A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19735 results in Negative / Null Result Report · page 8 of 658
Z. Arzoumanian, P. T. Baker, A. Brazier et al. · 2018 · The Astrophysical Journal
Abstract We search for an isotropic stochastic gravitational-wave background (GWB) in the newly released 11 year data set from the North American Nanohertz Observatory for Gravitational Waves (NANOGrav). While we find no evidence for a…
Lama Qasem, Antonia S. Cardew, Alexis Wilson et al. · 2012 · PLoS ONE
Dynamic body acceleration (DBA) has been used as a proxy for energy expenditure in logger-equipped animals, with researchers summing the acceleration (overall dynamic body acceleration--ODBA) from the three orthogonal axes of devices. The vector of the dynamic body acceleration (VeDBA) may be a better proxy so this study compared ODBA and VeDBA as proxies for rate of oxygen consumption using humans and 6 other species. Twenty-one humans on a treadmill ran at different speeds while equipped with two loggers, one in a straight orientation and the other skewed, while rate of oxygen consumption (V
Fang Fang Zhang, Roberto Cardarelli, Joan F. Carroll et al. · 2011 · Epigenetics
Reduced levels of global DNA methylation are associated with genomic instability and are independent predictors of cancer risk. Little is known about the environmental determinants of global DNA methylation in peripheral blood. We examined…
Diane Del Guercio, Jonathan Reuter · 2013 · The Journal of Finance
ABSTRACT To rationalize the well‐known underperformance of the average actively managed mutual fund, we exploit the fact that retail funds in different market segments compete for different types of investors. Within the segment of funds…
Dawn Waterworth, Sally L. Ricketts, Kijoung Song et al. · 2010 · Arteriosclerosis Thrombosis and Vascular Biology
OBJECTIVE: Genetic studies might provide new insights into the biological mechanisms underlying lipid metabolism and risk of CAD. We therefore conducted a genome-wide association study to identify novel genetic determinants of low-density…
David P. Baker, Juan León, Emily G. Smith Greenaway et al. · 2011 · Population and Development Review
Demographic research frequently reports consistent and significant associations between formal educational attainment and a range of health risks such as smoking, drug abuse, and accidents, as well as the contraction of many diseases, and…
David R. Mandel, Katy Eichas, J Holmes · 2010 · BMC Complementary and Alternative Medicine
BACKGROUND: Lactic acid-producing bacteria (LAB) probiotics demonstrate immunomodulating and anti-inflammatory effects and the ability to lessen the symptoms of arthritis in both animals and humans. This randomized, double-blind, placebo-controlled, parallel-design, clinical pilot trial was conducted to evaluate the effects of the LAB probiotic preparation, Bacillus coagulans GBI-30, 6086, on symptoms and measures of functional capacity in patients with rheumatoid arthritis (RA) in combination with pharmacological anti-arthritic medications. METHODS: Forty-five adult men and women with symptom
Ibán Amenabar, Simon Poly, Wiwat Nuansing et al. · 2013 · Nature Communications
Mid-infrared spectroscopy is a widely used tool for material identification and secondary structure analysis in chemistry, biology and biochemistry. However, the diffraction limit prevents nanoscale protein studies. Here we introduce…
L. A. Smith, Natalia Price, Vanessa Simonite et al. · 2013 · BMC Pregnancy and Childbirth
BACKGROUND: Our aim was to describe the range of perineal trauma in women with a singleton vaginal birth and estimate the effect of maternal and obstetric characteristics on the incidence of perineal tears. METHODS: We conducted a prospective observational study on all women with a planned singleton vaginal delivery between May and September 2006 in one obstetric unit, three freestanding midwifery-led units and home settings in South East England. Data on maternal and obstetric characteristics were collected prospectively and analysed using univariable and multivariable logistic regression. Th
Javier Cerrato Allende, Eva Cifré · 2018 · Frontiers in Psychology
The fact that the permeability between family and work scopes produces work-family conflict (WFC) is well established. As such, this research aims to check whether the unequal involvement in household chores between men and women is associated with increased WFC in women and men, interpreting the results also from the knowledge that arise from gender studies. A correlational study was carried out by means a questionnaire applied to 515 subjects (63% men) of two independent samples of Spanish men and women without emotional relationship, who lived with their heterosexual partner. As expected, r
Zarek Brot-Goldberg, Amitabh Chandra, Benjamin Handel et al. · 2017 · The Quarterly Journal of Economics
Abstract Measuring consumer responsiveness to medical care prices is a central issue in health economics and a key ingredient in the optimal design and regulation of health insurance markets. We leverage a natural experiment at a large…
Nicole Koenig‐Lewis, Morgan Marquet, Adrian Palmer et al. · 2015 · Service Industries Journal
Models of technology adoption, notably the Technology Acceptance Model and the Unified Theories of Acceptance and Use of Technology, provide good theoretical foundations for understanding mobile payment adoption. This study extends these…
Qi Guoyou, Zeng Sai-xing, Tam Chiming et al. · 2011 · Corporate Social Responsibility and Environmental Management
ABSTRACT Facing the challenge of environmental degradation in China, a growing number of firms have begun to integrate environmental management systems into their business strategies and develop green innovation strategies. Based on the…
Matthijs Rooduijn, Sarah L. de Lange, Wouter van der Brug · 2012 · Party Politics
In this article, we examine the programmatic reactions to the rise of populist parties. It has been argued that populism is not necessarily the prerogative of populist parties; it has been adopted by mainstream parties as well. The article…
Amélie C. M. Gaudin, Tor N. Tolhurst, Alan P. Ker et al. · 2015 · PLoS ONE
Cropping sequence diversification provides a systems approach to reduce yield variations and improve resilience to multiple environmental stresses. Yield advantages of more diverse crop rotations and their synergistic effects with reduced tillage are well documented, but few studies have quantified the impact of these management practices on yields and their stability when soil moisture is limiting or in excess. Using yield and weather data obtained from a 31-year long term rotation and tillage trial in Ontario, we tested whether crop rotation diversity is associated with greater yield stabili
Peter Oehen, Rafael Traber, Verena Widmer et al. · 2012 · Journal of Psychopharmacology
Psychiatrists and psychotherapists in the US (1970s to 1985) and Switzerland (1988-1993) used MDMA legally as a prescription drug, to enhance the effectiveness of psychotherapy. Early reports suggest that it is useful in treating…
Charles E. Vejnar, Evgeny M. Zdobnov · 2012 · Nucleic Acids Research
MicroRNAs, or miRNAs, post-transcriptionally repress the expression of protein-coding genes. The human genome encodes over 1000 miRNA genes that collectively target the majority of messenger RNAs (mRNAs). Base pairing of the so-called miRNA 'seed' region with mRNAs identifies many thousands of putative targets. Evaluating the strength of the resulting mRNA repression remains challenging, but is essential for a biologically informative ranking of potential miRNA targets. To address these challenges, predictors may use thermodynamic, evolutionary, probabilistic or sequence-based features. We dev
Damon Jones, David Molitor, Julian Reif · 2019 · The Quarterly Journal of Economics
Workplace wellness programs cover over 50 million U.S. workers and are intended to reduce medical spending, increase productivity, and improve well-being. Yet limited evidence exists to support these claims. We designed and implemented a…
Aris Alea Lapada, Frosyl F. Miguel, Dave Arthur Robledo et al. · 2020 · International Journal of Learning Teaching and Educational Research
Amidst the threat of COVID-19 pandemic in the Philippines, the educators, students, and the school are still coping and adjusting to the distance learning education. This study explored teachers' awareness about the COVID-19 pandemic and…
Adam Brufsky, Musa Mayer, Hope S. Rugo et al. · 2011 · Clinical Cancer Research
PURPOSE: registHER is a prospective, observational study of 1,023 newly diagnosed HER2-positive metastatic breast cancer (MBC) patients. EXPERIMENTAL DESIGN: Baseline characteristics of patients with and without central nervous system…
Gijsbert Stoet, David C. Geary · 2013 · PLoS ONE
We analyzed one decade of data collected by the Programme for International Student Assessment (PISA), including the mathematics and reading performance of nearly 1.5 million 15 year olds in 75 countries. Across nations, boys scored higher than girls in mathematics, but lower than girls in reading. The sex difference in reading was three times as large as in mathematics. There was considerable variation in the extent of the sex differences between nations. There are countries without a sex difference in mathematics performance, and in some countries girls scored higher than boys. Boys scored l
Xian‐Hu Zha, Kan Luo, Qiuwu Li et al. · 2015 · Europhysics Letters (EPL)
The two-dimensional material MXene has recently attracted interest for its excellent performance in diverse perspectives. Etched from the parental MAX phase with hydrofluoric acid, the synthesized MXene surface is normally functionalized…
M. Ackermann, M. Ajello, A. Allafort et al. · 2012 · The Astrophysical Journal
Recent detections of the starburst galaxies M82 and NGC 253 by gamma-ray telescopes suggest that galaxies rapidly forming massive stars are more luminous at gamma-ray energies compared to their quiescent relatives. Building upon those…
Michele T. Cole, Daniel J. Shelley, Louis B. Swartz · 2014 · The International Review of Research in Open and Distributed Learning
<p>This article presents the results of a three-year study of graduate and undergraduate students’ level of satisfaction with online instruction at one university. The study expands on earlier research into student satisfaction with e-learning. Researchers conducted a series of surveys over eight academic terms. Five hundred and fifty-three students participated in the study. Responses were consistent throughout, although there were some differences noted in the level of student satisfaction with their experience. There were no statistically significant differences in the level of satisf
Horacio J. Asbun, John Stauffer · 2012 · Journal of the American College of Surgeons
BACKGROUND: Minimal access surgery techniques have evolved to include complex surgical procedures. Laparoscopic pancreaticoduodenectomy (LPD) is a complex operation that pancreas surgeons have been slow to adopt. This article reviews our…
James J. Goedert, Gieira S. Jones, Xing Hua et al. · 2015 · JNCI Journal of the National Cancer Institute
We investigated whether the gut microbiota differed in 48 postmenopausal breast cancer case patients, pretreatment, vs 48 control patients. Microbiota profiles in fecal DNA were determined by Illumina sequencing and taxonomy of 16S rRNA genes. Estrogens were quantified in urine. Case-control comparisons employed linear and unconditional logistic regression of microbiota α-diversity (PD_whole tree) and UniFrac analysis of β-diversity, with two-sided statistical tests. Total estrogens correlated with α-diversity in control patients (Spearman Rho = 0.37, P = .009) but not case patients (Spearman
James H. Cole · 2020 · Neurobiology of Aging
The brain-age paradigm is proving increasingly useful for exploring aging-related disease and can predict important future health outcomes. Most brain-age research uses structural neuroimaging to index brain volume. However, aging affects multiple aspects of brain structure and function, which can be examined using multimodality neuroimaging. Using UK Biobank, brain-age was modeled in n = 2205 healthy people with T1-weighted MRI, T2-FLAIR, T2∗, diffusion-MRI, task fMRI, and resting-state fMRI. In a held-out healthy validation set (n = 520), chronological age was accurately predicted (r = 0.78,
Katrina L. Kaposi, Benjamin Mos, Brendan P. Kelaher et al. · 2013 · Environmental Science & Technology
There is increasing concern about the impacts of microplastics (<1 mm) on marine biota. Microplastics may be mistaken for food items and ingested by a wide variety of organisms. While the effects of ingesting microplastic have been…
Ingmar Schäfer, Eike-Christin von Leitner, Gerhard Schön et al. · 2010 · PLoS ONE
OBJECTIVE: Multimorbidity is a common problem in the elderly that is significantly associated with higher mortality, increased disability and functional decline. Information about interactions of chronic diseases can help to facilitate diagnosis, amend prevention and enhance the patients' quality of life. The aim of this study was to increase the knowledge of specific processes of multimorbidity in an unselected elderly population by identifying patterns of statistically significantly associated comorbidity. METHODS: Multimorbidity patterns were identified by exploratory tetrachoric factor ana
US Preventive Services Task Force, Douglas K Owens, Karina W. Davidson et al. · 2019 · JAMA
Importance: Pancreatic cancer is an uncommon cancer with an age-adjusted annual incidence of 12.9 cases per 100 000 person-years. However, the death rate is 11.0 deaths per 100 000 person-years because the prognosis of pancreatic cancer is…