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19,810 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessEnvironmental Science

The Origins and Control of Forest Fires in the Tropics

Clare Balboni, Robin Burgess, Benjamin Olken · 2025 · The Review of Economic Studies

Abstract Environmental externalities—uncompensated damages imposed on others—lie at the root of climate change, pollution, deforestation and biodiversity loss. Empirical evidence is limited, however, as to how externalities drive private decision making. We study one such behaviour, illegal tropical forest fires, using 15 years of daily satellite data covering over 107,000 fires across Indonesia. Weather-induced variation in fire spread risk and variation in who owns surrounding land allow us to identify how far externalities influence the decision to use fire. Relative to when all spread risk

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Gut Microbiota-Derived Short-Chain Fatty Acids in Inflammatory Bowel Disease: Mechanistic Insights into Gut Inflammation, Barrier Function, and Therapeutic Potential

Roberta Ottria, Susan Mirmajidi, Pierangela Ciuffreda · 2026 · International Journal of Molecular Sciences

This review delves into the complex relationship between short-chain fatty acids (SCFAs) produced by the gut microbiota and inflammatory bowel disease (IBD). IBD, which includes Crohn's disease and ulcerative colitis, is a group of chronic gastrointestinal disorders with an increasing global incidence. Despite extensive research, the exact etiopathogenesis remains elusive, although a complex interplay involving genetic predisposition, environmental influences, and abnormal immune responses against commensal gut microbes is widely recognized. SCFAs, primarily acetate and butyrate, emerge as key

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Negative / Null Result ReportOpen accessImmunology and Microbiology

A comprehensive overview of probiotics in aquaculture: from efficacy evaluation to diverse applications

Sanaa R. Elsegeny, Fatima S. Radwan, Yomna M. Elshamy et al. · 2025 · Annals of Microbiology

Abstract Background Aquaculture is an essential sector for global food security, providing protein-rich food, reducing pressure on wild stocks, creating jobs, and contributing to national economies. However, it faces major sustainability challenges, including disease outbreaks, inefficient feed utilization, and environmental impact. Main body The significance of probiotics in mitigating these issues is highlighted in this review. The current review underscores and highlights important considerations while developing or using probiotics in the aquaculture field: how strains are selected as cand

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Phylogenetic Analysis of Murine Leukemia Virus Sequences from Longitudinally Sampled Chronic Fatigue Syndrome Patients Suggests PCR Contamination Rather than Viral Evolution

Aris Katzourakis, Stéphane Hué, Paul Kellam et al. · 2011 · Journal of Virology

Xenotropic murine leukemia virus (MLV)-related virus (XMRV) has been amplified from human prostate cancer and chronic fatigue syndrome (CFS) patient samples. Other studies failed to replicate these findings and suggested PCR contamination…

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Negative / Null Result ReportOpen accessPsychology

Fourteen-Month-Olds Adapt Their Imitative Behavior in Light of a Model’s Constraints

Kata Gellén, David Buttelmann · 2017 · Child Development Research

Rather than reenacting every action they observe, preverbal infants adapt their imitative behavior. Although previous studies have revealed the capability of preverbal infants to imitate selectively, the question about the adaptability of this behavior on an individual level did not attract considerable scientific attention until now. In the current study, we investigated whether 14-month-old infants flexibly alternate their imitative response in accordance with a model’s changing physical constraints in a body-part imitation paradigm. Participants were presented with two novel actions whereby

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Negative / Null Result ReportOpen accessMedicine

Lack of replication of higher genetic risk load in men than in women with systemic lupus erythematosus

Elisa Alonso‐Perez, Marian Suarez-Gestal, Manuel Calaza et al. · 2014 · Arthritis Research & Therapy

INTRODUCTION: We aimed to replicate a recent study which showed higher genetic risk load at 15 loci in men than in women with systemic lupus erythematosus (SLE). This difference was very significant, and it was interpreted as indicating that men require more genetic susceptibility than women to develop SLE. METHODS: Nineteen SLE-associated loci (thirteen of which are shared with the previous study) were analyzed in 1,457 SLE patients and 1,728 healthy controls of European ancestry. Genetic risk load was calculated as sex-specific sum genetic risk scores (GRS(s)). RESULTS: Our results did not r

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Cross-Ancestry DNA Methylation Marks of Insulin Resistance in Pregnancy: An Integrative Epigenome-Wide Association Study

Nicolás Fragoso-Bargas, Hannah R. Elliott, Sindre Lee-Ødegård et al. · 2022 · Diabetes

Although there are some epigenome-wide association studies (EWAS) of insulin resistance, for most of them authors did not replicate their findings, and most are focused on populations of European ancestry, limiting the generalizability. In…

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Negative / Null Result ReportOpen accessMedicine

Feasibility of two levels of protein intake in patients with colorectal cancer: findings from the Protein Recommendation to Increase Muscle (PRIMe) randomized controlled pilot trial

Katherine L. Ford, Michael B. Sawyer, Sunita Ghosh et al. · 2024 · ESMO Open

•Patients were able to increase and sustain dietary protein intake from preintervention levels.•Over one-half of patients in the 2.0 g/kg/day group maintained or gained MM with a 12-week targeted nutrition intervention.•This work…

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Negative / Null Result ReportMedicine

The effects of prehospital TXA on mortality and neurologic outcomes in patients with traumatic intracranial hemorrhage: A subgroup analysis from the prehospital TXA for TBI trial

Susan Rowell, Eric N. Meier, Tatiana Hoyos Gomez et al. · 2024 · The Journal of Trauma: Injury, Infection, and Critical Care

BACKGROUND: In the prehospital tranexamic acid (TXA) for traumatic brain injury (TBI) trial, TXA administered within 2 hours of injury in the out-of-hospital setting did not reduce mortality in all patients with moderate/severe traumatic…

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Negative / Null Result ReportOpen accessImmunology and Microbiology

Laquinimod Modulates Human Astrocyte Function and Dampens Astrocyte-Induced Neurotoxicity during Inflammation

Emanuela Colombo, Rosaria Pascente, Daniela Triolo et al. · 2020 · Molecules

Astrocytes greatly participate to inflammatory and neurotoxic reactions occurring in neurodegenerative diseases and are valuable pharmacological targets to support neuroprotection. Here we used human astrocytes generated from reprogrammed fibroblasts as a cellular model to study the effect of the compound Laquinimod and its active metabolite de-Laquinimod on astrocyte functions and the astrocyte-neuron interaction. We show that human iAstrocytes expressed the receptor for the inflammatory mediator IL1 and responded to it via nuclear translocation of NFκB, an event that did not occur if cells w

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Negative / Null Result ReportOpen accessNeuroscience

Wearable EEG-Based Brain–Computer Interface for Stress Monitoring

Brian Premchand, Liyuan Liang, Kok Soon Phua et al. · 2024 · NeuroSci

Detecting stress is important for improving human health and potential, because moderate levels of stress may motivate people towards better performance at cognitive tasks, while chronic stress exposure causes impaired performance and health risks. We propose a Brain-Computer Interface (BCI) system to detect stress in the context of high-pressure work environments. The BCI system includes an electroencephalogram (EEG) headband with dry electrodes and an electrocardiogram (ECG) chest belt. We collected EEG and ECG data from 40 participants during two stressful cognitive tasks: the Cognitive Vig

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

The gut-lung axis: effects and mechanisms of gut microbiota on pulmonary diseases

Jiayi Liu, Weichen Hong, Zhendong Sun et al. · 2026 · Frontiers in Immunology

The proposal of the gut-lung axis has profoundly reshaped our understanding of the mechanisms underlying respiratory diseases. As a crucial component of this axis, the gut microbiota plays a central role in pulmonary immune regulation through inter-organ communication mediated by metabolic products. However, a systematic integration of mechanisms explaining how gut microbes achieve precise cross-organ immune regulation remains elusive. Existing research predominantly focuses on descriptive observations, such as the association between early-life microbiota dysbiosis and an increased risk of as

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Negative / Null Result ReportOpen accessEngineering

Mathematical Modeling of Operational Reliability of Mine Lifting Equipment Based on Censored Data

Denis A. Zadkov, Nikita MARTYUSHEV, Boris V. Malozyomov et al. · 2026 · Mathematics

In this study, a comprehensive mathematical method for modeling the operational reliability of mine hoisting equipment under conditions of incomplete and heavily censored data is developed. The analyzed dataset includes 259 observations collected over a five-year period for six critical components, with the overall level of censoring reaching 62% and exceeding 70% for long life mechanical subsystems. Considering right, left, and interval censoring, the paper proposes a unified statistical procedure that combines empirical estimation of failure rates with parametric identification using Weibull

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

A Deep Learning and Explainable AI-Based Approach for the Classification of Discomycetes Species

Aras Fahrettin Korkmaz, Fatih Ekinci, Şehmus Altaş et al. · 2025 · Biology

This study presents a novel approach for classifying Discomycetes species using deep learning and explainable artificial intelligence (XAI) techniques. The EfficientNet-B0 model achieved the highest performance, reaching 97% accuracy, a 97% F1-score, and a 99% AUC, making it the most effective model. MobileNetV3-L followed closely, with 96% accuracy, a 96% F1-score, and a 99% AUC, while ShuffleNet also showed strong results, reaching 95% accuracy and a 95% F1-score. In contrast, the EfficientNet-B4 model exhibited lower performance, achieving 89% accuracy, an 89% F1-score, and a 93% AUC. These

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Negative / Null Result ReportOpen accessMedicine

Relationship between central autonomic effective connectivity and heart rate variability: A Resting-state fMRI dynamic causal modeling study

Liangsuo Ma, Larry Keen, Joel L. Steinberg et al. · 2024 · NeuroImage

• Resting- state fMRI data were acquired from 34 healthy participants. • Effective connectivities (ECs) associated with HRV and heart rate were investigated. • Regression DCM and ICA were used to identify most relevant network nodes. • ECs…

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Negative / Null Result ReportOpen accessHealth Professions

Changes in Clinician Time Expenditure and Visit Quantity With Adoption of Artificial Intelligence–Powered Scribes

Lisa S. Rotenstein, A. Jay Holmgren, Robert Thombley et al. · 2026 · JAMA

Importance: Artificial intelligence (AI)-enabled scribes have been proposed to reduce electronic health record (EHR) burden and improve clinician satisfaction. There is limited evidence about their associated results across multiple sites…

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Negative / Null Result Report

“The more you did, the more it made sense”: Problem‐based learning to improve early evidence‐based practice in an undergraduate physiotherapy professional programme

Olive Lennon, Deirdre Phelan, Deborah Wallace et al. · 2019 · Physiotherapy Research International

Abstract Background and Purpose Evidence‐based practice (EBP), which integrates clinical reasoning skills, research evidence, and patient preference, has become standard in curricula for health care professional programs. Students however…

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Negative / Null Result Report

Eight Days of L-Citrulline or L-Arginine Supplementation Did Not Improve 200-m and 100-m Swimming Time Trials

Ozcan Esen, Mustafa Can Eser, Mekki Abdioglu et al. · 2022 · International Journal of Environmental Research and Public Health

The effects of L-citrulline or L-arginine supplementation on exercise performance are equivocal, and the effects on swimming performance are unclear. We aimed to assess whether 8-day supplementation with L-arginine or L-citrulline…

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Negative / Null Result Report

Physical activity and prenatal depression: going beyond statistical significance by assessing the impact of reliable and clinical significant change

Marina Vargas-Terrones, Taniya S. Nagpal, Maria Perales et al. · 2020 · Psychological Medicine

Abstract Background Previous literature supports exercise as a preventative agent for prenatal depression; however, treatment effects for women at risk for prenatal depression remain unexplored. The purpose of the study was to examine…

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