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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20261 results in Negative / Null Result Report · page 618 of 676

Negative / Null Result ReportMedicine

Differential impact of cumulative cerebral small-vessel disease burden on ischemic versus hemorrhagic stroke recurrence in hemorrhage-prone patients.

Park JH, Kwon SU · 2026 · Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

Background Total cerebral small-vessel disease (cSVD) score is a well-established predictor of vascular risks. However, the specific type of recurrent stroke associated with cSVD scores remains unclear in hemorrhage-prone patients-those…

View details →DOI: 10.1007/s10072-026-09105-1
Negative / Null Result ReportMedicine

Efficacy of Watercress (<i>Nasturtium officinale</i> R.Br.) Consumption on Blood Pressure, Oxidative Stress Biomarkers, and Estimated Cardiovascular Risk in Thai Middle-Aged Adults: A Randomized Placebo-Controlled Pilot Study.

Kijkuokool P, Rerkasem K, Fakfum P et al. · 2026 · Antioxidants (Basel, Switzerland)

Watercress ( Nasturtium officinale R.Br.) is a cruciferous vegetable rich in bioactive compounds that may improve cardiovascular disease (CVD) risk factors. However, clinical evidence regarding its direct impact on CVD risk remains…

View details →DOI: 10.3390/antiox15060766
Negative / Null Result ReportMedicine

Serum ceramides predict all-cause and cardiovascular mortality in Chinese incident hemodialysis patients: a retrospective cohort study.

Zhang S, Wu YL, Li ZY et al. · 2026 · Kidney research and clinical practice

Background This study explored serum ceramide (Cer) levels' association with all-cause and cardiovascular disease (CVD) mortality in Chinese incident hemodialysis (HD) patients. Methods This retrospective cohort study included 253 adults…

View details →DOI: 10.23876/j.krcp.25.227
Negative / Null Result ReportMedicine

Phase II study of lenalidomide maintenance after rituximab-methotrexatebased induction therapy in primary central nervous system lymphoma.

Lee JY, Kim SA, Yang DH et al. · 2026 · Haematologica

Adults with primary central nervous system lymphoma (PCNSL) who are ineligible for consolidative whole-brain radiotherapy (WBRT) or autologous stem-cell transplantation (ASCT) due to advanced age, comorbidities, or impaired performance…

View details →DOI: 10.3324/haematol.2026.300790
Negative / Null Result ReportMedicine

Unilateral posterior vertebral column resection versus bilateral approach for post-traumatic thoracic angular kyphosis: a propensity-matched non-inferiority study.

Ghobashy MK, AbdelFatah MA, Youssef ME et al. · 2026 · European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Purpose Posterior vertebral column resection (PVCR) for severe post-traumatic thoracic angular kyphosis is effective but carries high morbidity. This study compares unilateral PVCR (UPVCR) with traditional bilateral PVCR (BPVCR),…

View details →DOI: 10.1007/s00586-026-10078-0
Negative / Null Result Report

Theta Dual-Brain Stimulation of rTPJ Shapes Joint Agency

Kurihara Y, Tsuchiya A, Dumas G et al. · 2026 · Preprint

Summary Joint agency, the shared feeling of “we are doing this together”, has been linked to inter-brain synchrony, but its causal role in shaping this experience remains unclear. We applied dual transcranial alternating current…

View details →DOI: 10.64898/2026.03.10.710822
Negative / Null Result Report

Mental Health and Well-Being Among Community Paramedics in Ontario, Canada

Mausz J, Donnelly EA, Batt AM et al. · 2026 · Preprint

Objectives: Paramedics are at elevated risk for adverse mental health outcomes due to occupational exposures including trauma, workplace violence, and chronic operational stress. Community Paramedicine (CP) represents an evolving model of…

View details →DOI: 10.20944/preprints202605.0577.v1
Negative / Null Result ReportMedicine

Discordance between IHC/FISH and RNA expression-based assessment of ER/HER2 status, and its prognostic impact assessed by propensity score matching.

Nakauchi C, Masunaga N, Eguchi Y et al. · 2026 · BMC cancer

Background Immunohistochemistry (IHC) is widely used to determine estrogen receptor (ER) and human epidermal growth factor receptor 2 (HER2) status, which are crucial for predicting breast cancer recurrence and guiding adjuvant therapy…

View details →DOI: 10.1186/s12885-026-16081-4
Negative / Null Result ReportMedicine

Face-to-face vs. telerehabilitation for thoracic hyperkyphosis in children- A randomized controlled pilot study.

Gözener Canbülbül S, Canbülbül B, Özcan Şİ et al. · 2026 · Journal of pediatric rehabilitation medicine

PurposeThis pilot study aimed to compare the effects of face-to-face and telerehabilitation approaches on thoracic hyperkyphosis, back extensor muscle strength, and discomfort in children.MethodsA randomized clinical trial was conducted in…

View details →DOI: 10.1177/18758894261446171
Negative / Null Result ReportMedicine

The John Charnley Award: A Randomized Controlled Trial of Dual Mobility and Single Bearings for Patients at High Risk of Dislocation Following Primary Total Hip Arthroplasty.

Potluri AS, Yadav AS, Weintraub MT et al. · 2026 · The Journal of arthroplasty

Introduction This multicenter randomized controlled trial (RCT) sought to determine if dual-mobility bearings (DM) reduce dislocations in patients at high-risk for instability undergoing primary total hip arthroplasty (THA) compared to…

View details →DOI: 10.1016/j.arth.2026.06.018
Negative / Null Result ReportMedicine

Evaluation of corneal aberrations and meibomian gland function after botulinum toxin A in blepharospasm/hemifacial spasm.

Doganay D, Ismayilov AS, Sevınc D et al. · 2026 · Cutaneous and ocular toxicology

Purpose To evaluate the changes in aberrometry values on corneal topography and the function of the meibomian glands following therapeutic Botulinum toxin type A injections in patients with blepharospasm and hemifacial spasm. Materials and…

View details →DOI: 10.1080/15569527.2026.2673150
Negative / Null Result ReportMedicine

Modulation of oxidative stress mediates kaempferol induced enhancement of bovine oocyte In Vitro maturation developmental efficiency.

Wang H, Wang W, Li Y et al. · 2026 · Animal reproduction science

This study aimed to examine the protective effects of kaempferol on the in vitro maturation (IVM) of bovine oocytes and their subsequent embryonic development, and to investigate the underlying mechanisms. Bovine oocytes were cultured with…

View details →DOI: 10.1016/j.anireprosci.2026.108252
Negative / Null Result ReportMedicine

Tasting beer based on the tactile thickness of the glass lip

Ariga A, Kubo N, Koizumi T et al. · 2026 · Food Quality and Preference.

Multisensory research has demonstrated that the perceptual characteristics of a receptacle can influence how beverages are experienced, a phenomenon known as sensation transference. Previous studies have shown that the lip thickness of a…

Negative / Null Result Report

Do drugs with biliary toxicity cause cholangiocarcinoma?

Zong C, Lim K, Walker SA et al. · 2026 · Preprint

A bstract Many commonly used therapeutic drugs cause biliary toxicity, but it is unclear if they are directly responsible for the increasing incidence of cholangiocarcinoma (CCA). We tested experimentally and analyzed through a cohort…

View details →DOI: 10.64898/2026.03.31.715688
Negative / Null Result ReportMedicine

Incidence and associated factors of metachronous contralateral cryptorchidism after unilateral cryptorchidism: a retrospective cohort study.

Grande-Moreillo C, Pérez-López C, Vicente-Sánchez N et al. · 2026 · European journal of pediatrics

Acquired cryptorchidism is an increasingly recognized condition and may present bilaterally with a metachronous pattern. The objective of this study was to evaluate the incidence of acquired contralateral metachronous cryptorchidism and to…

View details →DOI: 10.1007/s00431-026-07154-4
Negative / Null Result ReportMedicine

Frequent Ambulatory Care Visits Predict Harmful Diagnostic Errors in High-Risk Hospitalized Patients: a Retrospective Cohort Study.

Goyal A, Konieczny K, Plombon S et al. · 2026 · Journal of general internal medicine

Background Diagnostic errors (DEs) are a major threat to hospital patient safety. Identifying admission-based predictors associated with harmful DEs may help improve diagnostic safety in high-risk populations. Objective To assess the…

View details →DOI: 10.1007/s11606-026-10527-y
Negative / Null Result ReportOpen accessMedicine

Effectiveness of Hyaluronic Acid Gel in Preventing Postoperative Intrauterine Adhesion Formation Following Operative Hysteroscopy.

Ciftci B, Karadag B · 2026 · International journal of women's health

Objective To evaluate the effectiveness of intrauterine hyaluronic acid (HA) gel application in preventing postoperative intrauterine adhesion formation following operative hysteroscopy. Methods This retrospective comparative study was…

View details →DOI: 10.2147/ijwh.s609095
Negative / Null Result ReportOpen accessMedicine

Trend and clinical outcomes of transcatheter aortic valve replacement in connective tissue disease from the national inpatient sample database (2016-2022).

Yasmin F, Rab AU, Asghar MS et al. · 2026 · Journal of cardiothoracic surgery

Purpose Given the systemic nature of connective tissue diseases (CTD), open surgical intervention for aortic stenosis is often considered high risk, making transcatheter aortic valve replacement (TAVR) a potentially preferable alternative.…

View details →DOI: 10.1186/s13019-026-04170-1
Negative / Null Result ReportMedicine

Short-term vaginal prasterone therapy induces steroid receptor modulation and extracellular matrix remodeling in human vaginal mucosa.

Tomczyk K, Yang-Jensen KC, Lorentzen LG et al. · 2026 · Scientific reports

Prasterone (dehydroepiandrosterone, DHEA) is increasingly used in the treatment of genitourinary syndrome of menopause (GSM), although its molecular effects on vaginal tissue remain insufficiently characterized. This prospective study…

View details →DOI: 10.1038/s41598-026-50491-5
Negative / Null Result ReportMedicine

Analysis of patients with hydrogen sulfide poisoning reported to the Taiwan Poison Control Center between 1986 and 2021.

Wen YC, Chu FY, Wang TH et al. · 2026 · Clinical toxicology (Philadelphia, Pa.)

Introduction Hydrogen sulfide exposure is a major cause of occupational poisoning and is frequently associated with life-threatening effects. This study aimed to investigate the patterns, poisoning severity, and predictors of severity in…

View details →DOI: 10.1080/15563650.2026.2675040
Negative / Null Result ReportMedicine

Age at menopause and risk of sarcopenia in postmenopausal women: evidence from the China health and retirement longitudinal study.

Li Y, Qin L, Wang Y et al. · 2026 · Reproductive health

Background Menopausal age is closely associated with women's health, but research on its association with sarcopenia risk remains insufficient. Our study aimed to explore how menopausal age affects the risk of sarcopenia in postmenopausal…

View details →DOI: 10.1186/s12978-026-02358-1
Negative / Null Result ReportMedicine

Nailfold capillaroscopy findings after anthracycline-based chemotherapy and their association with subclinical changes in left ventricular ejection fraction.

Kiracı M, Soytürk G, Köş FT et al. · 2026 · BMC cancer

Background Anthracyclines can induce endothelial and microvascular injury that precedes measurable myocardial dysfunction. However, reliable early markers of such injury are lacking. Nailfold capillaroscopy (NFC) is a noninvasive imaging…

View details →DOI: 10.1186/s12885-026-16187-9
Negative / Null Result ReportMedicine

Changes in female sexual function during the retirement transition.

Virkkunen V, Kero K, Stenholm S et al. · 2026 · Menopause (New York, N.Y.)

Objectives For many women, retirement represents a significant transition in late adulthood, which may result in many alterations in lifestyle habits and behavioral patterns. Several factors known to improve during the retirement…

View details →DOI: 10.1097/gme.0000000000002778
Negative / Null Result ReportOpen accessMedicine

Factors Influencing Interest in Urology Among Osteopathic and Allopathic Medical Students: A Single-Institution Cross-Sectional Survey.

Woodworth E, Sheppard C, Wong R et al. · 2026 · Cureus

Background Following the transition to a single-accreditation residency system, Doctor of Osteopathic Medicine (DO) and Doctor of Allopathic Medicine (MD) students now apply for the same urology residency positions. Despite this…

View details →DOI: 10.7759/cureus.107827
Negative / Null Result ReportMedicine

Differential Factor-Level MADRS Response Associated With Seizure Duration in Electroconvulsive Therapy: Exploratory Findings.

Swierkosz-Lenart K, Ranjbar S, Compagne C et al. · 2026 · The journal of ECT

Background Electroconvulsive therapy (ECT) is a widely used treatment for severe and treatment-resistant depression, with high efficacy but considerable interindividual variability of response. The neurophysiological mechanisms underlying…

View details →DOI: 10.1097/yct.0000000000001264
Negative / Null Result ReportMedicine

Cross-sectional and prospective relations between dysfunctional cognitive beliefs and obsessive-compulsive symptoms during late childhood and early adolescence: a test of two aetiological models.

Barcaccia B, Cervin M, Borrelli DF et al. · 2026 · Journal of child psychology and psychiatry, and allied disciplines

Background Obsessive-compulsive symptoms (OCS) often emerge during childhood and adolescence, and two aetiological models have been proposed. According to the first model, maladaptive cognitive beliefs facilitate the transformation of…

View details →DOI: 10.1111/jcpp.70077
Negative / Null Result ReportOpen accessMedicine

Dyadic Dynamic in Generalized Political Attitudes: Homophily, Relationship Satisfaction, and Convergence.

Miculka A, Imhoff R · 2026 · International review of social psychology

Despite the social nature of generalized political attitudes such as conspiracy mentality, right-wing authoritarianism (RWA), and social dominance orientation (SDO), dyadic phenomena concerning these attitudes have not been comprehensively…

View details →DOI: 10.5334/irsp.1102