A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
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Iannuzzi S, Müller M, Yu Y et al. · 2026 · Nature communications
The human immunodeficiency virus (HIV) infected approximately 1.1 million individuals in 2024. There is no effective vaccine or cure, and funding cuts in resource-limited settings threaten treatment access. Cost-effective and widely…
Ho LYW, Lai CKY, Ng SSM · 2026 · Topics in stroke rehabilitation
Background The performance fatigue index provides objective measures for assessing the impact of fatigue on performance and it may be utilized for monitoring functional outcomes in individuals with stroke; however, its psychometric…
Templado S, Almela-Rojo M, Barceló MD et al. · 2026 · Hearing research
Background Pigs are increasingly used as translational models for auditory research due to anatomical and physiological similarities with humans. However, normative auditory brainstem response (ABR) parameters in commercial pig breeds…
Kavanagh EW, Joynt AT, Pion AR et al. · 2026 · JCI insight
Cystic fibrosis (CF) is a life-limiting genetic disorder caused by deleterious variants in the CFTR gene that results in altered mucus impairing the airway epithelia. Durable correction of these variants in airway cells remains a…
Yin LX, Hidalgo CM, Bogan AW et al. · 2025 · JAMA otolaryngology-- head & neck surgery
Importance Circulating tumor human papillomavirus DNA (ctHPVDNA) is an important biomarker for the presence of HPV-associated oropharyngeal squamous cell carcinoma (OPSCC), but little is known about early postoperative kinetics of ctHPVDNA…
Chawana-Mutingwende TD, Ngara B, Mudadi LS et al. · 2026 · Journal of the International AIDS Society
Introduction Peripartum adolescent girls and young women (AGYW) with HIV have lower viral suppression compared to older women. But the recently introduced dolutegravir-based regimens and psychosocial peer motivation may improve viral…
Giampaolo T, Liotard MG, Cadoré JL et al. · 2026 · Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
Diagnosis of canine bacterial bronchopneumonia (bBP) is challenging and mostly based on bronchoalveolar lavage fluid (BALF) cytology and bacterial culture (BC) results. However, bacterial contamination of BALF is frequent, intracellular…
Gleichenhagen J, Kaiser N, Brüning T et al. · 2026 · Journal of clinical laboratory analysis
Background Microsampling using filter cards for dried blood spots (DBS) and dried plasma spots (DPS) is a well-established technique offering practical advantages for blood collection and subsequent processing. For DBS/DPS, only a small…
Kashiv P, Balwani M, Pasari AS et al. · 2026 · Cureus
Antibody-mediated rejection (ABMR) is conventionally defined by the presence of donor-specific anti-human leukocyte antigen (HLA) antibodies (DSA), characteristic microvascular injury on allograft biopsy, and evidence of complement…
Ifeh C, Allan E, Ndiaye A et al. · 2026 · Journal of food science
This study utilized collaborations with Senegalese women farmers to investigate the impact of lactic acid bacteria (LAB) fermentation of sorghum, baobab, and milk on nutritional and sensory qualities for plant-enriched yogurt. Using a…
Carroll M, Gao Z, He L · 2026 · Foods (Basel, Switzerland)
Trace quantifications of arsenic (As) in foods by energy-dispersive X-ray fluorescence (ED-XRF) spectrometry are hindered by spectral overlap from lead (Pb) at characteristic emission lines. This study employed artificial neural networks…
De Laender F, Gonzalez A, Bleeckx O et al. · 2026 · Preprint
We provide a general theoretical explanation for a longstanding result in spatial ecology: weak dispersal among habitat patches promotes local biodiversity. Using analytical approximations of spatial Lotka–Volterra competition models, we…
Zips N, Kulko E, Kath-Schorr S · 2026 · Chembiochem : a European journal of chemical biology
mRNA translation can be controlled through chemical modification of the 5'-Cap, yet systematic insights into structure-reactivity relationships of bioorthogonally activatable Cap analogues remain limited. Here, we report the synthesis of…
Strauss R, Wafula ST, Kobbe R et al. · 2026 · Open forum infectious diseases
We assessed baseline C-reactive protein (CRP) and procalcitonin levels in asymptomatic individuals from malaria-endemic West Africa. C-reactive protein remained unaffected by Plasmodium falciparum parasitemia, while procalcitonin (PCT) was…
Bongulto K, Tauchi H, Suzuki S et al. · 2026 · Preprint
Carbapenem-resistant Acinetobacter (CRA) has been associated with increased morbidity and mortality in clinical settings. In this study, we explored the transfer potential of a mobilizable plasmid-harboring blaOXA-72 gene between…
Hubbe M, Eibl RH · 2026 · Preprint
Leukocyte recruitment from blood into tissues involves sequential adhesive steps, including rolling and integrin-dependent arrest. VLA-4 can support firm adhesion and, in some settings, rolling interactions, whereas CD44–hyaluronan…
La Vignera S, Condorelli RA · 2026 · Diagnostics (Basel, Switzerland)
Normogonadotropic azoospermia (NOAN) represents a diagnostic and therapeutic challenge in male infertility, affecting men with normal gonadotropin levels but absent sperm in the ejaculate. Emerging evidence has identified…
Anam C, Amilia R, Naufal A et al. · 2026 · Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)
Purpose This study aims to evaluate statistical low-contrast detectability (SLCD) at multiple confidence levels (CLs) in computed tomography (CT) images and to determine the smallest detectable object sizes compared with human observers…
Aguettaz AK, Arribat Y, Schmitt A et al. · 2026 · Preprint
Perilipin 3 (PLIN3) is a lipid droplet–associated protein implicated in cellular lipid metabolism. We characterize a previously unrecognized alternative splicing event in human PLIN3 . The generated transcript PLIN3B is detectable at the…
Kakizaki J, Widada AA, Ichihashi N et al. · 2026 · Preprint
The emergence of heritable molecular information is a fundamental step in the origins of life. Prior to the evolution of defined self-reproducing RNAs in the RNA world hypothesis, mixtures of primordial oligonucleotides may have supported…
Loghin II, Vaţă A, Rusu ȘA et al. · 2026 · Medicina (Kaunas, Lithuania)
Background and Objectives. Mother-to-child transmission (MTCT) or vertical transmission of human immunodeficiency virus (HIV) is largely preventable in settings where prevention of MTCT (PVT) strategies are consistently implemented.…
Pisani M, Marcheschi P, Clemente A et al. · 2026 · Preprint
Aortic calcification represents a key marker of cardiovascular disease, detectable through medical imaging. This research investigates the use of artificial intelligence (AI) to assist radiologists in identifying aortic calcification in…
Liang A, Veetil S, Groom K et al. · 2026 · Preprint
Abstract Laser Powder Bed Fusion (LPBF) is a widely adopted additive manufacturing technique for producing geometrically metal components. While this process yields fine microstructures beneficial for strength, the associated rapid thermal…
Ware A, LaMountain J, White RC et al. · 2026 · Nature communications
The electromagnetic response of materials serves as the foundation for a broad range of vital applications, from imaging, to sensing, to classical and quantum communications. Here we demonstrate, theoretically and experimentally, a…
Ajibola G, Nelson BS, Niesar A et al. · 2026 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Background Broadly neutralizing antibodies (bNAbs) are a promising treatment option for children with HIV-1, but their long-term impact on virologic, immunologic, and clinical outcomes is unknown. Methods The Tatelo Study investigated dual…
· 2006
Data from well-conducted studies indicate that metformin levels in milk are low and infants would receive less than 0.5% of their mother's weight-adjusted dosage. Milk metformin levels are relatively constant during maternal metformin use,…
Reid L, Ganapathiraju S, Mancinelli S et al. · 2026 · Preprint
Retinoid-related orphan receptor gamma (RORγ) is a lineage-defining transcription factor for T helper 17 (Th17) cells and has long been considered selectively expressed within the immune system. However, accumulating evidence has…
Palenchar PM · 2026 · PloS one
Understanding how evolution shapes variability in gene expression is complicated by the interdependence of expression levels, expression variability, and evolutionary rates. Metrics that quantify variability independently of expression…
Senise G, Bodega F, Porta C et al. · 2026 · Cells
Cigarette smoke is a major inducer of oxidative stress, promoting reactive oxygen species (ROS) accumulation and contributing to the pathogenesis of chronic obstructive pulmonary disease (COPD) and lung cancer. Heated tobacco products…
· 2006
Infants receive citalopram in breastmilk, and it is detectable in low levels in the serum of some. The dosage that the infant receives and serum level achieved are probably related to the genetic metabolic capacity of the mother and…