A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
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James E. Hines, James D. Nichols, Jaime A. Collazo · 2014 · Methods in Ecology and Evolution
Summary Occupancy surveys collecting data from adjacent (sometimes correlated) spatial replicates have become relatively popular for logistical reasons. Hines et al . ( ) presented one approach to modelling such data for single‐season…
Lingjun Zuo, Xiangyang Zhang, Fei Wang et al. · 2012 · Alcoholism Clinical and Experimental Research
BACKGROUND: Alcohol and nicotine codependence can be considered as a more severe subtype of alcohol dependence. A portion of its risk may be attributable to genetic factors. METHODS: We searched for significant risk genomic regions…
Teshome Elshaday, Debela Kenenisa, Sultan Mohammed · 2018 · AFRICAN JOURNAL OF BUSINESS MANAGEMENT
This study aims at examining the determinants of the financial performance of private commercial banks in Ethiopia. The study uses secondary data for eight private banks which are in the industry for more than ten years. These banks are chosen from sixteen private commercial banks which are currently functional in Ethiopia banking industry. The data for this study is obtained from annual reports of the banks, minutes and the national bank report. Correlation and multiple linear regressions of panel data for the eight banks for the years 2007 to 2016 is analyzed using random effect model. E-Vie
Rishikesh Kankesh Patel, James Brouner, Owen Spendiff · 2015 · Journal of the International Society of Sports Nutrition
BACKGROUND: Dark chocolate (DC) is abundant in flavanols which have been reported to increase the bioavailability and bioactivity of nitric oxide (NO). Increasing NO bioavailability has often demonstrated reduced oxygen cost and performance enhancement during submaximal exercise. METHODS: Nine moderately-trained male participants volunteered to undertake baseline (BL) measurements that comprised a cycle V̇O(2max) test followed by cycling at 80% of their established gas exchange threshold (GET) for 20-min and then immediately followed by a two-minute time-trial (TT). Using a randomised crossove
Robert Z. Tashjian, Rahul Banerjee, Michael P. Bradley et al. · 2010 · The Journal of Knee Surgery
Sixty-eight patients undergoing outpatient knee arthroscopy for treatment of meniscal tears or loose bodies were divided into three treatment groups (zolpidem [24 patients], control [24 patients], and placebo [20 patients]). All groups…
Tia Stevens Andersen · 2015 · Criminal Justice and Behavior
Missing from the considerable body of literature on disproportionate minority contact is an examination of the factors that influence risk of juvenile arrest. Using the National Longitudinal Survey of Youth 1997, the author examines…
Zhiyong Liu, Weitao Yao, Yao Zhao et al. · 2021 · Cancer Management and Research
PURPOSE: Anlotinib is a novel tyrosine kinase inhibitor with promising anti-tumor activity in patients with advanced soft tissue sarcomas (STS) in China. Liposomal doxorubicin monotherapy showed an encouraging effect on this disease. The…
Yoon‐Koo Kang, Yung‐Jue Bang, Shunsuke Kondo et al. · 2020 · Clinical Cancer Research
Abstract Purpose: Patients with advanced gastric/gastroesophageal junction cancer (GC/GEJC) have limited treatment options after first-line therapy. Bintrafusp alfa is a first-in-class bifunctional fusion protein composed of the…
Wenshu Tang, Cario W. S. Lo, Wei Ma et al. · 2024 · Cell & Bioscience
BACKGROUND: Glioma is a highly heterogeneous brain tumor categorized into World Health Organization (WHO) grades 1-4 based on its malignancy. The suppressive immune microenvironment of glioma contributes significantly to unfavourable patient outcomes. However, the cellular composition and their complex interplays within the glioma environment remain poorly understood, and reliable prognostic markers remain elusive. Therefore, in-depth exploration of the tumor microenvironment (TME) and identification of predictive markers are crucial for improving the clinical management of glioma patients. RE
Cristian Ricci, Jeannine Baumgartner, Manja Zec et al. · 2018 · British Journal Of Nutrition
Accumulating evidence indicates that saturated fat intake is related to mortality risk increase, whereas unsaturated fat intake is associated with reduced mortality risk. The aim of the present study was to estimate the mortality risk…
Chetan Shenoy, Judy Boura, Pamela Orshaw et al. · 2010 · PLoS ONE
BACKGROUND: Chronic kidney disease (CKD) is strongly associated with adverse outcomes after percutaneous coronary intervention (PCI). There are limited data on the effectiveness of drug-eluting stents (DES) in patients with CKD. METHODOLOGY/PRINCIPAL FINDINGS: Of 3,752 consecutive patients enrolled in the Guthrie PCI Registry between 2001 and 2006, 436 patients with CKD - defined as a creatinine clearance <60 mL/min - were included in this study. Patients who received DES were compared to those who received bare metal stents (BMS). Patients were followed for a mean duration of 3 years after th
Kanan Patel, Gregg C. Fonarow, Dalane W. Kitzman et al. · 2012 · European Journal of Heart Failure
AIMS: To examine the clinical effectiveness of angiotensin receptor blockers (ARBs) in older patients with heart failure and preserved ejection fraction (HF-PEF). METHODS AND RESULTS: Of the 10 570 hospitalized HF-PEF patients, aged ≥ 65…
Sabrina Arnold, A. Richard Kitching, Véronique Witko‐Sarsat et al. · 2024 · The Lancet Rheumatology
Myeloperoxidase (MPO)-specific antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (MPO-ANCA-associated vasculitis) is one of two major ANCA-associated vasculitis variants characterised by systemic necrotising vasculitis with few or no immune deposits. MPO-ANCA-associated vasculitis predominantly affects small blood vessels and, in contrast to its counterpart proteinase 3-ANCA-associated vasculitis, is generally not associated with granulomatous inflammation. The kidneys and lungs are the most commonly affected organs. The pathogenesis of MPO-ANCA-associated vasculitis is characte
Henrik Falconer, Ulrika Joneborg, Kamilla Krawiec et al. · 2020 · Gynecologic Oncology
OBJECTIVE: Ultra-radical surgery to achieve complete resection in advanced epithelial ovarian cancer (EOC) has been widely accepted without strong supporting data. Our objective was to assess overall survival after a structured shift to an ultra-radical upfront surgical treatment algorithm and to investigate changes in the distribution of primary treatments after this shift. PATIENTS AND METHODS: In this population-based cohort study, all women with suspected EOC in the Stockholm-Gotland region of Sweden reported to the Swedish Quality Registry for Gynecologic Cancer (SQRGC) and National Cance
Bruce A. Rayton, Zeynep Y. Yalabik, Andriana Rapti · 2019 · Journal of Managerial Psychology
Purpose The purpose of this paper is to explore the relationship between fit (organization and job) perceptions and work engagement (WE). Design/methodology/approach The authors deployed a two-wave survey among 377 clerical employees of…
Eleni Karakike, Brendon P. Scicluna, Maria Roumpoutsou et al. · 2022 · Critical Care
BACKGROUND: Clarithromycin may act as immune-regulating treatment in sepsis and acute respiratory dysfunction syndrome. However, clinical evidence remains inconclusive. We aimed to evaluate whether clarithromycin improves 28-day mortality among patients with sepsis, respiratory and multiple organ dysfunction syndrome. METHODS: We conducted a multicenter, randomized, clinical trial in patients with sepsis. Participants with ratio of partial oxygen pressure to fraction of inspired oxygen less than 200 and more than 3 SOFA points from systems other than the respiratory function were enrolled betw
Andreas Nolte, Nico W. Funk, Latha Mukunda et al. · 2013 · PLoS ONE
The mechanisms of insect odor transduction are still controversial. Insect odorant receptors (ORs) are 7TM receptors with inverted membrane topology. They colocalize with a conserved coreceptor (Orco) with chaperone and ion channel function. Some studies suggest that insects employ exclusively ionotropic odor transduction via OR-Orco heteromers. Other studies provide evidence for different metabotropic odor transduction cascades, which employ second messenger-gated ion channel families for odor transduction. The hawkmoth Manduca sexta is an established model organism for studies of insect olfa
Ryosuke Omori, Yukihiko Nakata, Heidi L. Tessmer et al. · 2015 · Scientific Reports
Until the early 1990 s, incidences of Mycoplasma pneumoniae (MP) infection showed three to five year epidemic cycles in multiple countries, however, the mechanism for the MP epidemic cycle has not been understood. Here, we investigate the determinant of periodicity in MP incidence by employing a mathematical model describing MP transmission dynamics. Three candidates for the determinant of periodicity were evaluated: school-term forcing, minor variance in the duration of immunity, and epidemiological interference between MP serotypes. We find that minor variation in the duration of immunity at
José de León, Paula Mallory, Lorraine Maw et al. · 2011 · Annals of Clinical Psychiatry
BACKGROUND: In 2 Spanish case-control studies, low cholesterol levels in males were consistently associated with suicide attempts. METHODS: This US study tried to replicate the association between low cholesterol levels and suicide…
Denise Y. Geiskkovitch, Raquel Thiessen, James E. Young et al. · 2019
Robots that interact with children are becoming more common in places such as child care and hospital environments. While such robots may mistakenly provide nonsensical information, or have mechanical malfunctions, we know little of how…
Anne Line Engsbro, Christen Rune Stensvold, Henrik Nielsen et al. · 2012 · American Journal of Tropical Medicine and Hygiene
The role of Dientamoeba fragilis in irritable bowel syndrome (IBS) is incompletely known. We aimed to investigate whether eradication of D. fragilis alleviates symptoms in IBS. Twenty-five D. fragilis-positive IBS patients were treated…
Mohammad W. Marashdeh, Baker Ababneh, O. M. Lemine et al. · 2019 · Results in Physics
In this study, iron oxide (γ-Fe2O3) nanoparticles (IONs) were successfully synthesized using sol-gel method, and characterized by XRD and VSM. The potential application of the differently sized IONs (22 nm and 30 nm) as magnetic resonance…
Vijay Gondaliya, Govind Dhinaiya · 2017 · Zenodo (CERN European Organization for Nuclear Research)
Every investor and investment planner talk about risk tolerance and what people think is appropriate because there’s so much more to risk tolerance than what you can capture. Defining and understanding risk are important challenges for…
Ann L. Griffen, Zachary A. Thompson, Clifford J. Beall et al. · 2019 · Scientific Reports
Persons infected with HIV are particularly vulnerable to a variety of oral microbial diseases. Although various study designs and detection approaches have been used to compare the oral microbiota of HIV-negative and HIV-positive persons, both with and without highly active antiretroviral therapy (HAART), methods have varied, and results have not been consistent or conclusive. The purpose of the present study was to compare the oral bacterial community composition in HIV-positive persons under HAART to an HIV-negative group using 16S rRNA gene sequence analysis. Extensive clinical data was col
Carmen Kivistik, Jan Knobloch, Kairi Käiro et al. · 2020 · Frontiers in Microbiology
Differences in salinity are boundaries that act as barriers for the dispersal of most aquatic organisms. This creates distinctive biota in freshwater and brackish water (mesohaline) environments. To test how saline boundaries influence the diversity and composition of host-associated microbiota, we analyzed the microbiome within the digestive tract of Theodoxus fluviatilis, an organism able to cross the freshwater and mesohaline boundary. Alpha-diversity measures of the microbiome in freshwater and brackish water were not significantly different. However, the composition of the bacterial commu
Lisa L. Lacher, Mark C. Lewis · 2015
The use of online videos and flipped classrooms is a natural fit for many CS courses, especially in the introductory sequence, and the use of these techniques is growing. However, the benefits of these techniques depend heavily on student…
Rachel Hayes, Daniel Titheradge, Kate Allen et al. · 2019 · British Journal of Educational Psychology
BACKGROUND: Teaching is a stressful occupation with poor retention. The Incredible Years® Teacher Classroom Management (TCM) programme is a training programme that research has demonstrated may be an effective intervention for improving…
Jane Farmer, Mary Currie, Jeff Hyman et al. · 2011 · Scottish Medical Journal
Physician assistants (PAs) have medical training and work supervised by a doctor. In 2006-2008 the Scottish Government piloted use of USA-trained PAs. The aim of the paper is to evaluate the impact and contribution made by PAs to…
Tory A. Eisenlohr‐Moul, Susan S. Girdler, Jacqueline L. Johnson et al. · 2017 · Depression and Anxiety
BACKGROUND: Although traditionally dosed combined oral contraceptives (COCs) (21 days of active pills, 7 days of inactive pills) have not been demonstrated as superior to placebo for the treatment of premenstrual dysphoria (PMD), some…
Rolf Ulrich, Jeff Miller · 2020 · eLife
This article examines why many studies fail to replicate statistically significant published results. We address this issue within a general statistical framework that also allows us to include various questionable research practices (QRPs) that are thought to reduce replicability. The analyses indicate that the base rate of true effects is the major factor that determines the replication rate of scientific results. Specifically, for purely statistical reasons, replicability is low in research domains where true effects are rare (e.g., search for effective drugs in pharmacology). This point is