e-ISSN: Pending
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20289 results in Negative / Null Result Report · page 655 of 677

Negative / Null Result ReportMedicine

Effects of maternal peripartum supplementation with Schizochytrium oil on metabolic status, colostrum quality, and neonatal calf performance and immunity in dairy cows.

Song JM, Li SH, Peng WT et al. · 2026 · Journal of dairy science

The periparturient period in dairy cattle is characterized by significant metabolic stress, often involving a state of negative energy balance, heightened oxidative stress, and systemic inflammation. Supplementation with n-3 PUFA, such as…

View details →DOI: 10.3168/jds.2025-28101
Negative / Null Result ReportMedicine

Transforming clinical pharmacy practice models: the impact of a transitions of care model on patient outcomes.

Espinoza Ramirez J, Durango M, Santalo O et al. · 2026 · Journal of the American Pharmacists Association : JAPhA

Background Many organizations have developed criteria for pharmacy practice models; however, most of these models are not based on studies evaluating clinical outcomes. Currently, there is no consensus on the ideal pharmacy practice model.…

View details →DOI: 10.1016/j.japh.2026.103155
Negative / Null Result ReportMedicine

Assessment of the Impact of Two-Jaw Orthognathic Surgery on Three-Dimensional Airway Volume in Patients with Skeletal Class III Patterns.

Chang YJ, Hsu TC, Chan CH et al. · 2026 · The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

ObjectiveTo evaluate 3-dimensional pharyngeal airway changes following 2-jaw orthognathic surgery in skeletal Class III patients and to assess their association with surgical movements.DesignRetrospective observational study.SettingSingle…

View details →DOI: 10.1177/10556656261463034
Negative / Null Result ReportMedicine

The activation of thematic semantic relation representations is intrusive but modulated by thematic association strength: evidence from the Think/No-Think paradigm.

Shi K, Li J · 2026 · Psychological research

This study adopts the Think/No-Think (TNT) paradigm for the first time to examine whether activation of thematic semantic relation representations is intrusive. In Experiment 1, during the learning phase, participants memorized cue–target…

View details →DOI: 10.1007/s00426-025-02226-w
Negative / Null Result ReportMedicine

Effects of inpatient and outpatient cardiac rehabilitation on the 5-year prognosis in patients with acute myocardial infarction.

Suematsu Y, Minei A, Sumita Y et al. · 2026 · European journal of preventive cardiology

Aims Cardiac rehabilitation (CR) has been shown to improve the prognosis of patients with acute myocardial infarction (AMI). In Japan, the duration of hospitalization has shortened, resulting in a lower participation rate in CR among…

View details →DOI: 10.1093/eurjpc/zwaf705
Negative / Null Result ReportMedicine

When Randomization Is Not Enough: Divergent Beta-Blocker Trials and the Illusion of Universal Causality.

Omerovic E, Råmunddal T, Jha S et al. · 2026 · European heart journal. Cardiovascular pharmacotherapy

Two contemporary randomized trials of β-blocker therapy after myocardial infarction (MI) reached apparently conflicting conclusions. REBOOT, conducted in Spain and Italy, found no reduction in death or major cardiovascular events among…

View details →DOI: 10.1093/ehjcvp/pvag037
Negative / Null Result ReportMedicine

Rescue of conjunctival lymphatics after mitomycin C induced inhibition in rat eyes: An experimental study.

Mittal H, Thattaruthody F, Akella M et al. · 2026 · Indian journal of ophthalmology

Abstract This experiment was designed to study the effect of mitomycin C (MMC) on conjunctival lymphatics and the lymphangiogenesis potential of synthetic retinoic acid (ec23) in rat eyes. This prospective animal experimental study…

View details →DOI: 10.4103/ijo.ijo_1929_25
Negative / Null Result ReportMedicine

Accommodative changes after implantation of a foldable iris-fixated phakic intraocular lens for the correction of myopic astigmatism.

Royo M, Jiménez Á, Molina-Martin A et al. · 2026 · European journal of ophthalmology

PurposeTo analyze the amplitude of accommodation and its changes at a 6-month follow-up in healthy subjects implanted with an anterior chamber pIOL, assessing whether accommodative function is affected. Additionally, changes in visual…

View details →DOI: 10.1177/11206721261462300
Negative / Null Result ReportOpen accessMedicine

The effect of omalizumab treatment on inflammatory parameters in urticarial diseases: a retrospective study.

Temizel KA, Dursun P, Ikizoglu G · 2026 · Postepy dermatologii i alergologii

Introduction Chronic spontaneous urticaria (CSU) and urticarial vasculitis (UV) are chronic inflammatory skin disorders. Monoclonal anti-IgE therapy is widely approved for CSU and is increasingly investigated for its broader…

View details →DOI: 10.5114/ada.2026.161026
Negative / Null Result Report

Efficacy of painting wind turbine blades as a mitigation measure to reduce bird collisions in a Mediterranean wind farm

May R, Hernández Gómez MÁ, Aguirre Martínez JL et al. · 2026 · Preprint

One of the most notable impacts of wind energy is bird mortality due to collisions with wind turbines, making it necessary to adopt measures to prevent or mitigate this impact. In recent years, studies have been carried out to test the…

View details →DOI: 10.22541/authorea.15003733/v1
Negative / Null Result ReportOpen accessMedicine

Efficacy of 8% arginine associated with low-level laser therapy in the treatment of dentin hypersensitivity: randomized double-blind clinical trial.

Leal Barbosa V, Westenhofen D, Scherdien Silva P et al. · 2026 · Lasers in medical science

Purpose To evaluate the efficacy of 8% arginine-based desensitizing toothpaste and photobiomodulation (PBM), used alone or in combination, in the treatment of dentin hypersensitivity (DH). Materials and methods This randomized,…

View details →DOI: 10.1007/s10103-026-04927-z
Negative / Null Result ReportMedicine

Diagnostic assessment of artificial intelligence reconstruction on accelerated prostate MRI: a retrospective, paired, multi-reader multi-case study.

van Lohuizen Q, Fransen SJ, Yiasemis G et al. · 2026 · European radiology

Objectives To determine whether AI-reconstructed prostate MRI at reduced acquisition times maintains prostate cancer (PCa) detection performance comparable to conventional scans. Materials and methods This multicenter, retrospective,…

View details →DOI: 10.1007/s00330-026-12479-7
Negative / Null Result ReportMedicine

Comparison of incision and drainage procedure with drainage and ligation of the intersphincteric fistula tract in the treatment of deep perianal abscess.

Akay T, Arslan RS · 2026 · Scientific reports

Patients with deep perianal abscess (DPA) and transsphincteric fistula typically require incision and drainage as emergency treatment. However, recurrent abscesses and fistulas are common. This study aimed to evaluate the impact of…

View details →DOI: 10.1038/s41598-026-59144-z
Negative / Null Result ReportMedicine

Prevention of adhesive small bowel obstruction by anti-adhesion barriers: do they really work?

Verhulst E, Ten Broek R, Bislenghi G et al. · 2026 · Techniques in coloproctology

Postoperative intraabdominal adhesions remain one of the most common and clinically significant complications following abdominal and pelvic surgery. Adhesions contribute to adhesive small bowel obstruction (aSBO), chronic abdominal pain,…

View details →DOI: 10.1007/s10151-026-03350-4
Negative / Null Result ReportMedicine

Age-related susceptibility to paraquat-induced neurotoxicity in male wistar rats: effects on neurobehaviour, substantia nigra cytoarchitecture, and alpha-synuclein levels.

Ichie K, Asomugha A, Okafor I · 2026 · BMC neuroscience

Background Parkinson's disease (PD) is a progressive neurodegenerative disorder strongly associated with dopaminergic neuronal degeneration and alpha-synuclein pathology. Paraquat (PQ) has been implicated in Parkinsonian neurodegeneration;…

View details →DOI: 10.1186/s12868-026-01019-0
Negative / Null Result ReportMedicine

Feasibility, Acceptability, and Preliminary Efficacy of a Medication Intervention for Older Adults.

Somerville E, Bollinger RM, Haxton M et al. · 2026 · OTJR : occupation, participation and health

Interventions to address polypharmacy and improve adherence are insufficient for community-dwelling older adults. To examine the feasibility, acceptability, and preliminary efficacy of a tailored medication management intervention (TIMM)…

View details →DOI: 10.1177/15394492261442163
Negative / Null Result Report

Green biosynthesized silver nanoparticles using aqueous extract of Salix alba: antimicrobial and cytogenetic effects on mitosis

Shalash Al Maliky WK, Hasan Mohammed J, Dh Hazim M · 2026 · Preprint

Background Green synthesis of silver nanoparticles (AgNPs) using plant extracts has gained increasing attention as an environmentally friendly alternative to conventional chemical methods. Salix alba L contains bioactive phytochemicals…

View details →DOI: 10.12688/f1000research.172513.2
Negative / Null Result ReportMedicine

Efficacy and limitations of ultraviolet-C light for control of Lygus hesperus (Hemiptera: Miridae) eggs and nymphs in strawberry.

Koubek CT, Aghaee MA · 2026 · Journal of economic entomology

Lygus hesperus Knight (Hemiptera: Miridae) is a major pest of California strawberries, where feeding injury from nymphs and adults leads to fruit deformation and economic losses. Management relies heavily on insecticides, with supplemental…

View details →DOI: 10.1093/jee/toag142
Negative / Null Result ReportMedicine

Multidisciplinary team care and outcomes in FNCLCC grade 3 soft tissue sarcoma: a propensity score-matched and weighted cohort study.

Li Z, Li X, Yang B et al. · 2026 · Frontiers in oncology

Background Multidisciplinary team (MDT) care is widely advocated for soft tissue sarcoma (STS), yet real-world evidence in high-grade disease remains limited and subject to confounding. We investigated whether pre-treatment MDT care was…

View details →DOI: 10.3389/fonc.2026.1827237
Negative / Null Result ReportMedicine

A Randomized Controlled Trial Analyzing the Likeability, Usability, and In-Use Efficacy of Mineral Sunscreens Across Diverse Skin Tones.

Shah M, Burshtein J, Zakria D et al. · 2026 · Journal of drugs in dermatology : JDD

Background Mineral sunscreens are increasingly favorable among consumers. However, mineral sunscreens typically cause a white cast that can impact consumer selection and application. Objective This study measured the whitening effect of…

View details →DOI: 10.36849/jdd.9941
Negative / Null Result ReportOpen accessMedicine

Impact of Routine Intraoperative Lithotripsy on Surgical Strategy and Outcomes in Laparoscopic Bile Duct Exploration: A Single-Centre Cohort Study.

Elsamalouty I, Gupta A, Whitmore M et al. · 2026 · Cureus

Background Laparoscopic bile duct exploration (LBDE) enables single-stage management of common bile duct (CBD) stones. However, large or impacted stones often necessitate choledochotomy, which is associated with increased morbidity and…

View details →DOI: 10.7759/cureus.105472
Negative / Null Result ReportMedicine

Long-Term Functional Outcomes After Prehabilitation in Frail Older Adults Undergoing Colorectal Cancer Surgery: A One-Year Prospective Cohort Study.

Dobrzycka M, Wołoszyn P, Prud M et al. · 2026 · Journal of clinical medicine

Background : Frailty is associated with adverse postoperative outcomes and functional decline in older adults undergoing colorectal cancer (CRC) surgery. The long-term course of frailty and functional outcomes among patients undergoing…

View details →DOI: 10.3390/jcm15124731