A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20261 results in Negative / Null Result Report · page 635 of 676
Baranowska, Kiss, Szeleszczuk · 2026 · Pharmaceutics
Dipeptidyl peptidase-4 (DPP-4) is an established therapeutic target in the treatment of type 2 diabetes mellitus (T2DM), primarily due to its role in regulating incretin activity and glucose homeostasis. Although clinically approved DPP-4…
Marín, Fuentes-Martín, Sánchez et al. · 2026 · Pharmaceutics
Background/Objectives: Microtubule-targeting agents represent a pillar of cancer chemotherapy; however, their clinical utility is constrained by significant toxicity, pharmacokinetic instability, and susceptibility to multidrug resistance…
Raafat MH, Mourad KE, Elsyad MA · 2026 · BMC oral health
Background Reviewing the literature, the optimal implant position for 2-implant retained mandibular overdentures, which would be associated with improved peri-implant tissues, higher retention values, and better patient satisfaction,…
Arıkan M, Akarsu S · 2026 · Biomaterial investigations in dentistry
Objective To compare the physico-mechanical properties (microhardness, surface roughness, and flexural strength) of permanent 3D-printed dental resins with those of a resin nanoceramic computer-aided design and computer-aided manufacturing…
Salman A · 2026 · Journal of ophthalmology
Purpose To evaluate and compare the topographic and tomographic characteristics of post-laser in situ keratomileusis (LASIK) ectasia (PLE) with keratoconus (KC) and normal control eyes using the Sirius imaging system. Methods This…
Oh H, Kim J, Bai J · 2026 · Journal of oral microbiology
Background Dental caries, commonly known as tooth decay, is a progressive breakdown of tooth tissues caused by the biofilm-producing bacteria, Streptococcus mutans . S. mutans plays a primary role in the initiation and progression of…
Shariati S, Mohtadi S, Molavinia S et al. · 2026 · Scientific reports
Anti-diabetic medications have been found to reduce chemotherapy resistance. This study sought to investigate the role of Empagliflozin (Empa) as an anti-diabetic medication in reversing Cisplatin (Cis) resistance in EJ138 bladder cancer…
Gao H, Yu X, Guo Z · 2026 · Journal of the International Society of Sports Nutrition
Background Upper-body plyometric training (PT) enhances neuromuscular performance and power production. However, its application in swimming and its potential interaction with β-alanine (BA) supplementation remain largely unexplored.…
Alhassan A · 2026 · Preprint
Abstract The study aims to assess the effects of community-based nutrition education program on childhood nutrition for children 6months − 5years. Finding from the study indicate that the analysis of 100% response at baseline data (N =…
Golal E, Balci CN, Acar N · 2026 · Aging cell
Successful embryo development, acquisition of uterine receptivity, implantation, and decidualization during the peri-implantation window are essential events that ensure a healthy pregnancy. While ovarian aging has long been considered the…
Hobbs KJ, Ueda Y, Qu Y et al. · 2026 · Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)
Objectives To compare the performance of one point-of-care activated clotting time (ACT) machine (Vet-Tube), one point-of-care activated partial thromboplastin time (aPTT) machine (Coagulation DX), and one bench-top ACT machine (Medtronic…
William MFGBMF, Jamil NAB, Leong SS et al. · 2026 · Australasian journal of ultrasound in medicine
Aim Stand-off gel pads made of natural ingredients may provide a low-cost option in clinical ultrasound imaging. This study investigated the performance and safety of homemade pads. Methods Thirty stand-off gel pads were made of aloe vera,…
Dogantan S, Keskin A, Yücel BB et al. · 2026 · Revista da Associacao Medica Brasileira (1992)
Objective Familial Mediterranean fever, an autoinflammatory disease, is characterized by recurrent stereotypic febrile attacks associated with an inflammatory syndrome. Malondialdehyde, a lipid peroxidation marker, and soluble transferrin…
Şahin Çelik B, Ağdaş G, Genç V · 2026 · BMC cancer
Objective To compare the real-world outcomes of perioperative chemotherapy (ChT) and neoadjuvant chemoradiotherapy (CRT) in patients with locally advanced resectable distal esophageal and esophagogastric junction (EGJ) adenocarcinomas,…
Jiang J, Yang X, Du F et al. · 2026 · Medicine
Morphological changes in the meibomian glands following treatment of pediatric chalazion were assessed using an ocular surface analyzer, and the effects of surgical versus conservative management on gland morphology were systematically…
Zhang J · 2026 · PloS one
English writing competence is a significant manifestation of students' second language proficiency. However, comprehensive synchronic empirical research remains scarce regarding how students at application-oriented universities perform in…
Dongmo F, Kom B, Akiki À Tsang G et al. · 2026 · Annals of medicine and surgery (2012)
Background Sclerocarya birrea is used in traditional medicine for the treatment of many diseases, including gastritis, diarrhea, dysentery, and hemorrhoids. The objective of this study was to evaluate the efficacy of Sclerocarya birrea…
Çi̇men HN, Uğur S, Çıralı A et al. · 2026 · Nurse education in practice
Aim The aim of this study was to evaluate the effect of podcast-based educational content delivered to students on their knowledge, awareness and anxiety levels regarding Human Papillomavirus (HPV). Method This randomized controlled…
Wang S, Ma J, Ma S et al. · 2026 · Zhongguo gu shang = China journal of orthopaedics and traumatology
Objective To compare clinical efficacy of TightRope button-loop titanium plate elastic fixation and hollow tension screw fixation in treating ankle fractures with accompanying tibiofibular syndesmosis injury. Methods A retrospective…
Rezaiyan A, Sohrabi Z, Ramezani N et al. · 2026 · Journal of education and health promotion
Background Pregnancy is associated with a wide range of physiologic and psychologic changes that could affect a mother's body image and maternal-fetal attachment. One of the presented interventions regarding body image and maternal fetal…
Ha D, Jung K, Choi H et al. · 2026 · Veterinary medicine and science
Background Botanical ingredients can function as adjunctive therapies for managing inflammatory skin diseases. Objectives This study aimed to investigate the anti-inflammatory effects of a mixture of Boswellia serrata, Commiphora myrrha,…
Salim O, Chari A, Tahir MZ · 2026 · Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
Purpose Hemispherotomy is an established treatment for children with drug-resistant epilepsy. Recent reports have suggested a superiority of outcomes with the vertical approach compared to the traditional lateral approach. This study…
Jaiswal M, Hazare A, Karia H et al. · 2026 · Cureus
Introduction Growth assessment is a fundamental process in orthodontics as accurate determination of skeletal maturity guides the timing of treatment intervention. Biochemical and radiographic indicators can be used to evaluate growth…
Hammad A, Saleh ME, Shehab AA · 2026 · Cureus
Background Adolescent idiopathic scoliosis (AIS) is the most common form of spinal deformity in adolescents, characterized by a three-dimensional curvature of the spine with unknown etiology. Surgical intervention is indicated in…
Bozkurt SN, Kocasli S · 2026 · BMC complementary medicine and therapies
AIMS: The aim of this study was to the effects of music during the endoscopy procedure on anxiety, pain and vital signs. METHODS: This study was conducted as a randomized, controlled, double-blind trial. The study population consisted of…
MacFarlane AJ, Larson JH, Kucharik MP et al. · 2026 · Journal of shoulder and elbow arthroplasty
Background Presently, there is no quantifiable and objective criteria for defining severe glenoid bone loss (GBL) for primary reverse total shoulder arthroplasty (rTSA). In this study, we sought to establish quantifiable thresholds of…
Ishida H, Egashira H, Asano N et al. · 2026 · Cureus
Background Inflammation- and nutrition-related biomarkers such as the neutrophil-to-lymphocyte ratio (NLR) and prognostic nutritional index (PNI) have been reported as prognostic factors for ovarian cancer. However, their clinical…
Zheng X, Fu X, Shao Y et al. · 2026 · American journal of translational research
Objective To investigate the effect of remazolam combined with hydromorphone on postoperative cognitive function in elderly patients undergoing hip replacement. Methods 184 elderly patients who underwent hip replacement in Sir Run Run Shaw…
Li S, Chai H, Bao W et al. · 2026 · Preprint
Abstract Background: It is commonly recommended to restore the mechanical axis to within –0° ± 3° in valgus knee. However, the situation is quite different when the alignment is –3° or 3° in the presence of a compromised MCL in Ranawat…
Jin L, Zhang J, Zhang R et al. · 2026 · Ultrasonics sonochemistry
The aim of this study was to investigate the effects of ultrasound-assisted tumbling (100, 300, 500, and 700 W) with different treatment times (30, 60, 90, 120, 150, and 180 min) on the quality, myofibrillar protein structure, and protein…