The American Journal of Sports Medicine
Background: The Latarjet is a successful procedure but can be associated with significant complications, including failure. Iliac crest bone grafting (ICBG) is one of the salvage options for such failure. Purpose: To analyze factors…
View details →Failed Experiment ReportOpen accessBiochemistry, Genetics and Molecular Biology
Kevin G. Shim, Shane Zaidi, Jill Thompson et al. · 2017 · Molecular Therapy
Systemic viroimmunotherapy activates endogenous innate and adaptive immune responses against both viral and tumor antigens. We have shown that therapy with vesicular stomatitis virus (VSV) engineered to express a tumor-associated antigen…
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Pol Specenier, Jan B. Vermorken · 2012 · ISRN Oncology
The epidermal growth factor receptor (EGFR) is overexpressed in the vast majority of cases of squamous cell carcinoma of the head and neck (SCCHN). A high EGFR expression is associated with an unfavorable prognosis. Cetuximab is a chimeric human/murine IgG1 antibody which binds with high affinity to the EGFR. It is the only targeted agent which got approval for the treatment of SCCHN from the regulatory agencies of Europe and the United States, both in locoregionally advanced disease, in association with radiation, and in recurrent/metastatic disease. The outcome of trials involving other EGFR
View details →Failed Experiment ReportOpen accessImmunology and Microbiology
Dillon M. Betancourt, Juan Carlos Ramos, Glen N. Barber · 2015 · Journal of Virology
UNLABELLED: Adult T cell leukemia/lymphoma (ATL) is an aggressive cancer of CD4/CD25(+) T lymphocytes, the etiological agent of which is human T-cell lymphotropic virus type 1 (HTLV-1). ATL is highly refractory to current therapies, making…
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Kui Yang, Elizabeth Wills, Joel D. Baines · 2011 · Journal of Virology
Herpesvirus genomic DNA is cleaved from concatemers that accumulate in infected cell nuclei. Genomic DNA is inserted into preassembled capsids through a unique portal vertex. Extensive analyses of viral mutants have indicated that intact…
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Per Pfeiffer, Maryam B. Lustberg, Jacques Näsström et al. · 2022 · JNCI Cancer Spectrum
BACKGROUND: Calmangafodipir (CaM, PledOx) demonstrated efficacy in preventing patient-reported chemotherapy-induced peripheral neuropathy (CIPN) in a randomized phase 2 study in patients with metastatic colorectal cancer. The Preventive Treatment of OxaLiplatin Induced peripherAl neuRopathy (POLAR) program aimed to assess efficacy and safety of CaM in the prevention of CIPN in patients treated with oxaliplatin in adjuvant (POLAR-A, ClinicalTrials.gov.NCT04034355) or metastatic (POLAR-M, ClinicalTrials.gov.NCT03654729) settings. METHODS: Two randomized, placebo-controlled phase 3 trials investi
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Robert E. Coleman, Ying Zhou, Danielle Jandial et al. · 2021 · Advances in Therapy
INTRODUCTION: D-CARE, an international, phase 3, randomized, double-blind, placebo-controlled study in women with early-stage breast cancer at high risk of disease recurrence, failed to meet its primary endpoint-improvement in bone…
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John D. Morrey, Venkatraman Siddharthan, Hong Wang et al. · 2012 · PLoS ONE
West Nile virus (WNV) disease can be fatal for high-risk patients. Since WNV or its antigens have been identified in multiple anatomical locations of the central nervous system of persons or rodent models, one cannot know where to investigate the actual mechanism of mortality without careful studies in animal models. In this study, depressed respiratory functions measured by plethysmography correlated strongly with mortality. This respiratory distress, as well as reduced oxygen saturation, occurred beginning as early as 4 days before mortality. Affected medullary respiratory control cells may
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Penelope‐Georgia Papayanni, D. Chasiotis, Kiriakos Koukoulias et al. · 2021 · Clinical Infectious Diseases
BACKGROUND: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic poses an urgent need for the development of effective therapies for coronavirus disease 2019 (COVID-19). METHODS: We first tested SARS-CoV-2-specific…
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Kalpana Rajanala, Farokh Dotiwala, Arun K. Upadhyay · 2023 · Frontiers in Ophthalmology
Geographic atrophy (GA) is an advanced stage of age-related macular degeneration (AMD) that leads to gradual and permanent vision loss. GA is characterized by the loss of photoreceptor cells and retinal pigment epithelium (RPE), leading to distinct atrophic patches in the macula, which tends to increase with time. Patients with geographic atrophy often experience a gradual and painless loss of central vision, resulting in difficulty reading, recognizing faces, or performing activities that require detailed vision. The primary risk factor for the development of geographic atrophy is advanced ag
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Maria Fortunata Lofiego, Francesca Piazzini, Francesca Pia Caruso et al. · 2024 · Journal of Translational Medicine
BACKGROUND: Glioblastoma multiforme (GBM) is a highly aggressive primary brain tumor, that is refractory to standard treatment and to immunotherapy with immune-checkpoint inhibitors (ICI). Noteworthy, melanoma brain metastases (MM-BM), that share the same niche as GBM, frequently respond to current ICI therapies. Epigenetic modifications regulate GBM cellular proliferation, invasion, and prognosis and may negatively regulate the cross-talk between malignant cells and immune cells in the tumor milieu, likely contributing to limit the efficacy of ICI therapy of GBM. Thus, manipulating the tumor
View details →Failed Experiment ReportOpen accessPsychology
Li Fu, Roy P. C. Kessels, Joseph H. R. Maes · 2020 · Aging Neuropsychology and Cognition
Cognitive training research has revealed support for both the magnification and compensation accounts, respectively predicting larger or smaller training benefits for individuals already having strong cognitive abilities. A recent study in…
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Harm A.W.M. Tiddens, Eleni‐Rosalina Andrinopoulou, Joe McIntosh et al. · 2020 · PLoS ONE
A phase 3 randomized double blind controlled, trial in 238 people with cystic fibrosis (CF) and at least one nonsense mutation (nmCF) investigated the effect of ataluren on FEV1. The study was of 48 weeks duration and failed to meet its primary endpoint. Unexpectedly, while FEV1 declined, chest computed tomography (CT) scores using the Brody-II score as secondary outcome measures did not show progression in the placebo group. Based on this observation it was concluded that the role of CT scans in CF randomized clinical trials was limited. However, more sensitive scoring systems were developed
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Carmine Zoccali, Francesca Mallamaci, Luca De Nicola et al. · 2023 · Clinical Kidney Journal
Resistant hypertension (RH) is linked to an increased risk of cardiovascular and renal complications. Treatment options include non-pharmacological interventions, such as lifestyle modifications, and the use of specific antihypertensive…
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