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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

AllReplication FailureNegative / Null Result ReportFailed Experiment ReportAbandoned HypothesisMethods Dead-EndShort NoteNull DatasetProtocol

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

By fieldMedicine 12,285Computer Science 753Biochemistry, Genetics and Molecular Biology 437Social Sciences 308Psychology 306Physics 280Neuroscience 254Economics, Econometrics and Finance 205Environmental Science 182Mathematics 160Agricultural and Biological Sciences 146Engineering 146

19915 results in Negative / Null Result Report · page 653 of 664

Negative / Null Result ReportMedicine

Increased or decreased numbers of CpG dinucleotide motifs in the genome of influenza A virus do not affect in vitro virus phenotype.

Susma, Spronken, van Nieuwkoop et al. · 2026 · Journal of virology

Cytosine-phosphate-guanine (CpG) dinucleotide motifs are the most underrepresented motifs in RNA virus genomes, including those of the influenza A viruses (IAV). Previous studies have indicated that increasing the number of CpG motifs in…

View details →DOI: 10.1128/jvi.00047-26
Negative / Null Result ReportMedicine

The effect of clinical bibliotherapy on self-esteem, hope and depressive symptoms among adolescents living with sickle cell disorder in Ibadan, Nigeria: a non-randomized controlled pilot study.

Adeoye, Ani, Egbokhare et al. · 2026 · Psychology, health & medicine

Sickle Cell Disorder (SCD) is a complex, multi-system blood condition affecting 7.78 million people, with 80% of global cases in sub-Saharan Africa, especially Nigeria. The condition is associated with physical health complications and…

View details →DOI: 10.1080/13548506.2026.2694730
Negative / Null Result ReportMedicine

Neuroprotective mechanisms of Thai traditional brain tonic Phy-Blica-O against LPS-induced neuroinflammation: Inhibition of NF-κB in microglia and mice.

Kaewmanee, Ganesan, Choochana et al. · 2026 · PloS one

Phy-Blica-O (PBO) is a traditional Thai polyherbal formulation historically regarded as a brain tonic and memory enhancer. Despite its long-standing ethnomedicinal use, its neuroprotective mechanisms have not been scientifically validated.…

View details →DOI: 10.1371/journal.pone.0352429
Negative / Null Result ReportMedicine

A Quantitative in Vitro Framework Reveals State-Dependent Pharmacological Responses to Repeated Inflammatory Stimulation in Synovial Fibroblasts.

Yamada, Hosokawa, Mitoma et al. · 2026 · Biological & pharmaceutical bulletin

Rheumatoid arthritis is characterized by chronic synovial inflammation and recurrent flares, which are thought to involve joint-specific inflammatory memory. Synovial fibroblasts (SFs) contribute to this process through altered responses…

View details →DOI: 10.1248/bpb.b26-00213
Negative / Null Result ReportMedicine

Is socioeconomic position associated with hospital admissions? findings from a population-based cross-sectional study among middle-aged and older Malaysians.

Jawahir, Balqis, Lee et al. · 2026 · BMJ open

Guided by the Andersen Behavioural Model of Healthcare Utilisation, this study investigated the relationship between socioeconomic status, enabling factors and need factors in predicting hospital admission. Data were analysed from the…

View details →DOI: 10.1136/bmjopen-2025-103322
Negative / Null Result ReportMedicine

Cardioprotective role of antihypertensive treatment in chemotherapy-induced cardiotoxicity: umbrella review of meta-analyses of randomised controlled trials.

Rostami, Ashraf, Hosseininasab · 2026 · Open heart

Chemotherapy-induced cardiotoxicity is a major contributor to long-term cardiovascular morbidity among cancer survivors. ACE inhibitors (ACEIs), angiotensin receptor blockers and beta blockers have been proposed as prophylactic therapies;…

View details →DOI: 10.1136/openhrt-2026-004062
Negative / Null Result ReportMedicine

β-Blockers after myocardial infarction with preserved or mildly reduced left ventricular ejection fraction: Fragility of contemporary evidence.

Zuin, Chopard, Drachman et al. · 2026 · American heart journal plus : cardiology research and practice

β-Blockers have been traditionally prescribed after acute myocardial infarction (MI), but contemporary evidence in patients with preserved or mildly reduced left ventricular ejection fraction (LVEF ≥40%) have not provided…

View details →DOI: 10.1016/j.ahjo.2026.100810
Negative / Null Result ReportMedicine

Cerebellar cognitive-affective syndrome in Friedreich Ataxia.

Petit, Sayah, Indelicato et al. · 2026 · Journal of neurology

Increasing evidence suggests that cognition and affect may be affected in Friedreich Ataxia (FA). To investigate the Cerebellar Cognitive Affective Syndrome (CCAS) in patients with FA and evaluate its correlations with speech and clinical…

View details →DOI: 10.1007/s00415-026-13786-1
Negative / Null Result ReportMedicine

Low muscle mass predicts poor response to neoadjuvant chemotherapy in advanced ovarian cancer.

Esmer, Hafızoğlu, Bardakçı et al. · 2026 · Journal of ovarian research

Advanced epithelial ovarian cancer (EOC) is commonly diagnosed at late stages, and despite improvements with neoadjuvant chemotherapy (NACT) followed by interval debulking surgery (IDS), prognosis remains poor. Body composition has emerged…

View details →DOI: 10.1186/s13048-025-01960-4
Negative / Null Result ReportMedicine

Anti-complement and anticoagulant activities from the salivary glands and gut of Ctenocephalides felis felis (Siphonaptera: Pulicidae) in wild and domestic Carnivora hosts.

Rodrigues, Filho, Alves et al. · 2026 · Insect biochemistry and molecular biology

Ctenocephalides felis felis is an ectoparasite of global relevance, causing impacts at the One Health interface. The process of hematophagy depends on evolutionary adaptations, in which arthropods have evolved inhibitors of host hemostatic…

View details →DOI: 10.1016/j.ibmb.2026.104613
Negative / Null Result ReportMedicine

Species- and Processing-Dependent Variability of Ascorbic Acid in Fruits of 14 Rosa Species and its Redox Behavior toward Iron and Copper Ions.

Raal, Meos, Ainsaar et al. · 2026 · ACS omega

Ascorbic acid (AA) is a key phytochemical marker of rosehip ( Rosa spp.) fruits, but its functional behavior in complex plant matrices remains unclear. Here, we analyzed AA variability in fruits of 14 Rosa spp. (0.26-5.57% dry weight) and…

View details →DOI: 10.1021/acsomega.6c00617
Negative / Null Result ReportMedicine

High-Frequency Gastric Electrical Stimulation Selectively Remodels Nitrergic Neurons in the Gastric Antrum of Healthy Beagles.

Huang, Fu, Yang et al. · 2026 · Neuromodulation : journal of the International Neuromodulation Society

The study aimed to investigate the effects and mechanisms of high-frequency short-pulse gastric electrical stimulation (GES) on gastric emptying and specific myenteric neurons of the gastric antrum in healthy beagle dogs. Four healthy…

View details →DOI: 10.1016/j.neurom.2026.04.013
Negative / Null Result ReportMedicine

Associations Between Social Determinants of Health and Cardiovascular Complications After Hand Surgery: Examining the Role of Income, Unemployment, Insurance, and Education.

Sabet, Young, Lowder et al. · 2026 · Journal of surgical orthopaedic advances

This study examines the impact of social determinants of health (SDoH) on cardiovascular complications after hand surgery, focusing on income, unemployment, insurance, and education. Using PearlDiver data (2011 - 2022), adult patients with…

View details →
Negative / Null Result ReportMedicine

Studies on the Identification of the SND Gene Family in Pinus massoniana Lamb. and the Function of PmSND4 in Secondary Cell Wall Formation.

Song, Li, Yao et al. · 2026 · Plants (Basel, Switzerland)

SND (Secondary wall-associated NAC domain) transcription factors are core regulators of secondary cell wall formation in plants. To identify key genes involved in wood formation in Pinus massoniana Lamb. and elucidate the molecular…

View details →DOI: 10.3390/plants15111684
Negative / Null Result ReportMedicine

1,8-Cineole Alleviates PA-Induced Lipid Accumulation, Oxidative Stress, and Inflammation via the TLR4/MyD88/NF-κB Signaling Pathway.

Li, Zhan, Zhang et al. · 2026 · Molecules (Basel, Switzerland)

The present study investigates the effect of 1,8-cineole on improving lipid metabolism disorder by regulating oxidative stress and inflammation via the TLR4/MyD88/NF-κB pathway. 1,8-Cineole is a monoterpene compound widely found in…

View details →DOI: 10.3390/molecules31111933
Negative / Null Result ReportMedicine

Unilateral Ankle Exoskeleton Assistance Reshapes Gait: Temporal Parameters, Load Distribution, and Inter-Limb Symmetry.

Wang, Ding, Jing et al. · 2026 · IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society

Wearable exoskeletons have shown efficacy in gait rehabilitation and locomotor enhancement. Despite much work on the physiological and biomechanical aspects of human-exoskeleton interaction, systematic investigations into how exoskeleton…

View details →DOI: 10.1109/tnsre.2026.3702885
Negative / Null Result ReportMedicine

Evaluation of the Effects of Diabetes Mellitus and Periodontitis on Alveolar Bone Radiodensity Using Hounsfield Unit Measurement and Fractal Analysis.

Acipinar, Deveci, Balel · 2026 · Journal of imaging informatics in medicine

This retrospective study aimed to evaluate the effects of diabetes mellitus and periodontitis on alveolar bone density and trabecular bone quality using cone-beam computed tomography (CBCT) and to compare fractal analysis with Hounsfield…

View details →DOI: 10.1007/s10278-026-02023-w
Negative / Null Result ReportMedicine

Associations between thoracolumbar fascia deformation, erector spinae activity, and deadlift performance: a matched pairs study.

Brandl, Schmidt, Schleip et al. · 2026 · Journal of bodywork and movement therapies

Recent research has pointed to a crucial role of intra- and extramuscular fascial tissue in force transmission. The paraspinal fascia has been shown to contribute to the maintenance of spinal stability and paraspinal muscle activity. This…

View details →DOI: 10.1016/j.jbmt.2026.03.032
Negative / Null Result ReportMedicine

Effects of Nd:YAG Capsulotomy on the IC-8 Lens.

Tay, Mehta · 2026 · Journal of refractive surgery (Thorofare, N.J. : 1995)

To investigate the safety and efficacy of Nd:YAG capsulotomy to treat posterior capsule opacification in eyes implanted with the IC-8 Apthera intraocular lens (IOL) (Bausch Surgical). This was a retrospective, non-randomized,…

View details →DOI: 10.3928/1081597x-20260402-01
Negative / Null Result ReportMedicine

Perspective: Genicular artery embolization for knee osteoarthritis - When the hype doesn't match the evidence.

van Zadelhoff, van der Heijden, Bierma-Zeinstra et al. · 2025 · Osteoarthritis imaging

This paper summarizes the current evidence on genicular artery embolization (GAE) for the treatment of knee osteoarthritis (OA). The goal of this minimally invasive treatment is to reduce synovitis by embolizing peri‑genicular…

View details →DOI: 10.1016/j.ostima.2025.100376
Negative / Null Result ReportMedicine

Effects of heterologous expression of glycolysis enzymes on product formation in Clostridium thermocellum .

Chiarelli, Lynd, Bergamo et al. · 2026 · Metabolic engineering communications

Glycolysis is central to Clostridium thermocellum metabolism; however, strains engineered for high ethanol titer exhibit a decrease in the conversion of cellobiose to ethanol (i.e., cellobiose-to-ethanol yield), suggesting the presence of…

View details →DOI: 10.1016/j.mec.2026.e00279
Negative / Null Result ReportMedicine

[Biological Characteristics of Human Umbilical Cord Mesenchymal Stem Cells Transduced with a BMP4 -Carrying Adenovirus].

Guan, Li, Wu et al. · 2026 · Zhongguo shi yan xue ye xue za zhi

To evaluate the effects of Bone Morphogenetic Protein 4( BMP4 ) overexpression mediated by an adenoviral vector on immunophenotype features, migration ability, colony-forming ability, and early osteogenic differentiation potential of human…

View details →DOI: 10.19746/j.cnki.issn1009-2137.2026.02.040
Negative / Null Result ReportMedicine

Dose-dependent effects of dietary quercetin supplementation on growth performance, nutrient digestibility, meat composition, bone mineralization, and profitability in broilers.

Saied, Yousuf, Rahman et al. · 2026 · Journal of advanced veterinary and animal research

Objectives: This study aimed to determine the optimal dose of quercetin (plant origin) on growth performance, nutrient digestibility, meat composition, shank mineralization, and production costs in broilers. Materials and Methods: A total…

View details →DOI: 10.5455/javar.2026.m1007