Negative / Null Result ReportOpen accessMedicine
Sara Lindström, Fredrick R. Schumacher, Daniele Campa et al. · 2012 · Cancer Epidemiology Biomarkers & Prevention
BACKGROUND: A recent genome-wide association study (GWAS) of prostate cancer in a Japanese population identified five novel regions not previously discovered in other ethnicities. In this study, we attempt to replicate these five loci in a…
View details →DOI: 10.1158/1055-9965.epi-11-0870-tCited by 29 Negative / Null Result ReportOpen accessMedicine
Linda Zaharenko, Ineta Kalniņa, Kristine Geldnere et al. · 2016 · European Journal of Endocrinology
Objective(s) High variability in clinical response to metformin is often observed in type 2 diabetes (T2D) patients, and it highlights the need for identification of genetic components affecting the efficiency of metformin therapy. Aim of…
View details →DOI: 10.1530/eje-16-0347Cited by 29 Negative / Null Result ReportOpen accessMedicine
Cerissa L. Blaney, Mark L. Robbins, Andrea L. Paiva et al. · 2012 · American Journal of Health Promotion
PURPOSE: African-Americans have high rates of physical inactivity-related morbidity and mortality, thus effective interventions to increase exercise are necessary. Tailored interventions show promise, but measures need validation in this…
View details →DOI: 10.4278/ajhp.091214-quan-393Cited by 29 Negative / Null Result ReportNeuroscience
Harrison E. Vieth, Katie L. McMahon, Greig I. de Zubicaray · 2014 · Quarterly Journal of Experimental Psychology
How does the presence of a categorically related word influence picture naming latencies? In order to test competitive and noncompetitive accounts of lexical selection in spoken word production, we employed the picture-word interference…
View details →DOI: 10.1080/17470218.2014.923922Cited by 29 Negative / Null Result ReportOpen accessMedicine
Camila S. Halal, Diego G. Bassani, Iná S. Santos et al. · 2020 · Journal of Sleep Research
This study used data from 2,222 mothers and infants participating in a population-based birth cohort to verify whether maternal depression in the perinatal period was associated with poor infant sleep. Mothers who scored ≥13 points on the…
View details →DOI: 10.1111/jsr.13047Cited by 28 Negative / Null Result ReportOpen accessMathematics
Mathieu Guillaumé, Christine Schiltz, Amandine Van Rinsveld · 2020 · Journal of Numerical Cognition
Basic numerical abilities are generally assumed to influence more complex cognitive processes involving numbers, such as mathematics. Yet measuring non-symbolic number abilities remains challenging due to the intrinsic correlation between numerical and non-numerical dimensions of any visual scene. Several methods have been developed to generate non-symbolic stimuli controlling for the latter aspects but they tend to be difficult to replicate or implement. In this study, we describe the NASCO method, which is an extension to the method popularized by Dehaene, Izard, and Piazza (2005). Their pro
View details →DOI: 10.5964/jnc.v6i1.231Cited by 28 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
William R. Scott, Weihua Zhang, Marie Loh et al. · 2016 · PLoS ONE
South Asians are 1/4 of the world's population and have increased susceptibility to central obesity and related cardiometabolic disease. Knowledge of genetic variants affecting risk of central obesity is largely based on genome-wide association studies of common SNPs in Europeans. To evaluate the contribution of DNA sequence variation to the higher levels of central obesity (defined as waist hip ratio adjusted for body mass index, WHR) among South Asians compared to Europeans we carried out: i) a genome-wide association analysis of >6M genetic variants in 10,318 South Asians with focused analy
View details →DOI: 10.1371/journal.pone.0155478Cited by 28 Negative / Null Result ReportOpen accessPsychology
Matt Field, Lisa Di Lemma, Paul Christiansen et al. · 2016 · Psychology of Addictive Behaviors
Alcohol dependence is characterized by conflict between approach and avoidance motivational orientations for alcohol that operate in automatic and controlled processes. This article describes the first study to investigate the predictive validity of these motivational orientations for relapse to drinking after discharge from alcohol detoxification treatment in alcohol-dependent patients. One hundred twenty alcohol-dependent patients who were nearing the end of inpatient detoxification treatment completed measures of self-reported (Approach and Avoidance of Alcohol Questionnaire; AAAQ) and auto
View details →DOI: 10.1037/adb0000232Cited by 28 Negative / Null Result ReportOpen accessDecision Sciences
Anton Olsson-Collentine, Robbie C. M. van Aert, Marjan Bakker et al. · 2023 · Psychological Methods
-hacking) from this "multiverse" of outcomes can inflate effect size estimates and false positive rates. We studied the effects of researcher degrees of freedom and selective reporting using empirical data from extensive multistudy…
View details →DOI: 10.1037/met0000559Cited by 28 Negative / Null Result ReportOpen accessPsychology
Paweł A. Atroszko, Bartosz Atroszko, Edyta Charzyńska · 2021 · International Journal of Environmental Research and Public Health
Background: Relatively strong theoretical assumptions and previous studies concerning co-occurring addictive behaviors suggest a subpopulation representing general proclivity to behavioral addictions (BAs), and there are gender-specific subpopulations. This study aimed to compare latent profile analysis (LPA) and latent class analysis (LCA) as the methods of investigating different clusters of BAs in the general student population and among students positively screened for at least one BA. Participants and procedure: Analyses of six BAs (study, shopping, gaming, Facebook, pornography, and food
View details →DOI: 10.3390/ijerph18168590Cited by 28 Negative / Null Result ReportOpen accessMedicine
David Baumeister, Wolfgang Eich, Silvia Saft et al. · 2019 · Scientific Reports
There has been a surging interest in the putative role of peripheral growth factors in the pathophysiology of fibromyalgia, specifically in the peripheral sensitization that occurs in chronic pain disorders. This cross-sectional study set out to assess and compare brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in plasma samples from fibromyalgia patients and healthy controls. Plasma BDNF and NGF were measured in 89 fibromyalgia patients and 36 pain-free controls, and compared using ANCOVA controlling for potential confounders, as well as Bayesian methods for parameter e
View details →DOI: 10.1038/s41598-019-49403-7Cited by 28 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Ismaïl Ahmed, Pei‐Chen Lee, Christina M. Lill et al. · 2014 · PLoS Genetics
The etiology of Parkinson disease (PD) involves both genetic susceptibility and environmental exposures. In particular, coffee consumption is inversely associated with PD but the mechanisms underlying this intriguing association are unknown. According to a recent genome-wide gene-environment interaction study, the inverse coffee-PD association was two times stronger among carriers of the T allele of SNP rs4998386 in gene GRIN2A than in homozygotes for the C allele. We attempted to replicate this result in a similarly sized pooled analysis of 2,289 cases and 2,809 controls from four independent
View details →DOI: 10.1371/journal.pgen.1004788Cited by 28 Negative / Null Result ReportOpen accessHealth Professions
Cecilia Elam, Per Aagaard, Frode Slinde et al. · 2021 · Journal of Physical Therapy Science
[Purpose] To examine the effects of age and gender in an ageing population with respect to functional decline and the relationship between muscle power and functional capacity. [Participants and Methods] The cohort (N=154) was subdivided…
View details →DOI: 10.1589/jpts.33.250Cited by 28 Negative / Null Result ReportNeuroscience
Tong He, Ru Kong, Avram J. Holmes et al. · 2018
In recent years, deep learning has transformed the field of machine learning. In the field of neuroimaging, there are increasing interests in adopting deep learning techniques. However, deep neural networks (DNNs) usually need large…
View details →DOI: 10.1109/prni.2018.8423958Cited by 28 Negative / Null Result ReportOpen accessMedicine
Wouter M. IJgosse, Harry van Goor, Camiel Rosman et al. · 2020 · JMIR Serious Games
Background Surgical residents underutilize opportunities for traditional laparoscopic simulation training. Serious gaming may increase residents’ motivation to practice laparoscopic skills. However, little is known about the effectiveness of serious gaming for laparoscopic skills training. Objective The aim of this study was to establish construct validity for the laparoscopic serious game Underground. Methods All study participants completed 2 levels of Underground. Performance for 2 novel variables (time and error) was compared between novices (n=65, prior experience <10 laparoscopic proc
View details →DOI: 10.2196/17222Cited by 28 Negative / Null Result ReportOpen accessEngineering
Nour El Din El Sheikh, Esteban Paz, Juan Pinto et al. · 2021
The blocking performance of a heuristic and a deep reinforcement learning approach for resource provisioning in a dynamic multi-band elastic optical network is evaluated. The heuristic is based on a previous proposal that prioritises the…
View details →DOI: 10.23919/ondm51796.2021.9492334Cited by 28 Negative / Null Result ReportMedicine
Shahar Shelly, Pritikanta Paul, Hong‐Yan Bi et al. · 2020 · Neurology
OBJECTIVE: To improve myasthenia gravis (MG) autoantibody testing. METHODS: MG serologic tests with confirmatory or refuting clinical-electrodiagnostic (EDX) testing and cancer evaluations were reviewed over 4 years (2012-2015). All…
View details →DOI: 10.1212/wnl.0000000000010910Cited by 28 Negative / Null Result ReportOpen accessImmunology and Microbiology
D. Beaujean, Fedor Gassner, A Wong et al. · 2016 · BMC Public Health
BACKGROUND: Lyme disease or Lyme borreliosis (LB) is the most common tick-borne disease both in the United States and Europe. Children, in particular, are at high risk of contracting LB. Since child-specific educational tools on ticks, tick bites and LB are lacking, we developed an online educational video game. In this study, we compared the effectiveness of an online educational video game versus a newly developed leaflet aimed to improve prevention of tick bites and LB among Dutch schoolchildren. METHODS: A total of 887 children, aged 9-13 years and attending the two final years of primary
View details →DOI: 10.1186/s12889-016-3811-5Cited by 28 Negative / Null Result ReportPsychology
Natalie L. Wilver, Jesse R. Cougle · 2018 · Journal of Consulting and Clinical Psychology
OBJECTIVE: The current study extended upon previous research efforts by evaluating the utility and feasibility of an 8-session Internet-based interpretation bias modification (IBM) training protocol targeting evaluation- and…
View details →DOI: 10.1037/ccp0000372Cited by 28 Negative / Null Result ReportAgricultural and Biological Sciences
Patrick J. McIntyre, Sharon Y. Strauss · 2017 · Evolution
The geographic distributions of polyploids suggest they can have distinct and sometimes broader niches compared to diploids. However, relatively few field experiments have investigated whether range differences are associated with local…
View details →DOI: 10.1111/evo.13288Cited by 28 Negative / Null Result ReportOpen accessMedicine
Troels Yndigegn, Bertil Lindahl, Joakim Alfredsson et al. · 2022 · European Heart Journal - Cardiovascular Pharmacotherapy
AIMS: Most trials showing benefit of beta-blocker treatment after myocardial infarction (MI) included patients with large MIs and are from an era before modern biomarker-based MI diagnosis and reperfusion treatment. The aim of the…
View details →DOI: 10.1093/ehjcvp/pvac070Cited by 28 Negative / Null Result ReportOpen accessMedicine
Maria L.V. Dizon, Rakesh Rao, Shannon E. G. Hamrick et al. · 2019 · BMC Pediatrics
BACKGROUND: While intercenter variation (ICV) in anti-epileptic drug (AED) use in neonates with seizures has been previously reported, variation in AED practices across regional NICUs has not been specifically and systematically evaluated. This is important as these centers typically have multidisciplinary neonatal neurocritical care teams and protocolized approaches to treating conditions such as hypoxic ischemic encephalopathy (HIE), a population at high risk for neonatal seizures. To identify opportunities for quality improvement (QI), we evaluated ICV in AED utilization for neonates with H
View details →DOI: 10.1186/s12887-019-1441-7Cited by 28 Negative / Null Result Report
Bisakha Sen, Justin Blackburn, Michael A. Morrisey et al. · 2012 · Health Services Research
Objective To explore whether health care utilization changed among enrollees in Alabama's CHIP program, ALL Kids, following copayment increases at the beginning of fiscal year 2004. Data Sources Data on all ALL Kids enrollees over…
View details →DOI: 10.1111/j.1475-6773.2012.01384.xCited by 28 Negative / Null Result ReportOpen accessMedicine
Andreas Carus, Howard Gurney, Val Gebski et al. · 2013 · Journal of Translational Medicine
Chronic inflammation has been recognized to foster tumour development. Whether chemotherapy can be used to neutralize chronic inflammation is unclear. We evaluated baseline and nadir neutrophils in 111 patients (pts.) with non-small cell lung cancer (NSCLC) and 118 pts. with ovarian cancer (OC) treated with chemotherapy administered with dose-individualization to achieve nadir neutropenia of 1.5. We used predefined baseline neutrophil cut-offs 4.5 × 109/L (NSCLC) and 3.9 × 109/L (OC). Absence of chemotherapy-induced nadir neutropenia (CTCAE grade 0, neutrophils ≥ LLN) was seen in 23% of OC and
View details →DOI: 10.1186/1479-5876-11-189Cited by 28 Negative / Null Result ReportOpen accessSocial Sciences
Irene Mosca, Bláithín Ní Bhuachalla, Rose Anne Kenny · 2013 · BMC Cardiovascular Disorders
BACKGROUND: To assess prevalence rates of subjective and objective reports of two cardiovascular disorders (hypertension and hypercholesterolemia) for the same subset of respondents in a large-scale study. To determine whether and the extent to which the socioeconomic health gradient differed in the subjective and objective reports of the two cardiovascular disorders. METHODS: Data from the first wave (2009/2011) of The Irish Longitudinal Study on Ageing were used (n = 4,179). This is a nationally representative study of community-dwelling adults aged 50+ residing in Ireland. Subjective measur
View details →DOI: 10.1186/1471-2261-13-64Cited by 28 Negative / Null Result ReportOpen accessMedicine
Natalie Kashefi, Jonathan I. Nathan, Sharmila Dissanaike · 2014 · Plastic & Reconstructive Surgery Global Open
BACKGROUND: Smoke inhalation is a major source of morbidity and mortality. Heparin and N-acetylcysteine treatment has potential efficacy in inhalation injury. We investigated the impact of a heparin/N-acetylcysteine/albuterol nebulization…
View details →DOI: 10.1097/gox.0000000000000121Cited by 28 Negative / Null Result ReportOpen accessMedicine
Fang He, Huai‐Qiang Ju, Yi Ding et al. · 2020 · British Journal of Cancer
BACKGROUND: For patients with locally advanced rectal cancer (LARC), it is unclear whether neoadjuvant chemoradiotherapy-induced pathologic complete response (pCR) individuals would further benefit from adjuvant chemotherapy (ACT). METHODS: The pCR individuals who received different ACT cycles were paired by propensity score matching. Overall survival (OS), disease-free survival (DFS), local recurrence-free survival (LRFS), and distant metastasis-free survival (DMFS) were calculated by Kaplan-Meier and log-rank test. RESULTS: In total, 1041 pCR individuals were identified from 5567 LARC cases.
View details →DOI: 10.1038/s41416-020-0989-1Cited by 28 Negative / Null Result ReportOpen accessMedicine
Weikun Li, Murat Yalçın, Dhruba J. Bharali et al. · 2019 · Scientific Reports
Abstract The anti-angiogenic agent, diamino propane tetraiodothyroacetic acid (DAT), is a thyro-integrin (integrin αvβ3) antagonist anticancer agent that works via genetic and nongenetic actions. Tetraiodothyroacetic acid (tetrac) and DAT as thyroid hormone derivatives influence gene expression after they transport across cellular membranes. To restrict the action of DAT to the integrin αvβ3 receptors on the cell surface, we used DAT-conjugated PLGA nanoparticles (NDAT) in an active targeting mode to bind to these receptors. Preparation and characterization of NDAT is described, and both in vi
View details →DOI: 10.1038/s41598-019-44979-6Cited by 28 Negative / Null Result ReportOpen accessMedicine
Nilgün Mendil, Şahin Temel, Recep Civan Yüksel et al. · 2021 · TURKISH JOURNAL OF MEDICAL SCIENCES
Background/aim: High flow nasal cannula (HFNC) was mostly used in intensive care units (ICUs) with few studies in other departments. We hypothesized that HFNC applied at wards is beneficial for acute respiratory failure in hematological malignancy patients. Materials and methods: The study is a single center, randomized controlled study. Inclusion criteria were hypoxemic respiratory failure and hematological malignancy. Patients were randomized to either venturi mask/nasal cannula oxygen treatment or HFNC. Results: One hundred patients were included in the study. Median age was 58.5 (18–86) ye
View details →DOI: 10.3906/sag-2007-228Cited by 28 Negative / Null Result Report
Leon Deutsch, Damjan Osredkar, Janez Plavec et al. · 2021 · Metabolites
Spinal muscular atrophy (SMA) is a genetically heterogeneous group of rare neuromuscular diseases and was until recently the most common genetic cause of death in children. The effects of 2-month nusinersen therapy on urine, serum, and…
View details →DOI: 10.3390/metabo11040206Cited by 28 