Negative / Null Result ReportOpen accessComputer Science
Xi Yang, Xing He, Hansi Zhang et al. · 2020 · JMIR Medical Informatics
BACKGROUND: Semantic textual similarity (STS) is one of the fundamental tasks in natural language processing (NLP). Many shared tasks and corpora for STS have been organized and curated in the general English domain; however, such resources are limited in the biomedical domain. In 2019, the National NLP Clinical Challenges (n2c2) challenge developed a comprehensive clinical STS dataset and organized a community effort to solicit state-of-the-art solutions for clinical STS. OBJECTIVE: This study presents our transformer-based clinical STS models developed during this challenge as well as new mo
View details →DOI: 10.2196/19735Cited by 59 Negative / Null Result ReportOpen accessMedicine
Nienke M. Siebelink, Susan M. Bögels, Anne Speckens et al. · 2021 · Journal of Child Psychology and Psychiatry
BACKGROUND: Family mindfulness-based intervention (MBI) for child attention-deficit/hyperactivity disorder (ADHD) targets child self-control, parenting and parental mental health, but its effectiveness is still unclear. METHODS: MindChamp…
View details →DOI: 10.1111/jcpp.13430Cited by 58 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Xiao Fan, Wentao Han, Linhong Teng et al. · 2019 · New Phytologist
Brown algae have convergently evolved plant-like body plans and reproductive cycles, which in plants are controlled by differential DNA methylation. This contribution provides the first single-base methylome profiles of haploid gametophytes and diploid sporophytes of a multicellular alga. Although only c. 1.4% of cytosines in Saccharina japonica were methylated mainly at CHH sites and characterized by 5-methylcytosine (5mC), there were significant differences between life-cycle stages. DNA methyltransferase 2 (DNMT2), known to efficiently catalyze tRNA methylation, is assumed to methylate the
View details →DOI: 10.1111/nph.16125Cited by 58 Negative / Null Result ReportOpen accessImmunology and Microbiology
Cristiano Xavier Lima, Danielle G. Souza, Flávio A. Amaral et al. · 2015 · PLoS ONE
INTRODUCTION: Toll-like receptors (TLRs) play an important role in the recognition of microbial products and in host defense against infection. However, the massive release of inflammatory mediators into the bloodstream following TLR activation following sepsis is thought to contribute to disease pathogenesis. METHODS: Here, we evaluated the effects of preventive or therapeutic administration of monoclonal antibodies (mAbs) targeting either TLR2 or TLR4 in a model of severe polymicrobial sepsis induced by cecal ligation and puncture in mice. RESULTS: Pre-treatment with anti-TLR2 or anti-TLR4 m
View details →DOI: 10.1371/journal.pone.0132336Cited by 58 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Katarzyna A. Cieslik, George E. Taffet, Jeffrey R. Crawford et al. · 2013 · Journal of Molecular and Cellular Cardiology
We have demonstrated that scar formation after myocardial infarction (MI) is associated with an endogenous pool of CD44(pos)CD45(neg) multipotential mesenchymal stem cells (MSC). MSC differentiate into fibroblasts secreting collagen that forms a scar and mature into myofibroblasts that express alpha smooth muscle actin (α-SMA) that stabilizes the scar. In the aging mouse, cardiac repair after MI is associated with impaired differentiation of MSC; MSC derived from the aged hearts form dysfunctional fibroblasts that deposit less collagen in response to transforming growth factor beta-1 (TGF-β1)
View details →DOI: 10.1016/j.yjmcc.2013.07.005Cited by 58 Negative / Null Result ReportOpen accessMedicine
David Casadevall, Javier Gimeno, Sergi Clavé et al. · 2015 · Oncotarget
// David Casadevall 1, 6, * , Javier Gimeno 2, * , Sergi Clavé 3, 4, * , Álvaro Taus 1 , Lara Pijuan 2 , Miriam Arumí 1 , Marta Lorenzo 4 , Silvia Menéndez 4 , Israel Cañadas 4 , Joan Albanell 1, 4, 5 , Sergio Serrano 2 , Blanca Espinet 3, 4 , Marta Salido 3, 4 , Edurne Arriola 1, 4, # 1 Servei d’Oncologia Mèdica, Hospital del Mar, Barcelona, Spain 2 Servei de Patologia, Hospital del Mar, Barcelona, Spain 3 Laboratori de Citogenètica Molecular, Servei de Patologia, Hospital del Mar, Barcelona, Spain 4 Cancer Research Program, IMIM (Hospita
View details →DOI: 10.18632/oncotarget.3976Cited by 58 Negative / Null Result ReportOpen accessImmunology and Microbiology
Wenji Piao, Lisa W. Ru, Kurt H. Piepenbrink et al. · 2013 · Proceedings of the National Academy of Sciences
Toll/IL-1R resistance (TIR) domain-containing adapter-inducing IFN-β (TRIF) is a Toll-like receptor (TLR) adapter that mediates MyD88-independent induction of type I interferons through activation of IFN regulatory factor 3 and NFκB. We…
View details →DOI: 10.1073/pnas.1313575110Cited by 58 Negative / Null Result Report
Yongbo Wang, Xiang Gao, Pardis Pedram et al. · 2016 · Nutrients
Selenium (Se) is a trace element which plays an important role in adipocyte hypertrophy and adipogenesis. Some studies suggest that variations in serum Se may be associated with obesity. However, there are few studies examining the…
View details →DOI: 10.3390/nu8010024Cited by 58 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Rong Zhang, Yize Li, Timothy J. Cowley et al. · 2015 · Journal of Virology
UNLABELLED: Mouse hepatitis virus (MHV) isolates JHM.WU and JHM.SD promote severe central nervous system disease. However, while JHM.WU replicates robustly and induces hepatitis, JHM.SD fails to replicate or induce pathology in the liver.…
View details →DOI: 10.1128/jvi.03535-14Cited by 58 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Claudio Toma, Amaia Hervás, Bàrbara Torrico et al. · 2012 · Psychiatric Genetics
Impairment of language abilities is a common feature in autistic individuals. Heterozygous mutations in the Forkhead Box P2 (FOXP2) gene lead to a severe spoken language disorder. Recently, several studies have pinpointed the involvement…
View details →DOI: 10.1097/ypg.0b013e32835d6fc6Cited by 58 Negative / Null Result ReportOpen accessNeuroscience
Jonna Nilsson, Alexander V. Lebedev, Martin Lövdén · 2015 · Frontiers in Aging Neuroscience
Transcranial direct current stimulation (tDCS) has been put forward as a non-pharmacological alternative for alleviating cognitive decline in old age. Although results have shown some promise, little is known about the optimal stimulation parameters for modulation in the cognitive domain. In this study, the effects of tDCS over the dorsolateral prefrontal cortex (dlPFC) on working memory performance were investigated in thirty older adults. An N-back task assessed working memory before, during and after anodal tDCS at a current strength of 1 mA and 2 mA, in addition to sham stimulation. The st
View details →DOI: 10.3389/fnagi.2015.00230Cited by 58 Negative / Null Result ReportOpen accessMedicine
Timothy P. LaBranche, Alison M. Bendele, Brian C Omura et al. · 2016 · Annals of the Rheumatic Diseases
OBJECTIVE: To investigate whether the effects of nerve growth factor (NGF) inhibition with tanezumab on rats with medial meniscal tear (MMT) effectively model rapidly progressive osteoarthritis (RPOA) observed in clinical trials. METHODS:…
View details →DOI: 10.1136/annrheumdis-2015-208913Cited by 58 Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Batsirai Winmore Mazviona, T Sakahuhwa, M Dube · 2017 · RePEc: Research Papers in Economics
The study sought to examine factors affecting the performance of insurance companies in Zimbabwe. We utilized secondary data from twenty short-term insurance companies. The data was for the period from 2010 to 2014. We used factor analysis and multiple linear regression models to determine the factors affecting performance and identifying their impact. Our findings revealed that expense ratio, claims ratio and the size of a company significantly affect insurance companies’ performance negatively. Whilst leverage and liquidity affect performance positively. We recommend that insurance companies
View details →DOI: 10.5281/zenodo.2583456Cited by 58 Negative / Null Result ReportOpen accessMedicine
Anna Elisabet Olafsdottir, Daniel D. Reidpath, Subhash Pokhrel et al. · 2011 · BMC Public Health
BACKGROUND: The literature on health systems focuses largely on the performance of healthcare systems operationalised around indicators such as hospital beds, maternity care and immunisation coverage. A broader definition of health systems however, needs to include the wider determinants of health including, possibly, governance and its relationship to health and health equity. The aim of this study was to examine the relationship between health systems outcomes and equity, and governance as a part of a process to extend the range of indicators used to assess health systems performance. METHOD
View details →DOI: 10.1186/1471-2458-11-237Cited by 58 Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Kin Sibanda, Progress Hove-Sibanda, Herring Shava · 2018 · Acta Commercii
Orientation: Globally, the majority of Small and Medium-sized entities (SMEs) are resource constrained. As a result, not all SMEs are able to fully exploit the benefits associated with international trade as they face challenges when exporting their produce.Research purpose: This article presents an investigation into the impact of access to finance on firm performance and exporting behaviour of SMEs in Harare, Zimbabwe.Motivation for the study: The article stems from the observation that although there is a growing importance and contribution of SMEs worldwide, research has shown that only a
View details →DOI: 10.4102/ac.v18i1.554Cited by 58 Negative / Null Result ReportOpen accessMathematics
Lincoln Colling, Dénes Szűcs, Damiano De Marco et al. · 2020 · Advances in Methods and Practices in Psychological Science
The attentional spatial-numerical association of response codes (Att-SNARC) effect (Fischer, Castel, Dodd, & Pratt, 2003)—the finding that participants are quicker to detect left-side targets when the targets are preceded by small numbers and quicker to detect right-side targets when they are preceded by large numbers—has been used as evidence for embodied number representations and to support strong claims about the link between number and space (e.g., a mental number line). We attempted to replicate Experiment 2 of Fischer et al. by collecting data from 1,105 participants at 17 labs. Acr
View details →DOI: 10.1177/2515245920903079Cited by 58 Negative / Null Result ReportOpen accessMedicine
Karin Welén, Ebba Rosendal, Magnus Gisslén et al. · 2021 · European Urology
BACKGROUND: Men are more severely affected by COVID-19. Testosterone may influence SARS-CoV-2 infection and the immune response. OBJECTIVE: To clinically, epidemiologically, and experimentally evaluate the effect of antiandrogens on…
View details →DOI: 10.1016/j.eururo.2021.12.013Cited by 57 Negative / Null Result ReportPsychology
Ashley L. Ruba, Andrew N. Meltzoff, Betty M. Repacholi · 2019 · Developmental Psychology
There is extensive disagreement as to whether preverbal infants have conceptual categories for different emotions (e.g., anger vs. disgust). In addition, few studies have examined whether infants have conceptual categories of emotions…
View details →DOI: 10.1037/dev0000711Cited by 57 Negative / Null Result ReportMedicine
Tomris Özben · 2014 · Current Topics in Medicinal Chemistry
Radiation and some chemotherapeutic agents used in conventional cancer treatment generate reactive oxygen species (ROS), and a high ROS level diminishes cellular antioxidant capacity and leads to apoptosis and cancer cell death.…
View details →DOI: 10.2174/1568026615666141209160918Cited by 57 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Brett M. Kroncke, Amanda M. Duran, Jeffrey Mendenhall et al. · 2016 · Biochemistry
There is a compelling and growing need to accurately predict the impact of amino acid mutations on protein stability for problems in personalized medicine and other applications. Here the ability of 10 computational tools to accurately…
View details →DOI: 10.1021/acs.biochem.6b00537Cited by 57 Negative / Null Result ReportOpen accessMedicine
Chia‐Hsuin Chang, Jou‐Wei Lin, Fu‐Chun Chiu et al. · 2014 · Circulation Arrhythmia and Electrophysiology
BACKGROUND: This study examined the effect of radiofrequency catheter ablation (RFA) on reducing morbidity and mortality among patients with atrial fibrillation (AF). METHODS AND RESULTS: A retrospective cohort of patients with AF without…
View details →DOI: 10.1161/circep.113.000597Cited by 57 Negative / Null Result ReportDentistry
Daniel M. Mazzaferro, Ari M. Wes, Sanjay Naran et al. · 2017 · Plastic & Reconstructive Surgery
BACKGROUND: The effects of orthognathic surgery go beyond objective cephalometric correction of facial and dental disproportion and malocclusion, respectively. The authors hypothesized that there is tangible improvement following surgery…
View details →DOI: 10.1097/prs.0000000000003760Cited by 57 Negative / Null Result ReportOpen accessMedicine
Charles Honoré, V. Atallah, Olivier Mir et al. · 2017 · PLoS ONE
BACKGROUND: Desmoplastic Small Round Cell Tumor (DSRCT) is a rare disease affecting predominantly children and young adults and for which the benefit of hyperthermic intraperitoneal chemotherapy (HIPEC) after complete cytoreductive surgery (CCRS) remains unknown. METHODS: To identify patients with DSRCT without extraperitoneal metastases (EPM) who underwent CCRS between 1991 and 2015, a retrospective nation-wide survey was conducted by crossing the prospective and retrospective databases of the French Network for Rare Peritoneal Malignancies, French Reference Network in Sarcoma Pathology, Fren
View details →DOI: 10.1371/journal.pone.0171639Cited by 57 Negative / Null Result ReportOpen accessMedicine
Josep Tabernero, Paulo M. Hoff, Lin Shen et al. · 2022 · Gastric Cancer
BACKGROUND: Dual-targeted anti-HER2 therapy significantly improves outcomes in HER2-positive breast cancer and could be beneficial in other HER2-positive cancers. JACOB's end-of study analyses aimed to evaluate the long-term efficacy and safety of pertuzumab plus trastuzumab and chemotherapy for previously untreated HER2-positive metastatic gastric or gastroesophageal junction cancer. METHODS: Eligible patients were randomized 1:1 to pertuzumab/placebo plus trastuzumab and chemotherapy every 3 weeks. PRIMARY ENDPOINT: overall survival (OS). Secondary endpoints included progression-free surviva
View details →DOI: 10.1007/s10120-022-01335-4Cited by 57 Negative / Null Result ReportOpen accessMedicine
Clark DuMontier, Hajime Uno, Tammy T. Hshieh et al. · 2021 · Haematologica
We conducted a randomized controlled trial in older adults with hematologic malignancies to determine the impact of geriatrician consultation embedded in our oncology clinic alongside standard care. From February 2015 to May 2018,…
View details →DOI: 10.3324/haematol.2021.278802Cited by 57 Negative / Null Result ReportOpen accessMedicine
Sriram Balusu, Bart De Strooper · 2024 · Acta Neuropathologica
Although apoptosis, pyroptosis, and ferroptosis have been implicated in AD, none fully explains the extensive neuronal loss observed in AD brains. Recent evidence shows that necroptosis is abundant in AD, that necroptosis is closely linked to the appearance of Tau pathology, and that necroptosis markers accumulate in granulovacuolar neurodegeneration vesicles (GVD). We review here the neuron-specific activation of the granulovacuolar mediated neuronal-necroptosis pathway, the potential AD-relevant triggers upstream of this pathway, and the interaction of the necrosome with the endo-lysosomal p
View details →DOI: 10.1007/s00401-024-02747-5Cited by 57 Negative / Null Result ReportOpen accessMedicine
Manish R. Patel, Gerald S. Falchook, K Hamada et al. · 2021 · Cancer Medicine
Abstract Background Microsatellite‐stable (MSS) colorectal cancer (CRC) tends to be poorly immunogenic, with limited treatment options. In MSS CRC xenograft models, trifluridine/tipiracil (FTD/TPI) plus programed death 1 inhibitors resulted in synergistic antitumor activity and increased tumor immunogenicity. This phase 2 study evaluated FTD/TPI plus nivolumab in patients with MSS metastatic CRC. Methods This single‐arm, safety lead‐in study used a Simon's two‐stage design (enrolling 6 patients in the safety lead‐in, proceeding to stage 2 if ≥2 of the first 15 patients achieved a partial or co
View details →DOI: 10.1002/cam4.3630Cited by 57 Negative / Null Result ReportOpen accessNursing
Tae Gun Shin, Youn‐Jung Kim, Seung Mok Ryoo et al. · 2019 · Journal of Clinical Medicine
Background: Intravenous vitamin C and thiamine administration may be a potential adjuvant therapy for septic shock. We aimed to investigate the impact of early vitamin C and thiamine administration in septic shock patients. Methods: This retrospective before-and-after cohort study used data extracted from the Korean Shock Society’s prospective septic shock registry. We compared 28-day and in-hospital mortality rates between patients treated with intravenous vitamin C (3 g/12 h or 1.5 g/6 h) and thiamine (200 mg/12 h) <6 h after shock recognition from July through December 2017 (n = 229) and
View details →DOI: 10.3390/jcm8010102Cited by 57 Negative / Null Result ReportOpen accessMedicine
M. J. Ryan, Holly Morgan, Amedeo Chiribiri et al. · 2021 · European Heart Journal
Patients with ischaemic left ventricular dysfunction frequently undergo myocardial viability testing. The historical model presumes that those who have extensive areas of dysfunctional-yet-viable myocardium derive particular benefit from…
View details →DOI: 10.1093/eurheartj/ehab729Cited by 57 Negative / Null Result ReportOpen accessMedicine
Christoph Röllig, Hubert Serve, Richard Noppeney et al. · 2021 · Leukemia
Early results of the randomized placebo-controlled SORAML trial showed that, in patients with newly diagnosed acute myeloid leukaemia (AML), sorafenib led to a significant improvement in event-free (EFS) and relapse-free survival (RFS). In order to describe second-line treatments and their implications on overall survival (OS), we performed a study after a median follow-up time of 78 months. Newly diagnosed fit AML patients aged ≤60 years received sorafenib (n = 134) or placebo (n = 133) in addition to standard chemotherapy and as maintenance treatment. The 5-year EFS was 41 versus 27% (HR 0.6
View details →DOI: 10.1038/s41375-021-01148-xCited by 57 