e-ISSN: Pending
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19915 results in Negative / Null Result Report · page 657 of 664

Negative / Null Result ReportMedicine

Establishing Age-Specific and Sex-Specific Norms for Mitral Valve E-Point Septal Separation (EPSS) Measurements in Pediatric Patients.

Ruffin JC, Stem CT, Pletzer S et al. · 2026 · Pediatric emergency care

Objective Pediatric heart failure is a rare condition with significant morbidity that requires timely diagnosis and treatment. Mitral valve E-point septal separation (EPSS) may be used as an estimate of systolic function in this…

View details →DOI: 10.1097/pec.0000000000003625
Negative / Null Result ReportMedicine

Comparison of neuromelanin-sensitive magnetic resonance imaging using different magnetic resonance protocols on the same patients with Parkinson's disease.

Hirose R, Matsuura K, Ii Y et al. · 2026 · Journal of neural transmission (Vienna, Austria : 1996)

In Parkinson's disease (PD), neuronal loss occurs in the substantia nigra (SN) and locus coeruleus (LC). Previous studies using neuromelanin-sensitive magnetic resonance imaging (NMI) at 3T MRI have described the measurement methods and…

View details →DOI: 10.1007/s00702-026-03179-z
Negative / Null Result ReportMedicine

Mini-open Corpectomy and Posterior Spinal Fixation with Single-Position Surgery in Lateral Decubitus Position for Osteoporotic Thoracolumbar Vertebral Collapse in Elderly Patients.

Ikuma H, Hirose T, Kawasaki K et al. · 2026 · Acta medica Okayama

We evaluated the clinical outcomes and limitations of anterior and posterior combined surgery with a mini-open corpectomy applying an expandable cage (Xcore®) and percutaneous pedicle screw (PPS) fixation using single-position surgery in…

View details →DOI: 10.18926/amo/70454
Negative / Null Result ReportOpen accessMedicine

Evaluation of 980nm diode laser as adjunct to flap surgery.

Patil S, Raju KN, S Kotnoor S et al. · 2026 · Bioinformation

The additional clinical benefit of diode laser irradiation as an adjunct to open flap debridement (OFD) in the treatment of chronic periodontitis remains uncertain. Therefore, it is of interest to evaluate the impact of diode laser…

View details →DOI: 10.6026/973206300221689
Negative / Null Result ReportMedicine

Maintenance of occupational therapy for individuals with dementia: Findings from a pragmatic randomized controlled trial.

Pimouguet C, Kret M, Francis-Oliviero F et al. · 2026 · Journal of Alzheimer's disease : JAD

BackgroundThere is increasing interest in non-pharmacological approaches to address the needs of patients with Alzheimer's disease and other dementia. However, previous research highlighted the need to adapt interventions to the healthcare…

View details →DOI: 10.1177/13872877261442233
Negative / Null Result ReportMedicine

Motivational interviewing and air cleaners for smokers with COPD (MOVE): a randomized, double-blind, placebo-controlled trial.

Hansel NN, Putcha N, Woo H et al. · 2026 · American journal of respiratory and critical care medicine

Rationale Indoor particulate matter (PM) is linked to worse respiratory outcomes in adults with chronic obstructive -pulmonary disease (COPD). It is unclear if reducing indoor pollutants can improve respiratory health among current…

View details →DOI: 10.1093/ajrccm/aamag016
Negative / Null Result ReportOpen accessMedicine

Effectiveness of a Telemedicine Exercise Program to Improve Lung Function in Young Adults After COVID-19: A Pilot Study.

Wong ECH, Lo RWM, Kwan RLC et al. · 2026 · Healthcare (Basel, Switzerland)

Background : COVID-19 can have adverse effects on individuals' lung functions for up to 6 months or more after the episode. As a result, people may be reluctant to exercise, and this can have further adverse effects on their lung capacity…

View details →DOI: 10.3390/healthcare14060718
Negative / Null Result Report

Enhancing Student Engagement and Teamwork: Evidence from a Randomized Controlled Trial of the BOPPPS Model in College Volleyball Courses

Xie E, He Y, Cao T et al. · 2026 · Preprint

Abstract Background BOPPPS, which comprises six components—Bridge-in, Objective, Pre-assessment, Participatory Learning, Post-assessment, and Summary—is a student-centered structured teaching model widely applied in theoretical courses.…

View details →DOI: 10.21203/rs.3.rs-8477294/v1
Negative / Null Result ReportMedicine

Adolescents Who Underwent Revision Hip Arthroscopy Showed Comparable Magnitude of Improvement but Had Lower Clinical Benefit Rates and Higher Risk of Subsequent Surgeries Compared to a Propensity-Matched Primary Group at 2-Year Follow-Up.

Maldonado DR, Schab AR, Sikligar D et al. · 2026 · Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association

Purposes To compare minimum 2-year patient-reported outcomes measures (PROMs) between adolescents undergoing primary and revision hip arthroscopy. Methods Data were prospectively collected and retrospectively reviewed for adolescents who…

View details →DOI: 10.1002/arj.70139
Negative / Null Result ReportMedicine

Outcomes of Maximal Conventional Therapy Before Biological Treatment in Recurrent Chronic Rhinosinusitis With Nasal Polyps.

Topan YE, Bayar Muluk N, Yavuz R et al. · 2026 · The Journal of craniofacial surgery

Objective To determine whether biological therapy is a viable option for individuals with recurrent chronic rhinosinusitis with nasal polyps (CRSwNP), we will assess the clinical outcomes of maximal conventional therapy (MCT). Methods For…

View details →DOI: 10.1097/scs.0000000000012616
Negative / Null Result ReportMedicine

[C-Quant scattered light measurement and corneal densitometry in Fuchs endothelial dystrophy before and after DMEK].

Da Costa M, Seitz B, Munteanu C et al. · 2026 · Die Ophthalmologie

Background In Germany, each surgical corneal center defines individual criteria for the indications for Descemet membrane endothelial keratoplasty (DMEK). Clinical experience shows a clear discrepancy between best corrected visual activity…

View details →DOI: 10.1007/s00347-026-02422-y
Negative / Null Result ReportMedicine

Meme-Based Learning in Neuroanatomy: A Comparative Study on Effectiveness, Gender, and Student Performance Levels.

Eldesoqui M, Al-Batati A, Erfan OS et al. · 2026 · Clinical anatomy (New York, N.Y.)

Generation Z has different requirements, problems, expectations, and attitudes that they bring into the educational environment. Teachers have unprecedented challenges in addressing their needs and aspirations. Gamification involves…

View details →DOI: 10.1002/ca.70122
Negative / Null Result ReportMedicine

The effect of glandular frenulectomy on refractory lifelong premature ejaculation: a pilot study.

Roaiah MF, El Khayat YI, Saad El Din OA et al. · 2026 · Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica

Purpose Premature ejaculation (PE) is one of the most common male sexual disorders and is influenced by both psychological and biological factors. Despite available treatments, including psychosexual therapy and pharmacological…

View details →DOI: 10.4081/aiua.2026.14899
Negative / Null Result ReportMedicine

Impact of an 8-Week Targeted Potentiation Phase in the RAMP Warm-Up Protocol on Agility Performance in Female Police Officers.

Janković D, Kukić F, Radić I et al. · 2026 · Journal of strength and conditioning research

Abstract Janković, D, Kukić, F, Radić, I, Čvorović, A, Dawes, J, and Dopsaj, M. Impact of an 8-week targeted potentiation phase in the RAMP warm-up protocol on agility performance in female police officers. J Strength Cond Res XX(X):…

View details →DOI: 10.1519/jsc.0000000000005562
Negative / Null Result ReportMedicine

ST-Elevation Myocardial Infarction Complicated by Ventricular Septal Defect Is Associated With Very High Mortality Without Improvement Over Time.

Movahed MR, Rasti A, Hashemzadeh M · 2026 · Reviews in cardiovascular medicine

Background This study aimed to examine mortality trends among patients who presented with ST-elevation myocardial infarction (STEMI) complicated by ventricular septal defect (VSD) between 2016 and 2022. Methods Using the Nationwide…

View details →DOI: 10.31083/rcm49035
Negative / Null Result ReportMedicine

Tin(II) Dithiocarbamate-Derived SnS Nanoparticles for High-Performance Quantum Dot-Sensitized Solar Cells.

Vulindlela I, Paca AM, Meyer EL et al. · 2026 · Nanomaterials (Basel, Switzerland)

The increasing global demand for renewable energy has intensified the search for high-efficiency and cost-effective solar cell technologies. Quantum dot-sensitized solar cells (QDSSCs) have emerged as promising candidates due to their…

View details →DOI: 10.3390/nano16120718
Negative / Null Result ReportMedicine

Prediction of Clinically Significant Improvements During the Interdisciplinary Intensive Outpatient Program for Traumatic Brain Injury Using Machine Learning.

Srikanchana R, Samuel D, Powell J et al. · 2025 · Annals of biomedical engineering

Purpose The aim of this research was to assess the potential for machine learning to predict clinically significant patient improvement during a four-week interdisciplinary Intensive Outpatient Program (IOP) for traumatic brain injury…

View details →DOI: 10.1007/s10439-025-03853-5
Negative / Null Result ReportOpen accessMedicine

Non-Pharmacological Interventions for Symptom Cluster Management in Women with Cancer: A Scoping Review of Multicomponent and Mechanism-Based Approaches.

Irmala N, Solehati T, Sukmawati S · 2026 · International journal of women's health

Background Women with cancer frequently experience co-occurring symptoms, including cancer-related fatigue, sleep disturbance, and psychological distress, which negatively impact quality of life. Despite the increasing use of…

View details →DOI: 10.2147/ijwh.s612228
Negative / Null Result ReportMedicine

Similar performance with electrochemically deposited hydroxyapatite coating versus plasma porous spray in press-fit acetabular components for primary total hip arthroplasty: a randomised controlled study of early outcomes with DEXA.

Liu D, Turner D, Cadman J et al. · 2026 · Hip international : the journal of clinical and experimental research on hip pathology and therapy

Background Hydroxyapatite (HA) is an osteo-inductive material commonly added to the surface of components to enhance bone implant fixation; however, clinical studies have demonstrated inferior performance of HA coated acetabular cups in…

View details →DOI: 10.1177/11207000261445564
Negative / Null Result ReportMedicine

Absent Bone Marrow Edema on MRI in a Patient with Acute Vertebral Compression Fractures: Implications for Vertebral Augmentation.

Singh S, Galperin M, Waghray-Penmetcha T · 2026 · Pain medicine case reports

Background Vertebral compression fractures (VCFs) are a common and debilitating consequence of multiple myeloma (MM). Acute VCFs often benefit from percutaneous vertebral augmentation (PVA), indicated by bone marrow edema (BME) on MRI. We…

Negative / Null Result ReportMedicine

Ordering Practices and Utilization of a Next-Generation Sequencing Panel for Myeloproliferative Neoplasms.

Cooke T, Soderquist CR, Mansukhani MM et al. · 2026 · The journal of applied laboratory medicine

Background JAK2, CALR, and MPL mutations are defining features of myeloproliferative neoplasms (MPNs). Molecular testing for variants in these genes is standard of care in the diagnosis of MPNs. A high reimbursement denial rate led to…

View details →DOI: 10.1093/jalm/jfaf197
Negative / Null Result ReportMedicine

Use of rebamipide solution as a submucosal injection material to prevent esophageal stricture after endoscopic submucosal dissection: Animal study.

Hirai Y, Fujimoto A, Sasaki M et al. · 2026 · Endoscopy international open

Background and study aims It is desirable to develop a safe, cost-effective, and easy approach to prevent strictures after esophageal endoscopic submucosal dissection (ESD). We explored use of a novel rebamipide solution, an anti-ulcer…

View details →DOI: 10.1055/a-2820-3721
Negative / Null Result ReportMedicine

Addition of High-Dose Cytarabine to Fludarabine, Busulfan, and Melphalan Conditioning for Cord Blood Transplantation in Adult Acute Myeloid Leukemia.

Yamaguchi K, Watanabe O, Mitsuki T et al. · 2026 · Transplantation and cellular therapy

The clinical benefit of adding high-dose cytarabine (HDCA) to fludarabine (FLU), busulfan (BU), and melphalan (MEL)-based conditioning for cord blood transplantation (CBT) in acute myeloid leukemia (AML) remains unclear. We aimed to…

View details →DOI: 10.1016/j.jtct.2026.05.038
Negative / Null Result ReportMedicine

Sarcopenia modifies the survival benefit of triple therapy versus TACE alone in elderly patients with unresectable hepatocellular carcinoma: A multicenter retrospective cohort study.

Ye L, Yue W, Lin K et al. · 2026 · Scientific reports

Triple therapy combining transarterial chemoembolisation (TACE), tyrosine kinase inhibitors (TKIs), and immune checkpoint inhibitors (ICIs) has shown efficacy in unresectable hepatocellular carcinoma (HCC), but evidence in elderly patients…

View details →DOI: 10.1038/s41598-026-57283-x
Negative / Null Result ReportMedicine

Clinical Characteristics and Long-Term Outcomes of Atypical Choroid Plexus Papillomas: A Single-Center Experience of 40 Cases.

Zuo P, Jiang K, Zou W et al. · 2026 · Neurosurgery

Background and objectives Atypical choroid plexus papillomas (ACPPs) are exceedingly uncommon. The treatment strategies for managing this condition remain a topic of debate. The main aim of this study was to elucidate the clinical features…

View details →DOI: 10.1227/neu.0000000000004026
Negative / Null Result ReportMedicine

Effectiveness and safety of REVIVENT-TC system for the left ventricular reconstruction in ischaemic heart failure. A literature review.

Kakoudaki T, Poon SS, Kumar P · 2026 · Cardiovascular revascularization medicine : including molecular interventions

Background Surgical ventricular reconstruction (SVR) is not always feasible in patients with ischaemic cardiomyopathy and left ventricular (LV) aneurysm, due to high surgical risk. The Revivent-TC Transcatheter Ventricular Enhancement…

View details →DOI: 10.1016/j.carrev.2026.04.002
Negative / Null Result ReportMedicine

Is Adjuvant Chemotherapy Necessary for All Patients with pT3N0 Rectal Cancer after Upfront Surgery? A Multicenter Retrospective Study.

Kang KM, Lee HY, Ahn HM et al. · 2026 · Cancer research and treatment

Purpose The role of adjuvant chemotherapy (ACT) in pathologic T3N0 (pT3N0) rectal cancer, which has a favorable prognosis, remains controversial because high-risk groups for recurrence are not well defined. This study investigated…

View details →DOI: 10.4143/crt.2025.1308