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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20289 results in Negative / Null Result Report · page 671 of 677

Negative / Null Result ReportMedicine

Efficacy of Low-dose Aspirin in Preventing Hypertensive Disorders of Pregnancy in Women with Systemic Lupus Erythematosus: A Single-Center Retrospective Cohort Study.

Kohno C, Higuchi A, Miyagawa E et al. · 2026 · Modern rheumatology

Objectives Low-dose aspirin (LDA) is widely recommended to prevent hypertensive disorders of pregnancy (HDP). However, the evidence of its effectiveness in pregnancies with systemic lupus erythematosus (SLE) remains limited. This study…

View details →DOI: 10.1093/mr/roag028
Negative / Null Result ReportOpen accessMedicine

Lurasidone

· 2006

Lurasidone is more than 99% bound to plasma proteins, so it is unlikely that the drug would be excreted into milk in sufficient amounts to affect a breastfed infant. Data from one mother-infant pair appears to support the poor excretion…

Negative / Null Result ReportOpen accessMedicine

The Effects of Nitrate on Brown Fat Fraction and Activation in Older Adults With Type 2 Diabetes: A Randomised, Double-Blind and Placebo-Controlled Crossover Trial.

Neal RA, Corbett J, Costello JT et al. · 2026 · European journal of sport science

Type 2 diabetes mellitus (T2DM) is a metabolic disease characterised by chronic hyperglycaemia, whereas obesity is a major risk factor which increases morbidity and mortality. Treatments that alter white adipose tissue to express a…

View details →DOI: 10.1002/ejsc.70117
Negative / Null Result ReportMedicine

Role of Antipsychotic Agents for Adjunct Sedation.

DeGrado J, Devlin JW · 2025 · Critical care clinics

Antipsychotics are an attractive option for adjunctive sedation in critically ill adults given their sedating effects, short duration of action, lack of effect on respiratory drive, and multiple routes of administration but high-quality…

View details →DOI: 10.1016/j.ccc.2025.07.001
Negative / Null Result ReportOpen accessMedicine

Blood omega-3 fatty acids and coronary artery stenosis: a postmortem study.

Randall B, Leković A, Nikolić S et al. · 2025 · Lipids in health and disease

The role of omega-3 fatty acids in the atherosclerotic process remains unclear. Early studies demonstrated a profound anti-atherogenic effect of cod liver oil in a pig model, and autopsy reports from Alaska Natives consuming omega-3 rich…

View details →DOI: 10.1186/s12944-025-02697-1
Negative / Null Result ReportMedicine

Lack of Association of Initial Vasopressor Dosing with Survival and Cardiac Re-Arrest Likelihood After Return of Spontaneous Circulation.

Sharpe AR, Richardson K, Stanton M et al. · 2023 · The Journal of emergency medicine

Background Cardiac arrest occurs in approximately 350,000 patients outside the hospital and approximately 30,000 patients in the emergency department (ED) annually in the United States. When return of spontaneous circulation (ROSC) is…

View details →DOI: 10.1016/j.jemermed.2023.05.002
Negative / Null Result ReportMedicine

Coagulation factor XI in cirrhosis does not predict thrombo-hemorrhagic complications and hepatic decompensation.

Zanetto A, Campello E, Spiezia L et al. · 2024 · Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

Introduction Factor XI (FXI) is associated with thrombosis in patients without liver disease, but it alterations and prognostic value in cirrhosis are uncertain. Patients and methods We studied a prospective cohort of cirrhosis patients…

View details →DOI: 10.1016/j.dld.2024.05.020
Negative / Null Result ReportOpen accessMedicine

Dietary Diversity Score and Its Sociodemographic Determinants in School-Aged Children: Cross-Sectional Baseline Findings From a Quasi-experimental Study.

Singh T, Kumar S, Sinha S et al. · 2025 · Cureus

Background Dietary diversity is an essential component of nutritional adequacy, particularly for school-aged children who are undergoing rapid physical and cognitive development. Inadequate dietary diversity can lead to micronutrient…

View details →DOI: 10.7759/cureus.85804
Negative / Null Result ReportMedicine

Place of Death, Care Intensity, Symptom Prevalence, and Symptom Management for Patients With Stroke at End-of-Life.

Ramsburg H, Hinkle JL, MacKenzie Greenle M · 2026 · The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses

Background Each year in the United States, 795,000 people are diagnosed with a new or recurrent stroke, resulting in 165,393 deaths. However, little is known about the quality of end-of-life (EOL) care in this population, including the…

View details →DOI: 10.1097/jnn.0000000000000883
Negative / Null Result ReportMedicine

Intrapartum Glycemic Control and Clinical Outcomes.

Bitar G, Fishel Bartal M · 2025 · Diabetes spectrum : a publication of the American Diabetes Association

Current recommendations encourage strict intrapartum glycemic control for individuals with diabetes in pregnancy to optimize maternal and neonatal outcomes. However, established evidence is limited in providing a strong association between…

View details →DOI: 10.2337/dsi25-0010
Negative / Null Result ReportOpen accessMedicine

The effect of centralized care on the management of postoperative fluctuations in plasma sodium concentration after pediatric suprasellar brain tumor surgery.

Hulsmann SC, Zaal DC, van Gestel JPJ et al. · 2026 · Pituitary

PURPOSE: Children undergoing neurosurgery for (supra)sellar tumors are at risk of developing arginine vasopressin-deficiency (AVP-D), which can cause severe sodium fluctuations and associated neurological complications, prolonged…

View details →DOI: 10.1007/s11102-026-01666-w
Negative / Null Result ReportMedicine

Lack of Association between CD33 rs3865444 and Amyotrophic Lateral Sclerosis: A Case-Control Study.

Siokas V, Liampas I, Aloizou AM et al. · 2023 · Journal of integrative neuroscience

Background Microglial activation is considered to assume a role in the pathogenesis of Amyotrophic Lateral Sclerosis (ALS). To date, the relationship between ALS and the rs3865444 polymorphism of the cluster of differentiation 33 (CD33)…

View details →DOI: 10.31083/j.jin2204106
Negative / Null Result ReportOpen accessMedicine

Parent substance use and child-to-parent violence: A brief report.

Curtis A, Skvarc D, Brittain N et al. · 2025 · Drug and alcohol review

Introduction Substance use has been associated with child-to-parent violence (CPV), yet little is known about the contributing factors. This study investigated the association between parental substance use and substance involved child to…

View details →DOI: 10.1111/dar.14031
Negative / Null Result ReportOpen accessMedicine

Feeding Therapy and its Relationship to Timing of Independent Oral Feeding for Preterm Infants in the Neonatal Intensive Care Unit.

Nguyen TT, Pineda R, Reynolds S et al. · 2026 · Physical & occupational therapy in pediatrics

Aim To examine the relationship between feeding therapy and the timing of independent oral feeding (IOF) in preterm infants in the neonatal intensive care unit (NICU). Study design A retrospective analysis of 536 preterm infants ( Results…

View details →DOI: 10.1080/01942638.2025.2552136
Negative / Null Result ReportOpen accessMedicine

Frailty as Predictor for Early Functional Outcomes After Radical Prostatectomy.

Stankovic M, Weber C, Koser M et al. · 2025 · Journal of frailty, sarcopenia and falls

Objectives While chronological aging does not necessarily impair oncological outcomes after radical prostatectomy, the role of frailty remains less clear. This study aimed to evaluate whether frailty significantly affects early continence…

View details →DOI: 10.22540/jfsf-10-028
Negative / Null Result ReportOpen accessMedicine

The value of transpulmonary thermodilution parameters in predicting hemodynamic instability in intensive care patients undergoing continuous renal replacement therapy.

Keser CS, Erdemir M, Yilmaz M et al. · 2025 · BMC nephrology

Background Hemodynamic instability related to renal replacement therapy (HIRRT) is a serious complication of continuous renal replacement therapy (CRRT) in critically ill patients with acute kidney injury (AKI), significantly increasing…

View details →DOI: 10.1186/s12882-025-04712-0
Negative / Null Result ReportOpen accessMedicine

Neighborhood Physical Disinvestment and Incident Diabetes between visits 1 and 2 of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).

Smith CM, Spalt EW, Gallo LC et al. · 2026 · Journal of urban health : bulletin of the New York Academy of Medicine

Neighborhood-scale environmental factors, including disinvestment in infrastructure, may impact cardiometabolic disease risk. To our knowledge, no prior studies have investigated the association between neighborhood disinvestment and…

View details →DOI: 10.1007/s11524-026-01061-7
Negative / Null Result ReportOpen accessMedicine

Burden of atherosclerosis, cardiovascular risk factors and atrial fibrillation in individuals with covert brain infarcts in late midlife: the Akershus Cardiac Examination 1950 Study.

Ihle-Hansen H, Walle-Hansen MM, Berge T et al. · 2026 · BMJ open

Background Current expert consensus statements generally suggest cardiovascular risk assessment, including atrial fibrillation (AF) screening, on detection of covert brain infarctions (CBIs). However, evidence to guide management of CBI…

View details →DOI: 10.1136/bmjopen-2025-114232
Negative / Null Result ReportOpen accessMedicine

Histological signatures of hormone replacement therapy in the endometrium.

Abdalla M · 2026 · Frontiers in medicine

Background Hormone replacement therapy (HRT) is widely prescribed for managing menopausal symptoms, yet its effects on the endometrium remain clinically important. While large-scale studies have established that estrogen-only HRT increases…

View details →DOI: 10.3389/fmed.2026.1718508
Negative / Null Result ReportMedicine

Brain volumes in fetuses with congenital heart disease and placental vascular abnormalities.

O'Brien EA, Wypij D, Rofeberg V et al. · 2026 · Journal of perinatology : official journal of the California Perinatal Association

Objective Investigate the association between placental vascular abnormalities and regional brain volumes in congenital heart disease (CHD) fetuses with and without genetic abnormalities. Study design Secondary analysis of brain magnetic…

View details →DOI: 10.1038/s41372-026-02601-4
Negative / Null Result ReportOpen accessMedicine

Stable bloodstream infection rates despite rising colonization: insights from a hospital system using in-house polymerase chain reaction screening for <i>Candidozyma auris</i>.

Rosa R, Rosello G, Manzanillo K et al. · 2025 · Antimicrobial stewardship & healthcare epidemiology : ASHE

Following the implementation of in-house Candidozyma auris ( C. auris ) polymerase chain reaction as part of our surveillance strategy, we observed increasing incidence rates of colonization with C. auris already present at hospital…

View details →DOI: 10.1017/ash.2025.10076
Negative / Null Result ReportOpen accessMedicine

Ki67 and Lymphovascular Invasion as Histopathological Predictors of Residual Cancer Burden After Neoadjuvant Chemotherapy in Breast Cancer: A Retrospective Study.

Carabas BA, Țǎpoi DA, Costache M · 2026 · Diagnostics (Basel, Switzerland)

Background: Neoadjuvant chemotherapy (NAC) is widely used in the management of stage I-III breast cancer, with tumor regression serving as an important surrogate for long-term outcome. Identifying reliable pathological biomarkers…

View details →DOI: 10.3390/diagnostics16081213
Negative / Null Result ReportOpen accessMedicine

Helicobacter pylori in the Philippines: Social and Ecological Determinants of Seropositivity and Lack of Association With Systemic Inflammation.

Lee CC, Miller AA, Tallman PS et al. · 2025 · American journal of human biology : the official journal of the Human Biology Council

Helicobacter pylori (H. pylori) is a bacterium that infects the stomach and is associated with various gastrointestinal outcomes and increased cardiovascular disease risk. We examined the role of sex in and the social and ecological…

View details →DOI: 10.1002/ajhb.70069