e-ISSN: Pending
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19792 results in Negative / Null Result Report · page 78 of 660

Negative / Null Result ReportOpen accessMedicine

Myeloperoxidase-specific antineutrophil cytoplasmic antibody-associated vasculitis

Sabrina Arnold, A. Richard Kitching, Véronique Witko‐Sarsat et al. · 2024 · The Lancet Rheumatology

Myeloperoxidase (MPO)-specific antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (MPO-ANCA-associated vasculitis) is one of two major ANCA-associated vasculitis variants characterised by systemic necrotising vasculitis with few or no immune deposits. MPO-ANCA-associated vasculitis predominantly affects small blood vessels and, in contrast to its counterpart proteinase 3-ANCA-associated vasculitis, is generally not associated with granulomatous inflammation. The kidneys and lungs are the most commonly affected organs. The pathogenesis of MPO-ANCA-associated vasculitis is characte

View details →DOI: 10.1016/s2665-9913(24)00025-0Cited by 41
Negative / Null Result ReportOpen accessMedicine

Type of dietary fat intakes in relation to all-cause and cause-specific mortality in US adults: an iso-energetic substitution analysis from the American National Health and Nutrition Examination Survey linked to the US mortality registry

Cristian Ricci, Jeannine Baumgartner, Manja Zec et al. · 2018 · British Journal Of Nutrition

Accumulating evidence indicates that saturated fat intake is related to mortality risk increase, whereas unsaturated fat intake is associated with reduced mortality risk. The aim of the present study was to estimate the mortality risk…

View details →DOI: 10.1017/s0007114517003889Cited by 41
Negative / Null Result Report

Multiseason occupancy models for correlated replicate surveys

James E. Hines, James D. Nichols, Jaime A. Collazo · 2014 · Methods in Ecology and Evolution

Summary Occupancy surveys collecting data from adjacent (sometimes correlated) spatial replicates have become relatively popular for logistical reasons. Hines et al . ( ) presented one approach to modelling such data for single‐season…

View details →DOI: 10.1111/2041-210x.12186Cited by 41
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Genome‐Wide Significant Association Signals in IPO11‐HTR1A Region Specific for Alcohol and Nicotine Codependence

Lingjun Zuo, Xiangyang Zhang, Fei Wang et al. · 2012 · Alcoholism Clinical and Experimental Research

BACKGROUND: Alcohol and nicotine codependence can be considered as a more severe subtype of alcohol dependence. A portion of its risk may be attributable to genetic factors. METHODS: We searched for significant risk genomic regions…

View details →DOI: 10.1111/acer.12032Cited by 41
Negative / Null Result ReportOpen accessBusiness, Management and Accounting

Determinant of financial performance of commercial banks in Ethiopia: Special emphasis on private commercial banks

Teshome Elshaday, Debela Kenenisa, Sultan Mohammed · 2018 · AFRICAN JOURNAL OF BUSINESS MANAGEMENT

This study aims at examining the determinants of the financial performance of private commercial banks in Ethiopia. The study uses secondary data for eight private banks which are in the industry for more than ten years. These banks are chosen from sixteen private commercial banks which are currently functional in Ethiopia banking industry. The data for this study is obtained from annual reports of the banks, minutes and the national bank report. Correlation and multiple linear regressions of panel data for the eight banks for the years 2007 to 2016 is analyzed using random effect model. E-Vie

View details →DOI: 10.5897/ajbm2017.8470Cited by 41
Negative / Null Result ReportOpen accessSocial Sciences

The Incredible Years® Teacher Classroom Management programme and its impact on teachers’ professional self‐efficacy, work‐related stress, and general well‐being: Results from the STARS randomized controlled trial

Rachel Hayes, Daniel Titheradge, Kate Allen et al. · 2019 · British Journal of Educational Psychology

BACKGROUND: Teaching is a stressful occupation with poor retention. The Incredible Years® Teacher Classroom Management (TCM) programme is a training programme that research has demonstrated may be an effective intervention for improving…

View details →DOI: 10.1111/bjep.12284Cited by 41
Negative / Null Result ReportOpen accessMedicine

Significant effect of HIV/HAART on oral microbiota using multivariate analysis

Ann L. Griffen, Zachary A. Thompson, Clifford J. Beall et al. · 2019 · Scientific Reports

Persons infected with HIV are particularly vulnerable to a variety of oral microbial diseases. Although various study designs and detection approaches have been used to compare the oral microbiota of HIV-negative and HIV-positive persons, both with and without highly active antiretroviral therapy (HAART), methods have varied, and results have not been consistent or conclusive. The purpose of the present study was to compare the oral bacterial community composition in HIV-positive persons under HAART to an HIV-negative group using 16S rRNA gene sequence analysis. Extensive clinical data was col

View details →DOI: 10.1038/s41598-019-55703-9Cited by 41
Negative / Null Result ReportOpen accessNeuroscience

In situ Tip-Recordings Found No Evidence for an Orco-Based Ionotropic Mechanism of Pheromone-Transduction in Manduca sexta

Andreas Nolte, Nico W. Funk, Latha Mukunda et al. · 2013 · PLoS ONE

The mechanisms of insect odor transduction are still controversial. Insect odorant receptors (ORs) are 7TM receptors with inverted membrane topology. They colocalize with a conserved coreceptor (Orco) with chaperone and ion channel function. Some studies suggest that insects employ exclusively ionotropic odor transduction via OR-Orco heteromers. Other studies provide evidence for different metabotropic odor transduction cascades, which employ second messenger-gated ion channel families for odor transduction. The hawkmoth Manduca sexta is an established model organism for studies of insect olfa

View details →DOI: 10.1371/journal.pone.0062648Cited by 41
Negative / Null Result ReportMedicine

Lack of Replication of the Association of Low Serum Cholesterol and Attempted Suicide in Another Country Raises More Questions

José de León, Paula Mallory, Lorraine Maw et al. · 2011 · Annals of Clinical Psychiatry

BACKGROUND: In 2 Spanish case-control studies, low cholesterol levels in males were consistently associated with suicide attempts. METHODS: This US study tried to replicate the association between low cholesterol levels and suicide…

View details →DOI: 10.1177/104012371102300302Cited by 41
Negative / Null Result ReportOpen accessImmunology and Microbiology

The determinant of periodicity in Mycoplasma pneumoniae incidence: an insight from mathematical modelling

Ryosuke Omori, Yukihiko Nakata, Heidi L. Tessmer et al. · 2015 · Scientific Reports

Until the early 1990 s, incidences of Mycoplasma pneumoniae (MP) infection showed three to five year epidemic cycles in multiple countries, however, the mechanism for the MP epidemic cycle has not been understood. Here, we investigate the determinant of periodicity in MP incidence by employing a mathematical model describing MP transmission dynamics. Three candidates for the determinant of periodicity were evaluated: school-term forcing, minor variance in the duration of immunity, and epidemiological interference between MP serotypes. We find that minor variation in the duration of immunity at

View details →DOI: 10.1038/srep14473Cited by 41
Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance

Assessing Financial Risk Tolerance: Do Demographic, Socioeconomic And Attitudinal Factors Work?

Vijay Gondaliya, Govind Dhinaiya · 2017 · Zenodo (CERN European Organization for Nuclear Research)

Every investor and investment planner talk about risk tolerance and what people think is appropriate because there’s so much more to risk tolerance than what you can capture. Defining and understanding risk are important challenges for…

View details →DOI: 10.5281/zenodo.376797Cited by 41
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Impact of Salinity on the Gastrointestinal Bacterial Community of Theodoxus fluviatilis

Carmen Kivistik, Jan Knobloch, Kairi Käiro et al. · 2020 · Frontiers in Microbiology

Differences in salinity are boundaries that act as barriers for the dispersal of most aquatic organisms. This creates distinctive biota in freshwater and brackish water (mesohaline) environments. To test how saline boundaries influence the diversity and composition of host-associated microbiota, we analyzed the microbiome within the digestive tract of Theodoxus fluviatilis, an organism able to cross the freshwater and mesohaline boundary. Alpha-diversity measures of the microbiome in freshwater and brackish water were not significantly different. However, the composition of the bacterial commu

View details →DOI: 10.3389/fmicb.2020.00683Cited by 41
Negative / Null Result ReportOpen accessMaterials Science

The significant effect of size and concentrations of iron oxide nanoparticles on magnetic resonance imaging contrast enhancement

Mohammad W. Marashdeh, Baker Ababneh, O. M. Lemine et al. · 2019 · Results in Physics

In this study, iron oxide (γ-Fe2O3) nanoparticles (IONs) were successfully synthesized using sol-gel method, and characterized by XRD and VSM. The potential application of the differently sized IONs (22 nm and 30 nm) as magnetic resonance…

View details →DOI: 10.1016/j.rinp.2019.102651Cited by 41
Negative / Null Result ReportHealth Professions

Evaluation of physician assistants in National Health Service Scotland

Jane Farmer, Mary Currie, Jeff Hyman et al. · 2011 · Scottish Medical Journal

Physician assistants (PAs) have medical training and work supervised by a doctor. In 2006-2008 the Scottish Government piloted use of USA-trained PAs. The aim of the paper is to evaluate the impact and contribution made by PAs to…

View details →DOI: 10.1258/smj.2011.011109Cited by 41
Negative / Null Result ReportOpen accessMedicine

Effect of intravenous clarithromycin in patients with sepsis, respiratory and multiple organ dysfunction syndrome: a randomized clinical trial

Eleni Karakike, Brendon P. Scicluna, Maria Roumpoutsou et al. · 2022 · Critical Care

BACKGROUND: Clarithromycin may act as immune-regulating treatment in sepsis and acute respiratory dysfunction syndrome. However, clinical evidence remains inconclusive. We aimed to evaluate whether clarithromycin improves 28-day mortality among patients with sepsis, respiratory and multiple organ dysfunction syndrome. METHODS: We conducted a multicenter, randomized, clinical trial in patients with sepsis. Participants with ratio of partial oxygen pressure to fraction of inspired oxygen less than 200 and more than 3 SOFA points from systems other than the respiratory function were enrolled betw

View details →DOI: 10.1186/s13054-022-04055-4Cited by 41
Negative / Null Result ReportOpen accessBusiness, Management and Accounting

Fit perceptions, work engagement, satisfaction and commitment

Bruce A. Rayton, Zeynep Y. Yalabik, Andriana Rapti · 2019 · Journal of Managerial Psychology

Purpose The purpose of this paper is to explore the relationship between fit (organization and job) perceptions and work engagement (WE). Design/methodology/approach The authors deployed a two-wave survey among 377 clerical employees of…

View details →DOI: 10.1108/jmp-02-2018-0074Cited by 41
Negative / Null Result ReportSocial Sciences

The Effectiveness of Video Quizzes in a Flipped Class

Lisa L. Lacher, Mark C. Lewis · 2015

The use of online videos and flipped classrooms is a natural fit for many CS courses, especially in the introductory sequence, and the use of these techniques is growing. However, the benefits of these techniques depend heavily on student…

View details →DOI: 10.1145/2676723.2677302Cited by 41
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Treatment of Dientamoeba fragilis in Patients with Irritable Bowel Syndrome

Anne Line Engsbro, Christen Rune Stensvold, Henrik Nielsen et al. · 2012 · American Journal of Tropical Medicine and Hygiene

The role of Dientamoeba fragilis in irritable bowel syndrome (IBS) is incompletely known. We aimed to investigate whether eradication of D. fragilis alleviates symptoms in IBS. Twenty-five D. fragilis-positive IBS patients were treated…

View details →DOI: 10.4269/ajtmh.2012.11-0761Cited by 41
Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance

New evidence, old puzzles: Technology shocks and labor market dynamics

Almut Balleer · 2012 · Quantitative Economics

Can the standard search-and-matching labor market model replicate the business cycle fluctuations of the job finding rate and the unemployment rate? In the model, these fluctuations are driven by movements in productivity. This paper…

View details →DOI: 10.3982/qe35Cited by 40
Negative / Null Result ReportOpen accessSocial Sciences

Corrections of political misinformation: no evidence for an effect of partisan worldview in a US convenience sample

Ullrich K. H. Ecker, Brandon K. N. Sze, Matthew Andreotta · 2021 · Philosophical Transactions of the Royal Society B Biological Sciences

Misinformation often has a continuing effect on people's reasoning despite clear correction. One factor assumed to affect post-correction reliance on misinformation is worldview-driven motivated reasoning. For example, a recent study with an Australian undergraduate sample found that when politically situated misinformation was retracted, political partisanship influenced the effectiveness of the retraction. This worldview effect was asymmetrical, that is, particularly pronounced in politically conservative participants. However, the evidence regarding such worldview effects (and their symmetr

View details →DOI: 10.1098/rstb.2020.0145Cited by 40
Negative / Null Result ReportImmunology and Microbiology

Comparing identified and statistically significant lipids and polar metabolites in 15‐year old serum and dried blood spot samples for longitudinal studies

Jennifer Kyle, Cameron Casey, Kelly G. Stratton et al. · 2016 · Rapid Communications in Mass Spectrometry

RATIONALE: The use of dried blood spots (DBS) has many advantages over traditional plasma and serum samples such as the smaller blood volume required, storage at room temperature, and ability to sample in remote locations. However,…

View details →DOI: 10.1002/rcm.7808Cited by 40
Negative / Null Result ReportOpen accessImmunology and Microbiology

TCR repertoire diversity in Multiple Sclerosis: High-dimensional bioinformatics analysis of sequences from brain, cerebrospinal fluid and peripheral blood

Roberta Amoriello, Maria Chernigovskaya, Victor Greiff et al. · 2021 · EBioMedicine

BACKGROUND: T cells play a key role in the pathogenesis of multiple sclerosis (MS), a chronic, inflammatory, demyelinating disease of the central nervous system (CNS). Although several studies recently investigated the T-cell receptor…

View details →DOI: 10.1016/j.ebiom.2021.103429Cited by 40
Negative / Null Result ReportEngineering

Evaluating performance of selected vehicle following models using trajectory data under mixed traffic conditions

Narayana Raju, Shriniwas Arkatkar, Gaurang Joshi · 2019 · Journal of Intelligent Transportation Systems

This research work is focused on modeling vehicle following behavior under mixed traffic conditions. Vehicle-following behavior can be potentially utilized in building real-time drivers’ assistance systems or identifying collision escaping…

View details →DOI: 10.1080/15472450.2019.1675522Cited by 40
Negative / Null Result ReportMedicine

Lack of replication of interaction between EBNA1 IgG and smoking in risk for multiple sclerosis

Emilie Sundqvist, Peter Sundström, Magdalena Lindén et al. · 2012 · Neurology

BACKGROUND: Epstein-Barr virus infection, smoking, HLA-A*02, and DRB1*15 have all been proposed as risk factors for multiple sclerosis (MS). In 2010, Simon et al. described an interaction on the multiplicative scale between EBNA1…

View details →DOI: 10.1212/wnl.0b013e31826c1ab7Cited by 40
Negative / Null Result ReportOpen accessMedicine

Treatment of premenstrual dysphoria with continuous versus intermittent dosing of oral contraceptives: Results of a three-arm randomized controlled trial

Tory A. Eisenlohr‐Moul, Susan S. Girdler, Jacqueline L. Johnson et al. · 2017 · Depression and Anxiety

BACKGROUND: Although traditionally dosed combined oral contraceptives (COCs) (21 days of active pills, 7 days of inactive pills) have not been demonstrated as superior to placebo for the treatment of premenstrual dysphoria (PMD), some…

View details →DOI: 10.1002/da.22673Cited by 40
Negative / Null Result Report

Statistically supported real driving emission calibration: Using cycle generation to provide vehicle-specific and statistically representative test scenarios for Euro 7

Johannes Claßen, Stefan Pischinger, Sascha Krysmon et al. · 2020 · International Journal of Engine Research

The progression of emission legislation has intensified the efforts of the automotive industry to develop improved exhaust gas after-treatment systems. The requirement to fulfill Euro 6d-TEMP in real-world driving scenarios, the already…

View details →DOI: 10.1177/1468087420935221Cited by 40
Negative / Null Result ReportOpen accessNeuroscience

Direct stimulation of somatosensory cortex results in slower reaction times compared to peripheral touch in humans

David J. Caldwell, Jeneva A. Cronin, Jing Wu et al. · 2019 · Scientific Reports

Direct cortical stimulation (DCS) of primary somatosensory cortex (S1) could help restore sensation and provide task-relevant feedback in a neuroprosthesis. However, the psychophysics of S1 DCS is poorly studied, including any comparison to cutaneous haptic stimulation. We compare the response times to DCS of human hand somatosensory cortex through electrocorticographic grids with response times to haptic stimuli delivered to the hand in four subjects. We found that subjects respond significantly slower to S1 DCS than to natural, haptic stimuli for a range of DCS train durations. Median respon

View details →DOI: 10.1038/s41598-019-38619-2Cited by 40
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Differences between performance of F1 crossbreds and Holsteins at different production levels

Julie Clasen, Anders Fogh, Morten Kargo · 2018 · Journal of Dairy Science

Crossbreeding in dairy cattle has recently become of increased interest. However, farmers in Scandinavian countries are reluctant to implement crossbreeding in their herds, and one reason is the common opinion that only herds at a poor…

View details →DOI: 10.3168/jds.2018-14975Cited by 40
Negative / Null Result ReportMathematics

Can Computer-Assisted Discovery Learning Foster First Graders’ Fluency With the Most Basic Addition Combinations?

Arthur J. Baroody, Michael D. Eiland, David J. Purpura et al. · 2013 · American Educational Research Journal

In a 9-month training experiment, 64 first graders with a risk factor were randomly assigned to computer-assisted structured discovery of the add-1 rule (e.g., the sum of 7 + 1 is the number after “seven” when we count), unstructured…

View details →DOI: 10.3102/0002831212473349Cited by 40