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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20261 results in Negative / Null Result Report · page 633 of 676

Negative / Null Result ReportOpen accessMedicine

Risk factors for acute neurological complications in neonatal bacterial meningitis: a retrospective cohort study.

Zhang F, Yu Z, Pan J et al. · 2026 · Jornal de pediatria

Objective This study aimed to investigate the risk factors for acute neurological complications (ANCs) in neonates with bacterial meningitis (NBM). Methods This retrospective study analyzed 68 neonates (aged 0-28 days) with bacterial…

View details →DOI: 10.1016/j.jped.2026.101533
Negative / Null Result ReportMedicine

Effects of routine invasive management on reinfarction risk in older adults with frailty and non-ST-segment elevation myocardial infarction: a subanalysis of a randomised clinical trial.

Sanchis J, Bueno H, Martí Sánchez D et al. · 2025 · Heart (British Cardiac Society)

Background Clinical trials and meta-analyses indicate a reduced reinfarction risk with invasive management in older patients with non-ST-segment elevation myocardial infarction (NSTEMI). This study investigated whether similar benefits…

View details →DOI: 10.1136/heartjnl-2024-325254
Negative / Null Result Report

Heavy gravity combined with light gravity local anesthetic in subarachnoid anesthesia for cesarean section did not reduce the incidence of intraoperative hypotension in maternal women: a prospective cohort study

Qiao W, Liu L, Zhang X et al. · 2024 · Preprint

Abstract Background Subarachnoid anesthesia is the primary anesthetic method for elective cesarean section surgery, characterized by rapidly taking effect and reliable analgesia. However, subarachnoid anesthesia is prone to cause a high…

View details →DOI: 10.21203/rs.3.rs-5428405/v1
Negative / Null Result Report

Clinical impact of Enhanced Recovery After Spinal Surgery Protocols on One-Level Lumbar Arthrodesis: Results from a Single-Center Randomized Controlled Trial

Kashtiara A, Pauptit J, Thijs D et al. · 2025 · Preprint

Abstract BACKGROUND AND OBJECTIVES: Enhanced Recovery After Surgery (ERAS) protocols aim to improve surgical outcomes, by mitigating postoperative stress through multimodal perioperative care. In spinal surgery, such protocols—termed…

View details →DOI: 10.21203/rs.3.rs-7786792/v1
Negative / Null Result ReportOpen accessMedicine

Virtual Nursing for the Care of Hospitalized Patients.

Muir KJ, Maye A, McHugh MD et al. · 2025 · JAMA network open

Importance It is unknown if virtual nursing (VN) enhances care quality or improves the workload of bedside nurses in hospitals. Objective To describe what services VNs provide to patients and nurses in hospitals; to evaluate whether the…

View details →DOI: 10.1001/jamanetworkopen.2025.45597
Negative / Null Result ReportMedicine

Managing visceral leishmaniasis-associated hemophagocytic lymphohistiocytosis in pediatric patients: Clinical insights and treatment strategies.

Zhang J, Suo T, Cheng Y et al. · 2026 · Journal of investigative medicine : the official publication of the American Federation for Clinical Research

Hemophagocytic lymphohistiocytosis (HLH) secondary to visceral leishmaniasis (VL-HLH) is a severe and often fatal condition marked by systemic inflammation and immune dysfunction. In this retrospective cohort study at Shanxi Children's…

View details →DOI: 10.1177/10815589251390398
Negative / Null Result ReportMedicine

Extended use of point-of-care technology by acute community nurses during in-home assessment of older adults with potential acute respiratory conditions: a parallel-group, open-label, randomised controlled trial.

Smedemark SA, Jarbøl DE, Laursen CB et al. · 2026 · The lancet. Healthy longevity

Background Diagnosing acute respiratory conditions in adults older than 65 years is challenging due to age-related physiological changes, which increase diagnostic complexity and the risk of hospital admission. We investigated whether…

View details →DOI: 10.1016/j.lanhl.2026.100830
Negative / Null Result ReportOpen accessMedicine

C4/5 Facetectomy Is Associated With Improved Recovery of C5 Palsy in Severe Foraminal Stenosis After Posterior Cervical Decompression and Fusion.

Nakamura Y, Murata S, Yabe T et al. · 2026 · Cureus

Introduction C5 palsy is a disabling complication after posterior cervical decompression and fusion (PCDF). Whether C4/5 facetectomy reduces the incidence or improves the outcomes of C5 palsy remains uncertain. Therefore, this study aimed…

View details →DOI: 10.7759/cureus.109458
Negative / Null Result ReportMedicine

Effects of ILIB on anxiety and physiological parameters during third molar surgery: a pilot randomized trial.

Santos CMM, Mattos NM, Silva RAP et al. · 2025 · Lasers in medical science

This pilot study aimed to investigate the effects of intravascular laser irradiation of blood (ILIB) on anxiety levels and vital signs in patients undergoing third molar extraction. A randomized, placebo-controlled clinical trial was…

View details →DOI: 10.1007/s10103-025-04797-x
Negative / Null Result ReportMedicine

Timing of Preoperative Anti-VEGF for Vitrectomy in Proliferative Diabetic Retinopathy: A Competing-Risks Analysis of a Large Cohort.

Zhan J, Sun G, Li H et al. · 2026 · Ophthalmology. Retina

Objective To evaluate whether timing of preoperative anti-VEGF therapy given before vitrectomy for proliferative diabetic retinopathy (PDR) influences risks of postoperative vitreous hemorrhage (VH) and tractional retinal detachment (TRD).…

View details →DOI: 10.1016/j.oret.2025.12.019
Negative / Null Result ReportMedicine

Questioning routine antibiotic prophylaxis in sialendoscopy: a single-surgeon 164-case analysis.

Holland K, Gomeniouk O, Owen GS et al. · 2026 · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

Purpose Determine if there is a difference in post-operative infection rates in patients undergoing sialendoscopy who received pre-, post-operative, both pre and post, or no antibiotics. Methods Retrospective chart review of patients who…

View details →DOI: 10.1007/s00405-025-09854-3
Negative / Null Result ReportMedicine

The impact of muscle oxidative capacity on neuromuscular recovery after exercise-induced muscle damage.

Kipper CW, Kis P, Burleson KN et al. · 2026 · European journal of applied physiology

Objective Exercise-induced muscle damage (EIMD) compromises neuromuscular function and reduces exercise tolerance. Whether muscle oxidative capacity (MOC), an index of mitochondrial function, is reduced by EIMD or influences neuromuscular…

View details →DOI: 10.1007/s00421-025-06073-w
Negative / Null Result ReportMedicine

Gamma 3 vs Gamma 3 RC in Unstable Extracapsular Hip Fractures: A Prospective Randomized study.

Valle-Cruz JA, Lopiz Y, Garríguez-Pérez D et al. · 2026 · International orthopaedics

Purpose Rotational instability is a key factor in fixation failure of extracapsular hip fractures. The U-Blade (RC) lag screw was designed to improve rotational stability. This study aimed to compare mechanical complication rates between…

View details →DOI: 10.1007/s00264-025-06714-x
Negative / Null Result Report

Neonatal outcomes following a preconception lifestyle intervention in people at risk of gestational diabetes: secondary findings from the BEFORE THE BEGINNING randomised controlled trial

Sujan M, Skarstad H, Rosvold G et al. · 2025 · Preprint

Objectives Gestational diabetes mellitus (GDM), particularly when combined with overweight or obesity, is associated with adverse neonatal outcomes such as high birth weight and increased adiposity. We determined the effect of a…

View details →DOI: 10.1101/2025.10.01.25337073
Negative / Null Result ReportMedicine

Safety, Efficacy, and Immunogenicity of a Multivalent Adjuvanted S. aureus Vaccine in Adults with Recent Skin And Soft Tissue Infections: An Observer-blind, Randomized, Placebo-controlled, Multinational Phase 1/2 Trial.

Athan E, Greenberg RN, Baker DA et al. · 2026 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Background A vaccine that prevents Staphylococcus aureus skin and soft tissue infections (SA-SSTIs) would have a major impact on public health. Methods A two-part randomized study began with a phase 1, first-in-human, dose-escalation that…

View details →DOI: 10.1093/cid/ciag162
Negative / Null Result ReportMedicine

Prevention of premature birth: Impact of the Explicit Health Guarantee.

Carvajal-Encina F, Carvajal Rojas L · 2025 · Andes pediatrica : revista Chilena de pediatria

Prematurity is a challenge due to its high morbidity and mortality. The Explicit Health Guarantees (GES) for Premature Birth Prevention, implemented in 2005, have not been evaluated. Objective To evaluate the impact of the GES on perinatal…

View details →DOI: 10.32641/andespediatr.v96i5.5799
Negative / Null Result ReportMedicine

Fracture risk by post-cessation weight change in male patients with newly diagnosed type 2 diabetes mellitus.

Chung J, Park S, Park SJ et al. · 2026 · The American journal of medicine

Objective This study aimed to evaluate the conflicting effects of weight change and smoking cessation on fracture risk in male patients with newly diagnosed type 2 diabetes mellitus (T2DM). Methods Using the National Health Insurance…

View details →DOI: 10.1016/j.amjmed.2025.12.014
Negative / Null Result ReportMedicine

Effects of imeglimin on mitochondrial functions and ischemic brain damage in young and aging rats.

Paskeviciene E, Skemiene K, Pampuscenko K et al. · 2025 · Journal of pharmacological sciences

Imeglimin, a novel oral antidiabetic drug, has been suggested to affect mitochondrial functions in some types of cells and tissues, however, it has never been investigated whether aging has an impact on its pharmacological effects in the…

View details →DOI: 10.1016/j.jphs.2025.10.001
Negative / Null Result ReportOpen accessMedicine

Effect of Erector Spinae Plane Block Applied to Painful Herpes Zoster Patients Who Failed to Respond to Pregabalin Treatment on Immunological Marker Levels and Postherpetic Neuralgia Incidence Rate.

Büyükbezirci G, Demiralp N, Keles S et al. · 2026 · Journal of pain research

Purpose Postherpetic neuralgia (PHN) is one of the most debilitating complications of herpes zoster and represents a major cause of chronic neuropathic pain. Increasing evidence suggests that immune dysregulation plays a critical role in…

View details →DOI: 10.2147/jpr.s611477
Negative / Null Result ReportMedicine

Genetic profile of Lepr<sup>+</sup> skeletal stem/progenitor cells in the periodontal ligament and functional compensation during aging and bone repair.

Shidara S, Ito S, Desai K et al. · 2026 · Bone

Skeletal stem/progenitor cells (SSPCs) play a fundamental role in maintaining skeletal homeostasis throughout life. Leptin receptor (Lepr)-positive cells were initially identified as SSPCs in the long bone marrow and later in the…

View details →DOI: 10.1016/j.bone.2026.117833
Negative / Null Result ReportOpen accessMedicine

Intraoperative hypotension after remimazolam or propofol induction with sevoflurane maintenance in angiotensin II receptor blockers-treated patients: a randomized controlled trial.

Kim HJ, Kim N, Kim J et al. · 2025 · Scientific reports

Robot-assisted laparoscopic prostatectomy (RALP) is associated with hemodynamic shifts; patients on angiotensin receptor blockers (ARBs) are especially susceptible to intraoperative hypotension. We investigated whether induction with…

View details →DOI: 10.1038/s41598-025-23469-y
Negative / Null Result ReportMedicine

Increase in Diaphragm and Expiratory respiratory muscles thickness is not associated with postoperative pulmonary complications after thoracic surgery: A prospective ultrasound cohort study.

Berthoud V, Nguyen M, Vinay J et al. · 2026 · Anaesthesia, critical care & pain medicine

Introduction In thoracic surgery, all respiratory muscles have a significant increase in workload, and recruitment of these muscles may be important, especially in the presence of diaphragmatic dysfunction. Evaluating diaphragmatic and…

View details →DOI: 10.1016/j.accpm.2025.101683
Negative / Null Result ReportMedicine

A clinical shift toward personalized cochlear implantation: Using preoperative planning to optimize insertion depth.

Bircher B, Aebischer P, Wimmer W et al. · 2026 · American journal of otolaryngology

Objective To evaluate the clinical implementation of preoperative, anatomy-tailored planning for electrode selection in cochlear implantation, quantify planning accuracy under routine conditions, and identify factors associated with…

View details →DOI: 10.1016/j.amjoto.2025.104777
Negative / Null Result ReportMedicine

Effect of intraoperative dexmedetomidine on postoperative mental health in cardiac surgery: a randomized controlled trial.

Hao X, Zhang Z, Cai C et al. · 2026 · International journal of surgery (London, England)

Background Dexmedetomidine was widely used in anesthesia management during cardiac surgery. The purpose was to evaluate the safety and efficacy of intraoperative dexmedetomidine in the treatment of postoperative depression in adult…

View details →DOI: 10.1097/js9.0000000000003906
Negative / Null Result ReportMedicine

The Effect of a Water, Sanitation, and Hygiene Intervention on Clinical Trachoma: A Cluster-Randomised Trial.

Wittberg DM, Admassu F, Aragie S et al. · 2026 · Tropical medicine & international health : TM & IH

Objectives Few randomised trials have been done to assess the impact of hygiene interventions on trachoma even though hygiene improvements feature prominently in the strategy for global elimination of trachoma. This study's aim was to…

View details →DOI: 10.1111/tmi.70086
Negative / Null Result ReportMedicine

Efficacy and safety of heparin in preventing embolic events during transradial cerebral angiography: a randomised controlled trial.

Liu C, Deng G, Wang Y et al. · 2026 · Stroke and vascular neurology

Background Transradial access has become an increasingly preferred approach for cerebral angiography. However, embolic events, often clinically silent, remain a frequent concern. Despite routine use, the efficacy and safety of heparin…

View details →DOI: 10.1136/svn-2025-004887
Negative / Null Result ReportOpen accessMedicine

Dapagliflozin to Reduce Early Recurrence After Catheter Ablation for Atrial Fibrillation: The DARE-AF Randomized Clinical Trial.

Jiang C, Zhao Z, Yang Z et al. · 2026 · Circulation

Background Observational studies have suggested that SGLT2 (sodium-glucose cotransporter 2) inhibitors are associated with a lower risk of atrial fibrillation (AF) recurrence after catheter ablation in patients with AF with concomitant…

View details →DOI: 10.1161/circulationaha.125.077447