A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19915 results in Negative / Null Result Report · page 635 of 664
Kotsakis, Botto, Jazaeri et al. · 2026 · Journal of periodontology
Surface decontamination is integral to peri-implantitis treatment. However, abrasive mechanical methods can cause implant surface degradation with possible adverse biological effects. No human studies have examined whether these treatments…
Koç, Konyalıgil, Özen Yeşil et al. · 2026 · Orphanet journal of rare diseases
The aim of this study is to comparatively examine the effects of appetite loss and insufficient energy intake, which trigger poor metabolic control parameters, on appetite hormones and body mass index in children with intoxication-type…
Cengi̇z, Sarioğlu, Mazooğlu et al. · 2026 · BMC geriatrics
Benign Paroxysmal Positional Vertigo (BPPV) represents the most common cause of vertigo in the geriatric population. The condition constitutes a multidimensional clinical presentation characterized by dizziness, imbalance, fear of falling,…
Omidvar, Campbell, Alain et al. · 2026 · The European journal of neuroscience
The presentation of a rarely occurring auditory stimulus that contains a silent interval (or gap) among a sequence of frequently occurring stimuli that do not contain a gap can elicit a negative-going event-related potential known as the…
Iwata, Masuda, Yamamoto et al. · 2026 · Breast cancer (Tokyo, Japan)
We previously reported the 21-gene Oncotype DX® assay results from TransNEOS in patients enrolled in the phase 3 NEOS trial. However, the association between assay results and long-term prognosis has remained unclear. Of the 296…
Ge, Wei, Qi et al. · 2026 · NPJ precision oncology
Effective predictive biomarkers for immunotherapy in breast cancer remain elusive, limiting precision treatment strategies. Although the biological significance of HER2‑low expression has gained increasing attention, its impact on…
Büttner, Derman, Simonis et al. · 2026 · Clinical and experimental dental research
To evaluate serum IgG responses against Porphyromonas gingivalis gingipains RgpB and Kgp in patients with stage III and IV periodontitis and examine associations with clinical periodontal parameters. This exploratory cross-sectional study…
Tong, Guo, Xia et al. · 2026 · Respiration; international review of thoracic diseases
Transbronchial lung cryobiopsy (TBLC) is increasingly used to diagnose interstitial lung disease (ILD). However, the learning curve associated with this technique remains unclear. This retrospective analysis included the first 100 patients…
Chen, Xu, Yan et al. · 2026 · Surgical endoscopy
This multi-center study aimed to evaluate the clinical validity of the "up-to-seven" criteria (sum of tumor number and largest diameter ≤ 7) as an expanded threshold for curative liver resection in hepatocellular…
Zhang, Li, Chen et al. · 2026 · Surgical endoscopy
Neoadjuvant therapy is recommended for hepatocellular carcinoma at advanced stages. It is unknown whether robotic liver resection (RLR) is superior to open liver resection (OLR) after neoadjuvant therapy. We analyzed consecutive RLR and…
Rostamian, Moabedi, Poursalehi et al. · 2026 · Food & function
In this study, we evaluated the association between UPFs with HTGW in relation to oxidative stress and inflammation in Iranian adults, as no previous study had assessed these altogether. This cross-sectional study consisted of a sample of…
Giuretis, Wootton, Gillanders et al. · 2026 · Marine pollution bulletin
Stormwater is increasingly recognised as a contributor to microplastic contamination in aquatic environments. Yet, the contribution of rainfall in flushing microplastics through urban drainage systems into coastal environments remains less…
Esmaeilzadeh · 2026 · International journal of medical informatics
Patient portals provide direct access to clinical encounter data; however, comprehension barriers, especially for patients with limited health literacy, frequently prevent meaningful use, even for common acute conditions. Large language…
Ozatak, Sonmez, Ozatak et al. · 2026 · The Journal of emergency medicine
Intravenous adenosine is the standard first-line therapy for stable supraventricular tachycardia (SVT). However, transient post-cardioversion sinus pauses frequently complicate its use, causing clinical anxiety. Patient-specific factors…
Jia, Zhang, Pradeep et al. · 2026 · Journal of cardiovascular electrophysiology
Studies regarding sex and age differences in clinical outcomes of DCLP patients remain limited. This was a retrospective, single-center study, which evaluated the consecutive patients who underwent Aveir DCLP implantation between January…
Balkaya, Göçer, Demirbuğa · 2026 · Odontology
This study aimed to evaluate the polymerization, contact angle, surface tension, antibacterial activity, and bonding properties of experimental adhesives modified with the addition of casein phosphopeptide-amorphous calcium phosphate…
Caballero, Navarro, Vanos et al. · 2026 · Temperature (Austin, Tex.)
Personal cooling strategies are used to lower body core temperature. This controlled cross-over trial evaluates the efficacy of cooling strategies following exercise-induced heat exposure resulting in increased body temperature. Ten…
Miles, Sforza, Tan et al. · 2026 · bioRxiv : the preprint server for biology
Radiation therapy is integral to the curative treatment of childhood brain tumors but contributes to late neurocognitive impairment in survivors. FLASH (ultra-high dose rate, >40Gy/s) reduces normal-tissue toxicity in preclinical models,…
Romandini, AlKhelaifi, Macchiarola et al. · 2026 · Journal of experimental orthopaedics
The posterior tibial slope (PTS) is a key anatomical factor influencing anterior cruciate ligament (ACL) stability. Steeper slopes have been associated with increased anterior tibial translation (ATT) and a higher risk of graft failure…
Deokate, Acharya, Patil et al. · 2026 · International journal of critical illness and injury science
Early identification of high-risk sepsis patients remains a clinical priority. Hematological ratios such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) have emerged as…
Le, Chotikkakamthorn, Kasetsuwan et al. · 2026 · Clinical ophthalmology (Auckland, N.Z.)
This study aims to compare the effect of meibomian gland expression (MGX) combined with lid hygiene versus lid hygiene alone on the meibomian gland's morphology and function for obstructive meibomian gland dysfunction (oMGD). In this…
Yang, Liu, Yu et al. · 2026 · Frontiers in nutrition
This study aimed to examine the individual and combined associations of tea consumption and cigarette smoking with accelerated biological aging among oilfield workers. Logistic regression was used to assess the associations of tea…
de Mello, Castelletto, Seitsonen et al. · 2026 · Journal of peptide science : an official publication of the European Peptide Society
The self-assembly in aqueous solutions, cytocompatibility, and collagen production of lipopeptide C 16 -KTTKS and a variant with arginine substitution for lysine, C 16 -RTTRS, are investigated. C 16 -KTTKS is known commercially as Matrixyl…
Xinzhu, Kaixian, Yuxia et al. · 2026 · BMC public health
Somatic pain and depression are prevalent health concerns among Chinese adolescents. This study aims to examine the longitudinal reciprocal effects between these conditions in this population, explore the moderating role of gender, and…
Altiok, Kasapoglu · 2026 · Food science & nutrition
Producing instant herbal teas with consistent bioactive composition requires both efficient extraction and controlled drying to prevent compound degradation. This study developed instant linden tea ( Tilia spp.) by integrating…
Littleton, Thomas, Woodhead et al. · 2026 · Frontiers in immunology
Ischemic stroke thrombi contain complex immunothrombotic components, including neutrophil extracellular traps (NETs), which contribute to thrombus stability and resistance to fibrinolysis. However, the endogenous triggers of NETosis within…
Gadag, Arora, Kaskie et al. · 2026 · Health services research
We examined how the expansion of Medicaid audio-only coverage (MAOC) was associated with changes in mental health visit rates at Federally Qualified Health Centers (FQHCs). We used publicly available FQHC-level Uniform Data Systems (UDS)…
Parirokh, Manochehrifar, Nakahee et al. · 2026 · Iranian endodontic journal
The close relationship between pulp stones in the pulp chamber and pulp neurovascular tissues suggests that the presence of pulp stones may compromise successful anesthesia. The present study assessed the effect of pulp stone presence on…
Xiao, Zheng, Guo et al. · 2026 · Patient preference and adherence
Hypoglycemia is a frequent and burdensome complication in adolescents with type 1 diabetes mellitus (T1DM). Despite its high prevalence, structured interventions targeting hypoglycemia coping confidence remain scarce, especially in China.…
Coşansu, Osoria, Juneja · 2026 · Journal of food protection
This study investigated the effects of sodium chloride (NaCl), grape seed extract (GSE), and cooling duration on the growth of Clostridium perfringens in cooked ground beef during slow exponential cooling. Meat samples containing…