Negative / Null Result ReportOpen accessMedicine
Matilde Negrini, Giuseppe Tomasello, Marcus Davidsson et al. · 2022 · Journal of Parkinson s Disease
BACKGROUND: Preclinical rodent models for Parkinson's disease (PD) based on viral human alpha-synuclein (h-αSyn) overexpression recapitulate some of the pathological hallmarks as it presents in humans, such as progressive cell loss and additional synucleinopathy in cortical and subcortical structures. Recent studies have combined viral vector-based overexpression of human wild-type αSyn with the sequential or simultaneous inoculation of preformed fibrils (PFFs) derived from human αSyn. OBJECTIVE: The goal of the study was to investigate whether sequential or combined delivery of the AAV vector
View details →DOI: 10.3233/jpd-212555Cited by 27 Negative / Null Result ReportOpen accessMedicine
Mario Musella, Giovanna Berardi, Nunzio Velotti et al. · 2021 · Obesity Surgery
BACKGROUND: The laparoscopic sleeve gastrectomy (LSG) is the most common bariatric procedure performed worldwide while the laparoscopic adjustable gastric banding (LAGB) has been almost abandoned. Aim of this study was to retrospectively assess 10-year outcomes of LSG through a matched comparison with LAGB. MATERIALS AND METHODS: Retrospective search of prospectively maintained database of our university was carried out to find all patients that underwent LSG before December 2010. Each subject with LSG was matched one-to-one with a patient that had undergone LAGB in the same period with corres
View details →DOI: 10.1007/s11695-021-05735-wCited by 27 Negative / Null Result ReportOpen accessMedicine
Chao Yang, Jianqing Zhao, Lan Lin et al. · 2015 · Frontiers in Cellular and Infection Microbiology
Streptococcus suis (S.suis), a major swine pathogen, is also a severe threat to human health. Infection with highly virulent strains of S. suis can cause human Streptococcal toxic-shock-like syndrome (STSLS), which is associated with high serum pro-inflammatory cytokine levels and a high mortality rate. Our previous study indicated that highly virulent S. suis infection could activate the TREM-1 signaling pathway, which promotes host clearance of S. suis during early infection. However, it remained to be elicited whether TREM-1 signaling could be a target against STSLS in the presence of antib
View details →DOI: 10.3389/fcimb.2015.00079Cited by 27 Negative / Null Result ReportOpen accessArts and Humanities
Taro Oshikiri, 押切, 太郎, オシキリ, タロウ et al. · 2023 · Kobe University Repository Kernel (Kobe University)
Objective: To clarify whether routine thoracic duct (TD) resection improves the prognosis of patients with esophageal cancer after radical esophagectomy. Summary Background Data: Although TD resection can cause nutritional disadvantage and…
Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Ahmad Karimi, Yuna Min, C. Lu et al. · 2012 · Poultry Science
A total of 540 one-day-old male broiler chicks were used to evaluate the potential enhancing effects of a mixture of 2 commercial carbohydrase preparations on phytase efficacy. A nonphytate phosphorus (nPP) deficient diet (0.15%) was…
View details →DOI: 10.3382/ps.2012-02558Cited by 27 Negative / Null Result ReportOpen accessMedicine
Albert J. Auguste, Rose M. Langsjoen, Danielle L. Porier et al. · 2021 · Virology
We describe the isolation and characterization of a novel insect-specific flavivirus (ISFV), tentatively named Aripo virus (ARPV), that was isolated from Psorophora albipes mosquitoes collected in Trinidad. The ARPV genome was determined…
View details →DOI: 10.1016/j.virol.2021.07.004Cited by 27 Negative / Null Result ReportOpen accessMedicine
Jessica Oi‐Ling Tsang, Jie Zhou, Xiaoyu Zhao et al. · 2021 · Biomedicines
Enteroviruses are important causes of hand, foot, and mouth disease, respiratory infections, and neurological infections in human. A major hurdle for the development of anti-enterovirus agents is the lack of physiologically relevant evaluation platforms that closely correlate with the in vivo state. We established the human small intestinal organoids as a novel platform for characterizing the viral replication kinetics and evaluating candidate antivirals for enteroviruses. The organoids supported productive replication of enterovirus (EV)-A71, coxsackievirus B2, and poliovirus type 3, as evide
View details →DOI: 10.3390/biomedicines9010088Cited by 27 Negative / Null Result ReportOpen accessPsychology
Kathryn J. Lester, Susanna Roberts, Robert Keers et al. · 2015 · The British Journal of Psychiatry
BACKGROUND: We previously reported an association between 5HTTLPR genotype and outcome following cognitive-behavioural therapy (CBT) in child anxiety (Cohort 1). Children homozygous for the low-expression short-allele showed more positive…
View details →DOI: 10.1192/bjp.bp.114.154997Cited by 27 Negative / Null Result ReportOpen accessEnvironmental Science
William L. Baker, Mark A. Williams · 2018 · Ecological Applications
An understanding of how historical fire and structure in dry forests (ponderosa pine, dry mixed conifer) varied across the western United States remains incomplete. Yet, fire strongly affects ecosystem services, and forest restoration…
View details →DOI: 10.1002/eap.1688Cited by 27 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Shahzad Ahmad, Adelina Orellana, Isabelle Köhler et al. · 2020 · Alzheimer s Research & Therapy
BACKGROUND: Lysophosphatidic acids (LPAs) are bioactive signaling phospholipids that have been implicated in Alzheimer's disease (AD). It is largely unknown whether LPAs are associated with AD pathology and progression from mild cognitive impairment (MCI) to AD. METHODS: The current study was performed on cerebrospinal fluid (CSF) and plasma samples of 182 MCI patients from two independent cohorts. We profiled LPA-derived metabolites using liquid chromatography-mass spectrometry. We evaluated the association of LPAs with CSF biomarkers of AD, Aβ-42, p-tau, and total tau levels overall and stra
View details →DOI: 10.1186/s13195-020-00680-9Cited by 27 Negative / Null Result ReportMedicine
Sindu Vivekanandan, Richard Breene, Ramya Ramanujachar et al. · 2015 · Pediatric Blood & Cancer
BACKGROUND: Historically, the 5-year overall survival (OS) for metastatic medulloblastoma (MMB) was less than 40%. The strategy of post-operative induction chemotherapy (IC) followed by hyperfractionated accelerated radiotherapy (HART) and…
View details →DOI: 10.1002/pbc.25663Cited by 27 Negative / Null Result ReportOpen accessMedicine
Samuel Antwi‐Baffour, Jonathan Kofi Adjei, Peter Owadee Forson et al. · 2019 · Anemia
BACKGROUND: Glucose-6-phosphate dehydrogenase (G6PD) converts glucose-6-phosphate into 6-phosphogluconate in the pentose phosphate pathway and protects red blood cells (RBCs) from oxidative damage. Their deficiency therefore makes RBCs prone to haemolysis. Sickle cell disease (SCD) on the other hand is a hereditary blood disorder in which there is a single nucleotide substitution in the codon for amino acid 6 substituting glutamic acid with valine. SCD patients are prone to haemolysis due to the shape of their red blood cells and if they are deficient in G6PD, the haemolysis may escalate. Repo
View details →DOI: 10.1155/2019/3179173Cited by 27 Negative / Null Result ReportOpen accessNeuroscience
Recep A. Ozdemir, Sofia Kirkman, Justine R. Magnuson et al. · 2022 · Neuroimage Reports
Prior studies have suggested that oscillatory activity in cortical networks can modulate stimulus-evoked responses through time-varying fluctuations in neural excitation-inhibition dynamics. Studies combining transcranial magnetic…
View details →DOI: 10.1016/j.ynirp.2022.100132Cited by 27 Negative / Null Result ReportMaterials Science
Chun Zhu, Jinxia Liang, Binju Wang et al. · 2012 · Physical Chemistry Chemical Physics
The electronic and structural features of (oxo)manganese(V) corroles and their catalyzed oxygen atom transfers to thioanisole in different spin states have been investigated by the B3LYP functional calculations. Calculations show that…
View details →DOI: 10.1039/c2cp41647fCited by 27 Negative / Null Result ReportMedicine
Christopher J. Green, Jeffrey M P Holly, Antony Bayer et al. · 2014 · Journal of Alzheimer s Disease
BACKGROUND: The increasing incidence of cognitive impairment and dementia in an aging population poses a significant burden on healthcare. Consequently, identifying modifiable physiological factors which may influence the onset of…
View details →DOI: 10.3233/jad-132183Cited by 27 Negative / Null Result ReportMedicine
Alexandra Calmy, Mark Bloch, Handan Wand et al. · 2010 · HIV Medicine
BACKGROUND: Lipoatrophy can complicate thymidine analogue nucleoside reverse transcriptase inhibitor (tNRTI)-based antiretroviral therapy (ART). Lipoatrophy may be less likely with ART including ritonavir-boosted lopinavir (LPV/r). Small,…
View details →DOI: 10.1111/j.1468-1293.2009.00817.xCited by 27 Negative / Null Result ReportOpen accessMedicine
Kimberly L. Armstrong, Tun‐Hou Lee, Max Essex · 2011 · Antimicrobial Agents and Chemotherapy
Single-dose nevirapine (NVP) is quite effective in preventing transmission of the human immunodeficiency virus (HIV) from mother to child; however, many women develop resistance to NVP in this setting. Comparing outcomes of clinical studies reveals an increased amount of resistance in subtype C relative to that in other subtypes. This study investigates how nonnucleoside reverse transcriptase inhibitor (NNRTI) drug resistance mutations of subtype C affect replication capacity. The 103N, 106A, 106M, 181C, 188C, 188L, and 190A drug resistance mutations were placed in a reverse transcriptase (RT)
View details →DOI: 10.1128/aac.01505-10Cited by 27 Negative / Null Result ReportOpen accessPsychology
John F. Magnotti, Michael S. Beauchamp · 2018 · PLoS ONE
A common measure of multisensory integration is the McGurk effect, an illusion in which incongruent auditory and visual speech are integrated to produce an entirely different percept. Published studies report that participants who differ in age, gender, culture, native language, or traits related to neurological or psychiatric disorders also differ in their susceptibility to the McGurk effect. These group-level differences are used as evidence for fundamental alterations in sensory processing between populations. Using empirical data and statistical simulations tested under a range of conditio
View details →DOI: 10.1371/journal.pone.0202908Cited by 27 Negative / Null Result ReportComputer Science
Lu Yu, Jason Schwier, Ryan Craven et al. · 2013 · IEEE Transactions on Knowledge and Data Engineering
Hidden Markov models (HMMs) are used to analyze real-world problems. We consider an approach that constructs minimum entropy HMMs directly from a sequence of observations. If an insufficient amount of observation data is used to generate…
View details →DOI: 10.1109/tkde.2012.93Cited by 27 Negative / Null Result ReportOpen accessPsychology
Bartosz Sobczyk, Paweł Dobrowolski, Maciek Skorko et al. · 2015 · Frontiers in Psychology
The impact of video game playing on cognitive abilities has been the focus of numerous studies over the last 10 years. Some cross-sectional comparisons indicate the cognitive advantages of video game players (VGPs) over non-players (NVGPs) and the benefits of video game trainings, while others fail to replicate these findings. Though there is an ongoing discussion over methodological practices and their impact on observable effects, some elementary issues, such as the representativeness of recruited VGP groups and lack of genre differentiation have not yet been widely addressed. In this articl
View details →DOI: 10.3389/fpsyg.2015.01451Cited by 27 Negative / Null Result ReportEnvironmental Science
Amber White, Michelle Nault, Katherine D. McMahon et al. · 2022 · Environmental Science & Technology
Laboratory studies used to assess the environmental fate of organic chemicals such as pesticides fail to replicate environmental conditions, resulting in large errors in predicted transformation rates. We combine laboratory and field data…
View details →DOI: 10.1021/acs.est.2c03132Cited by 27 Negative / Null Result ReportOpen accessPsychology
Nori Jacoby, Merav Ahissar · 2015 · Journal of Vision
In the 1980s to 1990s, studies of perceptual learning focused on the specificity of training to basic visual attributes such as retinal position and orientation. These studies were considered scientifically innovative since they suggested…
View details →DOI: 10.1167/15.10.6Cited by 27 Negative / Null Result ReportMedicine
Ryan G. Overmayer, Matthew Driller · 2017 · International Journal of Sports Physiology and Performance
PURPOSE: To examine the efficacy of intermittent sequential pneumatic compression (ISPC) on exercise recovery and subsequent performance, when implemented between a 20-min cycling bout (simulated scratch race) and a 4-min cycling test…
View details →DOI: 10.1123/ijspp.2017-0207Cited by 27 Negative / Null Result ReportOpen accessMedicine
Kana Yoshioka, Akira Miyauchi, Mitsuhiro Fukushima et al. · 2016 · World Journal of Surgery
BACKGROUND: We reported phonatory recovery in the majority of 88 patients after recurrent laryngeal nerve (RLN) reconstruction. Here we analyzed factors that might influence the recovery, in a larger patient series. METHODS: At Kuma Hospital, 449 patients (354 females and 95 males) underwent RLN reconstruction with direct anastomosis, ansa cervicalis-to-RLN anastomosis, free nerve grafting, or vagus-to-RLN anastomosis; 47.4 % had vocal cord paralysis (VCP) preoperatively. Maximum phonation time (MPT) and mean airflow rate during phonation (MFR) were measured 1 year post surgery. Forty patients
View details →DOI: 10.1007/s00268-016-3634-7Cited by 27 Negative / Null Result ReportOpen accessMedicine
Meghan A. Baker, Bethany Baer, Martin Kulldorff et al. · 2019 · PLoS Medicine
BACKGROUND: Kawasaki disease is an acute vasculitis that primarily affects children younger than 5 years of age. Its etiology is unknown. The United States Vaccine Safety Datalink conducted postlicensure safety surveillance for 13-valent pneumococcal conjugate vaccine (PCV13), comparing the risk of Kawasaki disease within 28 days of PCV13 vaccination with the historical risk after 7-valent PCV (PCV7) vaccination and using chart-validation. A relative risk (RR) of 2.38 (95% CI 0.92-6.38) was found. Concurrently, the Food and Drug Administration (FDA) conducted a postlicensure safety review that
View details →DOI: 10.1371/journal.pmed.1002844Cited by 27 Negative / Null Result Report
Takudzwa C. Madzivanzira, Josie South, Olaf L. F. Weyl · 2021 · Freshwater Biology
Abstract Data on ecological impacts of freshwater crayfish invasions in Africa are scarce but invasion history suggests the likelihood of negative implications for biodiversity. To evaluate the potential for ecological impacts we describe…
View details →DOI: 10.1111/fwb.13691Cited by 27 Negative / Null Result ReportOpen accessEnvironmental Science
Kate M. Quigley, Magena R. Marzonie, Blake D. Ramsby et al. · 2021 · Frontiers in Marine Science
Novel restoration methods are currently under consideration worldwide to help coral reefs recover or become more resilient to higher temperature stress. Critical field-based information concerning the paradigm of “local is best” is lacking for many methods; information which is essential to determine the risk and feasibility associated with restoration. One method involves breeding corals from different reef regions with expected variation in heat tolerance and moving those offspring to new locations to enhance offspring survival; thereby augmenting local stock to enhance survival for anticipa
View details →DOI: 10.3389/fmars.2021.636177Cited by 27 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Mulundu Mwila, Blessing Mhlanga, Christian Thierfelder · 2021 · Scientific Reports
Abstract Declining soil fertility and negative impacts of climate effects threaten the food security of millions in Africa. Conservation Agriculture (CA) is a promising strategy to address these challenges. However, lack of viable economic entry points and short-term benefits for smallholders limit its adoption. Legume intensification can possibly increase the output per unit area, thus making the system more attractive. Rotations of maize with intensified legume systems were tested for three consecutive years under ridge and furrow (RF) tillage and CA to investigate: (a) increases in producti
View details →DOI: 10.1038/s41598-021-87594-0Cited by 27 Negative / Null Result Report
Talia Gonda, Frank P Deane, Ganapathi Murugesan · 2012 · Australian & New Zealand Journal of Psychiatry
Objective: The first aim of this study was to assess the proportion of patients who achieved reliable and clinically significant change over the course of treatment in an inpatient psychosocial rehabilitation program. The second aim was to…
View details →DOI: 10.1177/0004867412445527Cited by 27 Negative / Null Result Report
Jaeseok Bae, Jungjae Park, Heulbi Ahn et al. · 2021 · Optics Express
In this study, an optical method that allows simultaneous thickness measurements of two different layers distributed over a broad thickness range from several tens of nanometers to a few millimeters based on the integration of a…
View details →DOI: 10.1364/oe.440507Cited by 27 