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WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Corinna Ghirelli, Enkelejda Havari, Giulia Santangelo et al. · 2019 · International Journal of Manpower
Purpose The purpose of this paper is to evaluate a recent training programme for graduates, implemented in Italy and entitled Work Experience Laureati and Laureate, i.e. Work Experience for Graduates. The aim of the programme was to…
View details →Miguel Górgolas Hernández-Mora, Alfonso Cabello, Laura Prieto-Pérez et al. · 2020 · International Journal of Infectious Diseases
INTRODUCTION: Tocilizumab (TCZ) is an interleukin-6 receptor antagonist, which has been used for the treatment of severe SARS-CoV-2 pneumonia (SSP), which aims to ameliorate the cytokine release syndrome (CRS) induced acute respiratory…
View details →Hao Cheng, Xiaoying Zhang, Hui-dan Yang et al. · 2022 · Frontiers in Immunology
Objectives: We have reported previously that Belimumab, a human monoclonal antibody that inhibits B-cell activating factor(BAFF) could be an effective and safe option to treat Neuropsychiatric manifestations of SLE (NPSLE). To avoid inadequate efficacy of Belimumab and significant adverse events of often-used dose of cyclophosphamide (CYC) for SLE, we evaluated the efficacy, safety, and possible immune mechanisms of Belimumab treatment in combination with intermittent low-dose intravenous CYC for moderate-to-severe SLE. Methods: In this non blinded and parallel-group trial, we collected 82 cas
View details →Shipeng Gong, Ying-Ting Zhao, Yanhong Yu · 2011 · PubMed
AIM: To construct and examine models of the vascular networks using the technique of vascular corrosion casting in placentas collected from normal pregnancies and from pregnancies complicated by fetal growth restriction (FGR). METHODS:…
View details →Louis-Marie Galerneau, Sébastien Bailly, Jean‐Christian Borel et al. · 2020 · PLoS ONE
BACKGROUND: Obstructive sleep apnea (OSA) is associated with cardiovascular co-morbidities and mortality. Arterial stiffness is an independent predictor of cardiovascular risk and mortality, and is influenced by the presence of OSA and related comorbidities. There is a paucity of data regarding long-term evolution of arterial stiffness in CPAP-treated OSA patients. We aimed to prospectively study long term PWV variations and determinants of PWV deterioration. METHODS: In a prospective obese OSA cohort, at time of diagnosis and after several years of follow-up we collected arterial stiffness me
View details →Gustavo A. Ospina‐Tascón, José Luis Aldana, Alberto Garcı́a et al. · 2023 · Critical Care Medicine
OBJECTIVES: To investigate the effects of immediate start of norepinephrine versus initial fluid loading followed by norepinephrine on macro hemodynamics, regional splanchnic and intestinal microcirculatory flows in endotoxic shock.…
View details →Luigi Aurisicchio, Gennaro Ciliberto · 2011 · Cancers
Therapeutic vaccination against cancer is an important approach which, when combined with other therapies, can improve long-term control of cancer. In fact, the induction of adaptive immune responses against Tumor Associated Antigens (TAAs) as well as innate immunity are important factors for tumor stabilization/eradication. A variety of immunization technologies have been explored in last decades and are currently under active evaluation, such as cell-based, protein, peptide and heat-shock protein-based cancer vaccines. Genetic vaccines are emerging as promising methodologies to elicit immune
View details →Ayca Gucalp, Tiffany A. Traina · 2017 · Cancer
Patients with triple-negative breast cancer (TNBC) generally are considered a single clinical subgroup, defined by the lack of receptor expression, and are uniformly treated with cytotoxic chemotherapy. However, the advent of molecular…
View details →Jaime C. Sklar, Colten Wendel, Angela Zhang et al. · 2019 · Cornea
Purpose: To investigate the relationship between corneal collagen cross-linking (CXL) and the number of corneal transplants required for the treatment of keratoconus (KCN) in 2 major Canadian provinces. Methods: This is a retrospective…
View details →Jasmine C. Huynh, May Cho, Arta M. Monjazeb et al. · 2023 · Investigational New Drugs
BACKGROUND: Indoleamine-2,3-dioxygenase (IDO) helps orchestrate immune suppression and checkpoint inhibitor resistance in hepatocellular carcinoma (HCC). BMS-986,205 is a novel oral drug that potently and selectively inhibits IDO. This Phase I/II study evaluated the safety and tolerability of BMS-986,205 in combination with nivolumab as first-line therapy in advanced HCC. METHODS: IV on Day 1 of each 14-day cycle). The primary objective was to determine the safety and tolerability of this combination; secondary objectives were to obtain preliminary efficacy. RESULTS: Eight patients received a
View details →Elisa Thoral, Damien Roussel, Éric Gasset et al. · 2023 · Journal of Experimental Biology
Aquatic ecosystems can exhibit seasonal variation in resource availability and animals have evolved to cope with the associated caloric restriction. During winter in the NW Mediterranean Sea, the European sardine Sardina pilchardus…
View details →Guillaume Millot, Pauline Boddaert, Erika Parmentier-Decrucq et al. · 2018 · Annals of Translational Medicine
Background: Microaspiration is a major factor in ventilator-associated pneumonia (VAP) pathophysiology. Subglottic secretion drainage (SSD) aims at reducing its incidence. Methods: Single-center prospective observational study, performed…
View details →Zhengwu Lei, Dan Guo · 2021 · Blood Coagulation & Fibrinolysis
The purpose of this research is to investigate the correlation between coagulation parameters and survival on patients with breast cancer. A total of 244 patients with breast cancer and 84 patients with metastatic advanced breast cancer…
View details →Pate, KM, Pohlmeyer, C, Walker-Sperling, V et al. · 2015 · Journal of the International AIDS Society
Introduction Sensitive assays are needed for detection of residual HIV in patients with undetectable plasma viral loads to determine if eradication strategies are effective. The gold standard quantitative viral outgrowth assay (QVOA) underestimates the magnitude of the viral reservoir, while sensitive PCR-based assays lack the ability to distinguish replication competent from defective virus. We sought to determine whether xenograft of leukocytes from HIV-1 infected patients with undetectable plasma viral loads into severely immunocompromised mice would result in viral amplification and measur
View details →A.R.J.V. Vossen, H.H. van der Zee, N. Davelaar et al. · 2018 · Journal of the European Academy of Dermatology and Venereology
Abstract Background Treatment with apremilast has recently demonstrated clinically meaningful improvement in moderate hidradenitis suppurativa ( HS ). Objective To evaluate the change in expression of inflammatory markers in lesional skin…
View details →Yoshitaka Shimada, Yoshihito Takahashi, Hiroyoshi Iguchi et al. · 2013 · Journal of Medical Case Reports
Abstract Introduction Liver cavernous hemangioma is the most common noncystic hepatic lesion, and a hemangioma that undergoes degeneration and fibrous replacement is called a hepatic sclerosed hemangioma. Case presentation A 63-year-old…
View details →Shan Ren, Wenjing Wang, Junfeng Lu et al. · 2022 · Frontiers in Immunology
Objective In clinical practice, a substantial proportion of chronic hepatitis B virus (HBV) infections that do not fit into any of the usual immune states are considered to be in the “grey zone (GZ)”. This study aimed to investigate the…
View details →Juliana Chen, Harpreet Kaur, Joanna Jaques et al. · 2022 · Clinical Obesity
Summary Despite the obesity epidemic, there are relatively few multidisciplinary obesity services in Australia, and only limited data on the effectiveness of these services. The aim of this study was to evaluate the effectiveness of a…
View details →Jorge G. Ruiz, Allen D. Andrade, Ramanakumar Anam et al. · 2013 · The Diabetes Educator
Purpose The purpose of this study was to investigate whether computer-based programmed instruction (CPI) with a dynamic avatar (DA) improves retention of medication information better than text (controls) or better than CPI with text…
View details →Johan P. Mackenbach, Marina Karanikolos, Jamie Lopez Bernal et al. · 2015 · Scandinavian Journal of Public Health
Background: The upturn of life expectancy in Central and Eastern Europe in the 1990s, after a period of stagnation or even decline, is one of the main events in European population history of the late 20th century, but has not been…
View details →Winston A. Haynes, Kathy Kamath, Rebecca Waitz et al. · 2021 · Frontiers in Immunology
Identification of the antigens associated with antibodies is vital to understanding immune responses in the context of infection, autoimmunity, and cancer. Discovering antigens at a proteome scale could enable broader identification of…
View details →Melissa A. Snyder, Kieran McCann, Maryline J. Lalande et al. · 2016 · Journal of Neurochemistry
Abstract The sigma‐1 receptor (σ‐1R) is a chaperone protein located at the endoplasmic reticulum ( ER ) mitochondrial interface with roles in neuroprotection and cognition. Increasing evidence suggests that loss of σ‐1R function could…
View details →Lauren N. Forrest, Ross C. Jacobucci, Carlos M. Grilo · 2020 · Psychological Medicine
Abstract Background Eating-disorder severity indicators should theoretically index symptom intensity, impairment, and level of needed treatment. Two severity indicators for binge-eating disorder (BED) have been proposed (categories of…
View details →Hao Huang, Wei Song, Xue‐Yan Liu · 2021 · Global Change Biology
Abstract Anthropogenic nitrogen (N) emissions and deposition have been increasing over past decades. However, spatiotemporal variations of N deposition levels and major sources remain unclear in many regions, which hinders making…
View details →Volodymyr Dvornyk, Irina Ponomarenko, Oksana Minyaylo et al. · 2021 · PLOS ONE
Background and purpose The study analyzed the association of functionally significant polymorphisms of matrix metalloproteinases ( MMPs ) genes with the development of gastric ulcer (GU) in Caucasians from Central Russia. Methods The 781…
View details →Anne M Rowat, Catriona Graham, Martin Dennis · 2018 · BMJ Open Gastroenterology
Objective To establish the likely accuracy of pH testing to identify gastric aspirates at different pH cut-offs to confirm nasogastric tube placement. Methods This prospective observational study included a convenience sample of adult…
View details →Aydin Demircioğlu · 2023 · Diagnostics
In radiomics, utilizing features extracted from pretrained deep networks could result in models with a higher predictive performance than those relying on hand-crafted features. This study compared the predictive performance of models…
View details →Veeral Ajmera, Na Wang, Hanfei Xu et al. · 2023 · Alimentary Pharmacology & Therapeutics
Summary Background Adiposity amplifies the genetic risk of non‐alcoholic fatty liver disease (NAFLD). Aim We evaluated the association between overweight‐years, a cumulative exposure based on the product of the duration and severity of…
View details →Ihsen Abid, Nesrine Gafsi · 2025 · International Journal of Energy Economics and Policy
The purpose of this research paper is to examine the long-term dynamics between economic growth, technological integration, and environmental sustainability in Saudi Arabia from 1995 to 2023. It aims to identify the impact of key economic, technological, and environmental indicators, including GDP, ICT sector performance, foreign direct investment (FDI), trade, and ecological footprint, on the country’s development trajectory. The research employs a quantitative approach, using VAR-VECM models to analyze time-series data. The study applies Granger causality tests and impulse response functions
View details →Yi-Ting Chiu, Ariel Y. Deutch, Wei Wang et al. · 2026 · Nature Neuroscience
ABSTRACT Psychedelic drugs like lysergic acid diethylamide (LSD) and psilocybin have emerged as potentially transformative therapeutics for many neuropsychiatric diseases, including depression, anxiety, post-traumatic stress disorder,…
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