A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19915 results in Negative / Null Result Report · page 651 of 664
Berzaghi R, Lode K, Maia V et al. · 2026 · Preprint
Abstract Background: Cancer-associated fibroblasts (CAFs) are key components of the tumor microenvironment and active drivers of tumor progression, metastasis, and resistance to therapy. However, the effects of radiotherapy (RT) on CAFs…
Keven JB, Koinari M, Pombreaw C et al. · 2026 · Preprint
Abstract Background Although one of the most operationally challenging malaria control settings in the world, Papua New Guinea (PNG) has distributed over 20 million insecticide-treated nets (ITNs) in the last 15 years. Despite this…
Shin J, Lee KH, Kim JW · 2026 · Journal of affective disorders
Background Given that anxiety is highly comorbid in depressive adolescents, understanding the neural pathways underlying concurrent depression and anxiety could provide potential targets for treatment. We aimed to investigate treatment…
Chen Z, Millard A, Fernandez E · 2025 · Preprint
Multiple genetic variants associated with diet-related traits show strong signatures of natural selection 1–17 . To test whether these signals were indeed diet-driven, we conducted an empirical investigation. We compiled an isotopic…
Tanaka S, Hirata K, Uramaru K et al. · 2026 · Journal of neuroendovascular therapy
Objective This study aimed to evaluate the feasibility and safety of a computer-controlled local anesthetic delivery device during transradial cerebral angiography and to descriptively assess procedural pain and hemodynamic changes in an…
Yilmaz Y, Celik FB, Atici A et al. · 2026 · Journal of hypertension
Background The clinical relevance of tissue-selectivity among angiotensin-converting enzyme (ACE) inhibitors is debated. This study aimed to compare the effects of a lipophilic (quinapril) and a hydrophilic (lisinopril) ACE inhibitor on…
Korkmaz YY, Gungor F, Kudas I et al. · 2026 · Journal of clinical medicine
Background : Patients undergoing pancreatoduodenectomy (PD) after preoperative percutaneous transhepatic biliary drainage (PTBD) frequently develop bacterobilia. While bile culture positivity has been variably linked to postoperative…
Aguilera-Eguía R, Fuentes-Barría H, Avilés-Santos Y et al. · 2026 · Frontiers in sports and active living
Objective To describe sleep quality, perceived stress, and physical activity levels, as well as to identify the associations between these variables in fourth-year Kinesiology students at the Catholic University of the Most Holy Conception…
Lech D, Maksymowicz R, Matysek J et al. · 2026 · Journal of clinical medicine
Background: Microvascular free flap reconstruction is an established method for the management of complex head and neck defects in pediatric patients. However, the influence of perioperative anesthetic management on flap outcome in this…
Siddiqui TG, Simonsen THB, Lie Selle M et al. · 2026 · Scandinavian journal of primary health care
Background Z-hypnotics are commonly prescribed for insomnia, but their use in older adults is associated with an increased risk of adverse events. Aim We examined the long-term effect of brief intervention (BI) for inappropriate z-hypnotic…
Hussain A, Shah TH, Bashir S et al. · 2026 · ERJ open research
Respiratory muscle training can be used in conjunction with CPAP or in situations precluding use of CPAP therapy. It should be used as a complimentary measure rather than an alternative to CPAP. https://bit.ly/3JqDDU7.
van der Horst DEM, van Uden-Kraan CF, Stiggelbout AM et al. · 2026 · Patient education and counseling
Objective Effective patient-clinician communication is essential in chronic kidney disease (CKD) to support treatment adherence and slow down disease progression. In this proof-of-concept study we evaluated the effects of a CKD dashboard,…
Abdelnaby EA, Alhaider AK, Emam IA · 2026 · Reproduction in domestic animals = Zuchthygiene
This current work aimed to determine the impacts of melatonin implants on testicular artery blood flow and Doppler indices, in relation to hormonal profile in post-pubertal camels (Camelus dromedaries) under heat stress and non-breeding…
Elad B, Lotan D, Richter I et al. · 2026 · Journal of cardiovascular pharmacology
Abstract Vericiguat improves outcomes in heart failure (HF) by promoting vasodilation of the systemic and pulmonary arterial beds. Little is known about its impact on pulmonary artery pressure (PAP). We aimed to study this effect using…
Hafez E, Ashraf E, Saeed S et al. · 2026 · Cureus
Introduction Dental training requires prolonged static and forward-leaning working positions that may contribute to forward head posture. Forward head posture can be quantified using the craniovertebral angle (CVA) and may be associated…
Margas Z, Borkowska A, Kowalski K et al. · 2026 · Nutrients
Background The effects of fasting on serum kynurenines (KYNs) have been reported; however, no data are available on whether fasting also modifies their urinary excretion. Kidney organic anion transporters are involved in KYNs excretion,…
Ito R, Uchida M, Fujie S et al. · 2026 · European journal of applied physiology
Purpose This study aimed to examine the acute effects of continuous and interval cycling on salivary secretory immunoglobulin A (SIgA) and anti-microbial peptides. Methods In a randomized crossover trial, 12 healthy young untrained men (22…
Kopple JD, Bross R, Ekramzadeh M et al. · 2025 · The American journal of clinical nutrition
Background Many studies show that intestinal phosphate binders reduce serum phosphorus concentrations in hyperphosphatemic patients with chronic kidney failure. To our knowledge, there are virtually no studies of the effect of these…
Kuna M, Štefanović M, Barac E et al. · 2026 · International journal of molecular sciences
Having appropriate and meaningful diagnostic procedures is crucial in the approach to patients with chronic spontaneous urticaria (CSU), so we wanted to investigate relationships between CSU patients' common serum factors and clinical CSU…
Egorova AM · 2026 · Vavilovskii zhurnal genetiki i selektsii
Stress phytohormones - salicylic and jasmonic acids - participate in the plant defense response. The increase in the content of these compounds during plant infection by pathogens leads to the activation of signaling pathways, ultimately…
Tchitchinadze M, Milleron O, Eliahou L et al. · 2026 · The Annals of thoracic surgery
Background To evaluate the progress of care for patients with Marfan syndrome with FBN1 pathogenic variant carriers over the past 30 years. Methods Patients who visited the center were entered into a prospective registry. Aortic events…
Masturov YA, Hogan WB, Regal S et al. · 2026 · Orthopedics
Background Traditional guidance after posterior-approach total hip arthroplasty (THA) recommends return to driving at 6-8 weeks. Muscle-sparing direct anterior THA (A-THA) may enable earlier recovery. Our objective was to assess brake…
Galbiati F, Plessow F, Plummer L et al. · 2026 · Journal of neuroendocrinology
Arginine-vasopressin (AVP) deficiency (AVP-D) is caused by hypothalamic-pituitary damage of vasopressinergic neurons leading to polyuria and polydipsia. Diagnostic tests for AVP-D are limited by low accuracy and/or tolerability. Kisspeptin…
Saiful Islam M, Fujimori T, Miyanaga T et al. · 2025 · Journal of physics. Condensed matter : an Institute of Physics journal
The encapsulation of sulfur (S) within single-walled carbon nanotubes (S@SWCNTs) provides a unique opportunity to stabilize and study the structure and bonding of one-dimensional sulfur chains, which do not exist in a free state. In this…
Garrett JM, McCormick JJ, King KE et al. · 2026 · Experimental physiology
We examined whether seven consecutive days of warm-water immersion could elevate resting and exercise-induced levels of brain-derived neurotrophic factor (BDNF), irisin and klotho in older adults. These biomarkers support cognitive and…
Hamada R, Tamaki A, Murao M et al. · 2026 · Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
Purpose Bioelectrical impedance analysis (BIA) has emerged as a simple, noninvasive method for evaluating skeletal muscle. However, BIA is sensitive to fluctuations in body water and can overestimate skeletal muscle mass, which may obscure…
Parrott J, Joseph H, Vahidi E et al. · 2025 · Preprint
Abstract Engineering undergraduate students report high levels of mental health distress yet exhibit comparatively low rates of engagement with professional mental health services compared to students in other academic majors. These low…
Bayle JY, Onen F, Onen SH · 2025 · Sleep & breathing = Schlaf & Atmung
PURPOSE: The impact of remote monitoring (RM) on the likelihood of continuing CPAP therapy in apneic patients remains unknown in the long term and was addressed by a comparative cohort analysis. METHODS: The probability of continuing CPAP…
Rizzi C · 2025 · Preprint
A trial was carried out to profile the quality of stored eggs, at 15 °C and 75% RH until to 21 d, of 10 Italian breeds of the Veneto region with different productive purpose (egg laying purpose: Polverara nera – PO-B, Polverara bianca –…
Knezek SB, Engelen MPKJ, Coyle KS et al. · 2026 · Clinical nutrition (Edinburgh, Scotland)
Background Adding leucine (LEU) to protein meals enhances protein anabolism, but excess LEU reduces valine (VAL) and isoleucine (ILE) plasma concentrations. We examined in older adults whether additional LEU added to an essential amino…