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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21363 results · page 618 of 713

Negative / Null Result ReportMedicine

Morphometric Analysis of Lateral Nasal Wall and Pterygomaxillary Junction in Class II and III Skeletal Malocclusions: Implications for Orthognathic Surgical Strategy.

Pergel, Akkoyun · 2026 · The Journal of craniofacial surgery

In Le Fort I osteotomy, precise anatomic knowledge is essential to minimize intraoperative bleeding, particularly during lateral nasal wall osteotomy (LNO) and pterygomaxillary junction (PMJ) separation. This study aimed to evaluate the…

View details →DOI: 10.1097/scs.0000000000013069
Negative / Null Result ReportMedicine

Predictive Value of Neutrophils, Lymphocytes, Platelets, Neutrophil-Lymphocyte Ratio (NLR), and Platelets-Lymphocyte Ratio (PLR) in Preterm Labor: Single and Combined Indices.

Elmaradny, Aman, Alaskar et al. · 2026 · Obstetrics and gynecology international

Maternal neutrophils (N), lymphocyte, platelets (PLTs), neutrophil-lymphocyte ratio (NLR), and platelets-lymphocyte ratio (PLR) have been used to predict preterm birth. We studied changes in these markers in preterm labor (PTL) and whether…

View details →DOI: 10.1155/ogi/5401809
Negative / Null Result ReportMedicine

Prospective MRI-Based Comparison of Graft Maturation After ACL Reconstruction Using Quadriceps Versus Hamstring Tendon Autograft.

Erden, Ağır, Kayaalp et al. · 2026 · Orthopaedic journal of sports medicine

Biological graft maturation after anterior cruciate ligament (ACL) reconstruction is a prolonged and heterogeneous process that may not directly correlate with clinical recovery. Magnetic resonance imaging (MRI)-based signal intensity…

View details →DOI: 10.1177/23259671261449148
Negative / Null Result ReportMedicine

Mortality Outcome Post-MI after PCI and CABG Interventions.

Al-Naqdi, Alkhammasi, Al-Naqdi · 2026 · Global heart

Worldwide, heart-related conditions, including myocardial infarction (MI), persist as the leading cause of morbidity and mortality. The aim is to compare three-year mortality outcomes and identify causes of death among post-MI patients who…

View details →DOI: 10.5334/gh.1556
Negative / Null Result ReportMedicine

Good's syndrome and infections in a large retrospective cohort of thymoma.

Jia, Jin, Huan et al. · 2026 · Frontiers in immunology

Good's syndrome (GS) is an immunodeficiency associated with thymoma characterized by hypogammaglobulinemia. The co-existence of recurrent infections may be associated with quality of life and overall survival. Despite its relevance, the…

View details →DOI: 10.3389/fimmu.2026.1733466
Negative / Null Result ReportMedicine

Oliceridine in the Prevention of Catheter-Related Bladder Discomfort: A Single-Center, Randomized, Double-Blind, Prospective Trial.

Jiang, Gao, Yang et al. · 2026 · Drug design, development and therapy

To investigate whether oliceridine is more effective than morphine in reducing the incidence of moderate-to-severe catheter-related bladder discomfort (CRBD) in male patients after transurethral surgery. This prospective, randomized,…

View details →DOI: 10.2147/dddt.s605184
Negative / Null Result ReportMedicine

Detection and infection dynamics of Marseillevirus-like viruses in Aedes aegypti: Evidence for vertical and human exposure pathways.

Karalyan, Ross, Bayramyan et al. · 2026 · Acta tropica

Mosquito-specific viruses (MSVs) have garnered increasing interest, particularly those phylogenetically related to arboviruses. Among them, giant viruses of the phylum Nucleocytoviricota, such as Marseillevirus, have been detected in…

View details →DOI: 10.1016/j.actatropica.2026.108185
Negative / Null Result ReportMedicine

Effect of Visceral Manipulation Versus Integrated Neuromuscular Inhibition Technique in Shoulder Impingement Syndrome.

Elserty, Shokry, Altoury et al. · 2026 · Physiotherapy research international : the journal for researchers and clinicians in physical therapy

Shoulder pain during daily activities is a common musculoskeletal complaint affecting individuals across all age groups. Among its causes, Shoulder Impingement Syndrome (SIS) is one of the most prevalent. This study aimed to compare the…

View details →DOI: 10.1002/pri.70253
Negative / Null Result ReportMedicine

Outcome-driven dosimetry optimization for [ 177 Lu]Lu-PSMA-617 radiopharmaceutical therapy: proof of concept on single time point dosimetry optimization.

Hu, Seifert, Gomes et al. · 2026 · European journal of nuclear medicine and molecular imaging

Internal dosimetry in radiopharmaceutical therapy (RPT) traditionally prioritizes methodological optimization driven by physical dose accuracy. However, even recommended multiple-time-point (MTP) dosimetry remains subject to uncertainties…

View details →DOI: 10.1007/s00259-026-07936-w
Negative / Null Result ReportMedicine

Non-tobacco nicotine use and complications in single-level posterior lumbar and transforaminal lumbar interbody fusion.

Nguyen, Hall, Lebens et al. · 2026 · European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Over 300,000 lumbar fusion surgeries are performed annually for various indications. Tobacco use has previously been demonstrated to increase rates of nonunion and mechanical complications, but the impact of non-tobacco nicotine (NTN)…

View details →DOI: 10.1007/s00586-026-10081-5
Negative / Null Result ReportMedicine

Utilization of indocyanine green fluorescence angiography in redo IPAA surgery.

Gulmez, Hinduja, Ajredini et al. · 2026 · International journal of colorectal disease

Redo/revisional ileal pouch-anal anastomosis (IPAA) surgery is technically challenging and more likely to require mesenteric lengthening maneuvers, largely due to mesenteric reach issues, which may affect the perfusion of the critical…

View details →DOI: 10.1007/s00384-026-05162-2
Negative / Null Result ReportMedicine

Effects of Oxidative Stress and Antioxidant Activity in Uterine Flush Fluid During Early Postpartum on Reproductive Performance of Lactating Holstein-Friesian Dairy Cows.

Hagita, Miura, Shirasuna et al. · 2026 · Animal science journal = Nihon chikusan Gakkaiho

This study examined the impact of early postpartum uterine oxidative stress and antioxidant activity on subsequent reproductive performance in lactating Holstein-Friesian dairy cows. Uterine flush fluid samples were collected at…

View details →DOI: 10.1111/asj.70200
Negative / Null Result ReportMedicine

Inhaled corticosteroids monotherapy in childhood asthma: Any differential response rate between activated and prodrugs?

Majumder, Smyrnova, Ducharme · 2026 · The Journal of asthma : official journal of the Association for the Care of Asthma

The efficacy of inhaled corticosteroids (ICS) as prodrugs (inactive at delivery) has been compared to activated ICS, in mean changes in lung function and symptoms, with limited evidence on achieving control. We aimed to compare the…

View details →DOI: 10.1080/02770903.2026.2686931
Negative / Null Result ReportMedicine

Hemodynamic-guided V-A ECMO management for cardiogenic shock: Insight from initial experience from TWEET study (to wean an ECMO trials).

Nascimbene, Tosun, Nathan et al. · 2026 · Perfusion

BackgroundVeno-arterial extracorporeal membrane oxygenation (V-A ECMO) is used for refractory cardiogenic shock, yet optimal weaning strategies and the role of left ventricular (LV) venting remain unclear. The TWEET-1 study was designed as…

View details →DOI: 10.1177/02676591261458644
Negative / Null Result ReportMedicine

Efficacy of High Flow Nasal Cannula in Reducing Hypoxemia in Children Undergoing Elective Flexible Fibreoptic Bronchoscopy as Compared to Conventional Low Flow Nasal Cannula: A Randomized Controlled Trial.

Rajvanshi, Kumar, Goyal et al. · 2026 · Pediatric pulmonology

Flexible fibreoptic bronchoscopy (FFB) is widely used in pediatric pulmonology, though hypoxemia remains a primary concern during the procedure. High-flow nasal cannula (HFNC) has shown potential in reducing hypoxemia in adults undergoing…

View details →DOI: 10.1002/ppul.71683
Negative / Null Result ReportMedicine

Prospective observational comparative study of radiotherapy induced toxicities (xerostomia, skin reaction, and mucositis) between three-dimensional conformal radiotherapy and intensity modulated radiotherapy technique to oral cavity cancer of head and neck.

Dhakar, Ghori, Parihar et al. · 2026 · The Gulf journal of oncology

Oral cavity cancers often require radiotherapy (RT), leading to toxicities such as xerostomia, skin reactions, and mucositis. This study aims to compare these toxicities between three-dimensional conformal radiotherapy (3D-CRT) and…

Negative / Null Result ReportMedicine

Comparison of Interferon-Based and Interferon-Free Treatments on the Prognosis of Hepatocellular Carcinoma After Hepatitis C Virus-Sustained Virological Response: A Multicenter Study.

Itoh, Iseda, Yoshizumi et al. · 2026 · Cancer medicine

We examine the impact of interferon (IFN)-based and IFN-free treatment on the prognosis of hepatocellular carcinoma (HCC) after hepatitis C virus (HCV) sustained virological response (SVR). Clinical information was collected on 311 cases…

View details →DOI: 10.1002/cam4.71963
Negative / Null Result ReportMedicine

Oral health-related quality of life after early extraction of primary second molars in children with congenitally missing second premolars: a randomized controlled trial with matched controls.

Naoumova, Nawaia, Krekmanova · 2026 · European journal of orthodontics

Extraction of mandibular primary second molars in patients with congenitally missing second premolars may influence oral health-related quality of life (OHRQoL), yet this has not been previously investigated. To assess the impact of…

View details →DOI: 10.1093/ejo/cjag048
Negative / Null Result ReportMedicine

Utility of Postoperative Thyroid Hormone Levels in Predicting the Diagnosis of Adult Growth Hormone Deficiency in Patients Undergoing Surgery for Nonfunctioning Pituitary Neuroendocrine Tumor: A Pilot Study.

Tsujimoto, Yamashiro, Suzuki et al. · 2026 · International journal of endocrinology

Adult growth hormone deficiency (AGHD) is often diagnosed after surgery for nonfunctioning pituitary neuroendocrine tumor (NF-PitNET). While a growth hormone stimulation test (GHST) is required to establish its diagnosis, it is associated…

View details →DOI: 10.1155/ije/8842344
Negative / Null Result ReportMedicine

Task Shifting in Cardiac Ablations Compared With Percutaneous Coronary Interventions: The Japanese Circulation Society Chugoku-Shikoku Regional Survey Subanalysis.

Fukue, Suetomi, Matsuura et al. · 2026 · Circulation reports

As part of work-style reform for physicians, task shifting to non-physician healthcare professionals has been promoted in Japan. We previously reported task shifting results for percutaneous coronary interventions (PCI), but the status in…

View details →DOI: 10.1253/circrep.cr-25-0329
Negative / Null Result ReportMedicine

Robotic Mitral Valve Repair in Patients With Thoracic Deformity.

Tomita, Kakuta, Kainuma et al. · 2026 · Circulation reports

Robotic mitral valve repair (MVr) offers superior visualization and dexterity, potentially overcoming challenges in severe thoracic deformity such as pectus excavatum. This study compared surgical outcomes after MVr in patients with and…

View details →DOI: 10.1253/circrep.cr-26-0003
Negative / Null Result ReportMedicine

The Impact of Kidney Donor Profile Index and Human Leukocyte Antigen Mismatch on Graft Survival in Pediatric Kidney Transplant Recipients.

Ranabothu, Smith, Perkins et al. · 2026 · Pediatric transplantation

Pediatric kidney transplant recipients typically receive low-KDPI deceased donor kidneys but often experience higher HLA mismatches. The relationship between KDPI and HLA mismatch and their combined effect on graft and patient outcomes in…

View details →DOI: 10.1111/petr.70351
Negative / Null Result ReportMedicine

Gemcitabine-Based versus Fluoropyrimidine-Based Chemotherapy and Role of Platinum Combination for First-Line Palliative Systemic Treatment in Advanced Ampullary Adenocarcinoma.

Wonglhow, Wetwittayakhlang, Sunpaweravong et al. · 2026 · Cancer management and research

Ampullary adenocarcinoma is a rare malignancy with limited evidence on the efficacy of systemic chemotherapy for advanced disease. This study aimed to evaluate the treatment outcomes of gemcitabine- and fluoropyrimidine-based regimens and…

View details →DOI: 10.2147/cmar.s608153
Negative / Null Result ReportMedicine

Effect of body mass on physiological and time-trial performance responses to mixed-method cooling applied between exercise bouts in the heat.

Yanaoka, Tyler, Hasegawa · 2026 · Frontiers in physiology

This study investigated the effect of body mass (BM) on the efficacy of mixed-method cooling (ice slurry ingestion + cooling vest) applied between exercise bouts. Sixteen males completed two experimental trials in the heat (35°C, 50%…

View details →DOI: 10.3389/fphys.2026.1817856