Negative / Null Result ReportMedicine
Ueland T, Traaen GM, Hunt TE et al. · 2025 · Sleep medicine
Study objectives Obstructive sleep apnea (OSA) and atrial fibrillation (AF) are highly prevalent conditions sharing multiple risk factors including obesity. Adipokines secreted from adipose tissue could modify pathways affecting atrial…
View details →DOI: 10.1016/j.sleep.2025.106862 Negative / Null Result ReportMedicine
Penrod S, Forgit D, Griffin L · 2025 · American journal of speech-language pathology
Purpose The purpose of this study was to investigate whether the implementation of the Green Light Tool for the evaluation and treatment of tracheostomy patients hospitalized at Maine Medical Center affects the time to initiating oral…
View details →DOI: 10.1044/2025_ajslp-24-00466 Replication FailureOpen accessMedicine
Lin X, Ou J, Wu G et al. · 2025 · Biochemistry and biophysics reports
Introduction Venous malformations are the most common congenital vascular anomaly, accounting for 65 % of all congenital vascular abnormalities. This study aims to investigate the correlation between genetic polymorphisms of MALAT1 and the…
View details →DOI: 10.1016/j.bbrep.2025.102209 Replication Failure
Ma Y, Mayes MD, Guo X et al. · 2024 · Preprint
Abstract Objective This study aimed to examine whether a reported SSc-associated SNP rs2841277 in the PLD4 gene identified in an Asian population was also associated with SSc in US Caucasians. Methods The US Caucasian cohort consisting of…
View details →DOI: 10.21203/rs.3.rs-4238970/v1 Replication FailureOpen accessMedicine
Velaga SB, Alagorie AR, Nittala MG et al. · 2025 · Ophthalmology science
Purpose To evaluate the change in the area of reticular pseudodrusen (RPD) and choroidal thickness over 2 years in eyes with age-related macular degeneration (AMD). Design Longitudinal cohort study. Subjects The study reviewed 1332 eyes…
View details →DOI: 10.1016/j.xops.2025.100881 Replication FailureMedicine
Belica I, Blasko F, Sleziak I et al. · 2025 · Biological psychology
Resting heart rate variability (HRV) reflects rhythmic changes in heart rate over time associated with autonomic nervous system (ANS) activity. It has served as a predictor of health and the development of various diseases. Therefore, it…
View details →DOI: 10.1016/j.biopsycho.2025.109073 Negative / Null Result ReportOpen accessMedicine
Govender V, Govender K, Moodley D · 2026 · BMC infectious diseases
BACKGROUND: Maintaining viral suppression in the postpartum period is critical for preventing HIV transmission to sexual partners and breastfed infants. Despite systemic viral suppression, genital HIV shedding may still occur in some…
View details →DOI: 10.1186/s12879-026-12621-2 Negative / Null Result ReportMedicine
Kambara M, Ikawa F, Hidaka T et al. · 2025 · Neurosurgery
Background and objectives Some reports suggest that older patients with traumatic brain injury (TBI) are more likely to experience acute intracranial hemorrhage, resulting in poor outcomes. However, the association between precise…
View details →DOI: 10.1227/neu.0000000000003240 Negative / Null Result ReportMedicine
Rodriguez JA, Palermo NE, Song W et al. · 2026 · Diabetes technology & therapeutics
Continuous glucose monitors (CGMs) are becoming increasingly available, yet the relationship between CGM metrics and hemoglobin A1c (HbA1c) among individuals with prediabetes and normoglycemia remains unclear. We examined associations…
View details →DOI: 10.1177/15209156251379506 Negative / Null Result ReportMedicine
de Luis D, Primo D, Izaola O et al. · 2024 · European review for medical and pharmacological sciences
Objective Sarcopenia is a condition characterized by muscle mass loss. Skeletal muscle is capable of producing and secreting different molecules called myokines, and apelin is one of them. The literature contains contradictory data on the…
View details →DOI: 10.26355/eurrev_202406_36461 Negative / Null Result ReportOpen accessMedicine
Leibold P, Lteif C, Duarte JD · 2025 · Frontiers in genetics
Introduction Hypertension (HTN) is a leading risk factor for several cardiovascular diseases. While some previous studies reported that CYP3A5 variants were associated with decreased blood pressure and risk of HTN, others reported no…
View details →DOI: 10.3389/fgene.2025.1490863 Negative / Null Result ReportOpen accessMedicine
Solanki JD, Joshi DR, Atodaria KA et al. · 2025 · Journal of family medicine and primary care
Introduction Cardiovascular health is adversely affected by menopausal transition with reduced heart rate variability (HRV) as a manifest. Electrocardiogram (ECG) based 5 min HRV has worsening trend from premenopausal to postmenopausal…
View details →DOI: 10.4103/jfmpc.jfmpc_274_25 Negative / Null Result ReportMedicine
McHenry MS, Huo Y, Williams PL et al. · 2026 · Journal of acquired immune deficiency syndromes (1999)
Background Our objective was to evaluate the association between inflammatory biomarkers and NIH Toolbox cognitive outcomes in young adults with perinatal HIV exposure but uninfected (YAPHEU) and those with perinatal HIV (YAPHIV), with or…
View details →DOI: 10.1097/qai.0000000000003771 Negative / Null Result Report
Bontrager M, Worthy SJ, Leventhal L et al. · 2025 · Preprint
Summary Herbarium specimens are broadly distributed in space and time, enabling investigation of climate impacts on phenology and fitness. We reconstructed specimen “lived” climate from knowledge of germination cues and collection dates…
View details →DOI: 10.1101/2025.02.03.636077 Negative / Null Result ReportMedicine
Hunter JWS, Van Den Heuvel C, Stephenson L et al. · 2025 · The American journal of forensic medicine and pathology
Abstract Both obesity and opioid abuse are increasing in numbers globally. As these entities may be associated with significant respiratory compromise, it was hypothesized that synergism may occur and that as a result of this obese…
View details →DOI: 10.1097/paf.0000000000001029 Negative / Null Result Report
Christian K, Moritz C, Skelton K et al. · 2024 · Preprint
1. Reptiles are challenged with maintaining stable hydric states and viable body temperatures in a variable terrestrial environment. Reptiles can use behaviour to select favourable microhabitats as well as physiological adaptations, such…
View details →DOI: 10.32942/x28s4j Negative / Null Result ReportMedicine
Eskandarian S, Zafarani A, Tandel P et al. · 2025 · Molecular biology reports
Background Clopidogrel is a widely used antiplatelet drug for treating acute coronary syndrome. Its metabolism primarily involves the CYP2C19 isoenzyme, with CYP2C192 and CYP2C193 alleles associated with reduced metabolic activity.…
View details →DOI: 10.1007/s11033-025-10482-7 Negative / Null Result ReportOpen accessMedicine
Dias ALB, Nascimento JR, Brito-Sousa JD et al. · 2025 · PloS one
Background Glucose-6-phosphate dehydrogenase deficiency (G6PDd) is a common genetic disorder that impairs the cellular antioxidant response and has been hypothesized as a potential risk factor for severe outcomes in viral infections,…
View details →DOI: 10.1371/journal.pone.0331729 Negative / Null Result ReportOpen accessMedicine
van Dijkman SC, Félices M, Pandurangavittal B et al. · 2026 · British journal of clinical pharmacology
Aims Paroxetine is a selective serotonin reuptake inhibitor (SSRI), approved for treatment of major depressive disorder and anxiety disorders. Some SSRIs are known to prolong the QT interval; however, clinical evidence to establish a lack…
View details →DOI: 10.1002/bcp.70398 Negative / Null Result ReportMedicine
Soffer GK, Feinberg T, Kroll H et al. · 2025 · The Journal of asthma : official journal of the Association for the Care of Asthma
Objectives To assess the prevalence and perceived efficacy of complementary and alternative medicine (CAM) use among urban adolescents with asthma, building on a previous landmark study, and to determine if CAM use varied by asthma…
View details →DOI: 10.1080/02770903.2025.2475451 Negative / Null Result ReportOpen accessMedicine
Zhou C, Cui GY, Tang YH et al. · 2025 · World journal of diabetes
Background The association between ambient air pollution and glycolipid metabolic disorders (GMDs, including diabetes mellitus and dyslipidemia) is still not well understood, especially when it comes to the different effects of long-term…
View details →DOI: 10.4239/wjd.v16.i12.110028 Negative / Null Result ReportMedicine
Mayntz SP, Warncke S, Ladefoged LG et al. · 2025 · Journal of cardiology
Background Cardiovascular disease is a leading cause of mortality globally, with air pollution, particularly fine particulate matter (PM 2.5 ), recognized as a significant risk factor. While long-term accumulated exposure to PM 2.5 has…
View details →DOI: 10.1016/j.jjcc.2025.04.012 Negative / Null Result ReportOpen accessMedicine
Szczuko M, Szmigiel O, Szczuko U et al. · 2026 · Journal of clinical medicine
Background : Hashimoto's thyroiditis (HT) is the result of a complex interplay between genetic, environmental, and epigenetic factors. The role of cellular and humoral immunity in the pathogenesis of the disease is well-established.…
View details →DOI: 10.3390/jcm15030970 Negative / Null Result ReportOpen accessMedicine
Corrêa Matias Pereira C, Najafi Moghaddam Gilani V, Nazif-Munoz JI · 2024 · Frontiers in psychiatry
Objectives Aiming to disseminate information related to suicide prevention in Brazil, the " Setembro Amarelo " campaign has been conducted since 2015. The objective of this study is to assess the association between this campaign and…
View details →DOI: 10.3389/fpsyt.2024.1354030 Negative / Null Result Report
Gao Z, Yuan Y, Oleson JJ et al. · 2024 · Preprint
ABSTRACT Objectives This study investigated the relationships between the cochlear nerve (CN) health and sentence-level speech perception outcomes measured in quiet and noise in postlingually deafened adult cochlear implant (CI) users.…
View details →DOI: 10.1101/2024.11.16.24317332 Negative / Null Result Report
Lipschultz R, Salunga A, Castaneda P · 2024 · Preprint
Intro: To investigate if there is a relationship between the number of prenatal visits and the age at which hip dysplasia is diagnosed in infants. Methods: We conducted a retrospective chart review between January 2017 and December 2021,…
View details →DOI: 10.22541/au.171772785.54767085/v1 Negative / Null Result ReportOpen accessMedicine
Tabara Y, Matsumoto T, Murase K et al. · 2025 · Journal of cachexia, sarcopenia and muscle
Background Diaphragm thickness is a potential marker of sarcopenia in addition to muscle mass and strength at extremities. We aimed to clarify the descriptive epidemiology and prognostic significance of diaphragm thickness in the general…
View details →DOI: 10.1002/jcsm.13690 Negative / Null Result ReportOpen accessMedicine
Dadoo S, Vieider RP, Grandberg C et al. · 2026 · Orthopaedic journal of sports medicine
Background While quadriceps tendon (QT) autograft is being increasingly utilized for primary anterior cruciate ligament reconstruction (ACLR), there remains limited evaluation of how QT autograft diameter and the ratio of graft diameter to…
View details →DOI: 10.1177/23259671261433007 Negative / Null Result ReportOpen accessMedicine
Koerte IK, Wiegand TLT, Bonke EM et al. · 2026 · JAMA network open
Importance Repetitive head impacts (RHIs) are associated with later-life neurodegeneration. Because soccer is the most widely played sport among youth worldwide, identifying early changes associated with RHI is important. Objective To…
View details →DOI: 10.1001/jamanetworkopen.2026.19569 Negative / Null Result ReportOpen accessMedicine
Meza-Espinoza JP, Zavala-Rubio JD, Leal-Ugarte E et al. · 2025 · BMC research notes
Objective The CAPN10 gene encodes a protein that regulates insulin secretion and glucose uptake. Its variant Indel-19 has been associated with an increased risk of type 2 diabetes mellitus, diabetes-related traits, and some chronic…
View details →DOI: 10.1186/s13104-025-07184-5 