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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20289 results in Negative / Null Result Report · page 664 of 677

Negative / Null Result ReportOpen access

有酸素運動 (Aerobics) を中心にした一般教養体育実技の有効性と限界について-第一報:血液組成と体組成におよぼす影響-

田原, 靖昭, 西澤, 昭, 管原, 正志 et al. · 1991

Aerobic exercise class was opened and blood and physical composition were examined. Results indicated that no significant improvement on measured items was observed. Frequency of participation is suggested to be increased or class goal…

Negative / Null Result ReportOpen access

The SOS Pilot Study: a RCT of routine oxygen supplementation early after acute stroke—effect on recovery of neurological function at one week

Khalid Mustafa Ali (4461853), Christine Roffe (220471), Anushka Warusevitane (220475) et al. · 2011

Mild hypoxia is common after stroke and associated with poor long-term outcome. Oxygen supplementation could prevent hypoxia and improve recovery. A previous study of routine oxygen supplementation showed no significant benefit at 7 and 12…

Negative / Null Result ReportOpen access

Treatment outcomes of different prognostic groups of patients on cancer and leukemia group B trial 39801: induction chemotherapy followed by chemoradiotherapy compared with chemoradiotherapy alone for unresectable stage III non-small cell lung cancer

Akerley, Wallace, Herndon, James E. 2nd, Vokes, Everett E. et al. · 2017

BACKGROUND: In Cancer and Leukemia Group B 39801, we evaluated whether induction chemotherapy before concurrent chemoradiotherapy would result in improved survival and demonstrated no significant benefit from the addition of induction…

View details →DOI: 10.1097/jto.0b013e3181b27b33.
Negative / Null Result ReportOpen access

IL-24 regulated CXCR4 at post-transcriptional level.

Jiankang Jin (703171), Stephen J. Archibald (703175), Janani Panneerselvam (703170) et al. · 2015

A , RT-PCR analysis showed IL-24 reduced CXCR4 mRNA levels at 6 h and 24 h ( P B , CXCR4 promoter activity was determined using a luciferase reporter vector. Induction of IL-24 showed no significant reduction in luciferase activity…

View details →DOI: 10.1371/journal.pone.0122439.g004
Negative / Null Result ReportOpen access

Effects of α-MSH treatment on Caspase 3 activity.

Andrew W. Taylor (451751) · 2013

The macrophages lysates were assayed for protein concentration and Caspase 3 activity. There was no significant change of Caspase 3 activity in cells treated with α-MSH compared to SFM cells. The graft is the mean ± SD of Caspase 3…

View details →DOI: 10.1371/journal.pone.0074488.g004
Negative / Null Result ReportOpen access

Supplementary Table S1 from Radiation-induced Adaptive Response: New Potential for Cancer Treatment

Sandra Demaria (15026216), Shannon Martello (11246282), Molykutty J. Aryankalayil (5544962) et al. · 2020

Metabolic data from PC3 cells 6h, 24h, and 48h after SD or MF radiation. Samples were sent to Metabolon for processing. Results indicate decrease in glycolysis intermediates in SD sample at 6h. No significant changes to TCA cycle…

View details →DOI: 10.1158/1078-0432.22477403.v1
Negative / Null Result ReportOpen access

The MINERVA study design and rationale: A controlled randomized trial to assess the clinical benefit of minimizing ventricular pacing in pacemaker patients with atrial tachyarrhythmias

Manolis AS, Padeletti L., Mont L et al. · 2008

Dual-chamber (DDD) pacing has generally been regarded as "physiologic pacing" and therefore expected to be superior to ventricular pacing. Major randomized trials have so far failed to demonstrate significant reductions in the incidences…

View details →DOI: 10.1016/j.ahj.2008.05.004
Negative / Null Result ReportOpen access

Transient Crossed Aphasia: A Case Study with SPECT

José M. Ferro, Guilhermina Cantinho, Élia Baeta · 1991

A 45-year-old right-handed man developed “crossed” anomie aphasia, neglect and inaccurate reaching of his left arm in both hemispaces due to a right parietal haemorrhage. Aphasia cleared in a few days. SPECT failed to demonstrate crossed…

View details →DOI: 10.3233/ben-1991-4203
Negative / Null Result ReportOpen access

A pilot, double blind randomised controlled trial of prednisolone for women with recurrent miscarriage and raised uterine natural killer cell density [Abstract]

Dawood, Feroza, Farquharson, Roy G., Turner, M. A. et al. · 2011

Introduction: Multiple trials of immunotherapy for reproductive failure have failed to demonstrate significant benefit. A reason for this may be the lack of a test that selects which women will benefit from treatment. High density of…

View details →DOI: 10.1093/humrep/26.s1.34
Negative / Null Result ReportOpen access

Good laboratory practice: preventing introduction of bias at the bench

Macleod, Malcolm R.; id_orcid, Donnan, Geoffrey A., Traystman, RJ et al. · 2009

Background and Purpose—As a research community, we have failed to demonstrate that drugs which show substantial efficacy in animal models of cerebral ischemia can also improve outcome in human stroke. Summary of Review—Accumulating…

View details →DOI: 10.1038/jcbfm.2008.101
Negative / Null Result ReportOpen access

Subscriptions: Information about subscribing to Stroke is online at at UNIV OF EDINBURGH on Comments, Opinions, and Reviews Good Laboratory Practice Preventing Introduction of Bias at the Bench

Marc Fisher, Ulrich Dirnagl, Geoffrey A Donnan et al. · 2020

Background and Purpose-As a research community, we have failed to demonstrate that drugs which show substantial efficacy in animal models of cerebral ischemia can also improve outcome in human stroke. Summary of Review-Accumulating…

Negative / Null Result ReportOpen access

Feasibility of progesterone treatment for ischaemic stroke

Claire L. Gibson (6162488), Philip M. Bath (3111867) · 2015

Two multi-centre phase III clinical trials examining the protective potential of progesterone following traumatic brain injury have recently failed to demonstrate any improvement in outcome. Thus, it is timely to consider how this impacts…

Negative / Null Result ReportOpen access

Early effect of moderate altitude stress on plasma potassium in the dog

Armand J. Gold, Jeanne Q. Barry, Frederick P. Ferguson · 1960

Exposure of dogs to a simulated altitude of 30,000 feet for 30 minutes resulted in marked respiratory alkalosis and hypokalemia. The data failed to demonstrate, however, the appearance of the early transient hyperkalemic response which has…

View details →DOI: 10.1152/jappl.1960.15.1.37
Negative / Null Result ReportOpen access

Is there any role for the Hydroxychloroquine (HCQ) in refractory obstetrical antiphospholipid syndrome (APS) treatment?

Botta, Angela, De Carolis, S, Botta, A. et al. · 2015

The best therapy regimen for refractory obstetrical antiphospholipid syndrome remains to be determined. Additional treatments with steroids, plasma exchanges and immunoglobulins failed to show any beneficial effect. We present a case of a…

View details →DOI: 10.1016/j.autrev.2015.04.010
Negative / Null Result ReportOpen access

Carbon dioxide-induced amnesia in the cockroach Periplaneta americana

Wahlsten, Douglas, NC DOCKS at The University of North Carolina at Greensboro · 1968

Cockroaches (Periplaneta americana) learned to passively avoid electric shock in a two-compartment box after a single training trial. However, Ss exposed to CO2 gas immediately after the training trial failed to show retention of the…

Negative / Null Result ReportOpen access

Risk of dementia hospitalisation associated with cardiovascular risk factors in midlife and older age: the Atherosclerosis Risk in Communities (ARIC) study

Mosley, T H, Catellier, D, Sharrett, A R et al. · 2009

Cardiovascular risk factors are associated with a higher risk of developing dementia. Studies in older populations, however, have often failed to show this relationship. We assessed the association between cardiovascular risk factors…

View details →DOI: 10.17615/9nxm-j737