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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19918 results in Negative / Null Result Report · page 664 of 664

Negative / Null Result ReportOpen accessMedicine

KIF23 regulates cytoskeleton dynamics for cytokinesis and mitochondrial function during oocyte meiosis.

Zou YJ, Zhang KH, Lu PS et al. · 2026 · Cell communication and signaling : CCS

Cytoskeleton dynamics ensure multiple cellular progression during oocyte meiosis, which is critical for successful fertilization and early embryo development. KIF23, a member of the kinesin-6 superfamily, mediates intracellular transport…

View details →DOI: 10.1186/s12964-026-02906-z
Negative / Null Result ReportOpen accessMedicine

Effects of Ropivacaine-Based Thoracic Paravertebral Block versus Erector Spinae Plane Block on Quality of Recovery in Laparoscopic Colorectal Cancer Surgery: A Randomized Controlled Trial.

Shi S, Liang Y, Liu T et al. · 2026 · Drug design, development and therapy

Background Colorectal cancer remains a leading cause of cancer-related mortality worldwide. Postoperative pain can impair recovery. Thoracic paravertebral block (TPVB) and erector spinae plane block (ESPB) are regional analgesic techniques…

View details →DOI: 10.2147/dddt.s581084
Negative / Null Result ReportOpen accessMedicine

Functional data analysis of lower-limb joint kinematics during badminton lunges under fatigue.

Fang Y, Zhang X, Sun Y et al. · 2026 · Frontiers in bioengineering and biotechnology

Objective This study applied Functional Data Analysis (FDA) to investigate the effects of fatigue on lower-limb joint kinematics during badminton lunges. Methods Seventeen elite male badminton players executed both forward and 45° sideways…

View details →DOI: 10.3389/fbioe.2026.1741767
Negative / Null Result ReportMedicine

Evaluation of radiopacity in preheated fissure sealants: an in-vitro study.

Aydın Çetin EZ, Özmen B, Yılmaz B · 2026 · Oral radiology

OBJECTIVES: The use of preheated resin-containing materials is of increasing interest in contemporary dentistry. This study aimed to determine the effect of preheating on the radiopacity values of various fissure sealants. METHODS: In this…

View details →DOI: 10.1007/s11282-026-00919-5
Negative / Null Result ReportMedicine

High Abdominal Fat Deposition was Regulated by Abdominal Fatty Acid Synthesis Related Genes and Reduced Reproduction in Late Stage of Chinese Indigenous Wannan Yellow Chicken.

Yu H, Wu L, Wang H et al. · 2026 · Animal bioscience

Objective Compared with commercial laying hens, indigenous chicken breeds generally exhibit lower reproductive performance. This study aims to elucidate the impact of abdominal fat deposition on the reproductive performance of indigenous…

View details →DOI: 10.5713/ab.250869
Negative / Null Result ReportMedicine

Healing Integrity Determines Meniscal Extrusion After Isolated Medial Meniscus Posterior Root Repair in Knees With No Lower Limb Malalignment.

Kim JS, Hwang UJ, Woo CW et al. · 2026 · Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association

Purpose To investigate changes in meniscal extrusion and meniscal healing status following root repair, and the relationship between meniscal extrusion and healing conditions. Methods Patients who underwent isolated root repair between…

View details →DOI: 10.1002/arj.70337
Negative / Null Result ReportOpen accessMedicine

Evaluating poultry by-product meal, tomato pomace, and azolla with or without Natuzyme supplementation as sustainable alternatives to fish meal for Nile tilapia (Oreochromis niloticus).

Kamel AM, Mahmoud MM, Ibrahim MT et al. · 2026 · Tropical animal health and production

Several studies have predicted that developing countries will be unable to afford fish meal as a primary aquafeed protein source in the future. This experiment evaluated the effect of replacing fish meal (FM) with poultry by-product meal…

View details →DOI: 10.1007/s11250-026-05001-0
Negative / Null Result Report

Body Mass Index and Outcomes in HR+/HER2−Metastatic Breast Cancer Treated with Palbociclib: Insights from a National Real-World Study

Badau LM, Epure P, Margan M et al. · 2026 · Preprint

Background: /Objectives: The prognostic and predictive role of BMI in patients with HR+/HER2– MBC remains controversial, particularly in the era of CDK4/6 inhibitors. This study aimed to evaluate the association between baseline BMI and…

View details →DOI: 10.20944/preprints202604.1156.v1
Negative / Null Result ReportOpen accessMedicine

Monitoring the Adverse Implications of Coronavirus 2019-induced Pulmonary Complications on Patients' Respiratory Capacity and Physical Abilities with Moderate and Severe Signs during Interval Follow-up.

Aali F, Habibi Z, Aali F et al. · 2026 · Journal of medical signals and sensors

Background The respiratory system of individuals with coronavirus 2019 (COVID-19) experiences significant strain due to the body's immunological response and inflammation, leading to organ failure. Over time, patients have improvement in…

View details →DOI: 10.4103/jmss.jmss_15_25
Negative / Null Result ReportOpen accessMedicine

Endometrial HOXA-10, HOXA-11, ß-1 integrin, ECM-1, FAK, and CD44 immunohistochemical expressions in endometriosis-related recurrent IVF failure: a retrospective case-control study.

Toruk EŞ, Kaplan EA, Sarıbaş GS et al. · 2026 · Journal of ovarian research

BACKGROUND: Endometriosis is a common cause of infertility and is frequently associated with recurrent implantation failure in assisted reproductive technologies. Impaired endometrial receptivity, mediated by altered transcription factors,…

View details →DOI: 10.1186/s13048-026-02072-3
Negative / Null Result ReportOpen accessMedicine

Efficacy of Normobaric High-Flow Oxygen Therapy Combined with Low Molecular Weight Heparin in the Management of Fetal Growth Restriction: A Prospective Cohort Study.

He M, Zhao K, Wei Q et al. · 2026 · International journal of women's health

Objective This study investigated the clinical efficacy of adding normobaric high-flow oxygen therapy (NHFOT) to low molecular weight heparin (LMWH) and standard supportive care for the management of the present FGR cohort, idiopathic…

View details →DOI: 10.2147/ijwh.s574440
Negative / Null Result ReportMedicine

Outcomes of Patients With Reduced Left Ventricular Function Undergoing Left Atrial Appendage Occlusion.

Higgins AY, Huang CY, Zimmerman S et al. · 2026 · JACC. Clinical electrophysiology

Background Transcatheter left atrial appendage occlusion (LAAO) is an alternative treatment to prevent stroke in patients with atrial fibrillation. Patients with reduced left ventricular ejection fraction (LVEF) represent a particularly…

View details →DOI: 10.1016/j.jacep.2026.04.004
Negative / Null Result ReportMedicine

Single antiplatelet therapy vs oral anticoagulation monotherapy in patients with atrial fibrillation and coronary artery disease after successful catheter ablation: A target trial emulation.

Li F, Zhao Y, Peng X et al. · 2026 · Heart rhythm

Background The optimal long-term antithrombotic strategy in patients with atrial fibrillation (AF) and coronary artery disease (CAD) after successful catheter ablation (CA) remains uncertain. Objective This study aimed to compare the…

View details →DOI: 10.1016/j.hrthm.2026.05.027
Negative / Null Result ReportOpen accessMedicine

Evaluating the Effectiveness of Age Simulation Gloves.

Lüleci EH, Kedgley AE · 2026 · Human factors

ObjectiveThis study evaluated the effectiveness of age simulation gloves in replicating age-related declines in hand function.BackgroundCommercially available age simulation gloves are increasingly used. However, their ability to replicate…

View details →DOI: 10.1177/00187208261434691
Negative / Null Result ReportOpen accessMedicine

A comparative analysis of the performance of leading large language models on the endodontics section of the dentistry specialization exam in Türkiye.

Başkan B, Başkan HK, Koç N · 2026 · PloS one

Objective This study aimed to evaluate and compare the performance of eight contemporary LLMs on the endodontics section of the DUS, assessing their accuracy in both theoretical knowledge and simulated clinical scenarios from historical…

View details →DOI: 10.1371/journal.pone.0350457
Negative / Null Result ReportMedicine

Artificial intelligence-generated patient information on shoulder instability remains suboptimal: DeepSeek outperforms ChatGPT in completeness of content while ChatGPT is more readable.

Öğümsöğütlü E, Bozgeyik B, Huri G · 2026 · Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA

Purpose This study aimed to evaluate and compare the performance of the Chat Generative Pre-Trained Transformer (ChatGPT) and DeepSeek artificial intelligence (AI) models for patient information on shoulder instability. Methods Sixteen…

View details →DOI: 10.1002/ksa.70335
Negative / Null Result ReportOpen accessMedicine

Vitamin D receptor gene polymorphism and its association with the susceptibility to Helicobacter pylori infection in the Egyptian population with hepatocellular carcinoma.

Ibrahim A, Abdelhady SA, Rageh F et al. · 2026 · BMC gastroenterology

OBJECTIVE: This study aimed to estimate the frequency of H. pylori infection in patients with liver disorders, and identify the relationship between vitamin D receptor gene variants and susceptibility to H. pylori infections and HCC in…

View details →DOI: 10.1186/s12876-026-04740-6
Negative / Null Result ReportOpen accessMedicine

CBCT in Evaluation of Root Canal Preparation-A Scoping Review.

Vidal A, Teles AM, Cardoso M et al. · 2026 · Dentistry journal

Cone-beam computed tomography (CBCT) is widely utilized in endodontics for evaluating root canal shaping outcomes, offering critical three-dimensional imaging capabilities. This study aims to assess the differences in apical and root canal…

View details →DOI: 10.3390/dj14020114
Negative / Null Result ReportMedicine

Postoperative antibiotic prophylaxis following cardiac implantable electronic device implantation and the risk of device infection.

Mandler I, Krutik T, Biham O et al. · 2026 · Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing

BACKGROUND AND AIMS: Cardiac implantable electronic devices (CIEDs) are essential for the management of cardiac arrhythmias. Device infection is one of the most dismal complications of CIED implantation. The aim of this study is to assess…

View details →DOI: 10.1007/s10840-026-02323-9
Negative / Null Result ReportMedicine

Endoscopic myringoplasty of chronic suppurative otitis media: comparison in patients with dry ears to ones with wet ears.

Yang R, Li H, Duan M et al. · 2026 · Acta oto-laryngologica

Background Chronic suppurative otitis media (CSOM) is characterized by recurrent otorrhea and tympanic membrane perforation. The selection of surgical technique and suitable time for myringoplasty remain variable and unclear. Objectives…

View details →DOI: 10.1080/00016489.2026.2659356
Negative / Null Result ReportOpen accessMedicine

Are Skip Laminectomy and Oblique Corpectomy Effective Options to Treat Degenerative Cervical Myelopathy While Preserving Motion? Results of a Scoping Review.

Lomax JL, Mehta A, Vedantam A et al. · 2026 · Global spine journal

Study DesignScoping Literature Review.ObjectiveThe aim of this literature review is to examine the results of both skip laminectomy and oblique corpectomy in the setting of degenerative cervical myelopathy (DCM).MethodsA scoping review of…

View details →DOI: 10.1177/21925682251366642
Negative / Null Result ReportOpen accessMedicine

Health-related quality of life scores of ultralow rectal cancer patients after conformal sphincter preservation operation compared to newly derived preoperative EORTC QLQ-C30, CR38 reference values and EORTC QLQ-C30 norm.

Ding HB, Sun G, Yu GY et al. · 2026 · Frontiers in oncology

Background Postoperative quality of life (Post-QoL) is the key to measuring the effectiveness of sphincter-preserving operation such as Conformal sphincter preservation operation (CSPO) for ultralow rectal cancer. This study aimed to…

View details →DOI: 10.3389/fonc.2026.1724255