A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20261 results in Negative / Null Result Report · page 617 of 676
Moore MJ, Forkel SJ, Demeyere N · 2026 · Preprint
Lesion anatomy has been widely used to study post stroke cognitive outcomes, but it is unclear whether lesion-based measures provide clinically meaningful prognostic information beyond established predictors. Stroke survivors (n = 408)…
Bretzman J, Andrews J, Ge S et al. · 2026 · Journal of vascular and interventional radiology : JVIR
Purpose To determine the patency of portal vein stents in patients with pancreatic cancer, identify risk factors for stent occlusion, and determine whether anticoagulation improves stent patency. Materials and methods Patients with…
Corianò M, Pradegan N, Putortì F et al. · 2026 · Journal of cardiovascular development and disease
Pulmonary hypertension (PH) is associated with adverse outcomes after heart transplantation (HT). In 2022, the European Society of Cardiology introduced lower thresholds for pulmonary vascular resistance (PVR) to distinguish isolated…
Araga Y, Nakamura Y, Sugita C et al. · 2026 · Rinsho shinkeigaku = Clinical neurology
The patient was a 30-year-old man who was admitted to our department 2 months after the onset of anterograde amnesia. Cognitive function tests indicated memory impairment only. MRI FLAIR images of the head showed a high signal in the…
Pham TN, Chamseddine I, Lebhertz D et al. · 2026 · Physics in medicine and biology
Introduction. Radiation-induced optic neuropathy (RION) is a rare but functionally-disabling complication of radiotherapy for brain and head/neck tumors. Even with modern proton therapy and adherence to dose constraints, about 6% of…
Shi L, Li Y, Li C et al. · 2026 · International journal of clinical oncology
Background Comparative evidence for neoadjuvant chemoimmunotherapy (NCIT) versus neoadjuvant immunotherapy combined with chemoradiotherapy (NICRT) in locally advanced esophageal squamous cell carcinoma (ESCC) is limited. We compared…
Hatipoğlu Ö, Başar Ö, Mağat G et al. · 2026 · Scientific reports
Accurate detection of overhanging dental restorations on bitewing radiographs is clinically important but remains challenging due to subtle marginal discrepancies. This study aimed to develop and compare deep learning-based instance…
Packet B, Van Severen R, Cattani L et al. · 2026 · European journal of obstetrics, gynecology, and reproductive biology
Objectives To study the association between the subpubic arch angle and area, the latter a novel estimator of maternal pelvic outlet dimensions, and postpartum anal incontinence. Methods Convenience sample from a prospective observational…
Hwang S, Kim PH, Kim H et al. · 2026 · Preprint
Abstract Purpose Selumetinib is approved for the treatment of inoperable plexiform neurofibromas (PN) in patients with neurofibromatosis type 1 (NF1). However, its efficacy in treating NF1-associated diffuse neurofibromas (NF1-DN) or optic…
Aglen T, Matre KH, Selles RW et al. · 2026 · Journal of hand therapy : official journal of the American Society of Hand Therapists
Background Collagenase treatment can improve finger extension and hand function in patients with Dupuytren's disease. The role of hand therapy in enhancing or prolonging these effects remains unclear. Purpose The primary aim was to examine…
Steen JP, Jaiswal KS, Dilipkumar J et al. · 2026 · The journal of pain
The measurement performance of the Short-Form Brief Pain Inventory (BPI-SF) across IASP-recognized pain mechanisms remains unclear. We evaluated the reliability and structural validity of BPI-SF across clinician-assigned predominant…
Ghofranian A, Baird M, Reckhow J et al. · 2026 · Minerva obstetrics and gynecology
Background Luteal phase E2 priming is commonly used in patients with DOR to 30 synchronize follicular development before controlled ovarian hyperstimulation (COH). Some protocols 31 incorporate a GnRH antagonist during the luteal phase to…
Vardanega R, Lüdtke FL, Loureiro L et al. · 2026 · Journal of agricultural and food chemistry
This study investigated whether coencapsulation of cannabidiol (CBD) and piperine (PIP) in food-grade nanostructured lipid carriers (NLCs) enhances the CBD oral bioavailability. NLCs containing long-chain fatty acids were formulated with…
Unal RU, Ozhan O, Balkaya ES et al. · 2026 · Scientific reports
Sepsis frequently leads to cardiac dysfunction driven by oxidative stress (OS), inflammation, and conduction abnormalities. Nebivolol (NEB), a selective β1-blocker with vasodilatory and antioxidant properties, has shown organ-protective…
Perez SB, Lau JA · 2026 · Ecology
Identifying the factors mediating the resilience and invariability of plant communities and their associated ecosystem functions is critical to understand the ecological impacts of climate change. Prior work has explored how classic…
Wanjiku C · 2026 · Preprint
Abstract Background Timely initiation of breastfeeding within one hour of birth reduces neonatal mortality and supports optimal child development. Women who deliver by cesarean section (CS) face disproportionate barriers to early…
Biswas A, Zidan H, Kolodzey L et al. · 2026 · Regional anesthesia and pain medicine
Background Video-assisted thoracoscopic surgery (VATS) offers numerous advantages over open surgery; nevertheless, it remains associated with significant postoperative pain. Multiple regional anesthesia techniques have been explored, and…
Kominsky E, Ansari M, Moore M et al. · 2026 · Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
Objective To determine the association of positive margins and adjuvant radiotherapy on overall survival in parotid gland adenoid cystic carcinoma. Study design Retrospective cohort analysis. Setting National Cancer Database from 2004 to…
Buldur M, Sezer B · 2026 · Dental traumatology : official publication of International Association for Dental Traumatology
Background/aim Artificial intelligence-based chatbot systems are increasingly used for dental emergency guidance, yet the clinical value of sequential consultation remains unclear. This study investigated whether response order influences…
Ekhaguere OA, Kesman R, Reiter J et al. · 2026 · The Journal of pediatrics
Objective To evaluate whether static ultrasound improves first-attempt, nontraumatic lumbar puncture (LP) success compared with the traditional landmark technique in infants admitted to a neonatal intensive care unit (NICU). Study design…
Vranceanu AM, Szapary C, Crean M et al. · 2026 · The Gerontologist
Background and objectives We tested the feasibility and preliminary effects of the Mindfulness Self-Compassionate Care (MASC) program for dementia caregivers' stress triggered by the care recipients' neuropsychiatric symptoms. Research…
Alkhatatbeh T, Alkhatatbeh A, Liao Y et al. · 2026 · Annals of the New York Academy of Sciences
Intra-articular hyaluronic acid (IAHA) injections are used for knee osteoarthritis, but clinical response is highly variable. This study evaluated whether quantitative magnetic resonance imaging (MRI) radiomics provides incremental…
Schlaepfer CH, Lange SM, Lau GA et al. · 2026 · JAMA pediatrics
Importance People with spina bifida historically have worse survival. Despite health care improvements, survival improvement data are mixed. Objectives To compare survival for people with spina bifida to an unaffected cohort and to…
Isaacs J, Bendale G, Reiter C et al. · 2025 · Journal of reconstructive microsurgery
Polyethylene glycol (PEG) hydrogel is capable of fusing transected axons and restoring axonal continuity. The technique requires precise nerve coaptation alignment and stability, which is difficult to achieve utilizing conventional…
Kar N, Rana SS, Gupta R et al. · 2026 · Pancreas
Background and aims Endoscopic ultrasound (EUS)-guided drainage using a lumen-apposing metal stent (LAMS) has become the standard of care in managing symptomatic walled-off necrosis (WON). However, the role of nasocystic drainage (NCD) in…
Morningstar M, Edwards M, Yang L et al. · 2026 · CJEM
Objectives To systematically identify and describe optimal methodology used to improve the diagnostic accuracy of high-sensitivity cardiac troponin for diagnosis of myocardial infarction in patients with kidney dysfunction. Methods…
Sroypechr K, Hutchinson C, Satheannoppakao W et al. · 2026 · BMC nutrition
Background The folate status of women of reproductive age (WRA) in Thailand is suboptimal for reducing risk of neural tube defects (NTD). This research aimed to compare the effect of dietary folate education based on the health belief…
Thurm C, Keating LH, Raja MU et al. · 2026 · Respiratory medicine
Rationale Although low-dose computed tomography (LDCT) performed for lung cancer screening (LCS) frequently identifies previously unrecognized significant incidental findings (SIFs), the most effective way to report these findings remains…
Hong S, Lee S, Park JS et al. · 2026 · Journal of clinical medicine
Background : We evaluated whether adding S100B to NSE improved discrimination or high-specificity rule-in of poor neurological outcome after out-of-hospital cardiac arrest (OHCA). Methods : In this single-center retrospective cohort study,…
Fesseler L, Patzak A, Heinz V et al. · 2026 · Experimental physiology
High-intensity exercise induces systemic acidosis, which contributes to muscular performance decline. Controlled pre-exercise hyperventilation has been proposed as a non-invasive intervention to induce respiratory alkalosis and counteract…