Negative / Null Result ReportOpen accessMedicine
Alshuweishi Y, Binzomah Alghamdi F, Patrick K et al. · 2025 · Cells
AMP-activated protein kinase (AMPK) is activated by reduced cellular energy charge and mimics the action of insulin in muscle by stimulating increased trafficking of GLUT4 to the plasma membrane. In contrast, we have previously reported…
View details →DOI: 10.3390/cells14221811 Negative / Null Result Report
Kishinevsky M, Ferrer-Suay M, Ives AR · 2024 · Preprint
The enemy release hypothesis, that the success of invading species is due to release from natural enemies that occur in their home range but not in the new range, can be an important explanation for successful invasions. Testing this…
View details →DOI: 10.1101/2024.11.05.621954 Negative / Null Result ReportMedicine
Almutairi NM, Hayes J, Hampson KM et al. · 2025 · Vision research
Individuals with mild traumatic brain injury (mTBI) exhibit significant accommodative abnormalities. Accommodation microfluctuation (MFs) plays an important role in the accommodation steady-state control. This study was set to investigate…
View details →DOI: 10.1016/j.visres.2025.108545 Negative / Null Result ReportOpen accessMedicine
Kim AR, Jamka J, Jackson WF et al. · 2026 · Cells
Anticontractile factors secreted by perivascular adipose tissue (PVAT) play an important role in regulating vascular tone. This process is driven by the neurotransmitter norepinephrine (NE), but recent data show that adrenergic innervation…
View details →DOI: 10.3390/cells15100906 Negative / Null Result ReportMedicine
Mockett BG, Davies JWT, Mills ZB et al. · 2024 · Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Group I metabotropic glutamate receptors (Gp1-mGluRs) exert a host of effects on cellular functions, including enhancement of protein synthesis and the associated facilitation of long-term potentiation (LTP) and induction of long-term…
View details →DOI: 10.1098/rstb.2023.0481 Negative / Null Result ReportOpen accessMedicine
Fu SJ, Cheng KM, Hsiao CT et al. · 2024 · Cell communication and signaling : CCS
Loss-of-function mutations in the human gene encoding the neuron-specific Ca 2+ channel Ca V 2.1 are linked to the neurological disease episodic ataxia type 2 (EA2), as well as neurodevelopmental disorders such as developmental delay and…
View details →DOI: 10.1186/s12964-024-01960-9 Negative / Null Result ReportOpen accessMedicine
Videtta G, Sasia C, Quadrino S et al. · 2026 · Molecules (Basel, Switzerland)
Activation of microglia and resulting neuroinflammation are central processes that significantly contribute to neurodegenerative disease progression. Treatments capable of attenuating neuroinflammation are therefore an urgent medical need.…
View details →DOI: 10.3390/molecules31010196 Negative / Null Result ReportOpen accessMedicine
Nguyen AP, Hadi DL, Todd DA et al. · 2026 · Clinical pharmacology and therapeutics
Cinnamon (Cinnamomum spp.) is used as a culinary spice and dietary supplement. A major constituent, cinnamaldehyde, was previously shown to inactivate cytochrome P450 (CYP) 2A6 in vitro. A mechanistic static model predicted an ~5-fold…
View details →DOI: 10.1002/cpt.70218 Negative / Null Result ReportOpen accessMedicine
Xu C, Annapureddy H, Carson L et al. · 2026 · JCI insight
Antiretroviral therapy (ART) has prolonged the life expectancy of persons living with HIV, the majority of whom are now older than 50 years. Aging people with HIV are at increased risk for cardiovascular events driven by HIV-related…
View details →DOI: 10.1172/jci.insight.202434 Negative / Null Result ReportOpen accessMedicine
Brandt RB, Lansbergen CS, Kollenburg L et al. · 2025 · Headache
Background/objective Occipital nerve stimulation (ONS) has become an established therapy for medically intractable chronic cluster headache (MICCH), but unfortunately, one third of the patients do not respond satisfactorily. Reliable…
View details →DOI: 10.1111/head.14985 Negative / Null Result ReportMedicine
Hagedoorn L, Ruiz-Rodríguez A, Leijen I et al. · 2025 · Experimental gerontology
Background Perturbation-based training improves reactive stepping responses to prevent falling following a loss-of-balance. As there is currently no safe and feasible method for home-based practice, this randomized study investigated…
View details →DOI: 10.1016/j.exger.2024.112645 Negative / Null Result ReportMedicine
Chiang Yu Y, Lu D, Rege B et al. · 2024 · Journal of pharmaceutical sciences
The addition of antioxidants to pharmaceutical products is a potential approach to inhibit nitrosamine formation, particularly in solid oral dosage forms like tablets and capsules. The objective was to assess the effect of ten antioxidants…
View details →DOI: 10.1016/j.xphs.2024.03.005 Negative / Null Result ReportOpen accessMedicine
Gootjes C, Zwaginga JJ, Nikolic T et al. · 2026 · PloS one
Iscalimab is a nondepleting anti-CD40 monoclonal antibody, expected to suppress immune responses by blocking the costimulation by antigen-presenting cells through CD40-CD40L ligation. This therapeutic antibody indeed inhibited…
View details →DOI: 10.1371/journal.pone.0351131 Negative / Null Result ReportOpen accessMedicine
Forde G, Brucker BM, Becker Ifantides K et al. · 2024 · Toxins
OnabotulinumtoxinA (onabotA) is approved in the US for 12 therapeutic indications. Real-world data on onabotA multi-indication use are limited, often leading to delayed or reduced treatment. This study provides real-world evidence on the…
View details →DOI: 10.3390/toxins16100420 Negative / Null Result ReportMedicine
Goettel M, Werner C, Honarvar N et al. · 2024 · Toxicology
The fungicide fluxapyroxad (BAS 700 F) has been shown to significantly increase the incidence of liver tumours in male Wistar rats at dietary levels of 1500 and 3000 ppm and in female rats at a dietary level of 3000 ppm via a non-genotoxic…
View details →DOI: 10.1016/j.tox.2024.153828 Negative / Null Result ReportOpen accessMedicine
Kornienko TE, Chepanova AA, Kolobenko MV et al. · 2026 · Current issues in molecular biology
Tyrosyl-DNA phosphodiesterase 1 (TDP1) is a key enzyme for the repair of stalled topoi-somerase 1 (TOP1)-DNA complexes. We have previously developed a TDP1 inhibitor, compound OL9-116, which is capable of enhancing the action of the…
View details →DOI: 10.3390/cimb48040428 Negative / Null Result ReportOpen accessMedicine
Dalla Via J, Radavelli-Bagatini S, Sim M et al. · 2026 · Aging clinical and experimental research
Background Provision of vascular imaging results has been investigated to prompt changes towards healthy lifestyle behaviours, but effects on body composition and muscle health are unknown. Aim This secondary analysis of a 12-week…
View details →DOI: 10.1007/s40520-026-03335-1 Negative / Null Result ReportMedicine
Kaur J, Kaur M, Chakrapani V et al. · 2023 · Health education research
We report process evaluation findings from the 'SMART Eating' intervention trial, which significantly improved fat, sugar and salt (FSS), and fruits and vegetables (FVs) intake among adults. Intervention used information technology [short…
View details →DOI: 10.1093/her/cyad020 Negative / Null Result ReportOpen accessMedicine
Burman MA, Zuke JT · 2026 · PloS one
Early life pain and stress have lasting consequences on nervous system development that can interact with later stress or trauma to create a susceptibility to fear, anxiety, depression and chronic pain among other psychological disorders.…
View details →DOI: 10.1371/journal.pone.0326300 Negative / Null Result ReportOpen accessMedicine
Kim TE, Bae JW, Hong S et al. · 2025 · The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology
Donepezil, an acetylcholinesterase inhibitor, is widely used for managing the symptoms of Alzheimer's disease (AD), yet its clinical response varies widely among individuals. This study aims to investigate the influence of CYP2D6 genetic…
View details →DOI: 10.4196/kjpp.24.239 Negative / Null Result ReportOpen accessMedicine
Hu Q, Zhong W, Hu R · 2026 · Inquiry : a journal of medical care organization, provision and financing
Research on income inequality and obesity shows inconsistent results. This study tests if this relationship depends on a country's existing inequality level. We analyzed individual-level data (N = 22 938) from the 2011 and 2021…
View details →DOI: 10.1177/00469580261444418 Negative / Null Result ReportOpen accessMedicine
Abkur T, Boogers A, Grippe T et al. · 2025 · Movement disorders clinical practice
Background The coexistence of tics with Parkinson's disease (PD) is rare, as they often emerge at different ages, follow different trajectories and involve contrasting pathophysiological mechanisms related to dopamine availability and…
View details →DOI: 10.1002/mdc3.70111 Negative / Null Result ReportMedicine
Leproult I, Lemaire B, Portrat S · 2024 · Memory & cognition
Elaboration has emerged as a potential maintenance mechanism involved in the substantial contribution of long-term memory (LTM) to working memory (WM) performance. The objective of the current study was to determine whether elaborative…
View details →DOI: 10.3758/s13421-024-01615-7 Negative / Null Result ReportOpen accessMedicine
Lee KE, Nishi M, Kim J et al. · 2024 · Frontiers in endocrinology
Rationale MG53's known function in facilitating tissue repair and anti-inflammation has broad applications to regenerative medicine. There is controversy regarding MG53's role in the development of type 2 diabetes mellitus. Objective This…
View details →DOI: 10.3389/fendo.2024.1425426 Negative / Null Result ReportOpen accessMedicine
Krakowian D, Lach M, Żemła P et al. · 2025 · Cytotechnology
The HeLa 9903 cell line is used in the in vitro endocrine disruption assay (OECD 455). After treatment with an estrogen receptor agonist, the luminescence of these cells increases. However, some autoactivation of this test system may…
View details →DOI: 10.1007/s10616-025-00817-4 Negative / Null Result ReportMedicine
Nannoni E, Martelli G, Militerno G et al. · 2024 · Animal Feed Science and Technology.
The experiment aimed to obtain information on the water requirements, drinking behavior and drinking motivation of liquid-fed pigs and was conducted during the hot season. Eighty castrated male pigs (initial body weight: 36 kg) fed a…
View details →DOI: 10.1016/j.anifeedsci.2024.116004 Negative / Null Result ReportMedicine
Schumacher JD, van Holstein M, Zhou P et al. · 2025 · The Journal of neuroscience : the official journal of the Society for Neuroscience
Converging evidence suggests that orbitofrontal cortex (OFC) subregions subserve distinct roles in decision-making across a variety of tasks. Cost/benefit decisions can require an organism to choose between options based on information…
View details →DOI: 10.1523/jneurosci.1989-24.2025 Negative / Null Result Report
Furnival-Adams J, Houana A, Nicolas P et al. · 2024 · Preprint
Abstract Background Headlice are prevalent worldwide, with a higher burden in rural, lower-middle income settings. They can cause intense itchiness, discomfort, and secondary bacterial infections with potentially serious consequences.…
View details →DOI: 10.21203/rs.3.rs-5198695/v1 Negative / Null Result ReportOpen accessMedicine
Dekhne MS, Kunze KN, Chiu YF et al. · 2025 · Arthroplasty today
Background Patient-reported outcome measures (PROMs) assess quality of care after total joint arthroplasty (TJA) and will be mandatory for reporting by 2027 under the Center for Medicare and Medicare Services. This study evaluated the…
View details →DOI: 10.1016/j.artd.2025.101767 Negative / Null Result ReportMedicine
Robinson HL, Banks ML · 2026 · ASPET discovery
Rationale Mesocorticolimbic dopamine neurotransmission is hypothesized to play a central role in both cocaine reinforcement and amphetamine maintenance-induced decreases in cocaine self-administration. One method to selectively modulate…
View details →DOI: 10.1016/j.aspetd.2026.100020 