A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20261 results in Negative / Null Result Report · page 630 of 676
Halperin JJ, Granger D · 2026 · BMC neurology
Background CSF immunoglobulin (IgG) often informs diagnosis in CNS inflammatory disease- qualitatively (oligoclonal bands; OCBs), or quantitatively (CSF: serum IgG: albumin, e.g. IgG index). Most US laboratories estimate excess CSF IgG…
Jabbar Abd Sattar Hamoudi H, Wu M, Sanches M et al. · 2026 · Preprint
Background Suicide prediction models in psychiatry often rely on purely data-driven feature selection, which can produce unstable and clinically opaque predictor sets in modest-sized samples. We developed Evidence-Based AI LASSO (EBAL), an…
Moore MJ, Forkel SJ, Demeyere N · 2026 · Preprint
Lesion anatomy has been widely used to study post stroke cognitive outcomes, but it is unclear whether lesion-based measures provide clinically meaningful prognostic information beyond established predictors. Stroke survivors (n = 408)…
Bretzman J, Andrews J, Ge S et al. · 2026 · Journal of vascular and interventional radiology : JVIR
Purpose To determine the patency of portal vein stents in patients with pancreatic cancer, identify risk factors for stent occlusion, and determine whether anticoagulation improves stent patency. Materials and methods Patients with…
Corianò M, Pradegan N, Putortì F et al. · 2026 · Journal of cardiovascular development and disease
Pulmonary hypertension (PH) is associated with adverse outcomes after heart transplantation (HT). In 2022, the European Society of Cardiology introduced lower thresholds for pulmonary vascular resistance (PVR) to distinguish isolated…
Araga Y, Nakamura Y, Sugita C et al. · 2026 · Rinsho shinkeigaku = Clinical neurology
The patient was a 30-year-old man who was admitted to our department 2 months after the onset of anterograde amnesia. Cognitive function tests indicated memory impairment only. MRI FLAIR images of the head showed a high signal in the…
Pham TN, Chamseddine I, Lebhertz D et al. · 2026 · Physics in medicine and biology
Introduction. Radiation-induced optic neuropathy (RION) is a rare but functionally-disabling complication of radiotherapy for brain and head/neck tumors. Even with modern proton therapy and adherence to dose constraints, about 6% of…
Shi L, Li Y, Li C et al. · 2026 · International journal of clinical oncology
Background Comparative evidence for neoadjuvant chemoimmunotherapy (NCIT) versus neoadjuvant immunotherapy combined with chemoradiotherapy (NICRT) in locally advanced esophageal squamous cell carcinoma (ESCC) is limited. We compared…
Hatipoğlu Ö, Başar Ö, Mağat G et al. · 2026 · Scientific reports
Accurate detection of overhanging dental restorations on bitewing radiographs is clinically important but remains challenging due to subtle marginal discrepancies. This study aimed to develop and compare deep learning-based instance…
Packet B, Van Severen R, Cattani L et al. · 2026 · European journal of obstetrics, gynecology, and reproductive biology
Objectives To study the association between the subpubic arch angle and area, the latter a novel estimator of maternal pelvic outlet dimensions, and postpartum anal incontinence. Methods Convenience sample from a prospective observational…
Hwang S, Kim PH, Kim H et al. · 2026 · Preprint
Abstract Purpose Selumetinib is approved for the treatment of inoperable plexiform neurofibromas (PN) in patients with neurofibromatosis type 1 (NF1). However, its efficacy in treating NF1-associated diffuse neurofibromas (NF1-DN) or optic…
Aglen T, Matre KH, Selles RW et al. · 2026 · Journal of hand therapy : official journal of the American Society of Hand Therapists
Background Collagenase treatment can improve finger extension and hand function in patients with Dupuytren's disease. The role of hand therapy in enhancing or prolonging these effects remains unclear. Purpose The primary aim was to examine…
Steen JP, Jaiswal KS, Dilipkumar J et al. · 2026 · The journal of pain
The measurement performance of the Short-Form Brief Pain Inventory (BPI-SF) across IASP-recognized pain mechanisms remains unclear. We evaluated the reliability and structural validity of BPI-SF across clinician-assigned predominant…
Ghofranian A, Baird M, Reckhow J et al. · 2026 · Minerva obstetrics and gynecology
Background Luteal phase E2 priming is commonly used in patients with DOR to 30 synchronize follicular development before controlled ovarian hyperstimulation (COH). Some protocols 31 incorporate a GnRH antagonist during the luteal phase to…
Stanula A, Strzała M, Sadowski W et al. · 2026 · Scientific reports
Post-activation performance enhancement (PAPE) has been proposed as an acute strategy to improve explosive performance, yet its effects on sprint-swimming performance remain unclear, particularly when individualized recovery timing is…
Ogunsanya HY, Petit C, Audenaert K et al. · 2026 · Preprint
Belgian endive-derived biostimulant (BEE) was previously shown to enhance root and shoot growth of Arabidopsis thaliana and Plectranthus esculentus in in vitro culturing conditions. In this study, we evaluated the effect of BEE on A.…
Papadogiorgou G, Koskinioti P, Rodovitis V et al. · 2026 · Bulletin of entomological research
Thermal stress can affect the field performance of sterile males used in the sterile insect technique (SIT). We tested whether adding autoclaved Enterobacter as a dietary supplement improves thermal tolerance in sterile Vienna 8 genetic…
Hachiro K, Takashima N, Kamiya K et al. · 2026 · Circulation reports
Background The effectiveness of multiple arterial grafting (MAG) for hemodialysis (HD) patients is unclear. Methods and results We retrospectively analyzed 149 HD patients who underwent either MAG (n=97) or single arterial grafting (SAG)…
Xiang J, Hou J, Zhang H · 2025 · Endocrine-related cancer
Follicular thyroid carcinoma (FTC) and oncocytic thyroid carcinoma (OTC) are distinct entities with differing biological behaviors, yet optimal surgical and radioactive iodine (RAI) therapy management remains debated. Demographic,…
Lienert M, Stadler L, Kipfer N et al. · 2026 · Veterinary journal (London, England : 1997)
Objectives To investigate the effect of electroacupuncture on postoperative analgesia in dogs undergoing Tibial Tuberosity Advancement surgery. We hypothesise that acupuncture will reduce pain scores and the need for rescue analgesia…
Khan SMS, Arooj M, Khan RA · 2026 · Preprint
Abstract Background: Artificial Intelligence (AI), particularly large language models such as ChatGPT, is increasingly used in education for drafting, tutoring, and summarization. Assessment and feedback remain core but resource-intensive…
Zaki HF, Bishri J, Abdul Muqtadir M et al. · 2026 · Experimental eye research
Background Cone-rod dystrophy (CORD) and achromatopsia (ACHM) are inherited retinal dystrophies for which conventional adeno-associated virus (AAV) gene augmentation has important limitations, particularly in autosomal-dominant…
Znabu BF, Atif Z, devkota P · 2026 · Preprint
Abstract The brain continuously generates predictions about incoming sensory input and produces characteristic neural responses when those predictions are violated. In EEG oddball paradigms, these prediction-error responses manifest as the…
Blokzijl J, Kuijlaars IAR, Pisters MF et al. · 2026 · Haemophilia : the official journal of the World Federation of Hemophilia
Introduction The Haemophilia Activities List (HAL) is a disease-specific patient-reported outcome measure (PROM) that is widely used in both healthcare and research in people with inherited bleeding disorders (PWBD), but information on…
Velez T, Badaki-Makun O, Hirsch D et al. · 2026 · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
Objective Early identification of mortality risk in critically ill children with suspected infection remains challenging. Whether severity scores (SIRS, pSOFA, Phoenix) add incremental value beyond data-derived physiologic features in…
Al-Ibraheem A, Moghrabi S, Alsyouf B et al. · 2026 · Cancers
Background : [ 68 Ga]Ga-FAPI PET/CT demonstrates high sensitivity for tumor detection but limited specificity because benign fibro-inflammatory conditions may also show tracer uptake. Dual-time-point imaging has been proposed to improve…
Embry KR, Jayaraman C, Yang C et al. · 2026 · Journal of neuroengineering and rehabilitation
Background Powered knee and ankle prostheses generate mechanical energy to replicate biological leg function, yet direct comparisons with more commonly prescribed microprocessor-controlled knee prostheses are limited by methodological…
Herrera-Elizondo JL, Jiménez-Castillo RA, García-Compeán D et al. · 2026 · Revista de gastroenterologia de Mexico (English)
Introduction and aims The usefulness of metoclopramide for improving endoscopic visualization in upper gastrointestinal bleeding (UGIB) is controversial. Our primary aim was to evaluate the utility of metoclopramide 20 mg/IV for endoscopic…
Tamura T, Abe S, Matsui H et al. · 2026 · Journal of affective disorders
Background Dopaminergic dysfunction has been implicated in major depressive disorder (MDD), but dopamine transporter (DAT) imaging studies using conventional mean binding have yielded inconsistent findings. One possible contributor is that…
Naghizade B, Özyazgan İ, Bozkurt F et al. · 2026 · Journal of plastic, reconstructive & aesthetic surgery : JPRAS
Background Autologous fat grafting is widely used in plastic surgery, but graft survival remains unpredictable, particularly under compromised conditions such as cigarette smoking. Smoking impairs microcirculation and tissue oxygenation,…