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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20211 results in Negative / Null Result Report · page 91 of 674

Negative / Null Result ReportOpen accessNeuroscience

Activation of MEK/ERK signaling contributes to the PACAP-induced increase in guinea pig cardiac neuron excitability

John D. Tompkins, Todd A. Clason, Jean C. Hardwick et al. · 2016 · American Journal of Physiology-Cell Physiology

Pituitary adenylate cyclase (PAC)-activating polypeptide (PACAP) peptides ( Adcyap1) signaling at the selective PAC1 receptor ( Adcyap1r1) participate in multiple homeostatic and stress-related responses, yet the cellular mechanisms…

View details →DOI: 10.1152/ajpcell.00164.2016Cited by 29
Negative / Null Result ReportOpen accessPhysics and Astronomy

Morphology and metallicity of the Small Magellanic Cloud using RRab stars

Sukanta Deb, Harinder P. Singh, Subhash Kumar et al. · 2015 · Monthly Notices of the Royal Astronomical Society

We present a study of three-dimensional structure of the Small Magellanic Cloud (SMC). The V- and I-band light curves of the fundamental mode RR Lyrae (RRab) stars obtained by the Optical Gravitational Lensing Experiment-III project were…

View details →DOI: 10.1093/mnras/stv358Cited by 29
Negative / Null Result ReportOpen accessSocial Sciences

No association between numerical ability and politically motivated reasoning in a large US probability sample

Michael N. Stagnaro, Ben M Tappin, David G. Rand · 2023 · Proceedings of the National Academy of Sciences

The highly influential theory of "Motivated System 2 Reasoning" argues that analytical, deliberative ("System 2") reasoning is hijacked by identity when considering ideologically charged issues-leading people who are more likely to engage in such reasoning to be more polarized, rather than more accurate. Here, we fail to replicate the key empirical support for this theory across five contentious issues, using a large gold-standard nationally representative probability sample of Americans. While participants were more accurate in evaluating a contingency table when the outcome aligned with thei

View details →DOI: 10.1073/pnas.2301491120Cited by 29
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Take caution in using LLMs as human surrogates

Yuan Gao, Dokyun Lee, Gordon Burtch et al. · 2025 · Proceedings of the National Academy of Sciences

Recent studies suggest large language models (LLMs) can generate human-like responses, aligning with human behavior in economic experiments, surveys, and political discourse. This has led many to propose that LLMs can be used as surrogates…

View details →DOI: 10.1073/pnas.2501660122Cited by 29
Negative / Null Result ReportOpen accessPsychology

Network integration and limits to social inheritance in vervet monkeys

Jonathan Jarrett, Tyler R. Bonnell, Christopher Young et al. · 2018 · Proceedings of the Royal Society B Biological Sciences

, 12084 (doi:10.1038/ncomms12084)) has demonstrated that network structure can be maintained by a simple process of social inheritance. Here, we ask how juvenile vervet monkeys integrate into their adult grooming networks, using the model…

View details →DOI: 10.1098/rspb.2017.2668Cited by 29
Negative / Null Result ReportOpen accessMedicine

Replication of Five Prostate Cancer Loci Identified in an Asian Population—Results from the NCI Breast and Prostate Cancer Cohort Consortium (BPC3)

Sara Lindström, Fredrick R. Schumacher, Daniele Campa et al. · 2012 · Cancer Epidemiology Biomarkers & Prevention

BACKGROUND: A recent genome-wide association study (GWAS) of prostate cancer in a Japanese population identified five novel regions not previously discovered in other ethnicities. In this study, we attempt to replicate these five loci in a…

View details →DOI: 10.1158/1055-9965.epi-11-0870-tCited by 29
Negative / Null Result ReportOpen accessMedicine

Single nucleotide polymorphisms in the intergenic region between metformin transporter OCT2 and OCT3 coding genes are associated with short-term response to metformin monotherapy in type 2 diabetes mellitus patients

Linda Zaharenko, Ineta Kalniņa, Kristine Geldnere et al. · 2016 · European Journal of Endocrinology

Objective(s) High variability in clinical response to metformin is often observed in type 2 diabetes (T2D) patients, and it highlights the need for identification of genetic components affecting the efficiency of metformin therapy. Aim of…

View details →DOI: 10.1530/eje-16-0347Cited by 29
Negative / Null Result ReportOpen accessMedicine

Validation of the Measures of the Transtheoretical Model for Exercise in an Adult African-American Sample

Cerissa L. Blaney, Mark L. Robbins, Andrea L. Paiva et al. · 2012 · American Journal of Health Promotion

PURPOSE: African-Americans have high rates of physical inactivity-related morbidity and mortality, thus effective interventions to increase exercise are necessary. Tailored interventions show promise, but measures need validation in this…

View details →DOI: 10.4278/ajhp.091214-quan-393Cited by 29
Negative / Null Result ReportNeuroscience

Feature overlap slows lexical selection: Evidence from the picture–word interference paradigm

Harrison E. Vieth, Katie L. McMahon, Greig I. de Zubicaray · 2014 · Quarterly Journal of Experimental Psychology

How does the presence of a categorically related word influence picture naming latencies? In order to test competitive and noncompetitive accounts of lexical selection in spoken word production, we employed the picture-word interference…

View details →DOI: 10.1080/17470218.2014.923922Cited by 29
Negative / Null Result ReportOpen accessEngineering

Optimizing solar and wind forecasting with iHow optimization algorithm and multi-scale attention networks

Marwa Radwan, Abdelhameed Ibrahim‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬, M. A. Abdelsalam et al. · 2026 · Scientific Reports

Deep learning models often encounter two key challenges in developing intelligent and scalable forecasting frameworks for renewable energy systems: input feature space dimensionality and sensitivity to hyperparameter settings. These limitations increase computational cost and compromise generalization and robustness. This paper presents a hybrid deep learning-optimization framework that leverages cognitively inspired metaheuristics to address these challenges, employing the Binary iHow Optimization Algorithm (biHOW) for feature selection and its continuous counterpart, iHOW, for hyperparameter

View details →DOI: 10.1038/s41598-026-39632-yCited by 29
Negative / Null Result ReportOpen accessNursing

Toward Precision in Nutrition Therapy

Christian Stoppe, Aileen Hill, Kenneth B. Christopher et al. · 2024 · Critical Care Medicine

Precision in critical care nutrition is paramount, as it focuses nutrition interventions on those patients most likely to benefit, or those who might potentially be harmed. Critical care nutrition must therefore be tailored to individual…

View details →DOI: 10.1097/ccm.0000000000006537Cited by 29
Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology

Genetic association of the AKT1 gene with schizophrenia in a British population

Aditi Mathur, Matthew H. Law, Ian L. Megson et al. · 2010 · Psychiatric Genetics

OBJECTIVES: A number of studies have reported a genetic association of the AKT1 gene with schizophrenia, although some have failed to replicate the AKT1 association. This study was undertaken to further explore the AKT1 association with…

View details →DOI: 10.1097/ypg.0b013e32833a2234Cited by 29
Negative / Null Result ReportOpen accessMedicine

Exercise training effects on natural killer cells: a preliminary proteomics and systems biology approach

Francisco Llavero, Adrián Castillo‐García, Carmen Fiuza‐Luces et al. · 2026 · PubMed

BACKGROUND: Regular exercise, particularly moderate-intensity continuous training (MICT), can improve immune function. Natural killer (NK) cells, a subset of lymphocytes that react to infections, are the most responsive innate immune cells…

View details →DOI: 10.22029/eir.2021.1745Cited by 29
Negative / Null Result ReportOpen accessNursing

Effect of flaxseed oil in diet on fatty acid composition in the liver of Nile Tilapia (Oreochromis niloticus)

Ana Carolina de Aguiar, Damila Rodrigues de Morais, Leandra P. Santos et al. · 2026 · Archivos Latinoamericanos de Nutrición

This study analyzed the effects of different concentrations of flaxseed oil (FO) on the proximate composition and the contents of alpha-linolenic acid (LNA, 18:3n-3), eicosapentaenoic (EPA, 20:5n-3), and docosahexaenoic (DHA, 22:6n-3)…

View details →DOI: 10.37527/2007.57.3.009Cited by 29
Negative / Null Result ReportOpen accessSocial Sciences

The levers of political persuasion with conversational artificial intelligence

Kobi Hackenburg, Ben M Tappin, Luke Hewitt et al. · 2025 · Science

There are widespread fears that conversational artificial intelligence (AI) could soon exert unprecedented influence over human beliefs. In this work, in three large-scale experiments ( N = 76,977 participants), we deployed 19 large…

View details →DOI: 10.1126/science.aea3884Cited by 29
Negative / Null Result ReportOpen accessEngineering

Enhancing stability and power quality in electric vehicle charging stations powered by hybrid energy sources through harmonic mitigation and load management

S. M. Abd Elazim, M.H. Elkholy, Abdelrahman Elgarhy et al. · 2025 · Scientific Reports

Growing integration of renewable energy sources (RESs) into power grids has several advantages, including reduced greenhouse gas emissions and improved energy sustainability. Despite the related benefits, RES integration also poses actual…

View details →DOI: 10.1038/s41598-025-14143-4Cited by 29
Negative / Null Result ReportMedicine

Genome-Wide Significant Association Between a Sequence Variant at 15q15.2 and Lung Cancer Risk

Þórunn Rafnar, Patrick Sulem, Søren Besenbacher et al. · 2011 · Cancer Research

Genome-wide association studies (GWAS) have identified 3 genomic regions, at 15q24-25.1, 5p15.33, and 6p21.33, which associate with the risk of lung cancer. Large meta-analyses of GWA data have failed to find additional associations of…

View details →DOI: 10.1158/0008-5472.can-10-2852Cited by 28
Negative / Null Result Report

No Antidotal Effect of Intravenous Lipid Emulsion in Experimental Amitriptyline Intoxication Despite Significant Entrapment of Amitriptyline

Erik Litonius, Tomohisa Niiya, Pertti J. Neuvonen et al. · 2011 · Basic & Clinical Pharmacology & Toxicology

Abstract: Intravenous lipid emulsion has been used in the resuscitative treatment of intoxications caused by local anaesthetics and tricyclic antidepressants with seemingly beneficial results. We studied the effect of intravenous lipid…

View details →DOI: 10.1111/j.1742-7843.2011.00826.xCited by 28
Negative / Null Result ReportOpen accessSocial Sciences

I know that I know nothing: Can puncturing the illusion of explanatory depth overcome the relationship between attitudinal dissimilarity and prejudice?

Jan G. Voelkel, Mark J. Brandt, Matteo Colombo · 2018 · Comprehensive Results in Social Psychology

People are prejudiced toward groups they perceive as having a worldview dissimilar from their own. This link between perceived attitudinal dissimilarity and prejudice is so stable that it has been described as a psychological law. The current research tests whether reducing people’s (over-)confidence in their own understanding of policies by puncturing their illusion of explanatory depth in the political domain will reduce the link between perceived attitudinal dissimilarity and prejudice. In an initial pre-registered experiment (N = 296), we did not find support for our hypothesis, but explor

View details →DOI: 10.1080/23743603.2018.1464881Cited by 28
Negative / Null Result ReportOpen accessDecision Sciences

The influence of mortality and socioeconomic status on risk and delayed rewards: a replication with British participants

Gillian Pepper, Deirdre Corby, Rachel Bamber et al. · 2017 · PeerJ

Here, we report three attempts to replicate a finding from an influential psychological study (Griskevicius et al., 2011b). The original study found interactions between childhood SES and experimental mortality-priming condition in predicting risk acceptance and delay discounting outcomes. The original study used US student samples. We used British university students (replication 1) and British online samples (replications 2 and 3) with a modified version of the original priming material, which was tailored to make it more credible to a British audience. We did not replicate the interaction b

View details →DOI: 10.7717/peerj.3580Cited by 28
Negative / Null Result ReportOpen accessNeuroscience

Dynamic Interactions Between Hemispheres Reveal a Compensatory Pathway for Motor Recovery in Moderate-to-Severe Subcortical Stroke

Huaxin Fan, Hewei Wang, Zhengxu Lian et al. · 2026 · Journal of Stroke

BACKGROUND AND PURPOSE: Therapeutic target selection in noninvasive brain stimulation for poststroke motor recovery typically relies on the interhemispheric inhibition model, which is effective for mildly affected patients but offers…

View details →DOI: 10.5853/jos.2025.01725Cited by 28
Negative / Null Result ReportOpen accessComputer Science

Oracle and Human Baselines for Native Language Identification

Shervin Malmasi, Joel Tetreault, Mark Dras · 2015

We examine different ensemble methods, including an oracle, to estimate the upper-limit of classification accuracy for Native Language Identification (NLI). The oracle outperforms state-of-the-art systems by over 10% and results indicate that for many misclassified texts the correct class label receives a significant portion of the ensemble votes, often being the runner-up. We also present a pilot study of human performance for NLI, the first such experiment. While some participants achieve modest results on our simplified setup with 5 L1s, they did not outperform our NLI system, and this perf

View details →DOI: 10.3115/v1/w15-0620Cited by 28
Negative / Null Result Report

Spinal Muscular Atrophy after Nusinersen Therapy: Improved Physiology in Pediatric Patients with No Significant Change in Urine, Serum, and Liquor 1H-NMR Metabolomes in Comparison to an Age-Matched, Healthy Cohort

Leon Deutsch, Damjan Osredkar, Janez Plavec et al. · 2021 · Metabolites

Spinal muscular atrophy (SMA) is a genetically heterogeneous group of rare neuromuscular diseases and was until recently the most common genetic cause of death in children. The effects of 2-month nusinersen therapy on urine, serum, and…

View details →DOI: 10.3390/metabo11040206Cited by 28
Negative / Null Result Report

Climate change threatens archaeologically significant ice patches: insights into their age, internal structure, mass balance and climate sensitivity

Rune Strand Ødegård, Atle Nesje, Ketil Isaksen et al. · 2017 · The Cryosphere

Abstract. Despite numerous spectacular archaeological discoveries worldwide related to melting ice patches and the emerging field of glacial archaeology, governing processes related to ice patch development during the Holocene and their…

View details →DOI: 10.5194/tc-11-17-2017Cited by 28
Negative / Null Result Report

AI-accelerated protein-ligand docking for SARS-CoV-2 is 100-fold faster with no significant change in detection

Austin Clyde, Xuefeng Liu, Thomas Brettin et al. · 2023 · Scientific Reports

Abstract Protein-ligand docking is a computational method for identifying drug leads. The method is capable of narrowing a vast library of compounds down to a tractable size for downstream simulation or experimental testing and is widely…

View details →DOI: 10.1038/s41598-023-28785-9Cited by 28
Negative / Null Result ReportOpen accessMedicine

Maternal perinatal depression and infant sleep problems at 1 year of age: Subjective and actigraphy data from a population‐based birth cohort study

Camila S. Halal, Diego G. Bassani, Iná S. Santos et al. · 2020 · Journal of Sleep Research

This study used data from 2,222 mothers and infants participating in a population-based birth cohort to verify whether maternal depression in the perinatal period was associated with poor infant sleep. Mothers who scored ≥13 points on the…

View details →DOI: 10.1111/jsr.13047Cited by 28
Negative / Null Result ReportOpen accessMathematics

NASCO: A new method and program to generate dot arrays for non-symbolic number comparison tasks

Mathieu Guillaumé, Christine Schiltz, Amandine Van Rinsveld · 2020 · Journal of Numerical Cognition

Basic numerical abilities are generally assumed to influence more complex cognitive processes involving numbers, such as mathematics. Yet measuring non-symbolic number abilities remains challenging due to the intrinsic correlation between numerical and non-numerical dimensions of any visual scene. Several methods have been developed to generate non-symbolic stimuli controlling for the latter aspects but they tend to be difficult to replicate or implement. In this study, we describe the NASCO method, which is an extension to the method popularized by Dehaene, Izard, and Piazza (2005). Their pro

View details →DOI: 10.5964/jnc.v6i1.231Cited by 28