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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20261 results in Negative / Null Result Report · page 632 of 676

Negative / Null Result ReportMedicine

Opioid and healthcare service use in medical cannabis patients with chronic pain: a prospective study.

Sznitman S, Mabouk C, Said Z et al. · 2023 · BMJ supportive & palliative care

Background Various jurisdictions have legalised medical cannabis (MC) for use in chronic pain treatment. The objective of this study was to determine if the use of MC is related to a reduction in the use of prescription opioids and other…

View details →DOI: 10.1136/bmjspcare-2020-002661
Negative / Null Result ReportMedicine

Lack of association of superoxide dismutase I/D variant with osteopenia/osteoporosis in Turkish postmenopausal women.

Nacar MC, Yigit S · 2023 · Nucleosides, nucleotides & nucleic acids

Background Osteoporosis (OP) is a common systemic, metabolic bone disease that affects 40% of postmenopausal women. Oxidative stress (OS) ìs caused by reactive oxygen species (ROS), inhibits osteoblast differentiation and causes apoptosis…

View details →DOI: 10.1080/15257770.2023.2185785
Negative / Null Result ReportMedicine

Movement-evoked pain is not associated with pain at rest or physical function in knee osteoarthritis.

Lozano-Meca JA, Gacto-Sánchez M, Montilla-Herrador J · 2024 · European journal of pain (London, England)

Introduction Knee Osteoarthritis (KOA) is mainly characterized by pain. The assessment of KOA-related pain frequently focuses on different constructs subject to sources of bias or drawbacks, as the classical Pain at Rest (PAR).…

View details →DOI: 10.1002/ejp.2236
Negative / Null Result ReportOpen accessMedicine

C-reactive protein and fatigue after subarachnoid haemorrhage.

Daniel S, Hou R, Galea I et al. · 2025 · Brain, behavior, & immunity - health

Background Subarachnoid haemorrhage (SAH) is a severe type of intracranial bleed that causes significant morbidity. One of the most overlooked yet commonly reported symptom is persistent fatigue. Fatigue in the general population has been…

View details →DOI: 10.1016/j.bbih.2025.101046
Negative / Null Result ReportOpen accessMedicine

Anthropometric indicators and dental caries in the pediatric population of rural communities in the peruvian amazon: a cross-sectional study.

Aquino-Canchari CR, Parraga Camayo EF, Ambrosio Huaman EN et al. · 2025 · Revista cientifica odontologica (Universidad Cientifica del Sur)

Introduction Dental caries and nutritional alterations are common in childhood, particularly in rural communities with limited access to health services. Objective To determine the association between anthropometric indicators and the…

View details →DOI: 10.21142/2523-2754-1304-2025-264
Negative / Null Result ReportOpen accessMedicine

Investigating the association between demographic factors and patient satisfaction with recovery in the early phase after non-catastrophic musculoskeletal injuries: a cross-sectional study.

Maleki M, Modarresi S · 2025 · BMC research notes

Background Orthopedic injuries can negatively impact both the physical and mental health of patients. Ensuring patient satisfaction with their recovery is crucial for meeting patient-centered goals and enhancing overall health outcomes.…

View details →DOI: 10.1186/s13104-025-07210-6
Negative / Null Result ReportMedicine

Influence of matrix metalloproteinase 9 variant rs17576 on ischemic stroke risk and severity in acute coronary syndrome.

Bogari NM, Naffadi HM, Babalghith AO et al. · 2024 · Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

Background Ischemic injury is a common mechanism in both ischemic stroke (IS) and acute coronary syndrome (ACS). Matrix metalloproteinase 9 (MMP-9), an endopeptidase that degrades extracellular matrix, is important in the pathogenesis of…

View details →DOI: 10.1016/j.jstrokecerebrovasdis.2024.107824
Negative / Null Result ReportOpen accessMedicine

Combined Prognostic Value of Nutritional and Inflammatory Indices for Predicting Functionally Significant Coronary Stenosis Verified by FFR: The PNI-SII-GINI Study.

Aydın MZ, Arin CB, Teber MK et al. · 2026 · Journal of inflammation research

Background Systemic inflammatory and nutritional indices have been associated with coronary artery disease burden and prognosis; however, their ability to predict lesion-level functional ischemia remains uncertain. This study evaluated…

View details →DOI: 10.2147/jir.s585010
Negative / Null Result ReportOpen accessMedicine

Immunosuppressive Medications and Nonserious Infections in People With Rheumatoid Arthritis: A Prospective Cohort Study.

George MD, Gavigan K, Venkatachalam S et al. · 2026 · ACR open rheumatology

Objective People with rheumatoid arthritis (RA) are at increased risk of serious infection, but less is known about nonserious infections. Our prospective cohort study evaluated associations between medications for RA and the risk of…

View details →DOI: 10.1002/acr2.90050
Negative / Null Result ReportOpen accessMedicine

Social norm intervention in real-world supermarkets in the Netherlands: A quasi-experimental evaluation of effects on perceived social norms and meat substitute purchases.

Wolfswinkel SMM, Raghoebar S, de Vet E et al. · 2026 · Applied psychology. Health and well-being

Social norm perceptions are implicit rules of conduct that describe what is normal and acceptable behavior. Changing social norm perceptions through textual and physical social norm communications can be a promising approach to changing…

View details →DOI: 10.1111/aphw.70159
Negative / Null Result ReportOpen accessMedicine

Circulating Omentin Levels in Heart Failure: A Case-Control Study.

Currò D, Vergani E, Nicolazzi MA et al. · 2026 · International journal of molecular sciences

Cardiovascular diseases remain the leading cause of global mortality, with heart failure (HF) representing a critical clinical endpoint. HF is traditionally classified into two distinct phenotypes based on left ventricular ejection…

View details →DOI: 10.3390/ijms27093998
Negative / Null Result ReportOpen accessMedicine

Association between optical coherence tomography biomarkers and systemic inflammatory indices in neovascular age-related macular degeneration.

Kocamış Ö · 2026 · BMC ophthalmology

BACKGROUND: Neovascular age-related macular degeneration (nAMD) is a leading cause of irreversible central vision loss in elderly individuals. Increasing evidence indicates that systemic inflammation contributes to nAMD pathogenesis.…

View details →DOI: 10.1186/s12886-026-04753-5
Negative / Null Result ReportOpen accessMedicine

The association of previous and current non-chronic low back pain with daily physical activity in middle- and older-aged adults.

Gonçalves TR, Cunha DB, Mediano MFF et al. · 2025 · BMC public health

Background Low back pain (LBP) is a leading cause of years lived with disability. However, the association of non-chronic LBP with levels of daily physical activity (PA) remains poorly explored. This study investigated the association…

View details →DOI: 10.1186/s12889-025-21453-9
Negative / Null Result ReportMedicine

Lack of association between rs1049353 polymorphism of the CNR1 gene and suicide attempt frequency in Polish population.

Wierzbiński P, Henzler M, Hubska J · 2022 · Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego

Suicidal behaviour is a major public health problem in Poland. There is compelling evidence that genetic factors contribute to the risk for suicidal behavior. Studies suggest a link between single nucleotide polymorphism (SNP) rs1049353…

Negative / Null Result ReportOpen accessMedicine

Retrospective Study of Serum Vitamin D Levels and Metabolic-Associated Fatty Liver Disease in 222 Children and Adolescents Aged 6-18 Years With Obesity.

Gümüş CY, Özer Y, Kaşko Arıcı Y · 2026 · Medical science monitor : international medical journal of experimental and clinical research

BACKGROUND Vitamin D deficiency is common in pediatric obesity and has been proposed to contribute to metabolic-associated fatty liver disease (MAFLD). This retrospective study aimed to evaluate serum 25-hydroxyvitamin D (25[OH]D) levels…

View details →DOI: 10.12659/msm.952489
Negative / Null Result ReportMedicine

Neighborhood Deprivation and Breast Cancer Mortality Among Black and White Women.

Barber LE, Maliniak ML, Moubadder L et al. · 2024 · JAMA network open

Importance Neighborhood deprivation has been associated with increased breast cancer mortality among White women, but findings are inconsistent among Black women, who experience different neighborhood contexts. Accounting for interactions…

View details →DOI: 10.1001/jamanetworkopen.2024.16499
Negative / Null Result ReportOpen accessMedicine

Association between systolic blood pressure trajectories and successful aging in middle-aged and elderly Chinese individuals: a longitudinal study.

Xin Y, Qian X, Yang Y · 2025 · BMC public health

Background This study aimed to prospectively assess the relationship between systolic blood pressure (SBP) trajectories and successful aging in middle-aged and elderly Chinese individuals. Methods A total of 1,960 participants from the…

View details →DOI: 10.1186/s12889-025-25709-2
Negative / Null Result ReportOpen accessMedicine

The lack of association between different LDL-C levels and oxidized LDL in patients with type 2 diabetes.

Rabizadeh S, Seyedi SA, Nabipoorashrafi SA et al. · 2023 · Chronic diseases and translational medicine

Background High concentrations of low-density lipoprotein cholesterol (LDL-C) have been a known risk factor for cardiovascular diseases. Also, the role of oxidized LDL (ox-LDL) in forming atherosclerosis plaque has been proven. However, it…

View details →DOI: 10.1002/cdt3.84
Negative / Null Result ReportMedicine

Goal Concordance in the Advancing Symptom Alleviation with Palliative Treatment Clinical Trial of a Nurse and Social Worker Palliative Telecare Team Intervention.

Lange AV, Hess E, Barón AE et al. · 2026 · Journal of palliative medicine

Background Providing and measuring goal-concordant care is a priority. Objective Determine the effect of a nurse and social worker palliative telecare team intervention on goal concordance and participants' understanding of care focus.…

View details →DOI: 10.1177/10966218261444977
Negative / Null Result ReportMedicine

Association of serum sodium levels with fractures and mortality in patients undergoing maintenance hemodialysis.

Soeda K, Komaba H, Nakagawa Y et al. · 2024 · Journal of nephrology

Background Hyponatremia is implicated in pathological bone resorption and has been identified as a risk factor for bone fracture in the general population. However, there are limited data on the association between serum sodium levels and…

View details →DOI: 10.1007/s40620-024-01904-z
Negative / Null Result ReportOpen accessMedicine

Red meat intake during pregnancy and childhood and risk of type 1 diabetes: findings from the ABIS birth cohort.

Lampousi AM, Zeng J, Löfvenborg JE et al. · 2026 · Diabetologia

Aims/hypothesis The role of red meat in type 1 diabetes risk remains unclear. We examined whether maternal and early-life red meat intake is associated with the development of type 1 diabetes and whether such associations are modified by…

View details →DOI: 10.1007/s00125-026-06671-z
Negative / Null Result ReportMedicine

Plasma anti-CD4 IgG levels are associated with poor immune recovery in people with HIV initiating antiretroviral therapy.

Bowler SA, Premeaux TA, Ratzan L et al. · 2025 · AIDS (London, England)

A segment of people with HIV on effective antiretroviral therapy (ART) continue to experience poor immune recovery, leaving them at heightened risk of non-AIDS-defining events (NAEs). The production of anti-CD4 IgG autoreactive antibodies…

View details →DOI: 10.1097/qad.0000000000004044
Negative / Null Result ReportOpen accessMedicine

A case-control study on the diagnostic role of Omega-3 fatty acid levels in erythrocyte membranes of critically ill patients.

Dorchin M, Nasiri-Jounaghani M, Hashemi-Javaheri FS et al. · 2025 · Scientific reports

This study aimed to investigate the erythrocyte Omega-3 fatty acid index as a potential biomarker for clinical severity, nutritional status, and mortality risk in critically ill patients admitted to the intensive care unit (ICU). Using a…

View details →DOI: 10.1038/s41598-025-09391-3
Negative / Null Result ReportMedicine

Any Port in a Storm? Assessment of the Effects of Type and Brand of Condom in Safe-Sex Practices Through a Field Experiment in an <i>Hostal</i> in Lima.

Franco Vega I · 2026 · Journal of sex research

This study assessed the effects of condom types and brands on use in a free condom distribution intervention in hostales (love hotels). New policies are needed to overcome the low levels of contraceptive use in Perú. Hostales could serve…

View details →DOI: 10.1080/00224499.2026.2664807
Negative / Null Result ReportMedicine

Effectiveness of a School-Based Substance Use Prevention Program in Reducing Primary School Students' Intentions to Use Tobacco, Alcohol or Other Drugs in the Future.

Hodder RK, O'Brien KM, Wolfenden L et al. · 2026 · Health promotion journal of Australia : official journal of Australian Association of Health Promotion Professionals

Issue addressed Tobacco, alcohol and other drug use contribute significantly to the global burden of disease, with initiation typically occurring during childhood and adolescence. School-based substance use prevention interventions are…

View details →DOI: 10.1002/hpja.70189